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  1. CD25+CD4+ regulatory T cells participate in the regulation of immune responses. We recently demonstrated the presence of CD25brightCD4+ regulatory T cells with a capacity to control T cell proliferation in the jo...

    Authors: Duojia Cao, Ronald van Vollenhoven, Lars Klareskog, Christina Trollmo and Vivianne Malmström
    Citation: Arthritis Res Ther 2004 6:R335
    Content type: Research article Published on:

  4. The deciphering of the sequence of the human genome has raised the expectation of unravelling the specific role of each gene in physiology and pathology. High-throughput technologies for gene expression profil...

    Authors: Thomas Häupl, Veit Krenn, Bruno Stuhlmüller, Andreas Radbruch and Gerd R Burmester
    Citation: Arthritis Res Ther 2004 6:140
    Content type: Commentary Published on:

  5. Psoriasis and psoriatic arthritis are inflammatory diseases that respond well to anti-tumour necrosis factor-α therapy. To evaluate the effects of anti-tumour necrosis factor-α treatment on expression of adhes...

    Authors: Amber Y Goedkoop, Maarten C Kraan, Daisy I Picavet, Menno A de Rie, Marcel BM Teunissen, Jan D Bos and Paul P Tak
    Citation: Arthritis Res Ther 2004 6:R326
    Content type: Research article Published on:

  6. Outcome assessment in patients with rheumatoid arthritis (RA) includes measurement of physical function. We derived a scale to quantify global physical function in RA, using three performance-based rheumatolog...

    Authors: Agustín Escalante, Roy W Haas and Inmaculada del Rincón
    Citation: Arthritis Res Ther 2004 6:R315
    Content type: Research article Published on:

  7. Microvascular injury, oxidative stress, and impaired angiogenesis are prominent features of systemic sclerosis (SSc). We compared serum markers of these phenomena at baseline and after treatment with nifedipin...

    Authors: Yannick Allanore, Didier Borderie, Hervé Lemaréchal, Ohvanesse Garabed Ekindjian and André Kahan
    Citation: Arthritis Res Ther 2004 6:R309
    Content type: Research article Published on:

  8. Antibodies against cyclic citrullinated peptide (CCP) and rheumatoid factors (RFs) have been demonstrated to predate the onset of rheumatoid arthritis (RA) by years. A nested case–control study was performed w...

    Authors: Ewa Berglin, Leonid Padyukov, Ulf Sundin, Göran Hallmans, Hans Stenlund, Walther J van Venrooij, Lars Klareskog and Solbritt Rantapää Dahlqvist
    Citation: Arthritis Res Ther 2004 6:R303
    Content type: Research article Published on:

  10. Various genetic and environmental factors appear to be involved in systemic lupus erythematosus (SLE). Epstein–Barr virus (EBV) is among the environmental factors that are suspected of predisposing to SLE, bas...

    Authors: Uk Yeol Moon, Su Jin Park, Sang Taek Oh, Wan-Uk Kim, Sung-Hwan Park, Sang-Heon Lee, Chul-Soo Cho, Ho-Youn Kim, Won-Keun Lee and Suk Kyeong Lee
    Citation: Arthritis Res Ther 2004 6:R295
    Content type: Research article Published on:

  12. We evaluated the therapeutic effect of secretory phospholipase A2 (sPLA2)-inhibitory peptide at a cellular level on joint erosion, cartilage destruction, and synovitis in the human tumor necrosis factor (TNF) tra...

    Authors: Maung-Maung Thwin, Eleni Douni, Vassilis Aidinis, George Kollias, Kyoko Kodama, Kazuki Sato, Ramapatna L Satish, Ratha Mahendran and Ponnampalam Gopalakrishnakone
    Citation: Arthritis Res Ther 2004 6:R282
    Content type: Research article Published on:

  13. Bacterial infections play an important role in the multifactorial etiology of rheumatoid arthritis. The arthropathic properties of Gram-positive bacteria have been associated with peptidoglycan–polysaccharide ...

    Authors: Xiangli Li, Blair U Bradford, Frederick Dalldorf, Sanna M Goyert, Stephen A Stimpson, Ronald G Thurman and Sergei S Makarov
    Citation: Arthritis Res Ther 2004 6:R273
    Content type: Research article Published on:

  15. The aim of the present study was to investigate the effect of long-term infliximab treatment on various autoantibodies in patients with rheumatoid arthritis. Serum samples from 30 consecutive patients, who wer...

    Authors: Francesca Bobbio-Pallavicini, Claudia Alpini, Roberto Caporali, Stefano Avalle, Serena Bugatti and Carlomaurizio Montecucco
    Citation: Arthritis Res Ther 2004 6:R264
    Content type: Research article Published on:

  16. The severity of antigen-induced arthritis (AIA) is decreased in leptin-deficient ob/ob mice. However, joint inflammation in AIA depends on the immune response, which is impaired in ob/ob mice. In the present stud...

    Authors: Eiva Bernotiene, Gaby Palmer, Dominique Talabot-Ayer, Ildiko Szalay-Quinodoz, Michel L Aubert and Cem Gabay
    Citation: Arthritis Res Ther 2004 6:R256
    Content type: Research article Published on:

  22. We investigated the therapeutic potential and mechanism of action of IFN-β protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical si...

    Authors: Judith van Holten, Kris Reedquist, Pascale Sattonet-Roche, Tom JM Smeets, Christine Plater-Zyberk, Margriet J Vervoordeldonk and Paul P Tak
    Citation: Arthritis Res Ther 2004 6:R239
    Content type: Research article Published on:

  24. We investigated abnormalities of the hypothalamic–pituitary–gonadal axis and cortisol concentrations in women with fibromyalgia and chronic fatigue syndrome (CFS) who were in the follicular phase of their mens...

    Authors: Ali Gur, Remzi Cevik, Kemal Nas, Leyla Colpan and Serdar Sarac
    Citation: Arthritis Res Ther 2004 6:R232
    Content type: Research article Published on:

  25. Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b+ myeloblasts. Both disease manifestations are more pronounced in interferon-γ receptor knoc...

    Authors: Bert De Klerck, Isabelle Carpentier, Rik J Lories, Yvette Habraken, Jacques Piette, Geert Carmeliet, Rudi Beyaert, Alfons Billiau and Patrick Matthys
    Citation: Arthritis Res Ther 2004 6:R220
    Content type: Research article Published on:

  26. The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49–85 years with knee...

    Authors: Masaaki Takahashi, Kenichi Naito, Masashi Abe, Tomokazu Sawada and Akira Nagano
    Citation: Arthritis Res Ther 2004 6:R208
    Content type: Research article Published on:

  27. Induction of oral tolerance has long been considered a promising approach to the treatment of chronic autoimmune diseases, including rheumatoid arthritis (RA). Oral administration of type II collagen (CII) has...

    Authors: So-Youn Min, Sue-Yun Hwang, Kyung-Su Park, Jae-sun Lee, Kang-Eun Lee, Kyung-Wun Kim, Young-Ok Jung, Hyunk-Jae Koh, Ju-Ho Do, Haerim Kim and Ho-Youn Kim
    Citation: Arthritis Res Ther 2004 6:R213
    Content type: Research article Published on:

  30. The genetic background of rheumatoid arthritis (RA) is only partly understood, and several genes seem to be involved. The matrix metalloproteinases MMP1 (interstitial collagenase) and MMP3 (stromelysin 1) are tho...

    Authors: Sylvia Dörr, Nadine Lechtenböhmer, Rolf Rau, Gertraud Herborn, Ulf Wagner, Bertram Müller-Myhsok, Ingo Hansmann and Gernot Keyszer
    Citation: Arthritis Res Ther 2004 6:R199
    Content type: Research article Published on:

  32. Authors: Martin Skoumal, Günther Haberhauer, Josef Feyertag, Eva Maria Kittl, Kurt Bauer and Attila Dunky
    Citation: Arthritis Res Ther 2004 6:73
    Content type: Letter Published on:

  33. Endothelial cells are active participants in chronic inflammatory diseases. These cells undergo phenotypic changes that can be characterised as activated, angiogenic, apoptotic and leaky. In the present review...

    Authors: Jim Middleton, Laure Americh, Regis Gayon, Denis Julien, Luc Aguilar, Francois Amalric and Jean-Philippe Girard
    Citation: Arthritis Res Ther 2004 6:60
    Content type: Review Published on:

  34. T lymphocytes have been implicated in the pathogenesis of inflammatory arthritis for approximately 30 years. Over that period a vast literature has described the phenotype, location and behaviour of T cells de...

    Authors: Jeff Faint and Frances Hall
    Citation: Arthritis Res Ther 2004 6:55
    Content type: Meeting report Published on:

  35. Chronic T cell responses, as they occur in rheumatoid arthritis, are complex and are likely to involve many mechanisms. There is a growing body of evidence that, in concert with the T cell antigen receptor sig...

    Authors: Monika C Brunner-Weinzierl, Holger Hoff and Gerd-R Burmester
    Citation: Arthritis Res Ther 2004 6:45
    Content type: Review Published on:

  36. To determine the contribution of IL-1β, tumor necrosis factor alpha (TNF-α) and IL-17 to AP-1, NF-κB and Egr-1 activation in rheumatoid arthritis, the effect of the cytokines used alone or in combination was m...

    Authors: Corinne Granet, Wova Maslinski and Pierre Miossec
    Citation: Arthritis Res Ther 2004 6:R190
    Content type: Research article Published on:

  43. Authors: R Flierman, L Morgan, L van Duivenvoorde, RRP de Vries, WE Fibbe, TJW Huizinga, REM Toes and JM van Laar
    Citation: Arthritis Res Ther 2004 6(Suppl 1):95
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

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Arthritis Research & Therapy

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