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  1. The scientific and medical community remains skeptical regarding the efficacy of nutrition for osteoarthritis despite their broad acceptation by patients. In this context, this paper systematically reviews hum...

    Authors: Laurent G Ameye and Winnie SS Chee
    Citation: Arthritis Research & Therapy 2006 8:R127
    Content type: Research article Published on:

  2. Despite decades of research, only a very limited number of matrix metalloproteinase (MMP) inhibitors have been successful in clinical trials of arthritis. One of the central problems associated with this failu...

    Authors: Nathalie Simard, Gilles Boire, Artur J de Brum-Fernandes and Yves St-Pierre
    Citation: Arthritis Research & Therapy 2006 8:R125
    Content type: Research article Published on:

  3. The objective of the study was, with multidetector computed tomography (CT) as the reference method, to determine whether bone erosions in rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints detected wi...

    Authors: Uffe Møller Døhn, Bo J Ejbjerg, Michel Court-Payen, Maria Hasselquist, Eva Narvestad, Marcin Szkudlarek, Jakob M Møller, Henrik S Thomsen and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2006 8:R110
    Content type: Research article Published on:

  4. Rheumatoid arthritis (RA) is characterized by synovial hyperplasia and destruction of cartilage and bone. The fibroblast-like synoviocyte (FLS) population is central to the development of pannus by migrating i...

    Authors: James M Woods, Karolina Klosowska, Darrin J Spoden, Nataliya G Stumbo, Douglas J Paige, John C Scatizzi, Michael V Volin, Malathi S Rao and Harris Perlman
    Citation: Arthritis Research & Therapy 2006 8:R113
    Content type: Research article Published on:

  5. Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-α agents, few studies have examined the long-term effects. We evaluated 511 patients with long-sta...

    Authors: Bert Vander Cruyssen, Stijn Van Looy, Bart Wyns, Rene Westhovens, Patrick Durez, Filip Van den Bosch, Herman Mielants, Luc De Clerck, Ann Peretz, Michel Malaise, Leon Verbruggen, Nathan Vastesaeger, Anja Geldhof, Luc Boullart and Filip De Keyser
    Citation: Arthritis Research & Therapy 2006 8:R112
    Content type: Research article Published on:

  6. Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa, is a single-stranded-DNA-binding factor involved in DNA replication, repair, and recombination. There have been...

    Authors: Yoshioki Yamasaki, Sonali Narain, Liza Hernandez, Tolga Barker, Keigo Ikeda, Mark S Segal, Hanno B Richards, Edward KL Chan, Westley H Reeves and Minoru Satoh
    Citation: Arthritis Research & Therapy 2006 8:R111
    Content type: Research article Published on:

  7. The Fc gamma receptors have been shown to play important roles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine the immune response to an infection. W...

    Authors: Ann W Morgan, Jim I Robinson, Jennifer H Barrett, Javier Martin, Amy Walker, Sarah J Babbage, William ER Ollier, Miguel A Gonzalez-Gay and John D Isaacs
    Citation: Arthritis Research & Therapy 2006 8:R109
    Content type: Research article Published on:

  8. Stromal cells such as fibroblasts play an important role in defining tissue-specific responses during the resolution of inflammation. We hypothesized that this involves tissue-specific regulation of glucocorti...

    Authors: Rowan S Hardy, Andrew Filer, Mark S Cooper, Greg Parsonage, Karim Raza, Debbie L Hardie, Elizabeth H Rabbitt, Paul M Stewart, Christopher D Buckley and Martin Hewison
    Citation: Arthritis Research & Therapy 2006 8:R108
    Content type: Research article Published on:

  9. Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases. Stimulation of fibroblasts and human microvascular ...

    Authors: Paul Proost, Sofie Struyf, Tamara Loos, Mieke Gouwy, Evemie Schutyser, René Conings, Isabelle Ronsse, Marc Parmentier, Bernard Grillet, Ghislain Opdenakker, Jan Balzarini and Jo Van Damme
    Citation: Arthritis Research & Therapy 2006 8:R107
    Content type: Research article Published on:

  10. The influence of magnetic resonance imaging (MRI) devices at high field strengths on living tissues is unknown. We investigated the effects of a 3-tesla electromagnetic field (EMF) on the biosynthetic activity...

    Authors: Ilse-Gerlinde Sunk, Siegfried Trattnig, Winfried B Graninger, Love Amoyo, Birgit Tuerk, Carl-Walter Steiner, Josef S Smolen and Klaus Bobacz
    Citation: Arthritis Research & Therapy 2006 8:R106
    Content type: Research article Published on:

  11. With regard to rheumatoid arthritis, remission as currently used in the literature can have two meanings: either a state with persistent absence of clinical and radiological signs of disease activity without b...

    Authors: Annette HM van der Helm-van Mil, Ferdinand C Breedveld and Tom WJ Huizinga
    Citation: Arthritis Research & Therapy 2006 8:216
    Content type: Review Published on:

  12. As indicators of responsiveness to a tumour necrosis factor (TNF)α blocking agent (infliximab) are lacking in rheumatoid arthritis, we have used gene profiling in peripheral blood mononuclear cells to predict ...

    Authors: Thierry Lequerré, Anne-Christine Gauthier-Jauneau, Carine Bansard, Céline Derambure, Martine Hiron, Olivier Vittecoq, Maryvonne Daveau, Othmane Mejjad, Alain Daragon, François Tron, Xavier Le Loët and Jean-Philippe Salier
    Citation: Arthritis Research & Therapy 2006 8:R105
    Content type: Research article Published on:

  13. Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis. One of several complications of SSc, pulmonary arterial hypertension (PAH) can be refractory to treatment, both novel a...

    Authors: Yasushi Kawaguchi, Akiko Tochimoto, Masako Hara, Manabu Kawamoto, Tomoko Sugiura, Yasuhiro Katsumata, Jun Okada, Hirobumi Kondo, Mitsuo Okubo and Naoyuki Kamatani
    Citation: Arthritis Research & Therapy 2006 8:R104
    Content type: Research article Published on:

  14. In this study we examined the effect of ribbon-type (circular-type) NF-κB decoy oligodeoxynucleotides (RNODN) on osteoclast induction and activity. We extracted bone marrow cells from the femurs of rats and in...

    Authors: Yasuo Kunugiza, Tetsuya Tomita, Naruya Tomita, Ryuichi Morishita and Hideki Yoshikawa
    Citation: Arthritis Research & Therapy 2006 8:R103
    Content type: Research article Published on:

  15. Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen (CIX) is a protein of importance for cartilage integrity and stability. In this study we have backcros...

    Authors: Stefan Carlsen, Kutty Selva Nandakumar and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2006 8:R102
    Content type: Research article Published on:

  17. Killer cell immunoglobulin-like receptors (KIRs) and humaAn leukocyte antigen (HLA) loci are both highly polymorphic, and some HLA class I molecules bind and trigger cell-surface receptors specified by KIR genes....

    Authors: Carlos Lopez-Larrea, Miguel Angel Blanco-Gelaz, Juan Carlos Torre-Alonso, Jacome Bruges Armas, Beatriz Suarez-Alvarez, Laura Pruneda, Ana Rita Couto, Segundo Gonzalez, Antonio Lopez-Vázquez and Jesus Martinez-Borra
    Citation: Arthritis Research & Therapy 2006 8:R101
    Content type: Research article Published on:

  18. Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population worldwide. Previously, we showed that human T-cell leukemia virus type I-transgenic mice and interleukin-1 recept...

    Authors: Noriyuki Fujikado, Shinobu Saijo and Yoichiro Iwakura
    Citation: Arthritis Research & Therapy 2006 8:R100
    Content type: Research article Published on:

  20. This study was performed to investigate the transduction of a full-length superoxide dismutase (SOD) protein fused to transactivator of transcription (Tat) into human chondrocytes, and to determine the regulat...

    Authors: Hyun Ah Kim, Dae Won Kim, Jinseu Park and Soo Young Choi
    Citation: Arthritis Research & Therapy 2006 8:R96
    Content type: Research article Published on:

  21. The aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter (SERT) and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. Platelets were obtained f...

    Authors: Laura Bazzichi, Gino Giannaccini, Laura Betti, Giovanni Mascia, Laura Fabbrini, Paola Italiani, Francesca De Feo, Tiziana Giuliano, Camillo Giacomelli, Alessandra Rossi, Antonio Lucacchini and Stefano Bombardieri
    Citation: Arthritis Research & Therapy 2006 8:R99
    Content type: Research article Published on:

  22. Relaxin, a 6-kDa polypeptide hormone, is a potent mediator of matrix turnover and contributes to the loss of collagen and glycosaminoglycans (GAGs) from reproductive tissues, including the fibrocartilaginous p...

    Authors: Gihan Hashem, Qin Zhang, Takayuki Hayami, Jean Chen, Wei Wang and Sunil Kapila
    Citation: Arthritis Research & Therapy 2006 8:R98
    Content type: Research article Published on:

  23. An association between susceptibility to rheumatoid arthritis (RA) and a common -168A>G polymorphism in the MHC2TA gene with differential major histocompatibility complex (MHC) II molecule expression was recently...

    Authors: Babak Yazdani-Biuki, Kerstin Brickmann, Klaus Wohlfahrt, Thomas Mueller, Winfried März, Wilfried Renner, Manuela Gutjahr, Uwe Langsenlehner, Peter Krippl, Thomas C Wascher, Bernhard Paulweber, Winfried Graninger and Hans-Peter Brezinschek
    Citation: Arthritis Research & Therapy 2006 8:R97
    Content type: Research article Published on:

  24. Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity. On the basis of its...

    Authors: Bettina Sehnert, Philip Gierer, Saleh Ibrahim, Anja Kühl, Reinhard Voll, Kutty Selva Nandakumar, Rikard Holmdahl, Rupert Hallmann, Brigitte Vollmar and Harald Burkhardt
    Citation: Arthritis Research & Therapy 2006 8:R95
    Content type: Research article Published on:

  25. For female patients with rheumatoid arthritis, the availability of a host of new disease modifying antirheumatic drugs has raised important questions about fetal safety if a woman becomes pregnant while she is...

    Authors: Christina D Chambers, Zuhre N Tutuncu, Diana Johnson and Kenneth L Jones
    Citation: Arthritis Research & Therapy 2006 8:215
    Content type: Review Published on:

  26. Over 3500 patients with recent onset inflammatory polyarthritis (IP) have been recruited by the Norfolk Arthritis Register (NOAR) since 1990. Longitudinal data from this cohort have been used to examine the pr...

    Authors: Deborah PM Symmons and Alan J Silman
    Citation: Arthritis Research & Therapy 2006 8:214
    Content type: Review Published on:

  27. Statins, competitive inhibitors of hydroxymethylglutaryl-CoA reductase, have recently been shown to have a therapeutic effect in rheumatoid arthritis (RA). In RA, synovial fibroblasts in the synovial lining, a...

    Authors: Alison M Connor, Stuart Berger, Aru Narendran and Edward C Keystone
    Citation: Arthritis Research & Therapy 2006 8:R94
    Content type: Research article Published on:

  28. The autoimmune disease scleroderma (systemic sclerosis (SSc)) is characterized by extensive tissue fibrosis, causing significant morbidity. There is no therapy for the fibrosis observed in SSc; indeed, the und...

    Authors: Andrew Leask
    Citation: Arthritis Research & Therapy 2006 8:213
    Content type: Review Published on:

  31. Degeneration of the rotator cuff is often associated with inflammation of the subacromial bursa and focal mineralization of the supraspinatus tendon. Portions of the supraspinatus tendon distant from the inser...

    Authors: Jana Neuwirth, Renée AE Fuhrmann, Amanda Veit, Matthias Aurich, Ilmars Stonâns, Tilo Trommer, Peter Hortschansky, Susanna Chubinskaya and Juergen A Mollenhauer
    Citation: Arthritis Research & Therapy 2006 8:R92
    Content type: Research article Published on:

  33. Professional antigen-presenting cells, such as dendritic cells, macrophages and B cells have been implicated in the pathogenesis of rheumatoid arthritis, constituting a possible target for antigen-specific imm...

    Authors: Alexei von Delwig, Catharien MU Hilkens, Daniel M Altmann, Rikard Holmdahl, John D Isaacs, Clifford V Harding, Helen Robertson, Norman McKie and John H Robinson
    Citation: Arthritis Research & Therapy 2006 8:R93
    Content type: Research article Published on:

  34. IL-10 is a Th2 cytokine important for inhibiting cell-mediated immunity while promoting humoral responses. Human IL-10 (hIL-10) has anti-inflammatory, immunosuppressive as well as immunostimulatory characteris...

    Authors: Annahita Keravala, Eric R Lechman, Joan Nash, Zhibao Mi and Paul D Robbins
    Citation: Arthritis Research & Therapy 2006 8:R91
    Content type: Research article Published on:

  35. The objective of this study was to describe the rate of change in knee cartilage volume over 4.5 years in subjects with symptomatic knee osteoarthritis (OA) and to determine factors associated with cartilage l...

    Authors: Anita E Wluka, Andrew Forbes, Yuanyuan Wang, Fahad Hanna, Graeme Jones and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2006 8:R90
    Content type: Research article Published on:

  38. We previously established a role for the second messenger ceramide in protein kinase R (PKR)-mediated articular cartilage degradation. Ceramide is known to play a dual role in collagen gene regulation, with th...

    Authors: Sophie J Gilbert, Emma J Blain, Pamela Jones, Victor C Duance and Deborah J Mason
    Citation: Arthritis Research & Therapy 2006 8:R89
    Content type: Research article Published on:

  39. Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is based on a...

    Authors: Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo…
    Citation: Arthritis Research & Therapy 2006 8:209
    Content type: Review Published on:

  41. We have characterized the lymphocyte subset and the receptor molecules involved in inducing the secretion of TNF by monocytic cells in vitro. The TNF secreted by monocytic cells was measured when they were co-cul...

    Authors: Isidoro González-Álvaro, Carmen Domínguez-Jiménez, Ana M Ortiz, Vanessa Núñez-González, Pedro Roda-Navarro, Elena Fernández-Ruiz, David Sancho and Francisco Sánchez-Madrid
    Citation: Arthritis Research & Therapy 2006 8:R88
    Content type: Research article Published on:

  42. RNA interference (RNAi) is an evolutionarily conserved mechanism that is involved in the post-transcriptional silencing of genes. This process elicits the degradation or translational inhibition of mRNAs based...

    Authors: Andrew Jakymiw, Keigo Ikeda, Marvin J Fritzler, Westley H Reeves, Minoru Satoh and Edward KL Chan
    Citation: Arthritis Research & Therapy 2006 8:R87
    Content type: Research article Published on:

  43. Nuclear factor (NF)-κB is a key regulator of synovial inflammation. We investigated the effect of local NF-κB inhibition in rat adjuvant arthritis (AA), using the specific IκB kinase (IKK)-β blocking NF-κB ess...

    Authors: Sander W Tas, Margriet J Vervoordeldonk, Najat Hajji, Michael J May, Sankar Ghosh and Paul P Tak
    Citation: Arthritis Research & Therapy 2006 8:R86
    Content type: Research article Published on:

  44. Functioning is recognized as an important study outcome in rheumatoid arthritis (RA). The Comprehensive ICF Core Set for RA is an application of the International Classification of Functioning, Disability and ...

    Authors: Michaela Coenen, Alarcos Cieza, Tanja A Stamm, Edda Amann, Barbara Kollerits and Gerold Stucki
    Citation: Arthritis Research & Therapy 2006 8:R84
    Content type: Research article Published on:

  45. Many studies have reported that polymorphisms of the mannose-binding lectin (MBL) gene are associated with autoimmune disease. Here, we investigate the relationship between MBL gene polymorphisms and susceptib...

    Authors: Min Kang, Hong-Wei Wang, Pei-Xuan Cheng, Zun-Dong Yin, Xiao-Ou Li, Hong Shi and Xiu-Fen Hu
    Citation: Arthritis Research & Therapy 2006 8:R85
    Content type: Research article Published on:

  46. We studied the clinical and immunological effects of Rituximab (anti-CD20) therapy in patients with lupus nephritis. In an open clinical trial, 22 patients with active systemic lupus erythematosis and renal in...

    Authors: Mónica Vigna-Perez, Berenice Hernández-Castro, Octavio Paredes-Saharopulos, Diana Portales-Pérez, Lourdes Baranda, Carlos Abud-Mendoza and Roberto González-Amaro
    Citation: Arthritis Research & Therapy 2006 8:R83
    Content type: Research article Published on:

  47. We investigated lipid profiles and lipoprotein modification after immuno-intervention in patients with early rheumatoid arthritis (ERA). Fifty-eight patients with ERA who met the American College of Rheumatolo...

    Authors: Athanasios N Georgiadis, Eleni C Papavasiliou, Evangelia S Lourida, Yannis Alamanos, Christina Kostara, Alexandros D Tselepis and Alexandros A Drosos
    Citation: Arthritis Research & Therapy 2006 8:R82
    Content type: Research article Published on:

  48. The efficiency of activating latent transforming growth factor (TGF)-β1 in systemic lupus erythematosus (SLE) may control the balance between inflammation and fibrosis, modulating the disease phenotype. To test t...

    Authors: Michelle Jackson, Yasmeen Ahmad, Ian N Bruce, Beatrice Coupes and Paul EC Brenchley
    Citation: Arthritis Research & Therapy 2006 8:R81
    Content type: Research article Published on:

  49. Recently, we proposed a classification of HLA-DRB1 alleles that reshapes the shared epitope hypothesis in rheumatoid arthritis (RA); according to this model, RA is associated with the RAA shared epitope sequen...

    Authors: Laëtitia Michou, Pascal Croiseau, Elisabeth Petit-Teixeira, Sophie Tezenas du Montcel, Isabelle Lemaire, Céline Pierlot, José Osorio, Wafa Frigui, Sandra Lasbleiz, Patrick Quillet, Thomas Bardin, Bernard Prum, Françoise Clerget-Darpoux and François Cornélis
    Citation: Arthritis Research & Therapy 2006 8:R79
    Content type: Research article Published on:

  50. We conducted the present study to determine whether repair of erosions occurs in patients with rheumatoid arthritis (RA) treated with conventional disease-modifying anti-rheumatic drugs (DMARDs) and to compare...

    Authors: Haruko Ideguchi, Shigeru Ohno, Hideaki Hattori, Akiko Senuma and Yoshiaki Ishigatsubo
    Citation: Arthritis Research & Therapy 2006 8:R76
    Content type: Research article Published on:
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Arthritis Research & Therapy

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