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  1. In a cross between two mouse strains, the susceptible B10.RIII (H-2r) and resistant RIIIS/J (H-2r) strains, a locus on mouse chromosome 5 (Eae39) was previously shown to control experimental autoimmune encephalom...

    Authors: Therese Lindvall, Jenny Karlsson, Rikard Holmdahl and Ã…sa Andersson
    Citation: Arthritis Research & Therapy 2009 11:R10
    Content type: Research article Published on:

  2. TNFα is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNFα activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; howe...

    Authors: Jason S Rockel, Suzanne M Bernier and Andrew Leask
    Citation: Arthritis Research & Therapy 2009 11:R8
    Content type: Research article Published on:

  3. Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA is worse in females or males. Recent reports sug...

    Authors: Tuulikki Sokka, Sergio Toloza, Maurizio Cutolo, Hannu Kautiainen, Heidi Makinen, Feride Gogus, Vlado Skakic, Humeira Badsha, Tõnu Peets, Asta Baranauskaite, Pál Géher, Ilona Újfalussy, Fotini N Skopouli, Maria Mavrommati, Rieke Alten, Christof Pohl…
    Citation: Arthritis Research & Therapy 2009 11:R7
    Content type: Research article Published on:

  4. The high-affinity receptor for IgG Fcγ/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-...

    Authors: Yi Li, Pui Y Lee, Eric S Sobel, Sonali Narain, Minoru Satoh, Mark S Segal, Westley H Reeves and Hanno B Richards
    Citation: Arthritis Research & Therapy 2009 11:R6
    Content type: Research article Published on:

  5. The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proi...

    Authors: Olivier Jaen, Elisabeth Petit-Teixeira, Holger Kirsten, Peter Ahnert, Luca Semerano, Céline Pierlot, Francois Cornelis, Marie-Christophe Boissier and Geraldine Falgarone
    Citation: Arthritis Research & Therapy 2009 11:R5
    Content type: Research article Published on:

  6. The local production of pathogenic autoantibodies by plasma cells in synovium is one of the hallmarks of rheumatoid arthritis (RA). There may be a potential link between ectopic lymphoid neogenesis and the loc...

    Authors: Weijia Dong, Xiaoyan Li, Yuan Feng, Chunmei Fan, Zhinan Chen and Ping Zhu
    Citation: Arthritis Research & Therapy 2009 11:R4
    Content type: Research article Published on:

  7. In rheumatoid arthritis (RA), synovial fluid (SF) contains a large number of neutrophils that contribute to the inflammation and destruction of the joints. The SF also contains granulocyte-macrophage colony-st...

    Authors: Masayoshi Katano, Kazuki Okamoto, Mitsumi Arito, Yuki Kawakami, Manae S Kurokawa, Naoya Suematsu, Sonoko Shimada, Hiroshi Nakamura, Yang Xiang, Kayo Masuko, Kusuki Nishioka, Kazuo Yudoh and Tomohiro Kato
    Citation: Arthritis Research & Therapy 2009 11:R3
    Content type: Research article Published on:

  9. The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA).

    Authors: Yu M Tan, Mikkel Østergaard, Anthony Doyle, Nicola Dalbeth, Maria Lobo, Quentin Reeves, Elizabeth Robinson, William J Taylor, Peter B Jones, Karen Pui, Jamie Lee and Fiona M McQueen
    Citation: Arthritis Research & Therapy 2009 11:R2
    Content type: Research article Published on:

  10. Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various clinical manifestations. Several cytokines interact and play pathological roles in SLE, although the etiopatholo...

    Authors: Hooi-Ming Lee, Toru Mima, Hidehiko Sugino, Chieko Aoki, Yasuo Adachi, Naoko Yoshio-Hoshino, Kenichi Matsubara and Norihiro Nishimoto
    Citation: Arthritis Research & Therapy 2009 11:R1
    Content type: Research article Published on:

  11. Rheumatoid arthritis (RA) is characterized by synovial inflammation with local accumulation of mononuclear cells such as macrophages and lymphocytes. We previously demonstrated that intra-articular glucocortic...

    Authors: Dimitrios Makrygiannakis, Shankar Revu, Petra Neregård, Erik af Klint, Omri Snir, Cecilia Grundtman and Anca Irinel Catrina
    Citation: Arthritis Research & Therapy 2008 10:R147
    Content type: Research article Published on:

  12. Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematop...

    Authors: Nadia Zayed, Xinfang Li, Nadir Chabane, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicolas Duval and Hassan Fahmi
    Citation: Arthritis Research & Therapy 2008 10:R146
    Content type: Research article Published on:

  14. Rheumatoid arthritis (RA) associates with excessive cardiovascular morbidity and mortality, attributed to both traditional and novel cardiovascular risk factors. The metabolic syndrome, a cluster of classical ...

    Authors: Tracey E Toms, Vasileios F Panoulas, Karen MJ Douglas, Helen R Griffiths and George D Kitas
    Citation: Arthritis Research & Therapy 2008 10:R145
    Content type: Research article Published on:

  15. We estimated the cost effectiveness of concomitant proton pump inhibitors (PPIs) in relation to the occurrence of non-steroidal anti-inflammatory drug (NSAID) ulcer complications.

    Authors: Harald E Vonkeman, Louise MA Braakman-Jansen, Rogier M Klok, Maarten J Postma, Jacobus RBJ Brouwers and Mart AFJ van de Laar
    Citation: Arthritis Research & Therapy 2008 10:R144
    Content type: Research article Published on:

  16. During the last decade, the quantitative ultrasound technique has been widely employed as a versatile modality to investigate a thin but crucial tissue layer – the articular cartilage. Previous studies provide...

    Authors: Yong-Ping Zheng and Yan-Ping Huang
    Citation: Arthritis Research & Therapy 2008 10:125
    Content type: Editorial Published on:

  17. Antiphospholipid syndrome is diagnosed when arterial or venous thrombosis or recurrent miscarriages occur in a person in whom laboratory tests for antiphospholipid antibodies (anticardiolipin antibodies and/or...

    Authors: Gerard Espinosa and Ricard Cervera
    Citation: Arthritis Research & Therapy 2008 10:230
    Content type: Review Published on:

  18. Although vastus medialis and lateralis are important determinants of patellofemoral joint function, their relationship with patellofemoral joint structure is unknown. The aim of this study was to examine poten...

    Authors: Patricia A Berry, Andrew J Teichtahl, Ana Galevska-Dimitrovska, Fahad S Hanna, Anita E Wluka, Yuanyuan Wang, Donna M Urquhart, Dallas R English, Graham G Giles and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2008 10:R143
    Content type: Research article Published on:

  19. Antibodies against cyclic citrullinated peptides (CCPs) are useful for diagnosing rheumatoid arthritis (RA). Antibodies to mutated citrullinated vimentin (MCV) were described recently in RA. The aims of this s...

    Authors: Pascale Nicaise Roland, Sabine Grootenboer Mignot, Alessandra Bruns, Margarita Hurtado, Elisabeth Palazzo, Gilles Hayem, Philippe Dieudé, Olivier Meyer and Sylvie Chollet Martin
    Citation: Arthritis Research & Therapy 2008 10:R142
    Content type: Research article Published on:

  20. Interleukin-6 (IL-6) is thought to play a pathogenic role in rheumatoid arthritis and synovium is a major source of IL-6 release. We investigated the ability of retinoids to suppress IL-6 expression in IL-1-st...

    Authors: Mélanie Kirchmeyer, Meriem Koufany, Sylvie Sebillaud, Patrick Netter, Jean-Yves Jouzeau and Arnaud Bianchi
    Citation: Arthritis Research & Therapy 2008 10:R141
    Content type: Research article Published on:

  21. Although transforming growth factor β1 (TGFβ1) is known to be a potent inhibitor of proliferation in most cell types, it accelerates proliferation in certain mesenchymal cells, such as articular chondrocytes a...

    Authors: Tomoko Nakai, Joji Mochida and Daisuke Sakai
    Citation: Arthritis Research & Therapy 2008 10:R140
    Content type: Research article Published on:

  22. The prognostic implications of declining plasma gelsolin levels have been documented after a diverse variety of acute insults. Because gelsolin concentrations fall prior to the development of complications, a ...

    Authors: Mark J DiNubile
    Citation: Arthritis Research & Therapy 2008 10:124
    Content type: Editorial Published on:

  24. Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A co...

    Authors: Anders Tveita, Ole Petter Rekvig and Svetlana N Zykova
    Citation: Arthritis Research & Therapy 2008 10:229
    Content type: Review Published on:

  25. We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-β)-driven matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondr...

    Authors: Peter S Burrage, Adam C Schmucker, Yanqing Ren, Michael B Sporn and Constance E Brinckerhoff
    Citation: Arthritis Research & Therapy 2008 10:R139
    Content type: Research article Published on:

  26. The disease activity in patients with rheumatoid arthritis has improved during the past decade. The availability of new drugs and also a better assessment of the disease have been proposed to be responsible fo...

    Authors: Isidoro González-Alvaro, Miguel Angel Descalzo and Loreto Carmona
    Citation: Arthritis Research & Therapy 2008 10:R138
    Content type: Research article Published on:

  29. The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being ...

    Authors: Rebeccah J Mathews, Michael B Sprakes and Michael F McDermott
    Citation: Arthritis Research & Therapy 2008 10:228
    Content type: Review Published on:

  30. Sjögren syndrome (SjS) is a systemic autoimmune disease in which an immunological attack primarily against the salivary and lacrimal glands results in the loss of acinar cell tissue and function, leading to st...

    Authors: Cuong Q Nguyen, Janet G Cornelius, Lauren Cooper, Jonathan Neff, Joann Tao, Byung Ha Lee and Ammon B Peck
    Citation: Arthritis Research & Therapy 2008 10:R137
    Content type: Research article Published on:

  32. T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism of action are largely undetermined.

    Authors: Fang Du, Liang-jing Lü, Qiong Fu, Min Dai, Jia-lin Teng, Wei Fan, Shun-le Chen, Ping Ye, Nan Shen, Xin-fang Huang, Jie Qian and Chun-de Bao
    Citation: Arthritis Research & Therapy 2008 10:R136
    Content type: Research article Published on:

  33. Type II collagen is a DR4/DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at dif...

    Authors: Francesco Ria, Romina Penitente, Maria De Santis, Chiara Nicolò, Gabriele Di Sante, Massimiliano Orsini, Dario Arzani, Andrea Fattorossi, Alessandra Battaglia and Gian Franco Ferraccioli
    Citation: Arthritis Research & Therapy 2008 10:R135
    Content type: Research article Published on:

  35. Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investig...

    Authors: Hui Geng, Stefan Carlsen, Kutty Selva Nandakumar, Rikard Holmdahl, Anders Aspberg, Ã…ke Oldberg and Ragnar Mattsson
    Citation: Arthritis Research & Therapy 2008 10:R134
    Content type: Research article Published on:

  36. Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate t...

    Authors: Toshiyuki Okura, Kousuke Marutsuka, Hiroaki Hamada, Tomohisa Sekimoto, Tsuyoshi Fukushima, Yujiro Asada, Kazuo Kitamura and Etsuo Chosa
    Citation: Arthritis Research & Therapy 2008 10:R133
    Content type: Research article Published on:

  38. The present study established characteristics of tissue regrowth in patients suffering knee lesions treated with grafts of autologous chondrocytes grown on three-dimensional hyaluronic acid biomaterials.

    Authors: Paola Brun, Sally C Dickinson, Barbara Zavan, Roberta Cortivo, Anthony P Hollander and Giovanni Abatangelo
    Citation: Arthritis Research & Therapy 2008 10:R132
    Content type: Research article Published on:

  39. Autoantibodies to the ribosomal P proteins represent a highly specific marker for the diagnosis of systemic lupus erythematosus, where they have been associated with certain clinical manifestations. Historical...

    Authors: Michael Mahler, Jennifer T Ngo, Johannes Schulte-Pelkum, Tanja Luettich and Marvin J Fritzler
    Citation: Arthritis Research & Therapy 2008 10:R131
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2009 11:402

  40. Arthritis induced by immunisation with glucose-6-phosphate isomerase (GPI) in DBA/1 mice was proven to be T helper (Th) 17 dependent. We undertook this study to identify GPI-specific T cell epitopes in DBA/1 m...

    Authors: Keiichi Iwanami, Isao Matsumoto, Yoko Tanaka, Asuka Inoue, Daisuke Goto, Satoshi Ito, Akito Tsutsumi and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2008 10:R130
    Content type: Research article Published on:

  41. Cartilage thickness and volume loss measurements using quantitative magnetic resonance imaging (qMRI) are suggested to detect significant cartilage changes over short time intervals. We aimed to compare these ...

    Authors: Jean-Pierre Raynauld, Johanne Martel-Pelletier, François Abram, Marc Dorais, Boulos Haraoui, Denis Choquette, Peter Bias, Karl H Emmert, Stefan Laufer and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2008 10:R129
    Content type: Research article Published on:

  42. Patients with rheumatoid arthritis (RA) have an increased frequency of osteoporosis, mainly because of increased bone resorption. Reduction of disease activity is suggested to reduce bone remodelling. It might...

    Authors: Inga-Lill Engvall, Björn Svensson, Birgitta Tengstrand, Kerstin Brismar and Ingiäld Hafström
    Citation: Arthritis Research & Therapy 2008 10:R128
    Content type: Research article Published on:

  43. Treatment with sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be efficacious in the MRL/lpr and NZB × NZW F1 mouse models of lupus nephritis, indicating a critical role for the ...

    Authors: Padmalatha S Reddy, Holly M Legault, Joseph P Sypek, Mark J Collins, Elizabeth Goad, Samuel J Goldman, Wei Liu, Stuart Murray, Andrew J Dorner and Margot O'Toole
    Citation: Arthritis Research & Therapy 2008 10:R127
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2009 11:407

  44. There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atheroscl...

    Authors: Joan M Von Feldt
    Citation: Arthritis Research & Therapy 2008 10:121
    Content type: Editorial Published on:

  45. Congenital dysplasia of the hip is an abnormal seating of the femoral head in the acetabulum, mainly caused by shallow acetabulum and lax joint capsule. Genetic factors play a considerable role in the pathogen...

    Authors: Jin Dai, Dongquan Shi, Pengsheng Zhu, Jianghui Qin, Haijian Ni, Yong Xu, Chen Yao, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Jia Wei, Baorui Liu, Shiro Ikegawa, Qing Jiang and Yitao Ding
    Citation: Arthritis Research & Therapy 2008 10:R126
    Content type: Research article Published on:

  46. Recent data about radiographic progression during treatment with tumor necrosis factor-alpha (TNF-α) blocker agents in patients with ankylosing spondylitis (AS) have prompted an intensive discussion about the ...

    Authors: Heiner Appel, Louise Janssen, Joachim Listing, René Heydrich, Martin Rudwaleit and Joachim Sieper
    Citation: Arthritis Research & Therapy 2008 10:R125
    Content type: Research article Published on:

  47. The purpose of the present study was to systematically review the effect of cyclophosphamide treatment on pulmonary function in patients with systemic sclerosis and interstitial lung disease.

    Authors: Carlotta Nannini, Colin P West, Patricia J Erwin and Eric L Matteson
    Citation: Arthritis Research & Therapy 2008 10:R124
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2009 11:408

  48. Both experimental and clinical data provide evidence that vitamin D is one of those important environmental factors that can increase the prevalence of certain autoimmune diseases such as systemic lupus erythe...

    Authors: Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi and Edit Bodolay
    Citation: Arthritis Research & Therapy 2008 10:R123
    Content type: Research article Published on:

  50. Osteoarthritis (OA) is increasingly prevalent worldwide and is associated with a significant economic burden. Despite the increasing number of patients with OA, treatments to manage the condition remain sympto...

    Authors: Francis Berenbaum
    Citation: Arthritis Research & Therapy 2008 10(Suppl 2):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 10 Supplement 2

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Arthritis Research & Therapy

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