Stebbings S, Treharne GJ. Fatigue in rheumatic disease: an overview. Int J Clin Rheumatol. 2010;5:487–502.
Article
Google Scholar
Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken). 2013;65:1128–46.
Article
Google Scholar
Bergman MJ, Shahouri SH, Shaver TS, Anderson JD, Weidensaul DN, Busch RE, et al. Is fatigue an inflammatory variable in rheumatoid arthritis (RA)? Analyses of fatigue in RA, osteoarthritis, and fibromyalgia. J Rheumatol. 2009;36:2788–94.
Article
PubMed
Google Scholar
Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology (Oxford). 2006;45:885–9.
Article
CAS
Google Scholar
van Dartel SA, Repping-Wuts JW, van Hoogmoed D, Bleijenberg G, van Riel PL, Fransen J. Association between fatigue and pain in rheumatoid arthritis: does pain precede fatigue or does fatigue precede pain? Arthritis Care Res (Hoboken). 2013;65:862–9.
Article
Google Scholar
Kirwan J, Heiberg T, Hewlett S, Hughes R, Kvien T, Ahlmen M, et al. Outcomes from the Patient Perspective Workshop at OMERACT 6. J Rheumatol. 2003;30:868–72.
PubMed
Google Scholar
Singh H, Arya S, Talapatra P, Lather K, Mathur R, Singhania A, et al. Assessment of fatigue in rheumatoid arthritis (by Functional Assessment of Chronic Illness Therapy-Fatigue score) and its relation to disease activity and anemia. J Clin Rheumatol. 2014;20:87–90.
Article
PubMed
Google Scholar
Chauffier K, Paternotte S, Burki V, Durnez A, Elhai M, Koumakis E, et al. Fatigue in spondyloarthritis: a marker of disease activity. A cross-sectional study of 266 patients. Clin Exp Rheumatol. 2013;31:864–70.
PubMed
Google Scholar
Basu N, McClean A, Harper L, Amft EN, Dhaun N, Luqmani RA, et al. Explaining fatigue in ANCA-associated vasculitis. Rheumatology (Oxford). 2013;52:1680–5.
Article
Google Scholar
Lee YC, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Williams DA, et al. Subgrouping of patients with rheumatoid arthritis based on pain, fatigue, inflammation, and psychosocial factors. Arthritis Rheumatol. 2014;66:2006–14.
Article
PubMed Central
PubMed
Google Scholar
Wolfe F, Hawley DJ, Wilson K. The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol. 1996;23:1407–17.
CAS
PubMed
Google Scholar
Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD. Occurrence and correlates of fatigue in psoriatic arthritis. Ann Rheum Dis. 2009;68:1553–8.
Article
CAS
PubMed
Google Scholar
Hewlett S, Chalder T, Choy E, Cramp F, Davis B, Dures E, et al. Fatigue in rheumatoid arthritis: time for a conceptual model. Rheumatology (Oxford). 2011;50:1004–6.
Article
Google Scholar
Norheim KB, Jonsson G, Omdal R. Biological mechanisms of chronic fatigue. Rheumatology (Oxford). 2011;50:1009–18.
Article
CAS
Google Scholar
Rohleder N, Aringer M, Boentert M. Role of interleukin-6 in stress, sleep, and fatigue. Ann N Y Acad Sci. 2012;1261:88–96.
Article
CAS
PubMed
Google Scholar
Nicassio PM, Moxham EG, Schuman CE, Gevirtz RN. The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain. 2002;100:271–9.
Article
PubMed
Google Scholar
Neuberger GB, Press AN, Lindsley HB, Hinton R, Cagle PE, Carlson K, et al. Effects of exercise on fatigue, aerobic fitness, and disease activity measures in persons with rheumatoid arthritis. Res Nurs Health. 1997;20:195–204.
Article
CAS
PubMed
Google Scholar
Rongen-van Dartel SA, Repping-Wuts H, van Hoogmoed D, Knoop H, Bleijenberg G, van Riel PL, et al. Relationship between objectively assessed physical activity and fatigue in patients with rheumatoid arthritis: inverse correlation of activity and fatigue. Arthritis Care Res (Hoboken). 2014;66:852–60.
Article
CAS
Google Scholar
Stebbings SM, Treharne GJ, Jenks K, Highton J. Fatigue in patients with spondyloarthritis associates with disease activity, quality of life and inflammatory bowel symptoms. Clin Rheumatol. 2013;33:1467–74.
Article
PubMed
Google Scholar
Hammoudeh M, Zack DJ, Li W, Stewart VM, Koenig AS. Associations between inflammation, nocturnal back pain and fatigue in ankylosing spondylitis and improvements with etanercept therapy. J Int Med Res. 2013;41:1150–9.
Article
PubMed
Google Scholar
Goedendorp MM, Tack CJ, Steggink E, Bloot L, Bazelmans E, Knoop H. Chronic fatigue in type 1 diabetes: highly prevalent but not explained by hyperglycemia or glucose variability. Diabetes Care. 2014;37:73–80.
Article
PubMed
Google Scholar
Willems LM, Kwakkenbos L, Leite CC, Thombs BD, van den Hoogen FH, Maia AC, et al. Frequency and impact of disease symptoms experienced by patients with systemic sclerosis from five European countries. Clin Exp Rheumatol. 2014;32:S-88-93.
Pellino G, Sciaudone G, Caserta V, Candilio G, De Fatico GS, Gagliardi S, et al. Fatigue in inflammatory bowel diseases: relationship with age and disease activity. Int J Surg. 2014;12:S60–3.
Article
PubMed
Google Scholar
Meyers CA, Albitar M, Estey E. Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer. 2005;104:788–93.
Article
CAS
PubMed
Google Scholar
Reyes-Gibby CC, Wang J, Spitz M, Wu X, Yennurajalingam S, Shete S. Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. J Pain Symptom Manage. 2013;46:161–72.
Article
PubMed Central
PubMed
Google Scholar
Miaskowski C, Cooper BA, Dhruva A, Dunn LB, Langford DJ, Cataldo JK, et al. Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers. PLoS One. 2012;7:e40560.
Article
PubMed Central
CAS
PubMed
Google Scholar
Irwin MR. Inflammation at the intersection of behavior and somatic symptoms. Psychiatr Clin North Am. 2013;34:605–20.
Article
Google Scholar
Bower JE. Cancer-related fatigue: links with inflammation in cancer patients and survivors. Brain Behav Immun. 2007;21:863–71.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bower JE. Cancer-related fatigue - mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11:597–609.
Article
PubMed Central
CAS
PubMed
Google Scholar
Illi J, Miaskowski C, Cooper B, Levine JD, Dunn L, West C, et al. Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression. Cytokine. 2012;58:437–47.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bates DW, Schmitt W, Buchwald D, Ware NC, Lee J, Thoyer E, et al. Prevalence of fatigue and chronic fatigue syndrome in a primary care practice. Arch Intern Med. 1993;153:2759–65.
Article
CAS
PubMed
Google Scholar
Bowman SJ, Hamburger J, Richards A, Barry RJ, Rauz S. Patient-reported outcomes in primary Sjogren’s syndrome: comparison of the long and short versions of the Profile of Fatigue and Discomfort - Sicca Symptoms Inventory. Rheumatology (Oxford). 2009;48:140–3.
Article
CAS
Google Scholar
Jump RL, Robinson ME, Armstrong AE, Barnes EV, Kilbourn KM, Richards HB. Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support. J Rheumatol. 2005;32:1699–705.
PubMed
Google Scholar
Grayson PC, Amudala NA, McAlear CA, Leduc RL, Shereff D, Richesson R, et al. Illness perceptions and fatigue in systemic vasculitis. Arthritis Care Res (Hoboken). 2013;65:1835–43.
Article
Google Scholar
Gossec L, Berenbaum F, Chauvin P, Lamiraud K, Russo-Marie F, Joubert JM, et al. Reporting of patient-perceived impact of rheumatoid arthritis and axial spondyloarthritis over 10 years: a systematic literature review. Rheumatology (Oxford). 2014;53:1274–81.
Article
Google Scholar
Repping-Wuts H, Repping T, van Riel P, van Achterberg T. Fatigue communication at the out-patient clinic of Rheumatology. Patient Educ Couns. 2009;76:57–62.
Article
PubMed
Google Scholar
Repping-Wuts H, Fransen J, van Achterberg T, Bleijenberg G, van Riel P. Persistent severe fatigue in patients with rheumatoid arthritis. J Clin Nurs. 2007;16:377–83.
Article
PubMed
Google Scholar
van Hoogmoed D, Fransen J, Bleijenberg G, van Riel P. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology (Oxford). 2010;49:1294–302.
Article
Google Scholar
Haywood KL, Packham JC, Jordan KP. Assessing fatigue in ankylosing spondylitis: the importance of frequency and severity. Rheumatology (Oxford). 2013;53:552–6.
Article
Google Scholar
Hewlett S, Hehir M, Kirwan JR. Measuring fatigue in rheumatoid arthritis: a systematic review of scales in use. Arthritis Rheum. 2007;57:429–39.
Article
CAS
PubMed
Google Scholar
Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315–25.
Article
CAS
PubMed
Google Scholar
Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85:1186–96.
Article
CAS
PubMed
Google Scholar
Wolfe F. Fatigue assessments in rheumatoid arthritis: comparative performance of visual analog scales and longer fatigue questionnaires in 7760 patients. J Rheumatol. 2004;31:1896–902.
PubMed
Google Scholar
Conigliaro P, Triggianese P, Ippolito F, Lucchetti R, Chimenti MS, Perricone R. Insights on the role of physical activity in patients with rheumatoid arthritis. Drug Dev Res. 2014;75:S54–6.
Article
CAS
PubMed
Google Scholar
Scott DL. Leflunomide improves quality of life in rheumatoid arthritis. Scand J Rheumatol Suppl. 1999;112:23–9.
Article
CAS
PubMed
Google Scholar
Chauffier K, Salliot C, Berenbaum F, Sellam J. Effect of biotherapies on fatigue in rheumatoid arthritis: a systematic review of the literature and meta-analysis. Rheumatology (Oxford). 2012;51:60–8.
Article
CAS
Google Scholar
Strand V, Burmester GR, Zerbini CA, Mebus CA, Zwillich SH, Gruben D, et al. Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: patient-reported outcomes from a Phase 3 trial. Arthritis Care Res (Hoboken). 2015;67:475–83.
Article
CAS
Google Scholar
Strand V, Kosinski M, Gnanasakthy A, Mallya U, Mpofu S. Secukinumab treatment in rheumatoid arthritis is associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds. Health Qual Life Outcomes. 2014;12:31.
Article
PubMed Central
PubMed
Google Scholar
Wells G, Li T, Maxwell L, Maclean R, Tugwell P. Responsiveness of patient reported outcomes including fatigue, sleep quality, activity limitation, and quality of life following treatment with abatacept for rheumatoid arthritis. Ann Rheum Dis. 2008;67:260–5.
Article
CAS
PubMed
Google Scholar
Minnock P, Kirwan J, Bresnihan B. Fatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritis. Rheumatology (Oxford). 2009;48:1533–6.
Article
Google Scholar
Durcan L, Wilson F, Cunnane G. The effect of exercise on sleep and fatigue in rheumatoid arthritis: a randomized controlled study. J Rheumatol. 2014;41:1966–73.
Article
PubMed
Google Scholar
Hewlett S, Ambler N, Almeida C, Cliss A, Hammond A, Kitchen K, et al. Self-management of fatigue in rheumatoid arthritis: a randomised controlled trial of group cognitive-behavioural therapy. Ann Rheum Dis. 2011;70:1060–7.
Article
PubMed Central
PubMed
Google Scholar
Garip Y, Eser F, Aktekin LA, Bodur H. Fatigue in rheumatoid arthritis: association with severity of pain, disease activity and functional status. Acta Reumatol Port. 2011;36:364–9.
PubMed
Google Scholar
Huyser BA, Parker JC, Thoreson R, Smarr KL, Johnson JC, Hoffman R. Predictors of subjective fatigue among individuals with rheumatoid arthritis. Arthritis Rheum. 1998;41:2230–7.
Article
CAS
PubMed
Google Scholar
Norden DM, Bicer S, Clark Y, Jing R, Henry CJ, Wold LE, et al. Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function. Brain Behav Immun. 2014;43:76–85.
Article
PubMed
Google Scholar
Bluthe RM, Beaudu C, Kelley KW, Dantzer R. Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Res. 1995;677:171–6.
Article
CAS
PubMed
Google Scholar
Arnett SV, Clark IA. Inflammatory fatigue and sickness behaviour - lessons for the diagnosis and management of chronic fatigue syndrome. J Affect Disord. 2012;141:130–42.
Article
CAS
PubMed
Google Scholar
Neu D, Mairesse O, Montana X, Gilson M, Corazza F, Lefevre N, et al. Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome. Eur J Appl Physiol. 2014;114:1841–51.
Article
CAS
PubMed
Google Scholar
Heinzelmann M, Lee H, Rak H, Livingston W, Barr T, Baxter T, et al. Sleep restoration is associated with reduced plasma C-reactive protein and depression symptoms in military personnel with sleep disturbance after deployment. Sleep Med. 2014;15:1565–70.
Article
PubMed
Google Scholar
Masson C. Rheumatoid anemia. Joint Bone Spine. 2011;78:131–7.
Article
CAS
PubMed
Google Scholar
Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med. 2010;332:1351–62.
Google Scholar
Sprangers MA, Thong MS, Bartels M, Barsevick A, Ordonana J, Shi Q, et al. Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update. Qual Life Res. 2014;23:1997–2013.
Article
PubMed Central
PubMed
Google Scholar
Dantzer R, Heijnen CJ, Kavelaars A, Laye S, Capuron L. The neuroimmune basis of fatigue. Trends Neurosci. 2014;37:39–46.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mizuno K, Tajima K, Watanabe Y, Kuratsune H. Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge. Behav Brain Funct. 2014;10:25.
Article
PubMed Central
PubMed
Google Scholar
Tachibana A, Noah JA, Bronner S, Ono Y, Hirano Y, Niwa M, et al. Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: an fMRI approach. Behav Brain Funct. 2012;8:26.
Article
PubMed Central
PubMed
Google Scholar
Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140:774–815.
Article
PubMed Central
PubMed
Google Scholar
Thomson CA, McColl A, Cavanagh J, Graham GJ. Peripheral inflammation is associated with remote global gene expression changes in the brain. J Neuroinflammation. 2014;11:73.
Article
PubMed Central
PubMed
Google Scholar
Anisman H. Inflaming depression. J Psychiatry Neurosci. 2011;36:291–5.
Article
PubMed Central
PubMed
Google Scholar
Tweedie D, Sambamurti K, Greig NH. TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr Alzheimer Res. 2007;4:378–85.
Article
CAS
PubMed
Google Scholar
Schaible HG. Nociceptive neurons detect cytokines in arthritis. Arthritis Res Ther. 2014;16:470.
Article
PubMed Central
PubMed
Google Scholar
Richter F, Natura G, Loser S, Schmidt K, Viisanen H, Schaible HG. Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats. Arthritis Rheum. 2010;62:3806–14.
Article
CAS
PubMed
Google Scholar
Walsh DA, McWilliams DF. Mechanisms, impact and management of pain in rheumatoid arthritis. Nat Rev Rheumatol. 2014;10:581–92.
Article
CAS
PubMed
Google Scholar
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446–57.
Article
CAS
PubMed
Google Scholar
Zalli A, Jovanova O, Hoogendijk WJ, Tiemeier H, Carvalho LA. Low-grade inflammation predicts persistence of depressive symptoms. Psychopharmacology (Berl). 2015. [Epub ahead of print].
Iyengar RL, Gandhi S, Aneja A, Thorpe K, Razzouk L, Greenberg J, et al. NSAIDs are associated with lower depression scores in patients with osteoarthritis. Am J Med. 2013;126:1017. e11-8.
Article
PubMed
Google Scholar
Basterzi AD, Aydemir C, Kisa C, Aksaray S, Tuzer V, Yazici K, et al. IL-6 levels decrease with SSRI treatment in patients with major depression. Hum Psychopharmacol. 2005;20:473–6.
Article
CAS
PubMed
Google Scholar
Lasselin J, Capuron L. Chronic low-grade inflammation in metabolic disorders: relevance for behavioral symptoms. Neuroimmunomodulation. 2014;21:95–101.
CAS
PubMed
Google Scholar
Lampa J, Westman M, Kadetoff D, Agreus AN, Le Maitre E, Gillis-Haegerstrand C, et al. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proc Natl Acad Sci U S A. 2012;109:12728–33.
Article
PubMed Central
CAS
PubMed
Google Scholar
Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968–80.
Article
CAS
PubMed
Google Scholar
Laird BJ, McMillan DC, Fayers P, Fearon K, Kaasa S, Fallon MT, et al. The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer. Oncologist. 2013;18:1050–5.
Article
PubMed Central
PubMed
Google Scholar
Schrepf A, Clevenger L, Christensen D, DeGeest K, Bender D, Ahmed A, et al. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability. Brain Behav Immun. 2013;30:S126–34.
Article
PubMed Central
CAS
PubMed
Google Scholar
Watkins LR, Wiertelak EP, Goehler LE, Smith KP, Martin D, Maier SF. Characterization of cytokine-induced hyperalgesia. Brain Res. 1994;654:15–26.
Article
CAS
PubMed
Google Scholar
Maier SF, Wiertelak EP, Martin D, Watkins LR. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res. 1993;623:321–4.
Article
CAS
PubMed
Google Scholar
Maes M, Twisk FN, Kubera M, Ringel K. Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-alpha, PMN-elastase, lysozyme and neopterin. J Affect Disord. 2012;136:933–9.
Article
CAS
PubMed
Google Scholar
Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, et al. Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET Study. J Nucl Med. 2014;55:945–50.
Article
CAS
PubMed
Google Scholar
McLean MH, Dieguez Jr D, Miller LM, Young HA. Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut. 2015;64:332–41.
Article
CAS
PubMed
Google Scholar
Galland L. The gut microbiome and the brain. J Med Food. 2014;17:1261–72.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goksan S, Hartley C, Emery F, Cockrill N, Poorun R, Moultrie F, et al. fMRI reveals neural activity overlap between adult and infant pain. Elife. 2015;4. doi:10.7554/eLife.06356.