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  1. Fibronectin fragments have been found in the articular cartilage and synovial fluid of patients with osteoarthritis and rheumatoid arthritis. These matrix fragments can stimulate production of multiple mediato...

    Authors: David Long, Simon Blake, Xiao-Yu Song, Michael Lark and Richard F Loeser
    Citation: Arthritis Research & Therapy 2008 10:R23
    Content type: Research article Published on:

  2. Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins analy...

    Authors: Nicolas Delaleu, Heike Immervoll, Janet Cornelius and Roland Jonsson
    Citation: Arthritis Research & Therapy 2008 10:R22
    Content type: Research article Published on:

  3. In a recent research article in Arthritis Research and Therapy ('Analysis of C204 and the C4 binding protein in the MRL/lpr mouse'), Wenderfer and colleagues report that deficiency in C4 binding protein, a down-r...

    Authors: Michael M Frank and C Garren Hester
    Citation: Arthritis Research & Therapy 2008 10:104
    Content type: Editorial Published on:

  4. The objective of this study was to investigate the relationship of the IL-6 promoter variants G-597A, G-572C and G-174C (rs1800797, rs1800796 and rs1800795, respectively), which have been shown to affect both the...

    Authors: Olli-Pekka Kämäräinen, Svetlana Solovieva, Tapio Vehmas, Katariina Luoma, Hilkka Riihimäki, Leena Ala-Kokko, Minna Männikkö and Päivi Leino-Arjas
    Citation: Arthritis Research & Therapy 2008 10:R21
    Content type: Research article Published on:

  5. Communicating risk is difficult. Although different methods have been proposed – using numbers, words, pictures or combinations – none has been extensively tested. We used electronic and bibliographic searches...

    Authors: R Andrew Moore, Sheena Derry, Henry J McQuay and John Paling
    Citation: Arthritis Research & Therapy 2008 10:R20
    Content type: Research article Published on:

  6. Dietary flavonols may play an important role in the adjunct therapy of chronic inflammation. The availability of therapeutic formulations of pentahydroxyflavone glycoside, rutoside (RU), led us to investigate ...

    Authors: Tina Kauss, Daniel Moynet, Jérôme Rambert, Abir Al-Kharrat, Stephane Brajot, Denis Thiolat, Rachid Ennemany, Fawaz Fawaz and M Djavad Mossalayi
    Citation: Arthritis Research & Therapy 2008 10:R19
    Content type: Research article Published on:

  7. Magnetic resonance imaging (MRI) is increasingly used to examine joints for research purposes. It may detect both suspected and unsuspected abnormalities. This raises both clinical and ethical issues, especial...

    Authors: Rebecca Grainger, Stephen Stuckey, Richard O'Sullivan, Susan R Davis, Peter R Ebeling and Anita E Wluka
    Citation: Arthritis Research & Therapy 2008 10:R18
    Content type: Research article Published on:

  8. Studies investigating the effect of physical activity on risk for developing osteoarthritis at weight-bearing joints have reported conflicting results. We examine evidence to suggest that this may be due to th...

    Authors: Donna M Urquhart, Cathy Soufan, Andrew J Teichtahl, Anita E Wluka, Fahad Hanna and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2008 10:203
    Content type: Review Published on:

  9. Epidemiological studies of rheumatic diseases have been conducted during the past 20 years in China. The aim of this study was to clarify prevalence rates of common rheumatic diseases in China.

    Authors: Qing Yu Zeng, Ren Chen, John Darmawan, Zheng Yu Xiao, Su Biao Chen, Richard Wigley, Shun Le Chen and Nai Zheng Zhang
    Citation: Arthritis Research & Therapy 2008 10:R17
    Content type: Research article Published on:

  10. Toll-like receptors (TLRs) mediate signaling that triggers activation of the innate immune system, whereas heme oxygenase (HO)-1 (an inducible heme-degrading enzyme that is induced by various stresses) suppres...

    Authors: Yohei Kirino, Mitsuhiro Takeno, Reikou Watanabe, Shuji Murakami, Masayoshi Kobayashi, Haruko Ideguchi, Atsushi Ihata, Shigeru Ohno, Atsuhisa Ueda, Nobuhisa Mizuki and Yoshiaki Ishigatsubo
    Citation: Arthritis Research & Therapy 2008 10:R16
    Content type: Research article Published on:

  11. Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of ...

    Authors: Katarina Almehed, Helena Forsblad d'Elia, Maria Bokarewa and Hans Carlsten
    Citation: Arthritis Research & Therapy 2008 10:R15
    Content type: Research article Published on:

  12. CP-690550 is a small molecule inhibitor of Janus kinase 3 (JAK3), a critical enzyme in the signaling pathway of multiple cytokines (interleukin (IL)-2, -7, -15 and -21) that are important in various T cell fun...

    Authors: Anthony J Milici, Elizabeth M Kudlacz, Laurent Audoly, Samuel Zwillich and Paul Changelian
    Citation: Arthritis Research & Therapy 2008 10:R14
    Content type: Research article Published on:

  13. Osteoarthritis is influenced by genetic and environment factors, including mechanical stress; however, the relationship between running and the development of osteoarthritis remains a matter of controversy. We...

    Authors: Tao Tang, Takeshi Muneta, Young-Jin Ju, Akimoto Nimura, Kyosuke Miyazaki, Hiroyuki Masuda, Tomoyuki Mochizuki and Ichiro Sekiya
    Citation: Arthritis Research & Therapy 2008 10:R13
    Content type: Research article Published on:

  14. The aim of our study was to investigate the association between arthritic disease activity and antibodies to mutated citrullinated vimentin (anti-MCV), because such a relation has been suggested.

    Authors: Jennie Ursum, Markus MJ Nielen, Dirkjan van Schaardenburg, Ann R van der Horst, Rob J van de Stadt, Ben AC Dijkmans and Dörte Hamann
    Citation: Arthritis Research & Therapy 2008 10:R12
    Content type: Research article Published on:

  15. The present study was devised to understand the role of systemic indoleamine 2,3-dioxygenase (IDO) in the tolerance induction for orally tolerized mice in collagen-induced arthritis (CIA). We examined whether ...

    Authors: Min-Jung Park, So-Youn Min, Kyung-Su Park, Young-Gyu Cho, Mi-La Cho, Young-Ok Jung, Hyun-Sil Park, Soog-Hee Chang, Seok Goo Cho, Jun-Ki Min, Sung-Hwan Park and Ho-Youn Kim
    Citation: Arthritis Research & Therapy 2008 10:R11
    Content type: Research article Published on:

  18. The assessment of joints with active arthritis is a core component of widely used outcome measures. However, substantial variability exists within and across examiners in assessment of these active joint count...

    Authors: Steven J Spalding, C Kent Kwoh, Robert Boudreau, Joseph Enama, Julie Lunich, Daniel Huber, Louis Denes and Raphael Hirsch
    Citation: Arthritis Research & Therapy 2008 10:R10
    Content type: Research article Published on:

  19. Authors: Charlotte Wiell, Marcin Szkudlarek, Maria Hasselquist, Jakob M Møller, Aage Vestergaard, Jesper Nørregaard, Lene Terslev and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2008 10:402
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2007 9:R119

  20. Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in mouse development as...

    Authors: Rainer Zenz, Robert Eferl, Clemens Scheinecker, Kurt Redlich, Josef Smolen, Helia B Schonthaler, Lukas Kenner, Erwin Tschachler and Erwin F Wagner
    Citation: Arthritis Research & Therapy 2008 10:201
    Content type: Review Published on:

  21. Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic autoimmune disease that leads to progressive cartilage destruction. Advances in the treatment of RA-related destruction of cartilage require pr...

    Authors: Kristin Andreas, Carsten Lübke, Thomas Häupl, Tilo Dehne, Lars Morawietz, Jochen Ringe, Christian Kaps and Michael Sittinger
    Citation: Arthritis Research & Therapy 2008 10:R9
    Content type: Research article Published on:

  23. Faecal blood loss has been measured using autologous erythrocytes labelled with radioactive chromium for several decades, using generally similar methods. We conducted a systematic review of studies employing ...

    Authors: R Andrew Moore, Sheena Derry and Henry J McQuay
    Citation: Arthritis Research & Therapy 2008 10:R7
    Content type: Research article Published on:

  26. Biomarkers aid the study of osteoarthritis (OA) in a number of different ways. In this article we summarise briefly their multiple uses and reflect on how the study reported in a previous edition of Arthritis Res...

    Authors: Frances MK Williams and Tim D Spector
    Citation: Arthritis Research & Therapy 2008 10:101
    Content type: Editorial Published on:

  27. Rosiglitazone and pioglitazone are high-affinity peroxisome proliferator-activated receptor (PPAR)-γ agonists with potent anti-diabetic properties and potential anti-inflammatory effects. We compared the abili...

    Authors: Meriem Koufany, David Moulin, Arnaud Bianchi, Mikhaela Muresan, Sylvie Sebillaud, Patrick Netter, Georges Weryha and Jean-Yves Jouzeau
    Citation: Arthritis Research & Therapy 2008 10:R6
    Content type: Research article Published on:

  28. The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB × NZW) F1 murine lupus model.

    Authors: Seetha U Monrad, Paul D Killen, Marc R Anderson, Amanda Bradke and Mariana J Kaplan
    Citation: Arthritis Research & Therapy 2008 10:R5
    Content type: Research article Published on:

  29. Recent studies provide evidence of roles for integrins in mechanical signalling in bone and cartilage. Integrin signalling is modulated by various mechanisms, including interaction with other transmembrane pro...

    Authors: Mahmoud Orazizadeh, Herng Sheng Lee, Bianca Groenendijk, S Jane Millward Sadler, Malcolm O Wright, Frederik P Lindberg and Donald M Salter
    Citation: Arthritis Research & Therapy 2008 10:R4
    Content type: Research article Published on:

  30. Sox9 and p300 cooperate to induce expression of cartilage-specific matrix proteins, including type II collagen, aggrecan and link protein. Tumour necrosis factor (TNF)-α, found in arthritic joints, activates n...

    Authors: Jason S Rockel, Julie C Kudirka, Andrew J Guzi and Suzanne M Bernier
    Citation: Arthritis Research & Therapy 2008 10:R3
    Content type: Research article Published on:

  31. The relationship of circulating levels of receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) with the expression of these molecules in bone has not been established. The objective...

    Authors: David Findlay, Mellick Chehade, Helen Tsangari, Susan Neale, Shelley Hay, Blair Hopwood, Susan Pannach, Peter O'Loughlin and Nicola Fazzalari
    Citation: Arthritis Research & Therapy 2008 10:R2
    Content type: Research article Published on:

  32. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The protein is aberrantly expressed extracellularly in the s...

    Authors: Therese Östberg, Heidi Wähämaa, Karin Palmblad, Norimasa Ito, Pernilla Stridh, Maria Shoshan, Michael T Lotze, Helena Erlandsson Harris and Ulf Andersson
    Citation: Arthritis Research & Therapy 2008 10:R1
    Content type: Research article Published on:

  33. The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering t...

    Authors: Raimund W Kinne, Bruno Stuhlmüller and Gerd-R Burmester
    Citation: Arthritis Research & Therapy 2007 9:224
    Content type: Review Published on:

  34. For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustr...

    Authors: Ulf Müller-Ladner, Caroline Ospelt, Steffen Gay, Oliver Distler and Thomas Pap
    Citation: Arthritis Research & Therapy 2007 9:223
    Content type: Review Published on:

  35. This study investigated the release of prostaglandin E2 (PGE2) from cartilage following an impact load in vitro and the possible chondroprotective effect of cyclooxygenase-2 (COX-2) inhibition using non-steroidal...

    Authors: Janet E Jeffrey and Richard M Aspden
    Citation: Arthritis Research & Therapy 2007 9:R129
    Content type: Research article Published on:

  36. Synovial hyperplasia in rheumatoid arthritis (RA) has been associated with apoptosis deficiency of RA fibroblast-like synoviocytes (FLSs). Celecoxib is a non-steroidal anti-inflammatory drug that has been demo...

    Authors: Rachel Audo, Véronique Deschamps, Michael Hahne, Bernard Combe and Jacques Morel
    Citation: Arthritis Research & Therapy 2007 9:R128
    Content type: Research article Published on:

  37. The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheuma...

    Authors: John Bainbridge, Leigh Madden, David Essex, Michael Binks, Rajneesh Malhotra and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2007 9:R127
    Content type: Research article Published on:

  39. Clinical practice guidelines have been elaborated to summarize evidence related to the management of knee osteoarthritis and to facilitate uptake of evidence-based knowledge by clinicians. The objectives of th...

    Authors: Stéphane Poitras, Jérôme Avouac, Michel Rossignol, Bernard Avouac, Christine Cedraschi, Margareta Nordin, Chantal Rousseaux, Sylvie Rozenberg, Bernard Savarieau, Philippe Thoumie, Jean-Pierre Valat, Éric Vignon and Pascal Hilliquin
    Citation: Arthritis Research & Therapy 2007 9:R126
    Content type: Research article Published on:

  40. Natural killer (NK) cells play a crucial role in the immune response to micro-organisms and tumours. Recent evidence suggests that NK cells also regulate the adaptive T-cell response and that it might be possi...

    Authors: Casimir de Rham, Sylvie Ferrari-Lacraz, Sabrina Jendly, Gregory Schneiter, Jean-Michel Dayer and Jean Villard
    Citation: Arthritis Research & Therapy 2007 9:R125
    Content type: Research article Published on:

  42. The objective of the study was to examine pregnancy outcomes in women with systemic lupus erythematosus (SLE) and population controls in Trinidad. We performed a cross-sectional analysis of adverse outcomes in...

    Authors: Mariam Molokhia, Noreen Maconochie, Alan Leslie Patrick and Pat Doyle
    Citation: Arthritis Research & Therapy 2007 9:R124
    Content type: Research article Published on:

  43. Murine collagen-induced arthritis (CIA) has become a valuable animal model for elucidating pathogenic mechanisms and evaluating therapeutic effects for rheumatoid arthritis. Recent advances in digital imaging ...

    Authors: Jon Vincelette, Yifan Xu, Le-Ning Zhang, Caralee J Schaefer, Ronald Vergona, Mark E Sullivan, Thomas G Hampton and Yi-Xin (Jim) Wang
    Citation: Arthritis Research & Therapy 2007 9:R123
    Content type: Research article Published on:

  44. ANK is a multipass transmembrane protein transporter thought to play a role in the export of intracellular inorganic pyrophosphate and so to contribute to the pathophysiology of chondrocalcinosis. As transform...

    Authors: Frederic Cailotto, Arnaud Bianchi, Sylvie Sebillaud, Narayanan Venkatesan, David Moulin, Jean-Yves Jouzeau and Patrick Netter
    Citation: Arthritis Research & Therapy 2007 9:R122
    Content type: Research article Published on:

  45. Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors. PARs are activated by a serine-dependent cleavage generating a tethered activating ligand. PAR-2 was shown to be involve...

    Authors: Christelle Boileau, Nathalie Amiable, Johanne Martel-Pelletier, Hassan Fahmi, Nicolas Duval and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2007 9:R121
    Content type: Research article Published on:

  46. IL-1 plays a key role in disc degeneration and could be a valid target for inhibiting this process. IL-1 receptor antagonist (IL-1ra) might be a good candidate to inhibit IL-1 activity. However, many questions...

    Authors: Philippe Goupille, Denis Mulleman and Xavier Chevalier
    Citation: Arthritis Research & Therapy 2007 9:110
    Content type: Editorial Published on:

  47. Adoptive transfer of adjuvant-induced arthritis was used in this study to examine local macrophages and dendritic cells (DCs) during T cell-mediated synovial inflammation. We studied the influx of CD11b+CD11c+ pu...

    Authors: Mahin Moghaddami, Leslie G Cleland, Gorjana Radisic and Graham Mayrhofer
    Citation: Arthritis Research & Therapy 2007 9:R120
    Content type: Research article Published on:

  48. The aim of the present study was to assess ultrasonography (US) for the detection of inflammatory and destructive changes in finger and toe joints, tendons, and entheses in patients with psoriasis-associated a...

    Authors: Charlotte Wiell, Marcin Szkudlarek, Maria Hasselquist, Jakob M Møller, Aage Vestergaard, Jesper Nørregaard, Lene Terslev and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2007 9:R119
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:402

  49. Angiogenesis is involved in the pathogenesis of inflammatory arthritis, but little is known about the role of lymphangiogenesis in this setting. Here, we examined whether tumor necrosis factor (TNF) stimulates...

    Authors: Qian Zhang, Yan Lu, Steven T Proulx, Ruolin Guo, Zhenqiang Yao, Edward M Schwarz, Brendan F Boyce and Lianping Xing
    Citation: Arthritis Research & Therapy 2007 9:R118
    Content type: Research article Published on:

  50. Early in the pathological process of osteoarthritis (OA), subchondral bone remodelling, which is related to altered osteoblast metabolism, takes place. In the present study, we explored in human OA subchondral...

    Authors: Steeve Kwan Tat, Jean-Pierre Pelletier, Josep Vergés, Daniel Lajeunesse, Eulàlia Montell, Hassan Fahmi, Martin Lavigne and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2007 9:R117
    Content type: Research article Published on:
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Arthritis Research & Therapy

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