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  1. To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...

    Authors: Lukas Bütikofer, Pierre A. Varisco, O. Distler, O. Kowal-Bielecka, Y. Allanore, G. Riemekasten, P. M. Villiger and S. Adler
    Citation: Arthritis Research & Therapy 2020 22:59
    Content type: Research article Published on:

  2. European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc’s optimal management. Herein, we describe current treatment modalities and drug survival...

    Authors: S. Panopoulos, Κ. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, Α. Garyfallos, P. Sidiropoulos…
    Citation: Arthritis Research & Therapy 2020 22:56
    Content type: Research article Published on:

  3. Authors: Debbie M. Boeters and Annette H. M. van der Helm–van Mil
    Citation: Arthritis Research & Therapy 2020 22:55
    Content type: Letter Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:101

    The original article was published in Arthritis Research & Therapy 2020 22:17

  4. The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research...

    Authors: W. E. van Spil, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A.-C. Bay-Jensen, V. Byers Kraus, L. Carlesso, R. Christensen, M. Van Der Esch, P. Kent, J. Knoop, C. Ladel, C. B. Little, R. F. Loeser, E. Losina, K. Mills…
    Citation: Arthritis Research & Therapy 2020 22:54
    Content type: Research article Published on:

  5. The evaluation of quality of care in juvenile idiopathic arthritis (JIA) is critical for advancing patient outcomes but is not currently part of routine care across all centers in Canada. The study objective i...

    Authors: Claire E. H. Barber, Marinka Twilt, Tram Pham, Gillian R. Currie, Susanne Benseler, Rae S. M. Yeung, Michelle Batthish, Nicholas Blanchette, Jaime Guzman, Bianca Lang, Claire LeBlanc, Deborah M. Levy, Christine O’Brien, Heinrike Schmeling, Gordon Soon, Lynn Spiegel…
    Citation: Arthritis Research & Therapy 2020 22:53
    Content type: Research article Published on:

  6. Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the ...

    Authors: Julia Davis-Porada, Mimi Y. Kim, Marta M. Guerra, Carl A. Laskin, Michelle Petri, Michael D. Lockshin, Lisa R. Sammaritano, D. Ware Branch, Allen Sawitzke, Joan T. Merrill, Jill P. Buyon and Jane E. Salmon
    Citation: Arthritis Research & Therapy 2020 22:52
    Content type: Research article Published on:

  7. Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of inflammatory bowel diseases (IBD) and ankylosing spondyli...

    Authors: Aifeng Lin, Robert D. Inman, Catherine J. Streutker, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Florence W. L. Tsui
    Citation: Arthritis Research & Therapy 2020 22:51
    Content type: Research article Published on:

  8. Measurement of skin involvement is essential for the diagnosis and assessment of prognosis and disease progression in systemic sclerosis (SSc). The modified Rodnan skin score (mRSS) is the gold standard measur...

    Authors: T. Santiago, M. Santiago, M. Coutinho, M. J. Salvador and J. A. P. Da Silva
    Citation: Arthritis Research & Therapy 2020 22:50
    Content type: Research article Published on:

  9. Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S...

    Authors: Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos, Jessica Bertrand, Giuseppe Cirino, Alexander So and Nathalie Busso
    Citation: Arthritis Research & Therapy 2020 22:49
    Content type: Research article Published on:

  10. Skin fibrosis is the clinical hallmark of systemic sclerosis (SSc), where collagen deposition and remodeling of the dermis occur over time. The most widely used outcome measure in SSc clinical trials is the mo...

    Authors: Chase Correia, Seamus Mawe, Shane Lofgren, Roberta G. Marangoni, Jungwha Lee, Rana Saber, Kathleen Aren, Michelle Cheng, Shannon Teaw, Aileen Hoffmann, Isaac Goldberg, Shawn E. Cowper, Purvesh Khatri, Monique Hinchcliff and J. Matthew Mahoney
    Citation: Arthritis Research & Therapy 2020 22:48
    Content type: Research article Published on:

  11. Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety for the treatment of rheumatoid arthritis (RA) in randomized, controlled trials of up to 52 weeks’ duration. How...

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada
    Citation: Arthritis Research & Therapy 2020 22:47
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:155

  12. Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to AB...

    Authors: Waka Yokoyama-Kokuryo, Hayato Yamazaki, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Tsuneo Kondo, Seiji Nakamura, Ryoko Sakai, Fumio Hirano, Toshihiro Nanki, Ryuji Koike and Masayoshi Harigai
    Citation: Arthritis Research & Therapy 2020 22:46
    Content type: Research article Published on:

  13. The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the h...

    Authors: Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth and Tony R. Merriman
    Citation: Arthritis Research & Therapy 2020 22:45
    Content type: Research article Published on:

  14. Although observational epidemiological studies have found that smoking is positively associated with risk of rheumatoid arthritis (RA), assessing the causality of this relationship has remained elusive because...

    Authors: Yu Qian, Lingzhi Zhang, David J. H. Wu, Zhijun Xie, Chengping Wen and Yingying Mao
    Citation: Arthritis Research & Therapy 2020 22:44
    Content type: Research article Published on:

  15. In the GO-VIBRANT trial of intravenous golimumab in psoriatic arthritis (PsA), golimumab significantly inhibited radiographic progression. In post hoc analyses, we evaluated changes in total PsA-modified Sharp...

    Authors: Philip Mease, M. Elaine Husni, Shelly Kafka, Soumya D. Chakravarty, Diane D. Harrison, Kim Hung Lo, Stephen Xu, Elizabeth C. Hsia and Arthur Kavanaugh
    Citation: Arthritis Research & Therapy 2020 22:43
    Content type: Research article Published on:

  16. The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can ...

    Authors: A. van Caam, J. Aarts, T. van Ee, E. Vitters, M. Koenders, F. van de Loo, P. van Lent, F. van den Hoogen, R. Thurlings, M. C. Vonk and P. M. van der Kraan
    Citation: Arthritis Research & Therapy 2020 22:42
    Content type: Research article Published on:

  17. With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivi...

    Authors: Sae Ochi, Kazuyoshi Saito, Fumitaka Mizoguchi, Shigeaki Kato and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2020 22:41
    Content type: Research article Published on:

  18. To evaluate the value of 3 Tesla (T) magnetic resonance imaging (MRI) changes of flexor tendon pulleys for the differentiation of psoriatic (PsA) and rheumatoid arthritis (RA), using a novel 16-channel high-re...

    Authors: Daniel B. Abrar, Christoph Schleich, Sven Nebelung, Miriam Frenken, Karl Ludger Radke, Stefan Vordenbäumen, Ralph Brinks, Matthias Schneider, Benedikt Ostendorf, Dennis McGonagle and Philipp Sewerin
    Citation: Arthritis Research & Therapy 2020 22:40
    Content type: Research article Published on:

  19. To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren’s syndrome (pSS).

    Authors: Pierre-Marie Duret, Nicolas Meyer, Alain Saraux, Valérie Devauchelle-Pensec, Raphaele Seror, Véronique Le-Guern, Claire Larroche, Aleth Perdriger, Jean Sibilia, Vianney Guardiolle, Xavier Mariette and Jacques-Eric Gottenberg
    Citation: Arthritis Research & Therapy 2020 22:39
    Content type: Research article Published on:

  20. Unstimulated whole saliva (UWS) flow rate is one of the ACR/EULAR 2016 criteria for primary Sjögren’s syndrome (pSS). With a single threshold of ≤ 0.1 mL/min, UWS flow does not take into account the age- and s...

    Authors: Valentin Lacombe, Carole Lacout, Pierre Lozac’h, Alaa Ghali, Aline Gury, Christian Lavigne and Geoffrey Urbanski
    Citation: Arthritis Research & Therapy 2020 22:38
    Content type: Research article Published on:

  21. Hyperuricemia is closely associated with cardiovascular disease (CVD). However, it has not been definitively established whether this association is independent of traditional cardiovascular risk factors (CVRF...

    Authors: Panagiota Drivelegka, Helena Forsblad-d’Elia, Oskar Angerås, Göran Bergström, Caroline Schmidt, Lennart T. H. Jacobsson and Mats Dehlin
    Citation: Arthritis Research & Therapy 2020 22:37
    Content type: Research article Published on:

  22. To explore whether a prime-boost vaccination strategy, i.e., a dose of pneumococcal conjugate vaccine (PCV) and a dose of 23-valent polysaccharide vaccine (PPV23), enhances antibody response compared to single...

    Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic
    Citation: Arthritis Research & Therapy 2020 22:36
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:162

  23. Systemic lupus erythematous (SLE) disproportionately impacts patients of color and socioeconomically disadvantaged patients. Similar disparities in HIV were reduced through a World Health Organization-endorsed...

    Authors: Christie M. Bartels, Ann Rosenthal, Xing Wang, Umber Ahmad, Ian Chang, Nnenna Ezeh, Shivani Garg, Maria Schletzbaum and Amy Kind
    Citation: Arthritis Research & Therapy 2020 22:35
    Content type: Research article Published on:

  24. Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin ...

    Authors: Hui Li, Xiang Ding, Robert Terkeltaub, Hang Lin, Yuqing Zhang, Bin Zhou, Ke He, Kun Li, Zhichen Liu, Jie Wei, Yuanheng Yang, Hui Xie, Chao Zeng and Guanghua Lei
    Citation: Arthritis Research & Therapy 2020 22:34
    Content type: Research article Published on:

  25. Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition to IgG/IgM anti-cardiolipin antibodies (aCL)...

    Authors: Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L. Norman, Xuefeng Wang, Chengde Yang and Hui Shi
    Citation: Arthritis Research & Therapy 2020 22:33
    Content type: Research article Published on:

  26. Patients with systemic sclerosis (SSc) complicated by gastrointestinal dysmotility are difficult to treat and have high mortality. To clarify the pathogenesis of gastrointestinal manifestations, we aimed to de...

    Authors: Shunya Nakane, Masataka Umeda, Shin-ya Kawashiri, Akihiro Mukaino, Kunihiro Ichinose, Osamu Higuchi, Yasuhiro Maeda, Hideki Nakamura, Hidenori Matsuo and Atsushi Kawakami
    Citation: Arthritis Research & Therapy 2020 22:32
    Content type: Research article Published on:

  28. Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aime...

    Authors: Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega, Christian Agard, Yannick Allanore, Patrick Jego, Anne-Laure Fauchais, Jean-Robert Harlé, Sabine Berthier, Achille Aouba, Arsène Mekinian, Elisabeth Diot, Marie-Elise Truchetet…
    Citation: Arthritis Research & Therapy 2020 22:30
    Content type: Research article Published on:

  29. Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes ha...

    Authors: Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith and Christopher B. Little
    Citation: Arthritis Research & Therapy 2020 22:29
    Content type: Research article Published on:

  30. Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug ...

    Authors: Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth and Philip C. Robinson
    Citation: Arthritis Research & Therapy 2020 22:28
    Content type: Research article Published on:

  31. The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) i...

    Authors: Jerián González-Febles, Beatriz Rodríguez-Lozano, Carlos Sánchez-Piedra, Jorge Garnier-Rodríguez, Sagrario Bustabad, Martina Hernández-González, Enrique González-Dávila, Mariano Sanz and Federico Díaz-González
    Citation: Arthritis Research & Therapy 2020 22:27
    Content type: Research article Published on:

  32. C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, ...

    Authors: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech and Georg Schett
    Citation: Arthritis Research & Therapy 2020 22:26
    Content type: Research article Published on:

  33. Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (...

    Authors: Weiting Fang, Yuanyuan Zhang and Zhu Chen
    Citation: Arthritis Research & Therapy 2020 22:25
    Content type: Review Published on:

  34. 14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide ant...

    Authors: Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Shintaro Hirata, Tong Zhang, Fumi Uemura, Minoru Satoh, Norma Biln, Shingo Nakayamada, Walter P. Maksymowych and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2020 22:24
    Content type: Research article Published on:

  36. Authors: Jean-Pierre Pelletier and Jean-Pierre Raynauld
    Citation: Arthritis Research & Therapy 2020 22:22
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:179

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:23

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:21

  38. Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...

    Authors: Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2020 22:20
    Content type: Research article Published on:

  39. Magnetic resonance imaging (MRI) and ultrasonography (US) are more sensitive than clinical evaluation in assessing inflammation in rheumatoid arthritis (RA). Data is scarce regarding potential link between pat...

    Authors: Dorota Kuettel, Daniel Glinatsi, Mikkel Østergaard, Lene Terslev, Jette Primdahl, Sören Möller, Andreas Pedersen, Randi Petersen, Ulrich Weber and Kim Hørslev-Petersen
    Citation: Arthritis Research & Therapy 2020 22:19
    Content type: Research article Published on:

  40. Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...

    Authors: Désirée van der Heijde, Dafna D. Gladman, Arthur Kavanaugh and Philip J. Mease
    Citation: Arthritis Research & Therapy 2020 22:18
    Content type: Review Published on:

  41. Authors: Alfonse T. Masi and Roy Fleischmann
    Citation: Arthritis Research & Therapy 2020 22:17
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:121

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:55

  42. Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibi...

    Authors: Snigdha Samarpita, Joo Young Kim, Mahaboob Khan Rasool and Kyoung Soo Kim
    Citation: Arthritis Research & Therapy 2020 22:16
    Content type: Research article Published on:

  43. There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inh...

    Authors: Giovanni Cagnotto, Minna Willim, Jan-Åke Nilsson, Michele Compagno, Lennart T. H. Jacobsson, Saedis Saevarsdottir and Carl Turesson
    Citation: Arthritis Research & Therapy 2020 22:15
    Content type: Research article Published on:

  44. The long-term safety was assessed in patients with psoriatic arthritis who were treated with ixekizumab in three clinical trials (SPIRIT-P1/-P2/-P3).

    Authors: Bernard Combe, Proton Rahman, Hideto Kameda, Juan D. Cañete, Gaia Gallo, Noah Agada, Wen Xu and Mark C. Genovese
    Citation: Arthritis Research & Therapy 2020 22:14
    Content type: Research article Published on:

  45. Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion pr...

    Authors: B. Rauwel, Y. Degboé, D. Nigon, J.-F. Boyer, F. Abravanel, J. Izopet, B. Combe, A. Ruyssen-Witrand, A. Constantin, A. Cantagrel and J.-L. Davignon
    Citation: Arthritis Research & Therapy 2020 22:13
    Content type: Research article Published on:

  46. We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).

    Authors: Carolina Alvarez, Rebecca J. Cleveland, Todd A. Schwartz, Jordan B. Renner, Louise B. Murphy, Joanne M. Jordan, Leigh F. Callahan, Yvonne M. Golightly and Amanda E. Nelson
    Citation: Arthritis Research & Therapy 2020 22:12
    Content type: Research article Published on:

  47. Arthralgia and MRI-detected subclinical inflammation can precede the development of clinically evident rheumatoid arthritis (RA). However, part of the patients presenting with clinically suspect arthralgia (CS...

    Authors: Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2020 22:11
    Content type: Research article Published on:

  48. Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or...

    Authors: Andrew Henrey, Veronika Rypdal, Martin Rypdal, Thomas Loughin, Ellen Nordal and Jaime Guzman
    Citation: Arthritis Research & Therapy 2020 22:10
    Content type: Research article Published on:

  49. Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the ...

    Authors: Holly T. Philpott and Jason J. McDougall
    Citation: Arthritis Research & Therapy 2020 22:9
    Content type: Research article Published on:

  50. To explore the clinical patterns of patients with IgG4-related disease (IgG4-RD) based on laboratory tests and the number of organs involved.

    Authors: Jieqiong Li, Yu Peng, Yuelun Zhang, Panpan Zhang, Zheng Liu, Hui Lu, Linyi Peng, Liang Zhu, Huadan Xue, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang
    Citation: Arthritis Research & Therapy 2020 22:7
    Content type: Research article Published on:
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