Martel-Pelletier J, Lajeunesse D, Pelletier JP: Etiopathogenesis of osteoarthritis. Arthritis and Allied Conditions: A Textbook of Rheumatology. Edited by: Koopman WJ, Moreland LW. 2005, Baltimore: Lippincott, Williams & Wilkins, 2199-2226. 15
Google Scholar
Martel-Pelletier J, Welsch DJ, Pelletier JP: Metalloproteases and inhibitors in arthritic diseases. Best Pract Res Clin Rheumatol. 2001, 15: 805-829. 10.1053/berh.2001.0195.
Article
CAS
PubMed
Google Scholar
Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R: Proteinase-activated receptors. Pharmacol Rev. 2001, 53: 245-282.
CAS
PubMed
Google Scholar
Hollenberg MD, Compton SJ: International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev. 2002, 54: 203-217. 10.1124/pr.54.2.203.
Article
CAS
PubMed
Google Scholar
Trejo J: Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003, 307: 437-442. 10.1124/jpet.103.052100.
Article
CAS
PubMed
Google Scholar
Kawabata A, Kawao N, Kuroda R, Tanaka A, Itoh H, Nishikawa H: Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. Neuroreport. 2001, 12: 715-719. 10.1097/00001756-200103260-00020.
Article
CAS
PubMed
Google Scholar
Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, et al: Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med. 2001, 7: 821-826. 10.1038/89945.
Article
CAS
PubMed
Google Scholar
Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, et al: Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med. 2000, 6: 151-158. 10.1038/72247.
Article
CAS
PubMed
Google Scholar
Kelso EB, Ferrell WR, Lockhart JC, Elias-Jones I, Hembrough T, Dunning L, Gracie JA, McInnes IB: Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis Rheum. 2007, 56: 765-771. 10.1002/art.22423.
Article
CAS
PubMed
Google Scholar
Busso N, Frasnelli M, Feifel R, Cenni B, Steinhoff M, Hamilton J, So A: Evaluation of protease-activated receptor 2 in murine models of arthritis. Arthritis Rheum. 2007, 56: 101-107. 10.1002/art.22312.
Article
CAS
PubMed
Google Scholar
Ferrell WR, Lockhart JC, Kelso EB, Dunning L, Plevin R, Meek SE, Smith AJ, Hunter GD, McLean JS, McGarry F, et al: Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest. 2003, 111: 35-41. 10.1172/JCI200316913.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xiang Y, Masuko-Hongo K, Sekine T, Nakamura H, Yudoh K, Nishioka K, Kato T: Expression of proteinase-activated receptors (PAR)-2 in articular chondrocytes is modulated by IL-1beta, TNF-alpha and TGF-beta. Osteoarthritis Cartilage. 2006, 14: 1163-1173. 10.1016/j.joca.2006.04.015.
Article
CAS
PubMed
Google Scholar
Abe K, Aslam A, Walls AF, Sato T, Inoue H: Up-regulation of protease-activated receptor-2 by bFGF in cultured human synovial fibroblasts. Life Sci. 2006, 79: 898-904. 10.1016/j.lfs.2006.03.007.
Article
CAS
PubMed
Google Scholar
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986, 29: 1039-1049. 10.1002/art.1780290816.
Article
CAS
PubMed
Google Scholar
Boileau C, Pelletier JP, Tardif G, Fahmi H, Laufer S, Lavigne M, Martel-Pelletier J: The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. Ann Rheum Dis. 2005, 64: 891-898. 10.1136/ard.2004.026906.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boileau C, Martel-Pelletier J, Brunet J, Schrier D, Flory C, Boily M, Pelletier JP: PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect. Ann Rheum Dis. 2006, 65: 573-580. 10.1136/ard.2005.041855.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boileau C, Martel-Pelletier J, Brunet J, Tardif G, Schrier D, Flory C, El-Kattan A, Boily M, Pelletier JP: Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis Rheum. 2005, 52: 488-500. 10.1002/art.20809.
Article
CAS
PubMed
Google Scholar
Ritchie E, Saka M, Mackenzie C, Drummond R, Wheeler-Jones C, Kanke T, Plevin R: Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells. Br J Pharmacol. 2007, 150: 1044-1054. 10.1038/sj.bjp.0707150.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nystedt S, Ramakrishnan V, Sundelin J: The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem. 1996, 271: 14910-14915. 10.1074/jbc.271.25.14910.
Article
CAS
PubMed
Google Scholar
Yamaguchi Y, Mann DM, Ruoslahti E: Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature. 1990, 346: 281-284. 10.1038/346281a0.
Article
CAS
PubMed
Google Scholar
Droguett R, Cabello-Verrugio C, Riquelme C, Brandan E: Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation. Matrix Biol. 2006, 25: 332-341. 10.1016/j.matbio.2006.04.004.
Article
CAS
PubMed
Google Scholar
Sabri A, Muske G, Zhang H, Pak E, Darrow A, Andrade-Gordon P, Steinberg SF: Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res. 2000, 86: 1054-1061.
Article
CAS
PubMed
Google Scholar
Geng Y, Valbracht J, Lotz M: Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest. 1996, 98: 2425-2430.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zwerina J, Hayer S, Redlich K, Bobacz K, Kollias G, Smolen JS, Schett G: Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction. Arthritis Rheum. 2006, 54: 463-472. 10.1002/art.21626.
Article
CAS
PubMed
Google Scholar
Niculescu-Duvaz I, Phanish MK, Colville-Nash P, Dockrell ME: The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. Nephron Exp Nephrol. 2007, 105: e108-116. 10.1159/000100492.
Article
CAS
PubMed
Google Scholar
Martin MM, Buckenberger JA, Jiang J, Malana GE, Knoell DL, Feldman DS, Elton TS: TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. Am J Physiol Lung Cell Mol Physiol. 2007, 293: L790-799. 10.1152/ajplung.00099.2007.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE: Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 2000, 43: 801-811. 10.1002/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4.
Article
CAS
PubMed
Google Scholar
Pillinger MH, Rosenthal PB, Tolani SN, Apsel B, Dinsell V, Greenberg J, Chan ES, Gomez PF, Abramson SB: Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. J Immunol. 2003, 171: 6080-6089.
Article
CAS
PubMed
Google Scholar
Pei Y, Harvey A, Yu XP, Chandrasekhar S, Thirunavukkarasu K: Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects. Osteoarthritis Cartilage. 2006, 14: 749-758. 10.1016/j.joca.2006.01.017.
Article
PubMed
Google Scholar
Thomas B, Thirion S, Humbert L, Tan L, Goldring MB, Bereziat G, Berenbaum F: Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. Biochem J. 2002, 362: 367-373. 10.1042/0264-6021:3620367.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pelletier JP, Fernandes JC, Jovanovic DV, Reboul P, Martel-Pelletier J: Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. J Rheumatol. 2001, 28: 2509-2519.
CAS
PubMed
Google Scholar
Martel-Pelletier J, Faure MP, McCollum R, Mineau F, Cloutier JM, Pelletier JP: Plasmin, plasminogen activators and inhibitor in human osteoarthritic cartilage. J Rheumatol. 1991, 18: 1863-1871.
CAS
PubMed
Google Scholar
Pap G, Eberhardt R, Rocken C, Nebelung W, Neumann HW, Roessner A: Expression of stromelysin and urokinase type plasminogen activator protein in resection specimens and biopsies at different stages of osteoarthritis of the knee. Pathol Res Pract. 2000, 196: 219-226.
Article
CAS
PubMed
Google Scholar
Schwab W, Schulze-Tanzil G, Mobasheri A, Dressler J, Kotzsch M, Shakibaei M: Interleukin-1beta-induced expression of the urokinase-type plasminogen activator receptor and its co-localization with MMPs in human articular chondrocytes. Histol Histopathol. 2004, 19: 105-112.
CAS
PubMed
Google Scholar
Minisini AM, Fabbro D, Di Loreto C, Pestrin M, Russo S, Cardellino GG, Andreetta C, Damante G, Puglisi F: Markers of the uPA system and common prognostic factors in breast cancer. Am J Clin Pathol. 2007, 128: 112-117. 10.1309/M0GXVXA89BVLJ5C9.
Article
CAS
PubMed
Google Scholar
Simeone AM, Nieves-Alicea R, McMurtry VC, Colella S, Krahe R, Tari AM: Cyclooxygenase-2 uses the protein kinase C/interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. Int J Oncol. 2007, 30: 785-792.
CAS
PubMed
Google Scholar
Ottino P, Bazan HE: Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. Curr Eye Res. 2001, 23: 77-85. 10.1076/ceyr.23.2.77.5471.
Article
CAS
PubMed
Google Scholar
Wilson SR, Gallagher S, Warpeha K, Hawthorne SJ: Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. Prostate. 2004, 60: 168-174. 10.1002/pros.20047.
Article
CAS
PubMed
Google Scholar
Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R: Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol. 2000, 106: 537-545. 10.1067/mai.2000.109058.
Article
CAS
PubMed
Google Scholar
Kirkup AJ, Jiang W, Bunnett NW, Grundy D: Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats. J Physiol. 2003, 552: 589-601. 10.1113/jphysiol.2003.049387.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vergnolle N, Hollenberg MD, Sharkey KA, Wallace JL: Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol. 1999, 127: 1083-1090. 10.1038/sj.bjp.0702634.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD: Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci. 2001, 22: 146-152. 10.1016/S0165-6147(00)01634-5.
Article
CAS
PubMed
Google Scholar