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  1. The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variet...

    Authors: Marvin J Fritzler, Allan Wiik, Mark L Fritzler and Susan G Barr
    Citation: Arthritis Res Ther 2003 5:192
    Content type: Review Published on:

  4. Using electrophoretic mobility shift assays, we examined sequence-specific binding of DEK, a potential autoantigen in juvenile rheumatoid arthritis, to conserved Y-box regulatory sequences in class II MHC gene...

    Authors: Barbara S Adams, Hyuk C Cha, Joanne Cleary, Tan Haiying, Hongling Wang, Kajal Sitwala and David M Markovitz
    Citation: Arthritis Res Ther 2003 5:R226
    Content type: Research article Published on:

  6. Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin...

    Authors: Anna-Marie Fairhurst, John E Connolly, Katharine A Hintz, Nicolas J Goulding, Athos J Rassias, Mark P Yeager, William Rigby and Paul K Wallace
    Citation: Arthritis Res Ther 2003 5:R214
    Content type: Research article Published on:

  7. Clonal expansion of CD4+CD28- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4+ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist ...

    Authors: Andrzej Pawlik, Lidia Ostanek, Iwona Brzosko, Marek Brzosko, Marek Masiuk, Boguslaw Machalinski and Barbara Gawronska-Szklarz
    Citation: Arthritis Res Ther 2003 5:R210
    Content type: Research article Published on:

  9. Hormone replacement therapy (HRT) modulates the imbalance in bone remodeling, thereby decreasing bone loss. Sex hormones are known to influence rheumatic diseases. The aim of this study was to investigate the ...

    Authors: Helena Forsblad d'Elia, Lars-Ã…ke Mattsson, Claes Ohlsson, Elisabeth Nordborg and Hans Carlsten
    Citation: Arthritis Res Ther 2003 5:R202
    Content type: Research article Published on:

  11. The meeting consisted of 11 talks that illustrated the complexity of the pathogenetic mechanisms underlying systemic lupus erythematosus and aimed to identify ways in which cytokine modulation might affect tho...

    Authors: Anisur Rahman
    Citation: Arthritis Res Ther 2003 5:160
    Content type: Meeting report Published on:

  12. The pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA) remains obscure, although angiogenesis appears to play an important role. We recently confirmed an overexpression of two angiogenic factors...

    Authors: Alexandra Giatromanolaki, Efthimios Sivridis, Efstratios Maltezos, Nick Athanassou, Dimitrios Papazoglou, Kevin C Gatter, Adrian L Harris and Michael I Koukourakis
    Citation: Arthritis Res Ther 2003 5:R193
    Content type: Research article Published on:

  13. Changes in serum cartilage oligomeric matrix protein (COMP) were studied during a 6-month period from initiation of treatment of rheumatoid arthritis patients with either infliximab or etanercept, to elucidate...

    Authors: Meliha Crnkic, Bengt Månsson, Lotta Larsson, Pierre Geborek, Dick Heinegård and Tore Saxne
    Citation: Arthritis Res Ther 2003 5:R181
    Content type: Research article Published on:

  14. Interleukin-17 (IL-17) has been characterized as a proinflammatory cytokine produced by CD4+ CD45RO+ memory T cells. Overproduction of IL-17 was detected in the synovium of patients with rheumatoid arthritis (RA)...

    Authors: Astrid Kehlen, A Pachnio, K Thiele and J Langner
    Citation: Arthritis Res Ther 2003 5:R186
    Content type: Research article Published on:

  15. B cells are essential to the development of systemic lupus erythematosus (SLE). The chimeric monoclonal antibody rituximab depletes B cells by targeting the pan-B-cell surface marker CD20. Preliminary experien...

    Authors: Robert Eisenberg
    Citation: Arthritis Res Ther 2003 5:157
    Content type: Commentary Published on:

  18. Before the mid-1980s the only autoantibody widely used to assist in diagnosing vasculitic disease was IgG antibody to the α3 domain of the noncollagenous part of type IV collagen (anti-glomerular basement membran...

    Authors: Allan Wiik
    Citation: Arthritis Res Ther 2003 5:147
    Content type: Review Published on:

  19. We previously reported that autoantibodies (autoAbs) to the main epitope on CD69 reacted to its homologous amino acid sequence in low-density-lipoprotein-receptor-related protein 2 (LPR2), a multiligand recept...

    Authors: Seido Ooka, Toshihiro Matsui, Kusuki Nishioka and Tomohiro Kato
    Citation: Arthritis Res Ther 2003 5:R174
    Content type: Research article Published on:

  20. Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the ov...

    Authors: Shunsei Hirohata and Hirotoshi Kikuchi
    Citation: Arthritis Res Ther 2003 5:139
    Content type: Review Published on:

  22. To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts....

    Authors: Thomas Pap, Anja Claus, Susumu Ohtsu, Klaus M Hummel, Peter Schwartz, Susanne Drynda, Géza Pap, Andreas Machner, Bernhard Stein, Michael George, Renate E Gay, Wolfram Neumann, Steffen Gay and Wilhelm K Aicher
    Citation: Arthritis Res Ther 2003 5:R163
    Content type: Research article Published on:

  23. The present case–control study was conducted to investigate the relationship between smoking and rheumatoid arthritis, and to investigate formally the interaction between sex, smoking, and risk for developing ...

    Authors: Eswar Krishnan, Tuulikki Sokka and Pekka Hannonen
    Citation: Arthritis Res Ther 2003 5:R158
    Content type: Research article Published on:

  24. Depleting B cells with anti-CD20 monoclonal antibodies emerges as a new therapeutic strategy in autoimmune diseases. Preliminary clinical studies suggest therapeutic benefits in patients with classic autoantib...

    Authors: Jörg J Goronzy and Cornelia M Weyand
    Citation: Arthritis Res Ther 2003 5:131
    Content type: Commentary Published on:

  25. Increasing attention has been directed towards identifying non-T-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a hallmark of rheumatoid arthriti...

    Authors: Vassilis Aidinis, David Plows, Sylva Haralambous, Maria Armaka, Petros Papadopoulos, Maria Zambia Kanaki, Dirk Koczan, Hans Juergen Thiesen and George Kollias
    Citation: Arthritis Res Ther 2003 5:R140
    Content type: Research article Published on:

  26. To examine the effect of transforming growth factor (TGF)-β1 on the regulation of cartilage synthesis and other articular pathologies, we used adenovirus-mediated intra-articular gene transfer of TGF-β1 to bot...

    Authors: Zhibao Mi, Steven C Ghivizzani, Eric Lechman, Joseph C Glorioso, Christopher H Evans and Paul D Robbins
    Citation: Arthritis Res Ther 2003 5:R132
    Content type: Research article Published on:

  27. The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than d...

    Authors: Jill PG Urban and Sally Roberts
    Citation: Arthritis Res Ther 2003 5:120
    Content type: Review Published on:

  28. To evaluate the antioxidant activity of the glycosaminoglycans hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S), we used a rat model of collagen-induced arthritis (CIA). Arthritis was induced in Lewis ra...

    Authors: Giuseppe M Campo, Angela Avenoso, Salvatore Campo, Alida M Ferlazzo, Domenica Altavilla and Alberto Calatroni
    Citation: Arthritis Res Ther 2003 5:R122
    Content type: Research article Published on:

  29. CD44 is a multistructural cell-surface glycoprotein that can theoretically generate close to 800 isoforms by differential alternative splicing. At present, several dozen isoforms are known. The polymorphic nat...

    Authors: David Naor and Shlomo Nedvetzki
    Citation: Arthritis Res Ther 2003 5:105
    Content type: Review Published on:
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Arthritis Research & Therapy

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