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  1. Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently, a naturally occurring CD4+CD25+ T-cell subset that is anergic and also suppressive has been shown t...

    Authors: Tamas Bardos, Matyas Czipri, Csaba Vermes, Alison Finnegan, Katalin Mikecz and Jian Zhang
    Citation: Arthritis Res Ther 2003 5:R106
  2. Patients with systemic lupus erythematosus (SLE) have ongoing interferon-α (IFN-α) production and serum IFN-α levels are correlated with both disease activity and severity. Recent studies of patients with SLE ...

    Authors: Lars Rönnblom and Gunnar V Alm
    Citation: Arthritis Res Ther 2003 5:68
  3. The systematic analysis of polymorphisms across large parts of the human genome has begun to provide the first information on haplotypes and the problem of linkage disequilibrium across large genomic regions. ...

    Authors: John I Bell
    Citation: Arthritis Res Ther 2003 5:51
  4. In the present study we examined cartilage matrix repair following IL-1-induced matrix depletion. Previous data indicated that, in some cases, chondrocytes can synthesize macromolecules to establish a function...

    Authors: Ashley Williams, Rachel A Oppenheimer, Martha L Gray and Deborah Burstein
    Citation: Arthritis Res Ther 2003 5:R97
  5. Although a role for CD8+ T cells in the pathogenesis of rheumatoid arthritis (RA) has been suggested, the precise nature of their involvement is not fully understood. In the present study we examined the central ...

    Authors: Anastacia Maldonado, Yvonne M Mueller, Preethi Thomas, Paul Bojczuk, Carolyn O'Connors and Peter D Katsikis
    Citation: Arthritis Res Ther 2003 5:R91
  6. Advanced glycation end-product (AGE)-damaged IgG occurs as a result of hyperglycemia and/or oxidative stress. Autoantibodies to IgG-AGE were previously demonstrated in patients with severe, longstanding rheuma...

    Authors: Marianna M Newkirk, Raphaela Goldbach-Mansky, Jennifer Lee, Joseph Hoxworth, Angie McCoy, Cheryl Yarboro, John Klippel and Hani S El-Gabalawy
    Citation: Arthritis Res Ther 2003 5:R82
  7. Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the present study we examined the expression and regulatory mechanisms of IFN-γ inducible protein (IP)-10 in RA synovitis. ...

    Authors: Ryosuke Hanaoka, Tsuyoshi Kasama, Mizuho Muramatsu, Nobuyuki Yajima, Fumitaka Shiozawa, Yusuke Miwa, Masao Negishi, Hirotsugu Ide, Hideyo Miyaoka, Hitoshi Uchida and Mitsuru Adachi
    Citation: Arthritis Res Ther 2003 5:R74
  8. The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-ba...

    Authors: Rocky S Tuan, Genevieve Boland and Richard Tuli
    Citation: Arthritis Res Ther 2002 5:32
  9. Cyclooxygenase (COX)-2 selective inhibitors have been shown to have comparable efficacy to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with osteoarthritis (OA) and r...

    Authors: Marc C Hochberg
    Citation: Arthritis Res Ther 2002 5:28
  10. Autologous chondrocyte implantation is being used increasingly for the treatment of cartilage defects. In spite of this, there has been a paucity of objective, standardised assessment of the outcome and qualit...

    Authors: Sally Roberts, Iain W McCall, Alan J Darby, Janis Menage, Helena Evans, Paul E Harrison and James B Richardson
    Citation: Arthritis Res Ther 2002 5:R60
  11. While it has been established that IFN-γ is a strong activator of macrophages and a potent inhibitor of osteoclastogenesis in vitro, it is also known that this cytokine is produced in particular settings of infla...

    Authors: Willis Huang, Regis J O'Keefe and Edward M Schwarz
    Citation: Arthritis Res Ther 2002 5:R49
  12. The HLA-DRB1*0401 MHC class II molecule (DR4) is genetically associated with rheumatoid arthritis. It has been proposed that this MHC class II molecule participates in disease pathogenesis by presenting arthri...

    Authors: Jonathan A Hill, Dequn Wang, Anthony M Jevnikar, Ewa Cairns and David A Bell
    Citation: Arthritis Res Ther 2002 5:R40
  13. During rheumatoid arthritis there is enlargement and increased cellularity of the synovial lining of joints, before invasion by the synovium of the underlying cartilage and bone. This increased tissue mass req...

    Authors: Percy F Sumariwalla, Yihai Cao, Hua-Lin Wu, Marc Feldmann and Ewa M Paleolog Dr
    Citation: Arthritis Res Ther 2002 5:R32
  14. Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a...

    Authors: Peter Lamprecht, Anika Erdmann, Antje Mueller, Elena Csernok, Eva Reinhold-Keller, Konstanze Holl-Ulrich, Alfred C Feller, Hilke Bruehl and Wolfgang L Gross
    Citation: Arthritis Res Ther 2002 5:R25
  15. IL-10 is a potent immunoregulatory cytokine attenuating a wide range of immune effector and inflammatory responses. In the present study, we assess whether endogenous levels of IL-10 function to regulate the i...

    Authors: Alison Finnegan, Charles D Kaplan, Yanxia Cao, Hermann Eibel, Tibor T Glant and Jian Zhang
    Citation: Arthritis Res Ther 2002 5:R18
  16. We are pleased to announce a number of changes to the journal that will take effect from the start of 2003.

    Authors: Peter E Lipsky and Ravinder N Maini
    Citation: Arthritis Res Ther 2002 5:1
  17. In reactive and postinfectious arthritis the joints are generally sterile but the presence of bacterial antigens and nucleic acids has been reported. To investigate whether organisms traffic to affected joints...

    Authors: Charles J Cox, Karen E Kempsell and J S Hill Gaston
    Citation: Arthritis Res Ther 2002 5:R1
  18. Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of...

    Authors: Thomas Dörner and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2002 4:360
  19. Sjögren's syndrome is a multisystem inflammatory rheumatic disease that is classified into primary and secondary forms, with cardinal features in the eye (keratoconjunctivitis sicca) and mouth (xerostomia). Th...

    Authors: Anne Isine Bolstad and Roland Jonsson
    Citation: Arthritis Research & Therapy 2002 4:353
  20. IFN-β treatment is emerging as a potentially effective form of therapy in various immune-mediated conditions. The present review addresses the possible role of IFN-β in immune-mediated diseases such as multipl...

    Authors: Judith van Holten, Christine Plater-Zyberk and Paul P Tak
    Citation: Arthritis Research & Therapy 2002 4:346
  21. Patients with rheumatoid arthritis (RA) experience excess cardiovascular disease (CVD). We investigated the effects of disease-modifying antirheumatic drugs (DMARD) and dietary intervention on CVD risk in infl...

    Authors: Patrick H Dessein, Barry I Joffe and Anne E Stanwix
    Citation: Arthritis Research & Therapy 2002 4:R12
  22. To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis (SSc) is caused by a decrease in angiogenic factors and/or an increase in angiostatic factors, the potent proangiogenic molecules...

    Authors: Oliver Distler, Angela del Rosso, Roberto Giacomelli, Paola Cipriani, Maria L Conforti, Serena Guiducci, Renate E Gay, Beat A Michel, Pius Brühlmann, Ulf Müller-Ladner, Steffen Gay and Marco Matucci-Cerinic
    Citation: Arthritis Research & Therapy 2002 4:R11
  23. Nurse-like stromal cell lines from the synovial tissue of patients with rheumatoid arthritis (RA-SNC) produce, on coculture with lymphocytes, large amounts of proinflammatory cytokines. In the present paper, w...

    Authors: Eiji Takeuchi, Toshiyuki Tanaka, Eiji Umemoto, Tetsuya Tomita, Kenrin Shi, Koichiro Takahi, Ryuji Suzuki, Takahiro Ochi and Masayuki Miyasaka
    Citation: Arthritis Research & Therapy 2002 4:R10
  24. Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor (anti-TNF) therapy ...

    Authors: Juergen Braun and Joachim Sieper
    Citation: Arthritis Research & Therapy 2002 4:307
  25. Interleukin (IL)-12, being a major cytokine that induces T helper (Th) 1 differentiation and inflammatory response, has been postulated to be an important mediator of synovial inflammation in rheumatoid arthri...

    Authors: Milja Möttönen, Pia Isomäki, Reijo Luukkainen and Olli Lassila
    Citation: Arthritis Research & Therapy 2002 4:R9
  26. The chronic arthropathies of childhood share clinical and pathological features with rheumatoid arthritis (RA) in adults. Both are autoimmune diseases characterized by a destructive arthropathy. Both are likel...

    Authors: Sampath Prahalad and David N Glass
    Citation: Arthritis Research & Therapy 2002 4(Suppl 3):303

    This article is part of a Supplement: Volume 4 Supplement 3

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