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Page 48 of 155

  1. Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main eff...

    Authors: Åsa CM Johansson, Sophie Ohlsson, Åsa Pettersson, Anders A. Bengtsson, Daina Selga, Markus Hansson and Thomas Hellmark
    Citation: Arthritis Research & Therapy 2016 18:92
  2. Bruton’s tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects of HM71224, a novel Btk inhibitor, both in vitro and in a mouse model of experi...

    Authors: Jin Kyun Park, Joo-Yun Byun, Ji Ah Park, Yu-Yon Kim, Ye Ji Lee, Jeong In Oh, Sun Young Jang, Young Hoon Kim, Yeong Wook Song, Jeewoong Son, Kwee Hyun Suh, Young-Mi Lee and Eun Bong Lee
    Citation: Arthritis Research & Therapy 2016 18:91
  3. The role of macrophages in the pathogenesis of lupus nephritis, in particular their differentiation to a certain subtype (e.g., M1- or M2-like) modulating the inflammatory reaction, is unknown. Here we investi...

    Authors: Gregor Olmes, Maike Büttner-Herold, Fulvia Ferrazzi, Luitpold Distel, Kerstin Amann and Christoph Daniel
    Citation: Arthritis Research & Therapy 2016 18:90
  4. Disease flares are common in rheumatoid arthritis (RA) and are related to structural damage. However, few data on the impact of flares reported by patients on radiographic progression are available. Our aim wa...

    Authors: Francesca Ometto, Bernd Raffeiner, Livio Bernardi, Costantino Botsios, Nicola Veronese, Leonardo Punzi and Andrea Doria
    Citation: Arthritis Research & Therapy 2016 18:89

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:120

  5. Vacation can present a major problem to patients with rheumatoid arthritis (RA) treated with weekly subcutaneous biologics, including subcutaneous (SC) abatacept. Therefore, the replacement of four SC doses of...

    Authors: Ruediger B. Mueller, Michael Gengenbacher, Symi Richter, Jean Dudler, Burkhard Möller and Johannes von Kempis
    Citation: Arthritis Research & Therapy 2016 18:88
  6. Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 prod...

    Authors: Gautam Edhayan, Ray A. Ohara, W. Alex Stinson, M. Asif Amin, Takeo Isozaki, Christine M. Ha, G. Kenneth Haines III, Rachel Morgan, Phillip L. Campbell, Ali S. Arbab, Sean C. Friday, David A. Fox and Jeffrey H. Ruth
    Citation: Arthritis Research & Therapy 2016 18:87
  7. RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabol...

    Authors: David B. Bartlett, Margery A. Connelly, Hiba AbouAssi, Lori A. Bateman, K. Noelle Tune, Janet L. Huebner, Virginia B. Kraus, Deborah A. Winegar, James D. Otvos, William E. Kraus and Kim M. Huffman
    Citation: Arthritis Research & Therapy 2016 18:86
  8. In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF).

    Authors: Adem Polat, Cengizhan Acikel, Betul Sozeri, Ismail Dursun, Ozgur Kasapcopur, Nesrin Gulez, Dogan Simsek, Mehmet Saldir, Ipek Dokurel, Hakan Poyrazoglu, Sevcan Bakkaloglu, Ali Delibas, Zelal Ekinci, Nuray A. Ayaz, Yasar Kandur, Harun Peru…
    Citation: Arthritis Research & Therapy 2016 18:85
  9. B cells are capable of producing regulatory and effector cytokines. In patients with granulomatosis with polyangiitis (GPA), skewing of the pro- and anti-inflammatory cytokine balance may affect the risk of re...

    Authors: Judith Land, Wayel H. Abdulahad, Jan-Stephan F. Sanders, Coen A. Stegeman, Peter Heeringa and Abraham Rutgers
    Citation: Arthritis Research & Therapy 2016 18:84
  10. The aim of the study was to characterize synovial cells from OA synovium with low-grade and moderate-grade synovitis and to define the role of synovial macrophages in cell culture.

    Authors: Cristina Manferdini, Francesca Paolella, Elena Gabusi, Ylenia Silvestri, Laura Gambari, Luca Cattini, Giuseppe Filardo, Sandrine Fleury-Cappellesso and Gina Lisignoli
    Citation: Arthritis Research & Therapy 2016 18:83
  11. CT-P13 (Remsima®, Inflectra®) is a biosimilar of the infliximab reference product (RP; Remicade®). The aim of this study was to compare the 54-week efficacy, immunogenicity, safety, pharmacokinetics (PK) and p...

    Authors: Dae Hyun Yoo, Artur Racewicz, Jan Brzezicki, Roman Yatsyshyn, Edgardo Tobias Arteaga, Asta Baranauskaite, Carlos Abud-Mendoza, Sandra Navarra, Vladimir Kadinov, Irmgadt Goecke Sariego, Seung Suh Hong, Sung Young Lee and Won Park
    Citation: Arthritis Research & Therapy 2016 18:82
  12. We aimed to investigate the prognostic value of two biomarkers of tissue inflammation, matrix metalloproteinase-dependent degradation of C-reactive protein (CRPM) and connective tissue type I collagen turnover...

    Authors: Fatemeh Saberi Hosnijeh, Anne Sofie Siebuhr, Andre G. Uitterlinden, Edwin H. G. Oei, Albert Hofman, Morten A. Karsdal, Sita M. Bierma-Zeinstra, Anne C. Bay-Jensen and Joyce B. J. van Meurs
    Citation: Arthritis Research & Therapy 2016 18:81
  13. T-cell infiltrates may persist in muscle tissue of polymyositis (PM) and dermatomyositis (DM) patients despite aggressive immunosuppressive treatment. Here, we investigated to what extent persistent T cells in...

    Authors: Jayesh M. Pandya, Ingela Loell, Mohammad Shahadat Hossain, Mei Zong, Helene Alexanderson, Sukanya Raghavan, Ingrid E. Lundberg and Vivianne Malmström
    Citation: Arthritis Research & Therapy 2016 18:80
  14. Methotrexate (MTX) is one of the most widely used medications to treat rheumatoid arthritis (RA), and recent studies have also suggested the potential benefit of the drug for the treatment of osteoarthritis (O...

    Authors: Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, Naoaki Murao, Ryoichi Saitoh, Tadashi Morikawa and Haruhiko Sato
    Citation: Arthritis Research & Therapy 2016 18:79

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:121

  15. The aim was to establish how patients experience the impact of spondyloarthritis (SpA) on work disability and working life.

    Authors: Roberta Ramonda, Antonio Marchesoni, Antonio Carletto, Gerolamo Bianchi, Maurizio Cutolo, Gianfranco Ferraccioli, Enrico Fusaro, Salvatore De Vita, Mauro Galeazzi, Roberto Gerli, Marco Matucci-Cerinic, Giovanni Minisola, Carlomaurizio Montecucco, Raffaele Pellerito, Fausto Salaffi, Giuseppe Paolazzi…
    Citation: Arthritis Research & Therapy 2016 18:78
  16. The immunosuppressive and anti-inflammatory properties of mesenchymal stromal cells (MSC) have prompted their therapeutic application in several autoimmune diseases, including rheumatoid arthritis. Adult MSC a...

    Authors: Elena Gonzalo-Gil, María J. Pérez-Lorenzo, María Galindo, Rafael Díaz de la Guardia, Belén López-Millán, Clara Bueno, Pablo Menéndez, José L. Pablos and Gabriel Criado
    Citation: Arthritis Research & Therapy 2016 18:77
  17. 14-3-3η (eta) is a novel serum/plasma protein biomarker involved in the upregulation of inflammatory and joint damage factors. We analysed the association of 14-3-3η with the development of clinically apparent...

    Authors: Marian H. van Beers-Tas, Anthony Marotta, Maarten Boers, Walter P. Maksymowych and Dirkjan van Schaardenburg
    Citation: Arthritis Research & Therapy 2016 18:76
  18. CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of...

    Authors: Samuel Garcia, Linda M. Hartkamp, B Malvar-Fernandez, Inge E. van Es, Haishan Lin, Justin Wong, Li Long, James A. Zanghi, Andrew L. Rankin, Emma L. Masteller, Brian R. Wong, Timothy R. D. J. Radstake, Paul P. Tak and Kris A. Reedquist
    Citation: Arthritis Research & Therapy 2016 18:75
  19. Patients with rheumatoid arthritis (RA) in clinical remission may have ultrasound-defined synovitis according to the presence of power Doppler (PD) signal. The objective was to describe the immunopathologic ch...

    Authors: Julio Ramírez, Raquel Celis, Alicia Usategui, Virginia Ruiz-Esquide, Regina Faré, Andrea Cuervo, Raimon Sanmartí, José L. Pablos and Juan D. Cañete
    Citation: Arthritis Research & Therapy 2016 18:74
  20. Researchers in clinical trials in rheumatoid arthritis (RA) and osteoarthritis (OA) often measure pain levels with a visual analogue scale (VAS). Of interest to clinical practice and future clinical trial desi...

    Authors: Andreas Karabis, Stavros Nikolakopoulos, Shaloo Pandhi, Katerina Papadimitropoulou, Richard Nixon, Ricardo L. Chaves and R. Andrew Moore
    Citation: Arthritis Research & Therapy 2016 18:73
  21. Retention rate, efficacy, and safety of abatacept (ABA) was compared between patients with rheumatoid arthritis receiving ABA as monotherapy to those in combination ABA + conventional synthetic DMARD (csDMARD).

    Authors: Marie-Elise Truchetet, Nicolas Poursac, Thomas Barnetche, Emilie Shipley, Jacques-Eric Gottenberg, Bernard Bannwarth, Christophe Richez and Thierry Schaeverbeke
    Citation: Arthritis Research & Therapy 2016 18:72
  22. Rheumatoid arthritis (RA) is associated with an increased risk of myocardial infarction (MI) and post-MI fatality compared with the general population. In a previous study examining post-MI treatment in RA com...

    Authors: Joanne Tropea, Caroline A. Brand, Megan Bohensky and Sharon Van Doornum
    Citation: Arthritis Research & Therapy 2016 18:69
  23. With regard to switching tumor necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA), conflicting results have been reported as to whether the effectiveness of a second TNFi depends on the reaso...

    Authors: Adrian Ciurea, Pascale Exer, Ulrich Weber, Giorgio Tamborrini, Beate Steininger, Rudolf O. Kissling, Jürg Bernhard and Almut Scherer
    Citation: Arthritis Research & Therapy 2016 18:71
  24. The aim was to investigate the presence of feeding vessels in or in close proximity to extensor and flexor tendon sheaths at the wrists level and in finger flexor tendon sheaths in healthy controls, using 3D u...

    Authors: Mads Ammitzbøll-Danielsen, Iustina Janta, Søren Torp-Pedersen, Esperanza Naredo, Mikkel Østergaard and Lene Terslev
    Citation: Arthritis Research & Therapy 2016 18:70
  25. Fibromyalgia is a condition characterized by chronic widespread muscle pain and fatigue and associated with significant impairment in perceived function and reduced physical performance. The purpose of this st...

    Authors: Dana L. Dailey, Laura A. Frey Law, Carol G. T. Vance, Barbara A. Rakel, Ericka N. Merriwether, Leon Darghosian, Meenakshi Golchha, Katharine M. Geasland, Rebecca Spitz, Leslie J. Crofford and Kathleen A. Sluka
    Citation: Arthritis Research & Therapy 2016 18:68
  26. The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T–B interactions and production of pro-inflammatory cytokines....

    Authors: Yuri Ota, Hiroaki Niiro, Shun-ichiro Ota, Naoko Ueki, Hirofumi Tsuzuki, Tsuyoshi Nakayama, Koji Mishima, Kazuhiko Higashioka, Siamak Jabbarzadeh-Tabrizi, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Akiko Kukita, Hisakata Yamada, Hiroshi Tsukamoto and Koichi Akashi
    Citation: Arthritis Research & Therapy 2016 18:67
  27. CD271+ stromal cells (SCs) with multipotent stem cell capacity have been identified in synovial tissues, but their functional significance is unknown. We analyzed the distribution of CD271+ cells in inflammatory ...

    Authors: Manuel J. Del Rey, Regina Faré, Alicia Usategui, Juan D. Cañete, Beatriz Bravo, María Galindo, Gabriel Criado and José L. Pablos
    Citation: Arthritis Research & Therapy 2016 18:66
  28. Ephrins and their related receptors have been implicated in some developmental events. We have demonstrated that ephrin-B2 (EFNB2) could play a role in knee joint pathology associated with osteoarthritis (OA)....

    Authors: Gladys Valverde-Franco, Bertrand Lussier, David Hum, Jiangping Wu, Adjia Hamadjida, Numa Dancause, Hassan Fahmi, Mohit Kapoor, Jean-Pierre Pelletier and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2016 18:65
  29. Lubricin, a mucinous glycoprotein secreted by synoviocytes and chondrocytes plays an important role in reducing the coefficient of friction in mammalian joints. Elevated cartilage surface friction is thought t...

    Authors: Naga Padmini Karamchedu, Josef N. Tofte, Kimberly A. Waller, Ling X. Zhang, Tarpit K. Patel and Gregory D. Jay
    Citation: Arthritis Research & Therapy 2016 18:64
  30. Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.

    Authors: Peter Mandl, Silvia Hayer, Thomas Karonitsch, Petra Scholze, David Győri, Despoina Sykoutri, Stephan Blüml, Attila Mócsai, Gyula Poór, Sigismund Huck, Josef S. Smolen and Kurt Redlich
    Citation: Arthritis Research & Therapy 2016 18:63
  31. In this study, we sought to determine the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis factor (TNF), the effects of iNOS...

    Authors: Qianqian Liang, Yawen Ju, Yan Chen, Wensheng Wang, Jinlong Li, Li Zhang, Hao Xu, Ronald W. Wood, Edward. M. Schwarz, Brendan F. Boyce, Yongjun Wang and Lianping Xing
    Citation: Arthritis Research & Therapy 2016 18:62
  32. Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of in...

    Authors: Tue Wenzel Kragstrup, Stinne Ravn Greisen, Morten Aagaard Nielsen, Christopher Rhodes, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Malene Hvid, Thomas Vorup-Jensen, William H. Robinson, Jeremy Sokolove and Bent Deleuran
    Citation: Arthritis Research & Therapy 2016 18:61
  33. Treat to target (T2T) is widely accepted as the standard of care for patients with rheumatoid arthritis (RA) and has been shown to be more effective than traditional routine care. The objective of this study w...

    Authors: L. M. M. Steunebrink, G. A. Versteeg, H. E. Vonkeman, P. M. ten Klooster, H. H. Kuper, T. R. Zijlstra, P. L. C. M. van Riel and M. A. F. J. van de Laar
    Citation: Arthritis Research & Therapy 2016 18:60
  34. Preceding intervertebral disc (IVD) degeneration, the cell phenotype in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). Microarray analysis showed a correlation ...

    Authors: Frances C. Bach, Ying Zhang, Alberto Miranda-Bedate, Lucy C. Verdonschot, Niklas Bergknut, Laura B. Creemers, Keita Ito, Daisuke Sakai, Danny Chan, Björn P. Meij and Marianna A. Tryfonidou
    Citation: Arthritis Research & Therapy 2016 18:59
  35. In 2010, EULAR/PRINTO/PRES proposed new classification criteria for paediatric IgA vasculitis (IgAV) that have a higher diagnostic sensitivity than the 1990 ACR criteria. These criteria have so far not been ev...

    Authors: Alojzija Hočevar, Ziga Rotar, Vesna Jurčić, Jože Pižem, Saša Čučnik, Alenka Vizjak, Rianne van den Broeke and Matija Tomšič
    Citation: Arthritis Research & Therapy 2016 18:58
  36. Anti TNF drugs have been widely used in rheumatoid arthritis (RA) but only 70 to 80 % of patients respond to this therapy. Exploring the mode of action of anti-TNF drugs remains important in order to improve t...

    Authors: Jean Frédéric Boyer, Michel Baron, Arnaud Constantin, Yannick Degboé, Alain Cantagrel and Jean-Luc Davignon
    Citation: Arthritis Research & Therapy 2016 18:56
  37. The study was undertaken to assess the efficacy of methotrexate (MTX) monotherapy on the radiographic progression of individual rheumatoid arthritis (RA) patients, each of whom had received MTX monotherapy for...

    Authors: Kazuko Shiozawa, Takashi Yamane, Miki Murata, Ryosuke Yoshihara, Ken Tsumiyama, Shigeaki Imura and Shunichi Shiozawa
    Citation: Arthritis Research & Therapy 2016 18:55
  38. Bone marrow lesions (BMLs) are useful diagnostic and prognostic markers in knee osteoarthritis (OA), but what they represent at the tissue level remains unclear. The aim of this study was to provide comprehens...

    Authors: Dzenita Muratovic, Flavia Cicuttini, Anita Wluka, David Findlay, Yuanyuan Wang, Sophia Otto, David Taylor, Julia Humphries, Yearin Lee, Agatha Labrinidis, Ruth Williams and Julia Kuliwaba
    Citation: Arthritis Research & Therapy 2016 18:54
  39. Rheumatoid arthritis is characterised by progressive joint destruction and loss of periarticular bone mass. Hand bone loss (HBL) has therefore been proposed as an outcome measure for treatment efficacy. A defi...

    Authors: Lykke Midtbøll Ørnbjerg, Mikkel Østergaard, Trine Jensen, Lars Hyldstrup, Pernille Bach-Mortensen, Pernille Bøyesen, Anja Thormann, Ulrik Tarp, Wolfgang Peter Bøhme, Hanne Lindegaard, Uta Engling Poulsen, Anette Schlemmer, Niels Graudal, Anne Rødgaard, Jakob Espesen, Gina Birgitte Kollerup…
    Citation: Arthritis Research & Therapy 2016 18:53
  40. Advances in pathophysiology and treatment of ankylosing spondylitis (AS) was recently demonstrated. However, the effect of anti-TNF in the newly described inflammatory pathways involved pathogenesis of this di...

    Authors: Fernanda Manente Milanez, Carla G. S. Saad, Vilma T. Viana, Júlio C. B. Moraes, Grégory Vinícius Périco, Percival Degrava Sampaio-Barros, Célio R. Goncalves and Eloísa Bonfá
    Citation: Arthritis Research & Therapy 2016 18:52
  41. The development of EuroQol-5 dimensions (EQ-5D) utility over time in rheumatoid arthritis (RA) patients, treated with biologics other than tumour necrosis factor inhibitors (TNFi), based on the standard Britis...

    Authors: Anders Gülfe, Johan K. Wallman and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2016 18:51
  42. Activation of the type I interferon (IFN) response program is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM) and rheumatoid art...

    Authors: Tamarah D. de Jong, Saskia Vosslamber, Elise Mantel, Sander de Ridder, John G. Wesseling, Tineke C. T. M. van der Pouw Kraan, Cyra Leurs, Harald Hegen, Florian Deisenhammer, Joep Killestein, Ingrid E. Lundberg, Jiri Vencovsky, Mike T. Nurmohamed, Dirkjan van Schaardenburg, Irene E. M. Bultink, Alexandre E. Voskuyl…
    Citation: Arthritis Research & Therapy 2016 18:49
  43. Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure and function and increases the likelihood of re-injury. The mechanisms and expression profiles of fibrosis i...

    Authors: Henry C. J. Goodier, Andrew J. Carr, Sarah J. B. Snelling, Lucy Roche, Kim Wheway, Bridget Watkins and Stephanie G. Dakin
    Citation: Arthritis Research & Therapy 2016 18:48
  44. The approved dose of rituximab (RTX) in rheumatoid arthritis is 1000 mg × 2, but some data have suggested similar clinical efficacy with 500 mg × 2. The purpose of this study was to compare the effectiveness o...

    Authors: Katerina Chatzidionysiou, Elisabeth Lie, Evgeny Nasonov, Galina Lukina, Merete Lund Hetland, Ulrik Tarp, Ioan Ancuta, Karel Pavelka, Dan C. Nordström, Cem Gabay, Helene Canhão, Matija Tomsic, Piet L. C. M. van Riel, Juan Gomez-Reino, Tore K. Kvien and Ronald F. van Vollenhoven
    Citation: Arthritis Research & Therapy 2016 18:50

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:144

  45. It is well-known that increased frequency of neutrophils was found in patients with systemic lupus erythematosus (SLE). However, the immunomodulatory roles and mechanisms of neutrophils in SLE are poorly under...

    Authors: Qing Luo, Zikun Huang, Jianqing Ye, Yating Deng, Le Fang, Xue Li, Yang Guo, Hong Jiang, Beihua Ju, Qingshui Huang and Junming Li
    Citation: Arthritis Research & Therapy 2016 18:47
  46. Symptomatic knee osteoarthritis is a highly age and sex associated complex disease. Little is known about the causes behind this age and sex associated increase, or if genetic and environmental factors impacts...

    Authors: Søren Glud Skousgaard, Axel Skytthe, Sören Möller, Søren Overgaard and Lars Peter Andreas Brandt
    Citation: Arthritis Research & Therapy 2016 18:46
  47. Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necro...

    Authors: Michele Compagno, Birgitta Gullstrand, Søren Jacobsen, Gro Ø. Eilertsen, Jan Åke Nilsson, Christian Lood, Andreas Jönsen, Lennart Truedsson, Gunnar Sturfelt and Anders A. Bengtsson
    Citation: Arthritis Research & Therapy 2016 18:44
  48. Fibromyalgia (FM) can coexist with Spondyloarthritis (SpA) leading to diagnostic and treatment dilemmas, especially in the presence of enthesitis. With this study we aimed to estimate the prevalence of FM in S...

    Authors: Natalia Bello, Adrien Etcheto, Caroline Béal, Maxime Dougados and Anna Moltó
    Citation: Arthritis Research & Therapy 2016 18:42

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