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  1. Both TGFβ and estradiol (E2), a form of estrogen, are pro-fibrotic in the skin. In the connective tissue disease, systemic sclerosis (SSc), both TGFβ and E2 are likely pathogenic. Yet the regulation of TGFβ in...

    Authors: DeAnna Baker Frost, Alisa Savchenko, Adeyemi Ogunleye, Milton Armstrong and Carol Feghali-Bostwick
    Citation: Arthritis Research & Therapy 2021 23:68
    Content type: Research article Published on:

  2. Biological disease-modifying anti-rheumatic drugs (bDMARDs) can be tapered in some rheumatoid arthritis (RA) patients in sustained remission. The purpose of this study was to assess the feasibility of building...

    Authors: Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser…
    Citation: Arthritis Research & Therapy 2021 23:67
    Content type: Research article Published on:

  3. We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis (KOA) based on survey data obtained via a random, nationwide sample of Chinese individuals.

    Authors: Limin Wang, Han Lu, Hongbo Chen, Shida Jin, Mengqi Wang and Shaomei Shang
    Citation: Arthritis Research & Therapy 2021 23:65
    Content type: Research article Published on:

  4. Epidemiologic data suggest that patients with systemic lupus erythematosus (SLE) have a lower risk of breast cancer than women in the general population. In light of mechanistic studies suggesting that anti-DN...

    Authors: Ami A. Shah, Takeru Igusa, Daniel Goldman, Jessica Li, Livia Casciola-Rosen, Antony Rosen and Michelle Petri
    Citation: Arthritis Research & Therapy 2021 23:64
    Content type: Research article Published on:

  5. Takayasu arteritis (TA) is a rare disease, lacking convenient and feasible biomarkers to identify disease activity. We aimed to evaluate the value of complements in distinguishing active TA.

    Authors: Rongyi Chen, Lingying Ma, Peng Lv, Jiang Lin, Chaolun Li, Yan Yan, Xuejuan Jin, Xiaomin Dai, Zongfei Ji, Huiyong Chen, Lili Ma, Ying Sun and Lindi Jiang
    Citation: Arthritis Research & Therapy 2021 23:63
    Content type: Research article Published on:

  6. It is well established that patients with systemic sclerosis (SSc) have a disrupted lipid profile and an increased cardiovascular risk. Cholesterol efflux capacity (CEC), the ability of high-density lipoprotei...

    Authors: Iván Ferraz-Amaro, Esmeralda Delgado-Frías, Vanesa Hernández-Hernández, Hiurma Sánchez-Pérez, Laura de Armas-Rillo, Estefanía Armas-González, José David Machado and Federico Diaz-González
    Citation: Arthritis Research & Therapy 2021 23:62
    Content type: Research article Published on:

  7. Assessing risk perception (RP) helps explain how rheumatoid arthritis (RA) patients integrate their ideas concerning the disease and how this understanding affects their self-care management. Compliance with t...

    Authors: Irazú Contreras-Yáñez, Pilar Lavielle, Patricia Clark and Virginia Pascual-Ramos
    Citation: Arthritis Research & Therapy 2021 23:61
    Content type: Research article Published on:

  8. Bisphosphonates have been proposed as possible disease-modifying drugs in osteoarthritis. However, the evidence of their efficacy is poor and their outcomes presented a great heterogeneity. Therefore, the aim ...

    Authors: Silvia Fernández-Martín, Mónica López-Peña, Fernando Muñoz, María Permuy and Antonio González-Cantalapiedra
    Citation: Arthritis Research & Therapy 2021 23:60
    Content type: Review Published on:

  9. Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of disability and overall diminution of quality of life in the elderly population. Currently there is no cure for OA, partly due ...

    Authors: Ming Liu, Zikun Xie, Guang Sun, Liujun Chen, Dake Qi, Hongwei Zhang, Jieying Xiong, Andrew Furey, Proton Rahman, Guanghua Lei and Guangju Zhai
    Citation: Arthritis Research & Therapy 2021 23:59
    Content type: Research article Published on:

  10. Our previous studies reveal that impaired draining function of the synovial lymphatic vessel (LV) contributes to the pathogenesis of inflammatory arthritis, but the cellular and molecular mechanisms involved a...

    Authors: Qianqian Liang, Li Zhang, Hao Xu, Jinlong Li, Yan Chen, Edward M. Schwarz, Qi Shi, Yongjun Wang and Lianping Xing
    Citation: Arthritis Research & Therapy 2021 23:58
    Content type: Research article Published on:

  11. Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). The current knowledge of the prognostic factors for SLE-associated DAH is controversial. Thi...

    Authors: Mengdi Jiang, Ruxuan Chen, Lidan Zhao and Xuan Zhang
    Citation: Arthritis Research & Therapy 2021 23:57
    Content type: Research article Published on:

  12. A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the pr...

    Authors: Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz and Lars-Oliver Tykocinski
    Citation: Arthritis Research & Therapy 2021 23:56
    Content type: Research article Published on:

  13. To assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA).

    Authors: Bas A. de Vries, Stephan J. Breda, Bragi Sveinsson, Emily J. McWalter, Duncan E. Meuffels, Gabriel P. Krestin, Brian A. Hargreaves, Garry E. Gold and Edwin H. G. Oei
    Citation: Arthritis Research & Therapy 2021 23:55
    Content type: Research article Published on:

  14. The growing utilization of needle biopsy has challenged the current pathology consensus of IgG4-related disease (IgG4-RD). The aims of this study were to identify the histological characteristics of needle bio...

    Authors: Yanying Liu, Fei Yang, Xiying Chi, Yuxin Zhang, Jiangnan Fu, Wenjie Bian, Danhua Shen and Zhanguo Li
    Citation: Arthritis Research & Therapy 2021 23:54
    Content type: Research article Published on:

  15. Patient-reported outcomes (PROs) are increasingly used to track symptoms and to assess disease activity, quality of life, and treatment effectiveness. It is therefore important to understand which PROs patient...

    Authors: W. Benjamin Nowell, Kelly Gavigan, Carol L. Kannowski, Zhihong Cai, Theresa Hunter, Shilpa Venkatachalam, Julie Birt, Jennifer Workman and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2021 23:53
    Content type: Research article Published on:

  16. A20 haploinsufficiency (HA20) is an early-onset autoinflammatory disease caused by mutations in the TNFAIP3 gene, which encodes the protein A20. Numerous truncating mutations in the TNFAIP3 gene have been reporte...

    Authors: Saori Kadowaki, Kunio Hashimoto, Toyoki Nishimura, Kenichi Kashimada, Tomonori Kadowaki, Norio Kawamoto, Kohsuke Imai, Satoshi Okada, Hirokazu Kanegane and Hidenori Ohnishi
    Citation: Arthritis Research & Therapy 2021 23:52
    Content type: Research article Published on:

  17. To demonstrate equivalent efficacy of the proposed high-concentration (100 mg/ml), citrate-free adalimumab biosimilar CT-P17 to European Union-approved adalimumab (EU-adalimumab) in subjects with active rheuma...

    Authors: Jonathan Kay, Janusz Jaworski, Rafal Wojciechowski, Piotr Wiland, Anna Dudek, Marek Krogulec, Slawomir Jeka, Agnieszka Zielinska, Jakub Trefler, Katarzyna Bartnicka-Maslowska, Magdalena Krajewska-Wlodarczyk, Piotr A. Klimiuk, Sang Joon Lee, Yun Ju Bae, Go Eun Yang, Jae Kyoung Yoo…
    Citation: Arthritis Research & Therapy 2021 23:51
    Content type: Research article Published on:

  18. Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities. Hydrogel scaffolds have excellent potential for use in tissue engineering. Therefore, the aim of the pr...

    Authors: Yuan Li, Yanping Liu and Qiang Guo
    Citation: Arthritis Research & Therapy 2021 23:50
    Content type: Research article Published on:

  19. We hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD.

    Authors: Yutaro Soejima, Yohei Kirino, Mitsuhiro Takeno, Michiko Kurosawa, Masaki Takeuchi, Ryusuke Yoshimi, Yumiko Sugiyama, Shigeru Ohno, Yukiko Asami, Akiko Sekiguchi, Toshihisa Igarashi, Shohei Nagaoka, Yoshiaki Ishigatsubo, Hideaki Nakajima and Nobuhisa Mizuki
    Citation: Arthritis Research & Therapy 2021 23:49
    Content type: Research article Published on:

  20. Subclinical synovitis by ultrasound is a frequent finding in rheumatoid arthritis (RA) patients in remission and has been shown to be related to erosive progression, risk of flare and unsuccessful drug taperin...

    Authors: Lene Terslev, Cecilie Heegaard Brahe, Mikkel Østergaard, Viktoria Fana, Mads Ammitzbøll-Danielsen, Torsten Møller, Simon Krabbe, Merete Lund Hetland and Uffe Møller Døhn
    Citation: Arthritis Research & Therapy 2021 23:48
    Content type: Research article Published on:

  21. Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties in ch...

    Authors: Chao Xu, Su Ni, Chao Zhuang, Chenkai Li, Gongyin Zhao, Shijie Jiang, Liangliang Wang, Ruixia Zhu, Andre J. van Wijnen and Yuji Wang
    Citation: Arthritis Research & Therapy 2021 23:47
    Content type: Research article Published on:

  22. Fine-mapping of human leukocyte antigen (HLA) region for rheumatoid arthritis (RA) risk factors has identified several HLA alleles and its corresponding amino acid residues as independent signals (i.e., HLA-A, HL...

    Authors: Lay Kim Tan, Chun Lai Too, Lina Marcela Diaz-Gallo, Sulaiman Wahinuddin, Ing Soo Lau, Hussein Heselynn, Shahril Nor-Shuhaila, Suk Chyn Gun, Mageswaran Eashwary, Mohamed Said Mohd-Shahrir, Mohd Mokhtar Ainon, Rosman Azmillah, Othman Muhaini, Murad Shahnaz, Lars Alfredsson, Lars Klareskog…
    Citation: Arthritis Research & Therapy 2021 23:46
    Content type: Research article Published on:

  23. Behcet’s syndrome (BS) is a complex, heterogeneous disorder. However, classification of its subgroups is still debated. The purpose of this study was to investigate the clinical features and aggregation of pat...

    Authors: Jun Zou, Jian-feng Luo, Yan Shen, Jian-fei Cai and Jian-long Guan
    Citation: Arthritis Research & Therapy 2021 23:45
    Content type: Research article Published on:

  24. Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development.

    Authors: Amir Haddad, Tal Gazitt, Ilan Feldhamer, Joy Feld, Arnon Dov Cohen, Idit Lavi, Faten Tatour, Irena Bergman and Devy Zisman
    Citation: Arthritis Research & Therapy 2021 23:44
    Content type: Research article Published on:

  25. Limited information is available on the impact of treatment with a tumor necrosis factor inhibitor (TNFi) on structural lesions in patients with recent-onset axial spondyloarthritis (axSpA). We compared 2-year...

    Authors: Walter P. Maksymowych, Pascal Claudepierre, Manouk de Hooge, Robert G. Lambert, Robert Landewé, Anna Molto, Désirée van der Heijde, Jack F. Bukowski, Heather Jones, Ron Pedersen, Annette Szumski, Bonnie Vlahos and Maxime Dougados
    Citation: Arthritis Research & Therapy 2021 23:43
    Content type: Research article Published on:

  27. The efficacy and safety of ixekizumab (IXE) with and without continuous concomitant methotrexate (MTX), for up to 52 weeks of treatment, were evaluated in patients with active psoriatic arthritis (PsA).

    Authors: Bernard Combe, Tsen-Fang Tsai, J. Eugene Huffstutter, Aubrey Trevelin Sprabery, Chen-Yen Lin, So Young Park, Andris Kronbergs, Matthew M. Hufford and Peter Nash
    Citation: Arthritis Research & Therapy 2021 23:41
    Content type: Research article Published on:

  28. The goal of the study was to assess the diagnostic and prognostic utility of survivin in patients with juvenile idiopathic arthritis (JIA).

    Authors: Joanna Lipinska, Marcin Kaszkowiak, Beata Malachowska, Joanna Swidrowska-Jaros and Elzbieta Smolewska
    Citation: Arthritis Research & Therapy 2021 23:40
    Content type: Research article Published on:

  29. Curcumin (CUR), vitamin D3 (D3), and omega-3-fatty acids (O3FA) individually modulate inflammation and pain in arthritis. Although these supplements are widely used, their combinatorial effects have not been defi...

    Authors: Mahadevappa Hemshekhar, Vidyanand Anaparti, Hani El-Gabalawy and Neeloffer Mookherjee
    Citation: Arthritis Research & Therapy 2021 23:39
    Content type: Research article Published on:

  30. To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data.

    Authors: Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen and Feng Zhang
    Citation: Arthritis Research & Therapy 2021 23:38
    Content type: Research article Published on:

  31. Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to ana...

    Authors: Nils Rosshirt, Richard Trauth, Hadrian Platzer, Elena Tripel, Timo A. Nees, Hanns-Martin Lorenz, Theresa Tretter and Babak Moradi
    Citation: Arthritis Research & Therapy 2021 23:37
    Content type: Research article Published on:

  33. Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. Howev...

    Authors: Koji Aso, Seyed Mohsen Shahtaheri, Daniel F. McWilliams and David A. Walsh
    Citation: Arthritis Research & Therapy 2021 23:35
    Content type: Research article Published on:

  34. Pain is a frequent, yet inadequately explored challenge in patients with systemic sclerosis (SSc). This study aimed to conduct an extensive pain assessment, examining pain chronification and its association wi...

    Authors: Caroline Evers, Suzana Jordan, Britta Maurer, Mike Oliver Becker, Carina Mihai, Rucsandra Dobrota, Petra Hoederath and Oliver Distler
    Citation: Arthritis Research & Therapy 2021 23:34
    Content type: Research article Published on:

  35. Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of i...

    Authors: Jennifer Young-Glazer, Alberto Cisneros III, Erin M. Wilfong, Scott A. Smith, Leslie J. Crofford and Rachel H. Bonami
    Citation: Arthritis Research & Therapy 2021 23:33
    Content type: Research article Published on:

  36. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in...

    Authors: Johan Frostegård, Sabbir Ahmed, Ingiäld Hafström, Sofia Ajeganova and Mizanur Rahman
    Citation: Arthritis Research & Therapy 2021 23:32
    Content type: Research article Published on:

  37. Rheumatoid arthritis (RA) is an autoimmune disease of inflammatory joint damage, wherein C-reactive protein and autoantibodies including rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) ...

    Authors: Sora Mun, Jiyeong Lee, Mira Park, Jieun Shin, Mi-Kyoung Lim and Hee-Gyoo Kang
    Citation: Arthritis Research & Therapy 2021 23:31
    Content type: Research article Published on:

  38. To evaluate our hypotheses that, when rheumatoid arthritis (RA) flares postpartum, gene expression patterns are altered compared to (a) healthy women, (b) RA women whose disease activity is low or in remission...

    Authors: Matthew Wright, Mette K. Smed, J. Lee Nelson, Jørn Olsen, Merete L. Hetland, Vibeke Zoffmann and Damini Jawaheer
    Citation: Arthritis Research & Therapy 2021 23:30
    Content type: Research article Published on:

  39. Type I interferons (IFNs) play an important role in the pathophysiology of systemic lupus erythematosus (SLE). While cross-sectional data suggest an association between IFN-induced gene expression and SLE dise...

    Authors: Lloyd Mai, Arundip Asaduzzaman, Babak Noamani, Paul R. Fortin, Dafna D. Gladman, Zahi Touma, Murray B. Urowitz and Joan Wither
    Citation: Arthritis Research & Therapy 2021 23:29
    Content type: Research article Published on:

  40. To assess through systematic review and meta-analysis whether plasma exchange (PE) is associated with prognosis in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients.

    Authors: Yosuke Yamada, Makoto Harada, Yuuta Hara, Ryohei Iwabuchi, Koji Hashimoto, Shuhei Yamamoto and Yuji Kamijo
    Citation: Arthritis Research & Therapy 2021 23:28
    Content type: Review Published on:

  41. Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors o...

    Authors: Emil Rydell, Kristina Forslind, Jan-Ã…ke Nilsson, Magnus Karlsson, Kristina E. Ã…kesson, Lennart T. H. Jacobsson and Carl Turesson
    Citation: Arthritis Research & Therapy 2021 23:27
    Content type: Research article Published on:

  42. There are numerous non-biologic and biologic disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatoid arthritis (RA). Typical sequences of bDMARDs are not clear. Future treatment policies and trials sho...

    Authors: Daniel H. Solomon, Chang Xu, Jamie Collins, Seoyoung C. Kim, Elena Losina, Vincent Yau and Fredrik D. Johansson
    Citation: Arthritis Research & Therapy 2021 23:26
    Content type: Research article Published on:

  43. Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains ...

    Authors: Kieran Murray, Matthew Turk, Yousef Alammari, Francis Young, Phil Gallagher, Tajvur Saber, Ursula Fearon and Douglas J. Veale
    Citation: Arthritis Research & Therapy 2021 23:25
    Content type: Research article Published on:

  44. Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, whic...

    Authors: Chunyi Zhang, Congcong Gao, Xueqi Di, Siwan Cui, Wenfang Liang, Wenbo Sun, Menghui Yao, Shengyun Liu and Zhaohui Zheng
    Citation: Arthritis Research & Therapy 2021 23:24
    Content type: Research article Published on:

  45. Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are c...

    Authors: Wenchao Zhang, Lin Qi, Ruiqi Chen, Jieyu He, Zhongyue Liu, Wanchun Wang, Chao Tu and Zhihong Li
    Citation: Arthritis Research & Therapy 2021 23:23
    Content type: Review Published on:

  46. Systemic sclerosis starts with an early phase characterized by Raynaud’s phenomenon, puffy fingers/hands, autoantibodies, and a scleroderma nailfold microscopic pattern. Alterations in the nailfold microscopic...

    Authors: Khalid Daoudi, Brigit E. Kersten, Cornelia H. M. van den Ende, Frank H. J. van den Hoogen, Madelon C. Vonk and Chris L. de Korte
    Citation: Arthritis Research & Therapy 2021 23:22
    Content type: Research article Published on:

  47. Systemic sclerosis (SSc) is an acquired autoimmune disorder characterized by excessive accumulation of collagen and progressive tissue fibrosis. Although interstitial lung disease (ILD) complicates the majorit...

    Authors: Yiqun Li, Jing Huang, Chaojun Hu, Jiaxin Zhou, Dong Xu, Yong Hou, Chanyuan Wu, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng, Changzheng Liu, Qian Wang and Yan Zhao
    Citation: Arthritis Research & Therapy 2021 23:21
    Content type: Research article Published on:

  48. Scarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case-control study aims to survey the prevalence of scarring alopecia during the ...

    Authors: Yirong Xiang, Mengtao Li, Hui Luo, Yanhong Wang, Xinwang Duan, Cheng Zhao, Feng Zhan, Zhenbiao Wu, Hongbin Li, Min Yang, Jian Xu, Wei Wei, Lijun Wu, Hanxiao You, Junyan Qian, Xiaoxi Yang…
    Citation: Arthritis Research & Therapy 2021 23:20
    Content type: Research article Published on:

  49. Mixed connective tissue disease (MCTD) is a rare condition that is distinguished by the presence of specific U1-RNP antibodies. Information about its etiopathology and diagnostics is still unclear. miRNAs such...

    Authors: Barbara Stypińska, Aleksandra Lewandowska, Anna Felis-Giemza, Marzena Olesińska and Agnieszka Paradowska-Gorycka
    Citation: Arthritis Research & Therapy 2021 23:19
    Content type: Research article Published on:
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Arthritis Research & Therapy

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