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  1. In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we show...

    Authors: Isabel Ferreira, Sara Croca, Maria Gabriella Raimondo, Manjit Matharu, Sarah Miller, Ian Giles, David Isenberg, Yiannis Ioannou, John G. Hanly, Murray B. Urowitz, Nicole Anderson, Cynthia Aranow, Anca Askanase, Sang-Cheol Bae, Sasha Bernatsky, Ian N. Bruce…
    Citation: Arthritis Research & Therapy 2017 19:287
    Content type: Research article Published on:

  3. The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution from MCTD to ano...

    Authors: Silje Reiseter, Ragnar Gunnarsson, Jukka Corander, Joanna Haydon, May Brit Lund, Trond Mogens Aaløkken, Eli Taraldsrud, Siri Opsahl Hetlevik and Øyvind Molberg
    Citation: Arthritis Research & Therapy 2017 19:284
    Content type: Research article Published on:

  4. The use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function ...

    Authors: Lisa K. Stamp, Peter T. Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2017 19:283
    Content type: Research article Published on:

  5. Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations. Specific diagnostic biomarkers are la...

    Authors: Sheng-Mou Hou, Chun-Han Hou and Ju-Fang Liu
    Citation: Arthritis Research & Therapy 2017 19:282
    Content type: Research article Published on:

  6. An important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected synovial changes ass...

    Authors: Aliya Sarmanova, Michelle Hall, Gwen S. Fernandes, Archan Bhattacharya, Ana M. Valdes, David A. Walsh, Michael Doherty and Weiya Zhang
    Citation: Arthritis Research & Therapy 2017 19:281
    Content type: Research article Published on:

  7. Atsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis . A...

    Authors: Jian-lu Wei, Wenyu Fu, Yuan-jing Ding, Aubryanna Hettinghouse, Matin Lendhey, Ran Schwarzkopf, Oran D. Kennedy and Chuan-ju Liu
    Citation: Arthritis Research & Therapy 2017 19:280
    Content type: Research article Published on:

  8. There is an ongoing debate regarding the relevance of the 6-minute walking distance (6MWD) in systemic sclerosis (SSc) assessment, widely used as a usual test in these patients as well as an outcome measure in...

    Authors: Sébastien Sanges, Jonathan Giovannelli, Vincent Sobanski, Sandrine Morell-Dubois, Hélène Maillard, Marc Lambert, Céline Podevin, Nicolas Lamblin, Pascal De Groote, Jean-François Bervar, Thierry Perez, Régis Matran, Martine Rémy-Jardin, Pierre-Yves Hatron, Éric Hachulla and David Launay
    Citation: Arthritis Research & Therapy 2017 19:279
    Content type: Research article Published on:

  9. Giant cell arteritis (GCA) is the most common systemic vasculitis in persons older than 50 years. The highest incidence rates of the disease have been reported in Scandinavian countries. Our objective was to d...

    Authors: L. K. Brekke, A. P. Diamantopoulos, B-T. Fevang, J. Aβmus, E. Esperø and C. G. Gjesdal
    Citation: Arthritis Research & Therapy 2017 19:278
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:271

  10. Treatment with disease-modifying anti-rheumatic drugs (DMARDs) has raised concerns about the risk of malignancies in rheumatoid arthritis (RA) patients. However, the association between biologic DMARDs (bDMARD...

    Authors: Soo-Kyung Cho, Jiyoung Lee, Minkyung Han, Sang-Cheol Bae and Yoon-Kyoung Sung
    Citation: Arthritis Research & Therapy 2017 19:277
    Content type: Research article Published on:

  11. The risk of serious infectious events (SIEs) is increased in patients with rheumatoid arthritis (RA). The aim of this study was to develop an age-adjusted comorbidity index (AACI) to predict, using baseline ch...

    Authors: Jeffrey R. Curtis, Kevin Winthrop, Cathy O’Brien, Matladi N. Ndlovu, Marc de Longueville and Boulos Haraoui
    Citation: Arthritis Research & Therapy 2017 19:276
    Content type: Research article Published on:

  13. Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from “outsid...

    Authors: Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Plebańczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik and Włodzimierz Maśliński
    Citation: Arthritis Research & Therapy 2017 19:274
    Content type: Research article Published on:

  14. Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine a...

    Authors: Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2017 19:273
    Content type: Research article Published on:

  15. We previously demonstrated that fasciitis is a common lesion in dermatomyositis (DM) and that DM-associated fasciitis is detectable, as the result of the increased vascularity in the fascia, by power Doppler u...

    Authors: Ken Yoshida, Haruyasu Ito, Kazuhiro Furuya, Taro Ukichi, Kentaro Noda and Daitaro Kurosaka
    Citation: Arthritis Research & Therapy 2017 19:272
    Content type: Research article Published on:

  16. Clinical guidelines recommend knee muscle strengthening exercises to improve physical function. However, the amount of knee muscle strength increase needed for clinically relevant improvements in physical func...

    Authors: Michelle Hall, Rana S. Hinman, Martin van der Esch, Marike van der Leeden, Jessica Kasza, Tim V. Wrigley, Ben R. Metcalf, Fiona Dobson and Kim L. Bennell
    Citation: Arthritis Research & Therapy 2017 19:271
    Content type: Research article Published on:

  17. In addition to activated T cells, the immune checkpoint inhibitor “V domain-containing Ig suppressor of T-cell activation” (VISTA) is expressed by myeloid cell types, including macrophages and neutrophils. The...

    Authors: Sabrina Ceeraz, Susan K. Eszterhas, Petra A. Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti and Roy A. Fava
    Citation: Arthritis Research & Therapy 2017 19:270
    Content type: Research article Published on:

  18. The objective was to evaluate concordance between 2002 American-European Consensus Group (AECG) and 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteri...

    Authors: Maëlle Le Goff, Divi Cornec, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Rozenn Le Berre, Steeve Genestet, Béatrice Cochener, Sylvie Boisrame-Gastrin, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux and Valérie Devauchelle-Pensec
    Citation: Arthritis Research & Therapy 2017 19:269
    Content type: Research article Published on:

  19. We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) inv...

    Authors: Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio and Juan Duarte
    Citation: Arthritis Research & Therapy 2017 19:268
    Content type: Research article Published on:

  20. Our objective in this study was to examine whether stakeholders further endorse the core domain set proposed by the Outcome Measures in Rheumatology Trials (OMERACT) total joint replacement (TJR) working group.

    Authors: Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Millán, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn and Jasvinder A. Singh
    Citation: Arthritis Research & Therapy 2017 19:267
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:32

  21. In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE).

    Authors: Myriam Martin, Karolina I. Smoląg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A. Bengtsson and Anna M. Blom
    Citation: Arthritis Research & Therapy 2017 19:266
    Content type: Research article Published on:

  22. We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL)...

    Authors: Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole and Naoki Ishiguro
    Citation: Arthritis Research & Therapy 2017 19:265
    Content type: Research article Published on:

  23. Metabolic syndrome (MetS) may be associated with knee osteoarthritis (OA), but the association between the individual components and OA are not well-understood. We aimed to study the effect of hypercholesterol...

    Authors: Ane Larrañaga-Vera, Ana Lamuedra, Sandra Pérez-Baos, Ivan Prieto-Potin, Leticia Peña, Gabriel Herrero-Beaumont and Raquel Largo
    Citation: Arthritis Research & Therapy 2017 19:264
    Content type: Research article Published on:

  24. Adipokines are bioactive hormones secreted by adipose tissues. Resistin, an adipokine, plays important roles in the regulation of insulin resistance and inflammation. Resistin levels are known to be increased ...

    Authors: Hiroshi Sato, Sei Muraoka, Natsuko Kusunoki, Shotaro Masuoka, Soichi Yamada, Hideaki Ogasawara, Toshio Imai, Yoshikiyo Akasaka, Naobumi Tochigi, Hiroshi Takahashi, Kazuaki Tsuchiya, Shinichi Kawai and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2017 19:263
    Content type: Research article Published on:

  25. The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD i...

    Authors: Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Shoko Matsui, Yuhei Fujisawa, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa and Mitsuhiro Kawano
    Citation: Arthritis Research & Therapy 2017 19:262
    Content type: Research article Published on:

  26. Tumor necrosis factor-alpha (TNF-α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types. ...

    Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu
    Citation: Arthritis Research & Therapy 2017 19:261
    Content type: Research article Published on:

  27. We aimed to (i) evaluate the immediate effect of a soft knee brace on pain, activity limitations, self-reported knee instability, and self-reported knee confidence, and (ii) to assess the difference in effect ...

    Authors: Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Josien C. van den Noort, Leo D. Roorda, Willem Lems, Jos Twisk, Martijn Steultjens, James Woodburn, Jaap Harlaar and Joost Dekker
    Citation: Arthritis Research & Therapy 2017 19:260
    Content type: Research article Published on:

  28. Cancer is a significant complication contributing to increased mortality in idiopathic inflammatory myopathies (IIMs), and the association between IIMs and cancer has been extensively reported. Myositis-specif...

    Authors: Hanbo Yang, Qinglin Peng, Liguo Yin, Shanshan Li, Jingli Shi, Yamei Zhang, Xin Lu, Xiaoming Shu, Sigong Zhang and Guochun Wang
    Citation: Arthritis Research & Therapy 2017 19:259
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:71

  29. Aiming at rapid decrease of disease activity, there has been a trend to start with higher doses of methotrexate (MTX) in patients newly diagnosed with rheumatoid arthritis (RA), both as monotherapy and in comb...

    Authors: Sytske Anne Bergstra, Cornelia F. Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W. J. Huizinga and Robert B. M. Landewe
    Citation: Arthritis Research & Therapy 2017 19:258
    Content type: Research article Published on:

  30. Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a bioma...

    Authors: Xinyu Yang, Ke Lin, Shanmin Ni, Jianmin Wang, Qingqing Tian, Huaijun Chen, Matthew A. Brown, Kaidi Zheng, Weitao Zhai, Li Sun, Shengwei Jin and Jianguang Wang
    Citation: Arthritis Research & Therapy 2017 19:257
    Content type: Research article Published on:

  31. Treatment of systemic onset juvenile idiopathic arthritis JIA (sJIA), although dramatically improved, remains a challenge. Experience from clinical practice will be presented using data from the German Biologi...

    Authors: Gerd Horneff, Anna Carina Schulz, Jens Klotsche, Anton Hospach, Kirsten Minden, Ivan Foeldvari, Ralf Trauzeddel, Gerd Ganser, Frank Weller-Heinemann and Johannes Perter Haas
    Citation: Arthritis Research & Therapy 2017 19:256
    Content type: Research article Published on:

  32. Takayasu arteritis (TAK) is a large vessel vasculitis that rarely affects children. Data on childhood TAK are scarce. The aim of this study was to analyze the presenting features, course and outcome of childre...

    Authors: Florence A. Aeschlimann, Simon W. M. Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hebert, Damien Noone, Marinka Twilt, Christian Pagnoux, Susanne M. Benseler and Rae S. M. Yeung
    Citation: Arthritis Research & Therapy 2017 19:255
    Content type: Research article Published on:

  33. In the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorf...

    Authors: Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen and Anne Roivainen
    Citation: Arthritis Research & Therapy 2017 19:254
    Content type: Research article Published on:

  34. Glucocorticoids (GCs) are used in ~ 60% of patients with rheumatoid arthritis (RA). Although disease-modifying, they also have significant adverse effects. Understanding factors associated with GC use may help...

    Authors: Rachel J. Black, Susan Lester, Rachelle Buchbinder, Claire Barrett, Marissa Lassere, Lyn March, Samuel Whittle and Catherine L. Hill
    Citation: Arthritis Research & Therapy 2017 19:253
    Content type: Research article Published on:

  35. In this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complem...

    Authors: Di Miao, Dan-Yang Li, Min Chen and Ming-Hui Zhao
    Citation: Arthritis Research & Therapy 2017 19:252
    Content type: Research article Published on:

  36. Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective of this study was to evaluate the prevalence of major comorbidities in Chinese rheumatoid arthritis patients. We...

    Authors: Shangyi Jin, Mengtao Li, Yongfei Fang, Qin Li, Ju Liu, Xinwang Duan, Yi Liu, Rui Wu, Xiaofei Shi, Yongfu Wang, Zhenyu Jiang, Yanhong Wang, Chen Yu, Qian Wang, Xinping Tian, Yan Zhao…
    Citation: Arthritis Research & Therapy 2017 19:251
    Content type: Research article Published on:

  37. This study aimed to investigate the reliability and validity of serum matrix metalloproteinase-3 (MMP-3) levels and articular ultrasound (US) scores in assessing disease activity and therapeutic response in rh...

    Authors: Ling Zhou, Geng Wang, Xin Liu, Jing Song, Ling Chen and Huji Xu
    Citation: Arthritis Research & Therapy 2017 19:250
    Content type: Research article Published on:

  38. Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). To better understand their role, we evaluated m...

    Authors: Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee and Hani El-Gabalawy
    Citation: Arthritis Research & Therapy 2017 19:249
    Content type: Research article Published on:

  40. The aim was to assess the attainability and outcome of the lupus low disease activity state (LLDAS) in the early stages of systemic lupus erythematosus (SLE).

    Authors: Matteo Piga, Alberto Floris, Giulia Cappellazzo, Elisabetta Chessa, Mattia Congia, Alessandro Mathieu and Alberto Cauli
    Citation: Arthritis Research & Therapy 2017 19:247
    Content type: Research article Published on:

  41. Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in huma...

    Authors: Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes and Leendert A. Trouw
    Citation: Arthritis Research & Therapy 2017 19:246
    Content type: Research article Published on:

  42. Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macroph...

    Authors: Lilian Quero, Edveena Hanser, Tobias Manigold, André N. Tiaden and Diego Kyburz
    Citation: Arthritis Research & Therapy 2017 19:245
    Content type: Research article Published on:

  43. Liver enzyme elevation is an important and common adverse effect among patients with immune-mediated diseases who receive tumour necrosis factor inhibitors (anti-TNF), and has various causes. Hence, we evaluat...

    Authors: Ying-Ming Chiu, Mei-Shu Lai and K. Arnold Chan
    Citation: Arthritis Research & Therapy 2017 19:214
    Content type: Research article Published on:

  44. Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction for radiographic progression. ...

    Authors: Young Bin Joo, Yul Kim, Youngho Park, Kwangwoo Kim, Jeong Ah Ryu, Seunghun Lee, So-Young Bang, Hye-Soon Lee, Gwan-Su Yi and Sang-Cheol Bae
    Citation: Arthritis Research & Therapy 2017 19:244
    Content type: Research article Published on:

  45. Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without ar...

    Authors: Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman and Jochen Zwerina
    Citation: Arthritis Research & Therapy 2017 19:243
    Content type: Research article Published on:

  46. Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both seru...

    Authors: Jessica L. Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R. Bennett, Simone Appenzeller, Marisa S. Klein-Gitelman, Alexei A. Grom and Hermine I. Brunner
    Citation: Arthritis Research & Therapy 2017 19:242
    Content type: Research article Published on:

  47. Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage...

    Authors: Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit and Denis Poddubnyy
    Citation: Arthritis Research & Therapy 2017 19:240
    Content type: Research article Published on:

  48. The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE).

    Authors: Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau and Christophe Richez
    Citation: Arthritis Research & Therapy 2017 19:238
    Content type: Research article Published on:

  49. Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren’s syndrome (pSS). The aims of the current study...

    Authors: Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson and Kristofer Andréasson
    Citation: Arthritis Research & Therapy 2017 19:237
    Content type: Research article Published on:

  50. The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies.

    Authors: Chao Zeng, Jie Wei, Robert Terkeltaub, Tuo Yang, Hyon K. Choi, Yi-lun Wang, Dong-xing Xie, David J. Hunter, Yuqing Zhang, Hui Li, Yang Cui, Liang-jun Li and Guang-hua Lei
    Citation: Arthritis Research & Therapy 2017 19:236
    Content type: Research article Published on:
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Arthritis Research & Therapy

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