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  1. To develop personalized medicine strategies for improvement of patient management in rheumatoid arthritis, the clinical and molecular properties of the individual patients need to be well characterized. A cruc...

    Authors: Tamarah D de Jong, Saskia Vosslamber and Cornelis L Verweij
    Citation: Arthritis Research & Therapy 2014 16:110
    Content type: Editorial Published on:

  2. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important r...

    Authors: Fatima Ezzahra El Mansouri, Salwa-Sarah Nebbaki, Mohit Kapoor, Hassan Afif, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Mohamed Benderdour and Hassan Fahmi
    Citation: Arthritis Research & Therapy 2014 16:R113
    Content type: Research article Published on:

  3. Liver X receptors are established sensors of lipid and cholesterol homeostasis. Recent studies have reported that these receptors are involved in the regulation of inflammation and immune responses. We attempt...

    Authors: Ja-Young Jeon, Jin-Young Nam, Hyoun-Ah Kim, Yong-Beom Park, Sang-Cheol Bae and Chang-Hee Suh
    Citation: Arthritis Research & Therapy 2014 16:R112
    Content type: Research article Published on:

  4. The objective was to characterize the clinical and myopathologic features of patients with scleroderma-polymyositis (SSc-PM) overlap compared with a population of patients with systemic sclerosis (SSc) and pol...

    Authors: Kavish J Bhansing, Martin Lammens, Hanneke KA Knaapen, Piet LCM van Riel, Baziel GM van Engelen and Madelon C Vonk
    Citation: Arthritis Research & Therapy 2014 16:R111
    Content type: Research article Published on:

  6. Cartilage protein distribution and the changes that occur in cartilage ageing and disease are essential in understanding the process of cartilage ageing and age related diseases such as osteoarthritis. The aim...

    Authors: Mandy J Peffers, Berta Cillero-Pastor, Gert B Eijkel, Peter D Clegg and Ron MA Heeren
    Citation: Arthritis Research & Therapy 2014 16:R110
    Content type: Research article Published on:

  7. Our objective was to utilise network analysis to identify protein clusters of greatest potential functional relevance in the pathogenesis of oligoarticular and rheumatoid factor negative (RF-ve) polyarticular ...

    Authors: Adam Stevens, Stefan Meyer, Daniel Hanson, Peter Clayton and Rachelle Donn
    Citation: Arthritis Research & Therapy 2014 16:R109
    Content type: Research article Published on:

  8. Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor...

    Authors: Rachel Knevel, Diederik PC de Rooy, Tore Saxne, Elisabet Lindqvist, Martha K Leijsma, Nina A Daha, Bobby PC Koeleman, Roula Tsonaka, Jeanine J Houwing-Duistermaat, Joris JM Schonkeren, Rene EM Toes, Tom WJ Huizinga, Elisabeth Brouwer, Anthony G Wilson and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2014 16:R108
    Content type: Research article Published on:

  9. Despite the widespread use of magnetic resonance imaging (MRI) and Doppler ultrasound for the detection of rheumatoid arthritis (RA) disease activity, little is known regarding the association of imaging-detec...

    Authors: Martin Andersen, Mikael Boesen, Karen Ellegaard, Robin Christensen, Kalle Söderström, Niels Søe, Pieter Spee, Ulrik GW Mørch, Søren Torp-Pedersen, Else Marie Bartels, Bente Danneskiold-Samsøe, Nina Vendel, Lars Karlsson and Henning Bliddal
    Citation: Arthritis Research & Therapy 2014 16:R107
    Content type: Research article Published on:

  10. Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for compounds to improve the effect of classic steroids. We sought to unravel how a plant-original ...

    Authors: Jun Li, Juan Du, Dong Liu, Binbin Cheng, Fanfu Fang, Li Weng, Chen Wang and Changquan Ling
    Citation: Arthritis Research & Therapy 2014 16:R106
    Content type: Research article Published on:

  11. Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Currently, the relationship between pathogenic molecular drivers of disease in RA and therapeutic response is poorly unde...

    Authors: Glynn Dennis Jr, Cécile TJ Holweg, Sarah K Kummerfeld, David F Choy, A Francesca Setiadi, Jason A Hackney, Peter M Haverty, Houston Gilbert, Wei Yu Lin, Lauri Diehl, S Fischer, An Song, David Musselman, Micki Klearman, Cem Gabay, Arthur Kavanaugh…
    Citation: Arthritis Research & Therapy 2014 16:R90
    Content type: Research article Published on:

  12. Interleukin (IL)-33 is a proinflammatory cytokine contributing to the pathogenesis of rheumatoid arthritis (RA). The gene encoding IL-33 may serve as a genetic factor and be associated with the risk of RA. To ...

    Authors: Chun Li, Rong Mu, Jianping Guo, Xinyu Wu, Xin Tu, Xu Liu, Fanlei Hu, Shiwei Guo, Jiaxin Zhu, Huji Xu and Zhanguo Li
    Citation: Arthritis Research & Therapy 2014 16:R105
    Content type: Research article Published on:

  13. Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease, which can affect different organs. Increased proportions of CD4+CD25-Foxp3+ T cells have been described in SLE patients. The exact role of ...

    Authors: Michael Bonelli, Lisa Göschl, Stephan Blüml, Thomas Karonitsch, Carl-Walter Steiner, Günter Steiner, Josef S Smolen and Clemens Scheinecker
    Citation: Arthritis Research & Therapy 2014 16:R104
    Content type: Research article Published on:

  14. We hypothesized that serum levels of C-X-C motif chemokine 13 (CXCL13), a B-cell chemokine, would delineate a subset of rheumatoid arthritis (RA) patients characterized by increased humoral immunity.

    Authors: Jonathan D Jones, B JoNell Hamilton, Gregory J Challener, Artur J de Brum-Fernandes, Pierre Cossette, Patrick Liang, Ariel Masetto, Henri A Ménard, Nathalie Carrier, David L Boyle, Sanna Rosengren, Gilles Boire and William F C Rigby
    Citation: Arthritis Research & Therapy 2014 16:R103
    Content type: Research article Published on:

  15. Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function.

    Authors: Hubert Marotte, Pei-Suen Tsou, Tatiana Fedorova, Adam J Pinney, Benjamin Lewis and Alisa E Koch
    Citation: Arthritis Research & Therapy 2014 16:R102
    Content type: Research article Published on:

  16. The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic sta...

    Authors: Pier Luigi Meroni, Cecilia Beatrice Chighizola, Francesca Rovelli and Maria Gerosa
    Citation: Arthritis Research & Therapy 2014 16:209
    Content type: Review Published on:

  17. We investigated the clinical and serological features of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japan using data from a nationwide, prospective, inception cohor...

    Authors: Ken-ei Sada, Masahiro Yamamura, Masayoshi Harigai, Takao Fujii, Hiroaki Dobashi, Yoshinari Takasaki, Satoshi Ito, Hidehiro Yamada, Takashi Wada, Junichi Hirahashi, Yoshihiro Arimura and Hirofumi Makino
    Citation: Arthritis Research & Therapy 2014 16:R101
    Content type: Research article Published on:

  18. Radiography is an unreliable and insensitive tool for the assessment of structural lesions in the sacroiliac joints (SIJ). Magnetic resonance imaging (MRI) detects a wider spectrum of structural lesions but ha...

    Authors: Susanne J Pedersen, Stephanie Wichuk, Praveena Chiowchanwisawakit, Robert G Lambert and Walter P Maksymowych
    Citation: Arthritis Research & Therapy 2014 16:R100
    Content type: Research article Published on:

  19. The aim of this study was to investigate whether 14-3-3η, a specific isoform of a family of proteins regulating processes such as cellular signalling, activates cell-signalling pathways and induces factors kno...

    Authors: Walter P Maksymowych, Désirée van der Heijde, Cornelia F Allaart, Robert Landewé, Gilles Boire, Paul P Tak, Yuan Gui, Aziz Ghahary, Ruhangiz Kilani and Anthony Marotta
    Citation: Arthritis Research & Therapy 2014 16:R99
    Content type: Research article Published on:

  20. Our objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) to modulate phenotype of monocytes (Mo) and monocytes derived dendritic cells (MoDC) activated in response to toll-like receptor ...

    Authors: Yannick Degboé, Séverine Fruchon, Michel Baron, Delphine Nigon, Cédric Olivier Turrin, Anne-Marie Caminade, Rémy Poupot, Alain Cantagrel and Jean-Luc Davignon
    Citation: Arthritis Research & Therapy 2014 16:R98
    Content type: Research article Published on:

  21. CD4+CD25+/highCD127low/- regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analy...

    Authors: Babak Moradi, Philipp Schnatzer, Sébastien Hagmann, Nils Rosshirt, Tobias Gotterbarm, Jan Philippe Kretzer, Marc Thomsen, Hanns-Martin Lorenz, Felix Zeifang and Theresa Tretter
    Citation: Arthritis Research & Therapy 2014 16:R97
    Content type: Research article Published on:

  22. Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthr...

    Authors: Liang Ye, Zhongyang Wen, Yanqun Li, Bingni Chen, Ting Yu, Lanying Liu, Jinshun Zhang, Yanmei Ma, Shuying Xiao, Liping Ding, Li Li and Zhong Huang
    Citation: Arthritis Research & Therapy 2014 16:R96
    Content type: Research article Published on:

  23. Early diagnosis and effective monitoring of rheumatoid arthritis (RA) are important for a positive outcome. Instant treatment often results in faster reduction of inflammation and, as a consequence, less struc...

    Authors: Stéphanie Put, René Westhovens, Tony Lahoutte and Patrick Matthys
    Citation: Arthritis Research & Therapy 2014 16:208
    Content type: Review Published on:

  24. Tumor necrosis factor inhibitor (TNFi) therapy is effective for rheumatoid arthritis (RA). Some researchers have suggested that TNFi therapy affects B-cell homeostasis. We studied the effect of TNFi therapy on...

    Authors: Claire I Daien, Sarah Gailhac, Thibault Mura, Bernard Combe, Michael Hahne and Jacques Morel
    Citation: Arthritis Research & Therapy 2014 16:R95
    Content type: Research article Published on:

  26. Disease activity, severity and comorbidity contribute to increased mortality in patients with rheumatoid arthritis (RA). We evaluated the impact of age at disease onset on prognostic risk factors and treatment...

    Authors: Lena Innala, Ewa Berglin, Bozena Möller, Lotta Ljung, Torgny Smedby, Anna Södergren, Staffan Magnusson, Solbritt Rantapää-Dahlqvist and Solveig Wållberg-Jonsson
    Citation: Arthritis Research & Therapy 2014 16:R94
    Content type: Research article Published on:

  27. Sex hormones, especially estrogens, have been implicated in articular cartilage metabolism and the pathogenesis of postmenopausal osteoarthritis. The conversion by aromatase (CYP19A1) of androstenedione into e...

    Authors: Martin Schicht, Jana Ernst, Andrea Nielitz, Lars Fester, Michael Tsokos, Saskia S Guddat, Lars Bräuer, Judith Bechmann, Karl-Stefan Delank, David Wohlrab, Friedrich Paulsen and Horst Claassen
    Citation: Arthritis Research & Therapy 2014 16:R93
    Content type: Research article Published on:

  30. It is known that anticitrullinated peptide antibody (ACPA)–positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we s...

    Authors: Hanna W van Steenbergen, Jessica AB van Nies, Tom WJ Huizinga, Monique Reijnierse and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2014 16:R92
    Content type: Research article Published on:

  31. Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease and diagnosis is mainly clinical and radiological. Correlation between radiographic data and clinical status has been reported. Ho...

    Authors: Luigi Minafra, Valentina Bravatà, Michele Saporito, Francesco P Cammarata, Giusi I Forte, Salvatore Caldarella, Michele D’Arienzo, Maria C Gilardi, Cristina Messa and Filippo Boniforti
    Citation: Arthritis Research & Therapy 2014 16:R91
    Content type: Research article Published on:

  32. Authors: Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato and Antonino Saitta
    Citation: Arthritis Research & Therapy 2014 16:406
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2013 15:R120

  34. Arthritis is the most frequent manifestation of Blau syndrome, an autoinflammatory disorder caused by the genetic mutation of NOD2. However, detailed information on arthritis in Blau syndrome on which the therape...

    Authors: Kei Ikeda, Naotomo Kambe, Syuji Takei, Taiji Nakano, Yuzaburo Inoue, Minako Tomiita, Natsuko Oyake, Takashi Satoh, Tsuyoshi Yamatou, Tomohiro Kubota, Ikuo Okafuji, Nobuo Kanazawa, Ryuta Nishikomori, Naoki Shimojo, Hiroyuki Matsue and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2014 16:R89
    Content type: Research article Published on:

  35. Gout is characterized by episodes of intense joint inflammation in response to intra-articular monosodium urate monohydrate (MSU) crystals. miR-155 is crucial for the proinflammatory activation of human myeloi...

    Authors: Hye Mi Jin, Tae-Jong Kim, Jung-Ho Choi, Moon-Ju Kim, Young-Nan Cho, Kwang-Il Nam, Seung-Jung Kee, Jang Bae Moon, Seok-Yong Choi, Dong-Jin Park, Shin-Seok Lee and Yong-Wook Park
    Citation: Arthritis Research & Therapy 2014 16:R88
    Content type: Research article Published on:

  36. ETS1 is a negative regulator of the Th17 differentiation gene and plays a central role in the pathogenesis of autoimmune diseases. We aimed to investigate whether polymorphisms in ETS1 confer susceptibility to an...

    Authors: Shan Shan, Jie Dang, Jiangxia Li, Ze Yang, Hailing Zhao, Qian Xin, Xiaochun Ma, Yongchao Liu, Xianli Bian, Yaoqin Gong and Qiji Liu
    Citation: Arthritis Research & Therapy 2014 16:R87
    Content type: Research article Published on:

  37. Although the pathogenesis of systemic sclerosis (SSc) still remains unknown, recent studies have demonstrated that endothelins are deeply involved in the developmental process of fibrosis and vasculopathy asso...

    Authors: Kaname Akamata, Yoshihide Asano, Naohiko Aozasa, Shinji Noda, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama and Shinichi Sato
    Citation: Arthritis Research & Therapy 2014 16:R86
    Content type: Research article Published on:

  38. Patients with rheumatoid arthritis (RA) have increased risk of cardiovascular (CV) events. We sought to test the hypothesis that due to increased inflammation, CV disease and risk factors are associated with i...

    Authors: Helen Pahau, Matthew A Brown, Sanjoy Paul, Ranjeny Thomas and Vibeke Videm
    Citation: Arthritis Research & Therapy 2014 16:R85
    Content type: Research article Published on:

  39. Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory or degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-th...

    Authors: Dirk Woetzel, Rene Huber, Peter Kupfer, Dirk Pohlers, Michael Pfaff, Dominik Driesch, Thomas Häupl, Dirk Koczan, Peter Stiehl, Reinhard Guthke and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2014 16:R84
    Content type: Research article Published on:

  40. Our objective was to evaluate longitudinally the main bone-mass and quality predictors in young juvenile idiopathic arthritis (JIA) patients by using lumbar spine dual-energy X-ray absorptiometry (DXA) scan, r...

    Authors: Stefano Stagi, Loredana Cavalli, Carla Signorini, Federico Bertini, Marco Matucci Cerinic, Maria Luisa Brandi and Fernanda Falcini
    Citation: Arthritis Research & Therapy 2014 16:R83
    Content type: Research article Published on:

  42. Ligament and meniscal damage can cause joint disease. Arthritic joints contain increased amounts of epidermal growth factor receptor (EGFR) protein, and polymorphisms in EGFR are associated with arthritis risk. T...

    Authors: Danese M Joiner, Kennen D Less, Emily M Van Wieren, Yu-Wen Zhang, Daniel Hess and Bart O Williams
    Citation: Arthritis Research & Therapy 2014 16:R81
    Content type: Research article Published on:

  43. The aim of this study was to evaluate the safety and efficacy of rituximab (RTX) in a large cohort of patients with rheumatoid arthritis in routine care, and to monitor changes in daily practice since the intr...

    Authors: Joerg Wendler, Gerd R Burmester, Helmut Sörensen, Andreas Krause, Constanze Richter, Hans-Peter Tony, Andrea Rubbert-Roth, Peter Bartz-Bazzanella, Siegfried Wassenberg, Iris Haug-Rost and Thomas Dörner
    Citation: Arthritis Research & Therapy 2014 16:R80
    Content type: Research article Published on:

  44. In our present single-center pilot study, umbilical cord (UC)–derived mesenchymal stem cells (MSCs) had a good safety profile and therapeutic effect in severe and refractory systemic lupus erythematosus (SLE)....

    Authors: Dandan Wang, Jing Li, Yu Zhang, Miaojia Zhang, Jinyun Chen, Xia Li, Xiang Hu, Shu Jiang, Songtao Shi and Lingyun Sun
    Citation: Arthritis Research & Therapy 2014 16:R79
    Content type: Research article Published on:

  45. The prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation. The objective of this study was to ...

    Authors: Nathalie Saidenberg-Kermanac’h, Luca Semerano, Hilario Nunes, Danielle Sadoun, Xavier Guillot, Marouane Boubaya, Nicolas Naggara, Dominique Valeyre and Marie-Christophe Boissier
    Citation: Arthritis Research & Therapy 2014 16:R78
    Content type: Research article Published on:

  46. Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications of the disease, its pathogenesis still remains unclear. Previous studies revealed that antibodies reactiv...

    Authors: Shunsei Hirohata, Yoshiyuki Arinuma, Tamiko Yanagida and Taku Yoshio
    Citation: Arthritis Research & Therapy 2014 16:R77
    Content type: Research article Published on:

  47. The requirement for the immunoregulatory Mer tyrosine kinase (Mer) for optimal removal of apoptotic cells prompted us to look at its expression in systemic lupus erythematosus (SLE), in which apoptotic cell cl...

    Authors: Brendan A Hilliard, Gaetano Zizzo, Mehriban Ulas, Margaret K Linan, Jessica Schreiter and Philip L Cohen
    Citation: Arthritis Research & Therapy 2014 16:R76
    Content type: Research article Published on:

  48. Whilst arthroscopic surgery for the treatment of meniscal tears is the most commonly performed orthopaedic surgery, meniscal tears at the knee are frequently identified on magnetic resonance imaging in adults ...

    Authors: Veronica Mezhov, Andrew J Teichtahl, Rupert Strasser, Anita E Wluka and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2014 16:206
    Content type: Review Published on:

  49. Vitamin D deficiency has been reported to be common in patients with rheumatoid arthritis (RA) who have a higher prevalence of osteoporosis and hip fracture than healthy individuals. Genetic variants affecting...

    Authors: Shinji Yoshida, Katsunori Ikari, Takefumi Furuya, Yoshiaki Toyama, Atsuo Taniguchi, Hisashi Yamanaka and Shigeki Momohara
    Citation: Arthritis Research & Therapy 2014 16:R75
    Content type: Research article Published on:

  50. The aims of this study were to assess agreement between the currently used 2002 American–European Consensus Group (AECG) classification criteria and the new 2012 American College of Rheumatology (ACR) criteria...

    Authors: Divi Cornec, Alain Saraux, Béatrice Cochener, Jacques-Olivier Pers, Sandrine Jousse-Joulin, Yves Renaudineau, Thierry Marhadour and Valérie Devauchelle-Pensec
    Citation: Arthritis Research & Therapy 2014 16:R74
    Content type: Research article Published on:
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Arthritis Research & Therapy

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