Skip to main content

Articles

Page 109 of 155

  1. Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those...

    Authors: Christine Lyn Le Maitre, Anthony John Freemont and Judith Alison Hoyland
    Citation: Arthritis Research & Therapy 2007 9:R45
    Content type: Research article Published on:

  2. We explored the relationship of antibodies to the whole ribosomal P proteins (P0, P1, and P2) in cerebrospinal fluid (CSF) with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus ...

    Authors: Shunsei Hirohata, Yoshiyuki Arinuma, Maki Takayama and Taku Yoshio
    Citation: Arthritis Research & Therapy 2007 9:R44
    Content type: Research article Published on:

  3. The objective of this study was to analyse levels of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) in patients with primary Sjögren's syndrome (pSS) and to examine associations of M...

    Authors: Peter Willeke, Markus Gaubitz, Heiko Schotte, Christian Maaser, Wolfram Domschke, Bernhard Schlüter and Heidemarie Becker
    Citation: Arthritis Research & Therapy 2007 9:R43
    Content type: Research article Published on:

  4. The characteristics of rheumatoid arthritis (RA) pathology include the infiltration of inflammatory leukocytes, the proliferation of synovial cells, and the presence of extensive angiogenesis, referred to as r...

    Authors: Wan-Uk Kim, Seung-Ki Kwok, Kyung-Hee Hong, Seung-Ah Yoo, Jin-Sun Kong, Jongseon Choe and Chul-Soo Cho
    Citation: Arthritis Research & Therapy 2007 9:R42
    Content type: Research article Published on:

  5. Autologous chondrocyte implantation (ACI) is an effective clinical procedure for the regeneration of articular cartilage defects. BioSeed®-C is a second-generation ACI tissue engineering cartilage graft that is b...

    Authors: Christian Ossendorf, Christian Kaps, Peter C Kreuz, Gerd R Burmester, Michael Sittinger and Christoph Erggelet
    Citation: Arthritis Research & Therapy 2007 9:R41
    Content type: Research article Published on:

  6. An important feature of autoimmune diseases is the overlap of pathophysiological characteristics. Clustering of autoimmune diseases in families suggests that genetic variants may contribute to autoimmunity. Th...

    Authors: Ioanna Marinou, Douglas S Montgomery, Marion C Dickson, Michael H Binks, David J Moore, Deborah E Bax and Anthony G Wilson
    Citation: Arthritis Research & Therapy 2007 9:R40
    Content type: Research article Published on:

  7. Patients with rheumatoid arthritis (RA) are at risk of excess mortality, predominantly owing to cardiovascular (CV) events. The receptor for advanced glycation end products (RAGE) has been implicated in the pe...

    Authors: Lisa Carroll, Ian H Frazer, Malcolm Turner, Thomas H Marwick and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2007 9:R39
    Content type: Research article Published on:

  8. Synovial pathophysiology is a complex and synergistic interplay of different cell populations with tissue components, mediated by a variety of signaling mechanisms. All of these mechanisms drive the affected j...

    Authors: Anette Knedla, Elena Neumann and Ulf Müller-Ladner
    Citation: Arthritis Research & Therapy 2007 9:209
    Content type: Review Published on:

  9. The effect of abatacept, a selective T-cell co-stimulation modulator, on vaccination has not been previously investigated. In this open-label, single-dose, randomized, parallel-group, controlled study, the eff...

    Authors: Lee Tay, Francisco Leon, George Vratsanos, Ralph Raymond and Michael Corbo
    Citation: Arthritis Research & Therapy 2007 9:R38
    Content type: Research article Published on:

  10. The objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-α) promoter genotype/haplotype markers. Each p...

    Authors: João Eurico Fonseca, João Cavaleiro, José Teles, Elsa Sousa, Valeska L Andreozzi, Marília Antunes, Maria A Amaral-Turkman, Helena Canhão, Ana F Mourão, Joana Lopes, Joana Caetano-Lopes, Pamela Weinmann, Marta Sobral, Patrícia Nero, Maria J Saavedra, Armando Malcata…
    Citation: Arthritis Research & Therapy 2007 9:R37
    Content type: Research article Published on:

  11. The development of increasingly high-throughput and sensitive mass spectroscopy-based proteomic techniques provides new opportunities to examine the physiology and pathophysiology of many biologic fluids and t...

    Authors: Reuben Gobezie, Alvin Kho, Bryan Krastins, David A Sarracino, Thomas S Thornhill, Michael Chase, Peter J Millett and David M Lee
    Citation: Arthritis Research & Therapy 2007 9:R36
    Content type: Research article Published on:

  12. High-mobility group chromosomal box protein 1 (HMGB1) is a structural nuclear protein that promotes inflammation when present extracellularly. Aberrant, extracellular HMGB1 expression has been demonstrated in ...

    Authors: Karin Palmblad, Erik Sundberg, Margarita Diez, Riikka Söderling, Ann-Charlotte Aveberger, Ulf Andersson and Helena Erlandsson Harris
    Citation: Arthritis Research & Therapy 2007 9:R35
    Content type: Research article Published on:

  13. This prospective study examined the association between physical activity and the incidence of self-reported stiff or painful joints (SPJ) among mid-age women and older women over a 3-year period. Data were co...

    Authors: Kristiann C Heesch, Yvette D Miller and Wendy J Brown
    Citation: Arthritis Research & Therapy 2007 9:R34
    Content type: Research article Published on:

  14. Chondrogenesis is a process involving stem-cell differentiation through the coordinated effects of growth/differentiation factors and extracellular matrix (ECM) components. Recently, mesenchymal stem cells (MS...

    Authors: Farida Djouad, Bruno Delorme, Marielle Maurice, Claire Bony, Florence Apparailly, Pascale Louis-Plence, François Canovas, Pierre Charbord, Danièle Noël and Christian Jorgensen
    Citation: Arthritis Research & Therapy 2007 9:R33
    Content type: Research article Published on:

  15. Recently, two studies provided convincing evidence that IFN regulatory factor 5 (IRF5) gene polymorphisms are significantly associated with systemic lupus erythematosus (SLE) in several white populations. To repl...

    Authors: Hyoung Doo Shin, Yoon-Kyoung Sung, Chan-Bum Choi, Soo Ok Lee, Hye Won Lee and Sang-Cheol Bae
    Citation: Arthritis Research & Therapy 2007 9:R32
    Content type: Research article Published on:

  17. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor involved in the regulation of many cellular processes. We and others have previously shown that PPARγ activators display anti-inflamma...

    Authors: Hassan Afif, Mohamed Benderdour, Leandra Mfuna-Endam, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicholas Duval and Hassan Fahmi
    Citation: Arthritis Research & Therapy 2007 9:R31
    Content type: Research article Published on:

  20. Joint inflammation and destruction have been linked to the deregulation of the highly synthetic fibroblast-like synoviocytes (FLSs), and much of our current understanding of the mechanisms that underlie synovi...

    Authors: Tracey Weiler, Qiujiang Du, Oleg Krokhin, Werner Ens, Ken Standing, Hani El-Gabalawy and John A Wilkins
    Citation: Arthritis Research & Therapy 2007 9:R30
    Content type: Research article Published on:

  21. Cell therapy, pioneered for the treatment of malignancies in the form of bone marrow transplantation, has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem...

    Authors: Francesco Dazzi, Jacob M van Laar, Andrew Cope and Alan Tyndall
    Citation: Arthritis Research & Therapy 2007 9:206
    Content type: Review Published on:

  22. Significant levels of circulating immune complexes (ICs) containing rheumatoid factors and immunoglobulin G in peripheral blood are a characteristic feature of rheumatoid arthritis (RA). ICs interact through F...

    Authors: Anna-Marie Fairhurst, Paul K Wallace, Ali SM Jawad and Nicolas J Goulding
    Citation: Arthritis Research & Therapy 2007 9:R29
    Content type: Research article Published on:

  23. Monosodium urate crystals stimulate monocytes and macrophages to release IL-1β through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes wit...

    Authors: Alexander So, Thibaut De Smedt, Sylvie Revaz and Jürg Tschopp
    Citation: Arthritis Research & Therapy 2007 9:R28
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:233

  24. The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping ...

    Authors: Pierre-Antoine Gourraud, Philippe Dieudé, Jean-Frédéric Boyer, Leonor Nogueira, Anne Cambon-Thomsen, Bernard Mazières, François Cornélis, Guy Serre, Alain Cantagrel and Arnaud Constantin
    Citation: Arthritis Research & Therapy 2007 9:R27
    Content type: Research article Published on:

  25. The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were ...

    Authors: Leonid Kalichman, Yuqing Zhang, Jingbo Niu, Joyce Goggins, Daniel Gale, Yanyan Zhu, David T Felson and David J Hunter
    Citation: Arthritis Research & Therapy 2007 9:R26
    Content type: Research article Published on:

  26. Functional links between bone remodeling and the immune system in chronic inflammatory arthritis are mediated, in part, by the ligand of receptor activator of nuclear factor-kappa-B (RANK-L). Because neutrophi...

    Authors: Patrice E Poubelle, Arpita Chakravarti, Maria J Fernandes, Karine Doiron and Andrée-Anne Marceau
    Citation: Arthritis Research & Therapy 2007 9:R25
    Content type: Research article Published on:

  27. CTLA-4 encodes cytotoxic T lymphocyte-associated antigen-4, a cell-surface molecule providing a negative signal for T-cell activation. CTLA-4 gene polymorphisms have been widely studied in connection with genetic...

    Authors: Jacques-Eric Gottenberg, Pascale Loiseau, Mariam Azarian, Chun Chen, Nicolas Cagnard, Eric Hachulla, Xavier Puechal, Jean Sibilia, Dominique Charron, Xavier Mariette and Corinne Miceli-Richard
    Citation: Arthritis Research & Therapy 2007 9:R24
    Content type: Research article Published on:

  28. There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently pre...

    Authors: Claudia Mauri and Michael R Ehrenstein
    Citation: Arthritis Research & Therapy 2007 9:205
    Content type: Review Published on:

  29. Estrogen deficiency is one of the most frequent causes of osteoporosis in women and a possible cause of bone loss in men. But the mechanism involved remains largely unknown. Estrogen deficiency leads to an inc...

    Authors: Roberto Pacifici
    Citation: Arthritis Research & Therapy 2007 9:102
    Content type: Commentary Published on:

  30. Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this combination, even ...

    Authors: Makoto Soejima, Tomoko Sugiura, Yasushi Kawaguchi, Manabu Kawamoto, Yasuhiro Katsumata, Kae Takagi, Ayako Nakajima, Tadayuki Mitamura, Akio Mimori, Masako Hara and Naoyuki Kamatani
    Citation: Arthritis Research & Therapy 2007 9:R23
    Content type: Research article Published on:

  31. In chronic inflammatory diseases, such as rheumatoid arthritis, inflammation acts as an independent cardiovascular risk factor and the use of anti-inflammatory drugs, such as anti-tumor necrosis factor alpha (...

    Authors: Jean Frédéric Boyer, Patricia Balard, Hélène Authier, Bruno Faucon, José Bernad, Bernard Mazières, Jean-Luc Davignon, Alain Cantagrel, Bernard Pipy and Arnaud Constantin
    Citation: Arthritis Research & Therapy 2007 9:R22
    Content type: Research article Published on:

  32. We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic change...

    Authors: Changhai Ding, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Abram, Jean-Pierre Raynauld, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2007 9:R21
    Content type: Research article Published on:

  33. In this study we examine the extracellular role of galectin-3 (gal-3) in joint tissues. Following intra-articular injection of gal-3 or vehicle in knee joints of mice, histological evaluation of articular cart...

    Authors: Audrée Janelle-Montcalm, Christelle Boileau, Françoise Poirier, Jean-Pierre Pelletier, Mélanie Guévremont, Nicolas Duval, Johanne Martel-Pelletier and Pascal Reboul
    Citation: Arthritis Research & Therapy 2007 9:R20
    Content type: Research article Published on:

  34. Rheumatoid arthritis is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. Oxidized low-density lipoprotein (oxLDL), the ant...

    Authors: Evangelia S Lourida, Athanasios N Georgiadis, Eleni C Papavasiliou, Athanasios I Papathanasiou, Alexandros A Drosos and Alexandros D Tselepis
    Citation: Arthritis Research & Therapy 2007 9:R19
    Content type: Research article Published on:

  35. Aseptic loosening of a joint prosthesis is associated with remodelling of bone tissue in the vicinity of the prosthesis. In the present study, we investigated the effects of synovial fluid (SF) from patients w...

    Authors: Martin K Andersson, Pernilla Lundberg, Acke Ohlin, Mark J Perry, Anita Lie, André Stark and Ulf H Lerner
    Citation: Arthritis Research & Therapy 2007 9:R18
    Content type: Research article Published on:

  36. Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential ...

    Authors: Catherine M Kolf, Elizabeth Cho and Rocky S Tuan
    Citation: Arthritis Research & Therapy 2007 9:204
    Content type: Review Published on:

  37. Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption p...

    Authors: Georg Schett
    Citation: Arthritis Research & Therapy 2007 9:203
    Content type: Review Published on:

  38. Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of...

    Authors: Steven K Lundy, Sujata Sarkar, Laura A Tesmer and David A Fox
    Citation: Arthritis Research & Therapy 2007 9:202
    Content type: Review Published on:

  39. A major question concerning the immunopathology of rheumatoid arthritis is why the disease is localized to particular joints. A possible explanation could be the presence within the synovium of cells that fost...

    Authors: Takahiro Ochi, Hideki Yoshikawa, Tomoko Toyosaki-Maeda and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2007 9:201
    Content type: Review Published on:

  40. Non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclo-oxygenase-2 (COX-2) inhibitors, cause upper gastrointestinal (GI) symptoms that are relieved by treatment with esomeprazole. We assesse...

    Authors: Christopher J Hawkey, Nicholas J Talley, James M Scheiman, Roger H Jones, Göran Långström, Jorgen Næsdal and Neville D Yeomans
    Citation: Arthritis Research & Therapy 2007 9:R17
    Content type: Research article Published on:

  41. A recent prospective study showed that higher consumption of red meat and total protein was associated with increased risk for inflammatory polyarthritis. We therefore prospectively examined the relationship b...

    Authors: Elizabeth Benito-Garcia, Diane Feskanich, Frank B Hu, Lisa A Mandl and Elizabeth W Karlson
    Citation: Arthritis Research & Therapy 2007 9:R16
    Content type: Research article Published on:

  42. Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in animal models of autoimmune diseases. Chemokines play an important role in the development of autoimmune diseases in...

    Authors: Hitoshi Hasegawa, Atsushi Inoue, Masatake Muraoka, Jun Yamanouchi, Tatsuhiko Miyazaki and Masaki Yasukawa
    Citation: Arthritis Research & Therapy 2007 9:R15
    Content type: Research article Published on:

  43. The etiology of osteoarthritis is multifactorial, with inflammatory, metabolic, and mechanical causes. Pain in osteoarthritis is initiated by mild intra-articular inflammation and degeneration of articular car...

    Authors: Bettina Beyreuther, Noëlle Callizot and Thomas Stöhr
    Citation: Arthritis Research & Therapy 2007 9:R14
    Content type: Research article Published on:

  44. Preclinical osteoarthritis (OA) models are often employed in studies investigating disease-modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal evaluation of OA pathogenesis in a...

    Authors: C Thomas G Appleton, David D McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M Bernier, James L Henry, David W Holdsworth and Frank Beier
    Citation: Arthritis Research & Therapy 2007 9:R13
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:407

  45. Recent studies have implicated the dying cell as a potential reservoir of modified autoantigens that might initiate and drive systemic autoimmunity in susceptible hosts. A number of subunits of the exosome, a ...

    Authors: Geurt Schilders, Reinout Raijmakers, Kelen CR Malmegrim, Lieselotte Vande Walle, Xavier Saelens, Wilma Vree Egberts, Walther J van Venrooij, Peter Vandenabeele and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2007 9:R12
    Content type: Research article Published on:

  46. Patient Acceptable Symptom State (PASS) is an absolute threshold proposed for symptomatic variables in osteoarthritis (OA) to determine the point beyond which patients consider themselves well and, as such, ar...

    Authors: Maxime Dougados, Alan Moore, Shaohua Yu and Xavier Gitton
    Citation: Arthritis Research & Therapy 2007 9:R11
    Content type: Research article Published on:

  47. Pseudoporphyria (PP) is characterized by skin fragility, blistering and scarring in sun-exposed skin areas without abnormalities in porphyrin metabolism. The phenylpropionic acid derivative group of nonsteroid...

    Authors: Susanne G Schäd, Andrea Kraus, Imme Haubitz, Jiri Trcka, Henning Hamm and Hermann J Girschick
    Citation: Arthritis Research & Therapy 2007 9:R10
    Content type: Research article Published on:

  48. Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro

    Authors: Alan Tyndall, Ulrich A Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia…
    Citation: Arthritis Research & Therapy 2007 9:301
    Content type: Meeting report Published on:

  49. The antibody-mediated targeted delivery of cytokines to sites of disease is a promising avenue for cancer therapy, but it is largely unexplored for the treatment of chronic inflammatory conditions. Using both ...

    Authors: Eveline Trachsel, Frank Bootz, Michela Silacci, Manuela Kaspar, Hartwig Kosmehl and Dario Neri
    Citation: Arthritis Research & Therapy 2007 9:R9
    Content type: Research article Published on:

  50. Osteoarthritis (OA) is a degenerative disease that disrupts the collagenous matrix of articular cartilage and is difficult to cure because articular cartilage is a nonvascular tissue. Treatment of OA has targe...

    Authors: Yoo-Sin Park, Si-Woong Lim, Il-Hoon Lee, Tae-Jin Lee, Jong-Sung Kim and Jin Soo Han
    Citation: Arthritis Research & Therapy 2007 9:R8
    Content type: Research article Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us