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  1. Patients with diffuse cutaneous systemic sclerosis (dcSSc) have a poor prognosis. The importance of monitoring subjective measures of functioning and disability, such as the Health Assessment Questionnaire-Dis...

    Authors: Yannick Allanore, Sylvie Bozzi, Augustin Terlinden, Doerte Huscher, Caroline Amand, Christina Soubrane, Elise Siegert, László Czirják, Patricia E. Carreira, Eric Hachulla, Elisabetta Zanatta, Mengtao Li, Paolo Airò, Fabian A. Mendoza, Edoardo Rosato and Oliver Distler
    Citation: Arthritis Research & Therapy 2020 22:257
  2. Emerging evidence suggests that microRNAs (miRs) are associated with the progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived from mesenchymal stem cells (MSCs) in OA prog...

    Authors: Xue Chen, Yuanyuan Shi, Pan Xue, Xinli Ma, Junfeng Li and Jun Zhang
    Citation: Arthritis Research & Therapy 2020 22:256
  3. The aim of this study was to investigate the role of serum IgE levels in the clinical features and outcomes of IgG4-related disease (IgG4-RD).

    Authors: Jiaxin Zhou, Yu Peng, Linyi Peng, Di Wu, Jing Li, Nan Jiang, Jieqiong Li, Hui Lu, Zheng Liu, Xuan Luo, Fei Teng, Yunyun Fei, Wen Zhang, Yan Zhao and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2020 22:255
  4. Obesity is overrepresented in patients with psoriatic arthritis (PsA) and associated with increased disease activity. We have previously shown in 41 patients with PsA (Caspar criteria) and obesity (body mass i...

    Authors: Eva Klingberg, Sofia Björkman, Björn Eliasson, Ingrid Larsson and Annelie Bilberg
    Citation: Arthritis Research & Therapy 2020 22:254
  5. A previous analysis of the Veterans Affairs Rheumatoid Arthritis (VARA) registry showed that more than half of the patients with rheumatoid arthritis (RA) did not receive a major therapeutic change (MTC) despi...

    Authors: Brian C. Sauer, Wei Chen, Yizhe Xu, Jincheng Shen, Neil A. Accortt, David H. Collier and Grant W. Cannon
    Citation: Arthritis Research & Therapy 2020 22:253
  6. Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune condition characterized by joint synovial inflammation. Current treatments include methotrexate (MTX), biologic agents, and Janus kinase (JAK) in...

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Jay Erdman, Yuichiro Kaneko, Masako Saito, Chieri Higashitani, Ronald Smulders and Christopher Lademacher
    Citation: Arthritis Research & Therapy 2020 22:252
  7. Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders that are considered to be different diseases due to their unique molecular mechanisms and pathogenesis. Chemokines and their corresp...

    Authors: Sheng-Mou Hou, Po-Chun Chen, Chieh-Mo Lin, Mei-Ling Fang, Miao-Ching Chi and Ju-Fang Liu
    Citation: Arthritis Research & Therapy 2020 22:251
  8. Increased levels of cytokines, including interleukin-6 (IL-6), reflect inflammation and have been shown to be predictive of therapeutic responses, fatigue, pain, and depression in patients with rheumatoid arth...

    Authors: Vibeke Strand, Susan H. Boklage, Toshio Kimura, Florence Joly, Anita Boyapati and Jérôme Msihid
    Citation: Arthritis Research & Therapy 2020 22:250
  9. Porphyromonas gingivalis (Pg) infection causes periodontal disease and exacerbates rheumatoid arthritis (RA). It is reported that inoculation of periodontopathogenic bacteria (i.e., Pg) can alter gut microbiota c...

    Authors: Yuta Hamamoto, Kazuhisa Ouhara, Syuichi Munenaga, Mikio Shoji, Tatsuhiko Ozawa, Jyunzo Hisatsune, Isamu Kado, Mikihito Kajiya, Shinji Matsuda, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Shintaro Hirata, Kotaro Tanimoto, Koji Nakayama, Hiroyuki Kishi…
    Citation: Arthritis Research & Therapy 2020 22:249
  10. The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP an...

    Authors: Takeshi Iwasaki, Shuichiro Nakabo, Chikashi Terao, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Yasuo Miura, Kimiko Yurugi, Taira Maekawa, Myrthe A. M. van Delft, Leendert A. Trouw, Takao Fujii, Tsuneyo Mimori…
    Citation: Arthritis Research & Therapy 2020 22:248
  11. There has been a shift in recent years to using ultrasound (US) and magnetic resonance imaging (MRI) as first-line investigations for suspected cranial large vessel vasculitis (LVV) and is a new recommendation...

    Authors: Ashley Yip, Elizabeth Torrey Jernberg, Mohammad Bardi, Julia Geiger, Frode Lohne, Wolfgang Andreas Schmidt, Geirmund Myklebust and Andreas P. Diamantopoulos
    Citation: Arthritis Research & Therapy 2020 22:247
  12. Interstitial lung disease (ILD) is a severe complication with poor prognosis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Prevalence of AAV-associated ILD (AAV-ILD) in Japan is c...

    Authors: Aya Kawasaki, Natsumi Namba, Ken-ei Sada, Fumio Hirano, Shigeto Kobayashi, Kenji Nagasaka, Takahiko Sugihara, Nobuyuki Ono, Takashi Fujimoto, Makio Kusaoi, Naoto Tamura, Kunihiro Yamagata, Takayuki Sumida, Hiroshi Hashimoto, Shoichi Ozaki, Hirofumi Makino…
    Citation: Arthritis Research & Therapy 2020 22:246
  13. The majority of CD4+ T helper (Th) cells found in the synovial fluid (SF) of patients with rheumatoid arthritis (RA) express CXCR3, a receptor associated with Th1 cells. In blood, subsets of Th2 and Th17 cells al...

    Authors: Jonathan Aldridge, Anna-Karin H. Ekwall, Linda Mark, Beatrice Bergström, Kerstin Andersson, Inger Gjertsson, Anna-Carin Lundell and Anna Rudin
    Citation: Arthritis Research & Therapy 2020 22:245
  14. Gout is predicted by a number of comorbidities and lifestyle factors. We aimed to identify discrete phenotype clusters of these factors in a Swedish population-based health survey. In these clusters, we calcul...

    Authors: Tahzeeb Fatima, Peter M. Nilsson, Carl Turesson, Mats Dehlin, Nicola Dalbeth, Lennart T. H. Jacobsson and Meliha C. Kapetanovic
    Citation: Arthritis Research & Therapy 2020 22:244
  15. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported...

    Authors: Vibeke Strand, Jeffrey Kaine, Rieke Alten, Gene Wallenstein, Annette Diehl, Harry Shi, Rebecca Germino and Christopher W. Murray
    Citation: Arthritis Research & Therapy 2020 22:243
  16. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody tests are often measured at the time of rheumatoid arthritis (RA) diagnosis but may not be repeated and therefore not available in el...

    Authors: Jeffrey R. Curtis, Fenglong Xie, Hong Zhou, David Salchert and Huifeng Yun
    Citation: Arthritis Research & Therapy 2020 22:242
  17. Remission or the lowest possible disease activity is the main target in the management of systemic lupus erythematosus (SLE). Anyway, conflicting data are present in the literature regarding the correlation be...

    Authors: Elena Elefante, Chiara Tani, Chiara Stagnaro, Viola Signorini, Alice Parma, Linda Carli, Dina Zucchi, Francesco Ferro and Marta Mosca
    Citation: Arthritis Research & Therapy 2020 22:241
  18. Angiogenesis plays a central role in the pathophysiology of rheumatic diseases. Patients with psoriatic arthritis (PsA) demonstrate increased vascularity over patients with rheumatoid arthritis (RA), with unkn...

    Authors: Michal A. Rahat, Mirna Safieh, Elina Simanovich, Eliran Pasand, Tal Gazitt, Amir Haddad, Muna Elias and Devy Zisman
    Citation: Arthritis Research & Therapy 2020 22:240
  19. Necroptosis is a form of regulated necrosis that is involved in various autoimmune diseases. Mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as a key executor of necroptosis; however, ...

    Authors: Mingjiao Zhang, Hongyu Jie, Yong Wu, Xinai Han, Xing Li, Yi He, Xingliang Shi, Yuwei Luo, Ying Sun, Jinlong Yang, Jing Yang, Shulv Quan, Xiaobin Lao, Liping Tan and Erwei Sun
    Citation: Arthritis Research & Therapy 2020 22:239
  20. The organization of minor salivary glands (MSG) infiltrates, in patients with Sjögren’s syndrome (SS), associates with disease severity and progression. Aberrant regulation of lymphocyte autophagy is involved ...

    Authors: Serena Colafrancesco, Marta Vomero, Valentina Iannizzotto, Antonina Minniti, Cristiana Barbati, Francesca Arienzo, Linda Mastromanno, Tania Colasanti, Raffaella Izzo, Saba Nayar, Elena Pipi, Bruna Cerbelli, Carla Giordano, Francesco Ciccia, Fabrizio Conti, Guido Valesini…
    Citation: Arthritis Research & Therapy 2020 22:238
  21. Nailfold videocapillaroscopy (NVC) is a feasible method that allows the observation of the microvascular changes that mark the course of systemic sclerosis (SSc). In previous studies, we demonstrated that the ...

    Authors: Nicoletta Del Papa, Francesca Pignataro, Wanda Maglione, Antonina Minniti, Domenico Sambataro, Gianluca Sambataro, Gabriele Valentini, Roberto Caporali and Claudio Vitali
    Citation: Arthritis Research & Therapy 2020 22:237
  22. It is not elucidated that there is treatment-related damage in elderly patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV).

    Authors: Ken-Ei Sada, Keiji Ohashi, Yosuke Asano, Keigo Hayashi, Michiko Morishita, Haruki Watanabe, Yoshinori Matsumoto, Shouichi Fujimoto, Yoshinari Takasaki, Kunihiro Yamagata, Shogo Banno, Hiroaki Dobashi, Koichi Amano, Masayoshi Harigai, Yoshihiro Arimura and Hirofumi Makino
    Citation: Arthritis Research & Therapy 2020 22:236
  23. Tissue released blood-based biomarkers can provide insight into drug mode of action and response. To understand the changes in extracellular matrix turnover, we analyzed biomarkers associated with joint tissue...

    Authors: Christian S. Thudium, Anne C. Bay-Jensen, Suntara Cahya, Ernst R. Dow, Morten A. Karsdal, Alisa E. Koch, Wenling Zhang and Robert J. Benschop
    Citation: Arthritis Research & Therapy 2020 22:235
  24. Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are probably ...

    Authors: Anne Briolay, Alaeddine El Jamal, Paul Arnolfo, Benoît Le Goff, Frédéric Blanchard, David Magne and Carole Bougault
    Citation: Arthritis Research & Therapy 2020 22:234
  25. Sex differences with regard to clinical manifestations and response to tumor necrosis factor inhibitors (TNFi) have been delineated for the radiographic form of axial spondyloarthritis (axSpA). More limited ev...

    Authors: Regula Neuenschwander, Monika Hebeisen, Raphael Micheroli, Kristina Bürki, Pascale Exer, Karin Niedermann, Michael J. Nissen, Almut Scherer and Adrian Ciurea
    Citation: Arthritis Research & Therapy 2020 22:233
  26. The transmembrane-TNF transgenic mouse, TgA86, has been shown to develop spontaneously peripheral arthritis with signs of axial involvement. To assess similarity to human spondyloarthritis, we performed detail...

    Authors: Eleni Christodoulou-Vafeiadou, Christina Geka, Lydia Ntari, Ksanthi Kranidioti, Eleni Argyropoulou, Florian Meier, Marietta Armaka, Iordanis Mourouzis, Constantinos Pantos, Maritina Rouchota, George Loudos, Maria C. Denis, Niki Karagianni and George Kollias
    Citation: Arthritis Research & Therapy 2020 22:232
  27. miR-431-5p is dysregulated in various cancers and plays an important function in the development of cancer. However, its role in fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) r...

    Authors: Yuejiao Wang, Kailin Zhang, Xiaowei Yuan, Neili Xu, Shuai Zhao, Linxin Hou, Lili Yang and Ning Zhang
    Citation: Arthritis Research & Therapy 2020 22:231
  28. Mycophenolate mofetil (MMF) is an established therapy for systemic sclerosis (SSc), but its pharmacokinetics in this disease remains unexplored. We have investigated drug exposure in MMF-treated patients with ...

    Authors: Kristofer Andréasson, Karl Neringer, Dirk M. Wuttge, Dan Henrohn, Jan Marsal and Roger Hesselstrand
    Citation: Arthritis Research & Therapy 2020 22:230
  29. The reduction of finger joint space width (JSW) in patients with rheumatoid arthritis (RA) is strongly associated with joint destruction. Treatment with certolizumab pegol (CZP), a PEGylated anti-TNF, has been...

    Authors: Alexander Pfeil, Anica Nussbaum, Diane M. Renz, Tobias Hoffmann, Ansgar Malich, Marcus Franz, Peter Oelzner, Gunter Wolf and Joachim Böttcher
    Citation: Arthritis Research & Therapy 2020 22:229
  30. C-reactive protein (CRP) has two natural isomers: C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytopla...

    Authors: Kai-Li Wu, Qing-Hui Liang, Bin-Tao Huang, Na Ding, Bo-Wei Li and Jian Hao
    Citation: Arthritis Research & Therapy 2020 22:228
  31. Adherence is a key factor for therapeutic success in patients with rheumatoid arthritis (RA). The aim of this study was to determine whether results from the 5-item Compliance Questionnaire for Rheumatology (C...

    Authors: Fausto Salaffi, Marco Di Carlo, Marina Carotti, Luca Ceccarelli, Sonia Farah, Daniela Marotto, Valeria Giorgi and Piercarlo Sarzi-Puttini
    Citation: Arthritis Research & Therapy 2020 22:227
  32. The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein...

    Authors: Irini Genitsaridi, Irini Flouri, Dimitris Plexousakis, Konstantinos Marias, Kyriaki Boki, Fotini Skopouli, Alexandros Drosos, George Bertsias, Dimitrios Boumpas and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2020 22:226
  33. Patients with ankylosing spondylitis (AS) are at increased risk of depression. This increased risk has been hypothesized to be solely secondary due to AS-related symptoms, or additionally due to a common infla...

    Authors: Casper Webers, Carmen Stolwijk, Olga Schiepers, Thea Schoonbrood, Astrid van Tubergen, Robert Landewé, Désirée van der Heijde and Annelies Boonen
    Citation: Arthritis Research & Therapy 2020 22:225
  34. Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) disease. Adiponectin is involved in the metabolism of glucose and lipids with favourable effects on CV disease, especially ...

    Authors: Eric Toussirot, Hubert Marotte, Denis Mulleman, Grégoire Cormier, Fabienne Coury, Philippe Gaudin, Emmanuelle Dernis, Christine Bonnet, Richard Damade, Jean-Luc Grauer, Tassadit Ait Abdesselam, Caroline Guillibert-Karras, Frédéric Lioté, Pascal Hilliquin, Antoinette Sacchi, Daniel Wendling…
    Citation: Arthritis Research & Therapy 2020 22:224
  35. Hydroxychloroquine (HCQ) levels can be measured in both serum and whole blood. No cut-off point for non-adherence has been established in serum nor have these methods ever been compared. The aims of this study...

    Authors: Benoit Blanchet, Moez Jallouli, Marie Allard, Pascale Ghillani-Dalbin, Lionel Galicier, Olivier Aumaître, François Chasset, Véronique Le Guern, Frédéric Lioté, Amar Smail, Nicolas Limal, Laurent Perard, Hélène Desmurs-Clavel, Du Le Thi Huong, Bouchra Asli, Jean-Emmanuel Kahn…
    Citation: Arthritis Research & Therapy 2020 22:223
  36. The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis...

    Authors: Hong Ki Min, Ji-Yeon Won, Bo-Mi Kim, Kyung-Ann Lee, Seoung-Joon Lee, Sang-Heon Lee, Hae-Rim Kim and Kyoung-Woon Kim
    Citation: Arthritis Research & Therapy 2020 22:222
  37. Monocytes as precursors of osteoclasts in rheumatoid arthritis (RA) are well demonstrated, while monocyte subsets in osteoclast formation are still controversial. Tyro3 tyrosine kinase (Tyro3TK) is a member of...

    Authors: Jimeng Xue, Liling Xu, Huaqun Zhu, Mingxin Bai, Xin Li, Zhen Zhao, Hua Zhong, Gong Cheng, Xue Li, Fanlei Hu and Yin Su
    Citation: Arthritis Research & Therapy 2020 22:221
  38. A20, also known as TNF-α-induced protein 3 (TNFAIP3), is an anti-inflammatory protein that plays an important part in both immune responses and cell death. Impaired A20 function is associated with several huma...

    Authors: Yongyao Wu, Xiaomin He, Ning Huang, Jiayun Yu and Bin Shao
    Citation: Arthritis Research & Therapy 2020 22:220
  39. To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD).

    Authors: Renjiao Li, Wen-Jun Zhu, Faping Wang, Xiaoju Tang and Fengming Luo
    Citation: Arthritis Research & Therapy 2020 22:202
  40. To compare the glycosaminoglycan (GAG) content of lumbar intervertebral disks (IVDs) of patients with ankylosing spondylitis (AS) and healthy volunteers and to investigate the association of GAG depletion and ...

    Authors: Daniel B. Abrar, Christoph Schleich, Styliani Tsiami, Anja Müller-Lutz, Karl Ludger Radke, Neela Holthausen, Miriam Frenken, Matthias Boschheidgen, Gerald Antoch, Johanna Mucke, Philipp Sewerin, Juergen Braun, Sven Nebelung and Xenofon Baraliakos
    Citation: Arthritis Research & Therapy 2020 22:219
  41. To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK).

    Authors: Arsene Mekinian, David Saadoun, Eric Vicaut, Sara Thietart, Bertrand Lioger, Patrick Jego, Alexandre Bleibtreu, Nicolas Limal, Jerome Connault, Jacques-Eric Gottenberg, Pauline Lhorte, Jean Pierre Bertola, Juliette Delforge, Nicole Ferreira-Maldent, Antoinette Perlat, Zohra Talib…
    Citation: Arthritis Research & Therapy 2020 22:218
  42. Individuals at risk of developing rheumatoid arthritis (RA) may benefit from lifestyle or pharmacological interventions aimed at primary prevention. The same may apply to individuals at risk of axial spondyloa...

    Authors: Laurette van Boheemen, Janne W. Bolt, Marieke M. ter Wee, Henriëtte M. de Jong, Marleen G. van de Sande and Dirkjan van Schaardenburg
    Citation: Arthritis Research & Therapy 2020 22:217
  43. The anterior chest wall (ACW) involvement is characteristic of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, yet little research has focused on its magnetic resonance imaging (MRI) ...

    Authors: Meiyan Yu, Yihan Cao, Junqiu Li, Yanan Zhang, Yuqian Ye, Lun Wang, Ziwei Huang, Xinyu Lu, Chen Li and Jianwei Huo
    Citation: Arthritis Research & Therapy 2020 22:216
  44. A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ r...

    Authors: Lei Peng, Song Jin, Jiping Lu, Chao Ouyang, Jiang Guo, Zhongyu Xie, Huiyong Shen and Peng Wang
    Citation: Arthritis Research & Therapy 2020 22:215
  45. We aimed to assess the impact of systemic lupus erythematosus (SLE) on the risk of infection after total hip arthroplasty (THA).

    Authors: Chien-Hao Chen, Tien-Hsing Chen, Yu-Sheng Lin, Dave W. Chen, Chi-Chin Sun, Liang-Tseng Kuo and Shih-Chieh Shao
    Citation: Arthritis Research & Therapy 2020 22:214
  46. An increased risk of cardiovascular (CV) complications has been described in patients with rheumatoid arthritis (RA). It is the result of the combined effect of classic CV risk factors and others that are spec...

    Authors: Ana M. Fernández-Ortiz, Ana M. Ortiz, Silvia Pérez, Esther Toledano, Lydia Abásolo, Miguel A. González-Gay, Santos Castañeda and Isidoro González-Álvaro
    Citation: Arthritis Research & Therapy 2020 22:213
  47. Dual-energy CT (DECT) can acknowledge differences in tissue compositions and can colour-code tissues with specific features including monosodium urate (MSU) crystals. However, when evaluating gout patients, DE...

    Authors: Sara Nysom Christiansen, Felix Christoph Müller, Mikkel Østergaard, Ole Slot, Jakob M. Møller, Henrik F. Børgesen, Kasper Kjærulf Gosvig and Lene Terslev
    Citation: Arthritis Research & Therapy 2020 22:212
  48. Few clinical trials have investigated the prevention of radiographic progression in children with juvenile idiopathic arthritis treated with antirheumatic drugs. This study aimed to investigate radiographic pr...

    Authors: Clara Malattia, Nicolino Ruperto, Silvia Pederzoli, Elena Palmisani, Angela Pistorio, Carine Wouters, Pavla Dolezalova, Berit Flato, Stella Garay, Gabriella Giancane, Chris Wells, Wendy Douglass, Hermine I. Brunner, Fabrizio De Benedetti and Angelo Ravelli
    Citation: Arthritis Research & Therapy 2020 22:211
  49. In contrast to other chronic rheumatic musculoskeletal diseases such as rheumatoid arthritis, comorbidities in axial spondyloarthritis (axSpA) and their impact on disease outcomes are less well studied. The ai...

    Authors: Imke Redeker, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy
    Citation: Arthritis Research & Therapy 2020 22:210
  50. To examine the relation between inflammatory potential of diet and incident knee osteoarthritis (OA) and the role of BMI in the association of interest.

    Authors: Qiang Liu, James R. Hebert, Nitin Shivappa, Jianjun Guo, Ke Tao, Chao Zeng, Guanghua Lei, Jianhao Lin and Yuqing Zhang
    Citation: Arthritis Research & Therapy 2020 22:209

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