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  1. Previous studies of long-term treatment response in fibromyalgia and other chronic pain states have generally been limited to approximately one year, leaving questions about the longer-term durability of respo...

    Authors: Daniel J Clauw, Philip J Mease, Robert H Palmer, Joel M Trugman and Yong Wang
    Citation: Arthritis Research & Therapy 2013 15:R88
    Content type: Research article Published on:

  2. While microvascular disease is well described in systemic sclerosis (SSc), it is still unclear whether the occurrence of ischemic macrovascular events and atherosclerosis is enhanced among patients with SSc.

    Authors: Annica Nordin, Kerstin Jensen-Urstad, Lena Björnådal, Susanne Pettersson, Anders Larsson and Elisabet Svenungsson
    Citation: Arthritis Research & Therapy 2013 15:R87
    Content type: Research article Published on:

  3. Rheumatoid arthritis (RA) patients with structural progression are in most need of immediate treatment to maintain tissue integrity. The serum protein fingerprint, type I collagen degradation mediated by matri...

    Authors: Anne Sofie Siebuhr, Anne C Bay-Jensen, Diana J Leeming, Adam Plat, Inger Byrjalsen, Claus Christiansen, Désirée van de Heijde and Morten A Karsdal
    Citation: Arthritis Research & Therapy 2013 15:R86
    Content type: Research article Published on:

  4. Angiogenesis plays a critical role in synovial inflammation and joint destruction in rheumatoid arthritis (RA). Vascular endothelial growth factor A (VEGF-A) and angiopoietins are two important mediators of sy...

    Authors: Young-Sool Hah, Young Jun Koh, Hye Song Lim, Hyun-Ok Kim, Yun-Hong Cheon, Hae Sook Noh, Kyu Yun Jang, Sang Yong Lee, Gyun Min Lee, Gou Young Koh and Sang-Il Lee
    Citation: Arthritis Research & Therapy 2013 15:R85
    Content type: Research article Published on:

  5. The ability to degrade neutrophil extracellular traps (NETs) is reduced in a subset of patients with systemic lupus erythematosus (SLE). NETs consist of chromatin covered with antimicrobial enzymes and are nor...

    Authors: Jonatan Leffler, Birgitta Gullstrand, Andreas Jönsen, Jan-Åke Nilsson, Myriam Martin, Anna M Blom and Anders A Bengtsson
    Citation: Arthritis Research & Therapy 2013 15:R84
    Content type: Research article Published on:

  6. This randomized, controlled study on patients with polymyositis or dermatomyositis was based on three hypotheses: patients display impaired endurance due to reduced aerobic capacity and muscle weakness, endura...

    Authors: Li Alemo Munters, Maryam Dastmalchi, Abram Katz, Mona Esbjörnsson, Ingela Loell, Balsam Hanna, Maria Lidén, Håkan Westerblad, Ingrid E Lundberg and Helene Alexanderson
    Citation: Arthritis Research & Therapy 2013 15:R83
    Content type: Research article Published on:

  7. Polymorphisms in the interferon regulatory factor 5 (IRF5) gene are associated with susceptibility to systemic lupus erythematosus, rheumatoid arthritis and other diseases through independent risk and protective ...

    Authors: Elisa Alonso-Perez, Romina Fernandez-Poceiro, Emilie Lalonde, Tony Kwan, Manuel Calaza, Juan J Gomez-Reino, Jacek Majewski and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2013 15:R82
    Content type: Research article Published on:

  8. The aim of this study was to determine whether hypercholesterolemia increases articular damage in a rabbit model of chronic arthritis.

    Authors: I Prieto-Potín, JA Roman-Blas, MJ Martínez-Calatrava, R Gómez, R Largo and Gabriel Herrero-Beaumont
    Citation: Arthritis Research & Therapy 2013 15:R81
    Content type: Research article Published on:

  9. Adipose-derived stem cells (ASCs) have the potential to differentiate into cartilage under stimulation with some reported growth and transcriptional factors, which may constitute an alternative for cartilage r...

    Authors: Idalia Garza-Veloz, Viktor J Romero-Diaz, Margarita L Martinez-Fierro, Ivan A Marino-Martinez, Manuel Gonzalez-Rodriguez, Herminia G Martinez-Rodriguez, Marcela A Espinoza-Juarez, Dante A Bernal-Garza, Rocio Ortiz-Lopez and Augusto Rojas-Martinez
    Citation: Arthritis Research & Therapy 2013 15:R80
    Content type: Research article Published on:

  11. Anti-TNF drugs have proven to be effective against spondyloarthritis (SpA), although 30% of patients fail to respond or experience adverse events leading to treatment discontinuation. In rheumatoid arthritis, ...

    Authors: Chamaida Plasencia, Dora Pascual-Salcedo, Sara García-Carazo, Leticia Lojo, Laura Nuño, Alejandro Villalba, Diana Peiteado, Florencia Arribas, Jesus Díez, Maria Teresa López-Casla, Emilio Martín-Mola and Alejandro Balsa
    Citation: Arthritis Research & Therapy 2013 15:R79
    Content type: Research article Published on:

  12. Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of ...

    Authors: Caroline Charpin, Fanny Arnoux, Marielle Martin, Eric Toussirot, Nathalie Lambert, Nathalie Balandraud, Daniel Wendling, Elisabeth Diot, Jean Roudier and Isabelle Auger
    Citation: Arthritis Research & Therapy 2013 15:R78
    Content type: Research article Published on:

  13. AMP-activated protein kinase (AMPK) maintains cultured chondrocyte matrix homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes. Liver kin...

    Authors: Freyr Petursson, Matt Husa, Ron June, Martin Lotz, Robert Terkeltaub and Ru Liu-Bryan
    Citation: Arthritis Research & Therapy 2013 15:R77
    Content type: Research article Published on:

  14. The present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.

    Authors: Nicholas Peake, Nyan Su, Manoj Ramachandran, Pramod Achan, Donald M Salter, Dan L Bader, Amie J Moyes, Adrian J Hobbs and Tina T Chowdhury
    Citation: Arthritis Research & Therapy 2013 15:R76
    Content type: Research article Published on:

  15. Pain affects the quality of life for millions of individuals and is a major reason for healthcare utilization. As populations age, medical personnel will need to manage more and more patients suffering from pa...

    Authors: Anne Tuskey and David Peura
    Citation: Arthritis Research & Therapy 2013 15(Suppl 3):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 3

  16. NSAIDs are prescribed widely but have rare serious gastrointestinal side effects. More recently, adverse cardiovascular effects of these drugs have also been recognized, leading to the withdrawal of some agent...

    Authors: James M Scheiman
    Citation: Arthritis Research & Therapy 2013 15(Suppl 3):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 3

  17. The characteristic of a biomarker that makes it a useful surrogate is the ability to identify a high risk of clinically important benefits or harms occurring in the future. A number of definitions or descripti...

    Authors: R Andrew Moore
    Citation: Arthritis Research & Therapy 2013 15(Suppl 3):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 3

  18. NSAIDs are among the most commonly used drugs worldwide and their beneficial therapeutic properties are thoroughly accepted. However, they are also associated with gastrointestinal (GI) adverse events. NSAIDs ...

    Authors: Carlos Sostres, Carla J Gargallo and Angel Lanas
    Citation: Arthritis Research & Therapy 2013 15(Suppl 3):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 3

  21. Hepatocyte growth factor (HGF) is a potent proangiogenic molecule that induces neovascularization. The HGF antagonist, NK4, competitively antagonizes HGF binding to its receptor. In the present study, we deter...

    Authors: Sachi Tsunemi, Tsuyoshi Iwasaki, Sachie Kitano, Kunio Matsumoto, Misato Takagi-Kimura, Shuji Kubo, Tomoko Tamaoki and Hajime Sano
    Citation: Arthritis Research & Therapy 2013 15:R75
    Content type: Research article Published on:

  22. Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this r...

    Authors: Shouan Zhu, Huanhuan Liu, Yan Wu, Boon Chin Heng, Pengfei Chen, Hua Liu and Hong Wei Ouyang
    Citation: Arthritis Research & Therapy 2013 15:217
    Content type: Review Published on:

  23. Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense against viruses. Through their cytolytic capacity and generation of cytokines and chemokines, NK cells modulate ...

    Authors: Leslie A Fogel, Wayne M Yokoyama and Anthony R French
    Citation: Arthritis Research & Therapy 2013 15:216
    Content type: Review Published on:

  24. Altered phenotypes of circulating monocytes of patients with systemic sclerosis (SSc) have been reported, but the role of these alterations in the pathogenesis of SSc remains unclear. This study was undertaken...

    Authors: Ayako Masuda, Hidekata Yasuoka, Takashi Satoh, Yuka Okazaki, Yukie Yamaguchi and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2013 15:R74
    Content type: Research article Published on:

  30. Monosodium urate crystals (MSU), the etiological agent of gout, are one of the most potent proinflammatory stimuli for neutrophils. The modulation of MSU-induced neutrophil activation by inhibitory receptors r...

    Authors: Valérie Gagné, Louis Marois, Jean-Michel Levesque, Hugo Galarneau, Mireille H Lahoud, Irina Caminschi, Paul H Naccache, Philippe Tessier and Maria JG Fernandes
    Citation: Arthritis Research & Therapy 2013 15:R73
    Content type: Research article Published on:

  31. Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. However, validated immunoassay kits to test this specificity have not been commercially...

    Authors: Yoshinao Muro, Kazumitsu Sugiura and Masashi Akiyama
    Citation: Arthritis Research & Therapy 2013 15:116
    Content type: Editorial Published on:

  32. The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA).

    Authors: Wayel H Abdulahad, Nikola Lepse, Coen A Stegeman, Minke G Huitema, Berber Doornbos-van der Meer, Henko Tadema, Abraham Rutgers, Pieter C Limburg, Cees GM Kallenberg and Peter Heeringa
    Citation: Arthritis Research & Therapy 2013 15:R70
    Content type: Research article Published on:

  33. Systemic sclerosis (SSc) is an autoimmune disease characterized by chronic inflammation, vascular injury and excessive fibrosis. CD163 is a scavenger receptor which affects inflammatory response and may contri...

    Authors: Otylia Kowal-Bielecka, Marek Bielecki, Serena Guiducci, Beata Trzcinska-Butkiewicz, Małgorzata Michalska-Jakubus, Marco Matucci-Cerinic, Marek Brzosko, Dorota Krasowska, Lech Chyczewski and Krzysztof Kowal
    Citation: Arthritis Research & Therapy 2013 15:R69
    Content type: Research article Published on:

  34. IL-10--producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce immunological tolerance and, in turn, to inhibit t...

    Authors: Janette Furuzawa-Carballeda, Gabriela Hernández-Molina, Guadalupe Lima, Yahaira Rivera-Vicencio, Karen Férez-Blando and Luis Llorente
    Citation: Arthritis Research & Therapy 2013 15:R68
    Content type: Research article Published on:

  35. Data from clinical studies on the long-term efficacy and safety of anti-tumor necrosis factor (TNF)-α therapy in patients with ankylosing spondylitis (AS) are scarce. This is the first report on continuous tre...

    Authors: Xenofon Baraliakos, Hildrun Haibel, Claudia Fritz, Joachim Listing, Frank Heldmann, Juergen Braun and Joachim Sieper
    Citation: Arthritis Research & Therapy 2013 15:R67
    Content type: Research article Published on:

  36. We evaluated the presence of Porphyromonas gingivalis (Pg) DNA in the synovial tissue through synovial biopsy and in other compartments of rheumatoid arthritis (RA) patients in comparison with patients affected b...

    Authors: Michele Ciro Totaro, Paola Cattani, Francesco Ria, Barbara Tolusso, Elisa Gremese, Anna Laura Fedele, Sara D'Onghia, Simona Marchetti, Gabriele Di Sante, Silvia Canestri and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2013 15:R66
    Content type: Research article Published on:

  38. It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intesti...

    Authors: Mary-Ellen Costello, Dirk Elewaut, Tony J Kenna and Matthew A Brown
    Citation: Arthritis Research & Therapy 2013 15:214
    Content type: Review Published on:

  39. The aim of this study was to examine the association between functional polymorphisms in the pro-inflammatory P2X7 receptor and the Ro/La autoantibody response in primary Sjögren's syndrome (pSS).

    Authors: Susan Lester, Leanne Stokes, Kristen K Skarratt, Ben J Gu, Kathy L Sivils, Christopher J Lessard, James S Wiley and Maureen Rischmueller
    Citation: Arthritis Research & Therapy 2013 15:R71
    Content type: Research article Published on:

  40. Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition w...

    Authors: Jasmin B Kuemmerle-Deschner, Helmut Wittkowski, Pascal N Tyrrell, Ina Koetter, Peter Lohse, Katharina Ummenhofer, Fabian Reess, Sandra Hansmann, Assen Koitschev, Christoph Deuter, Anja Bialkowski, Dirk Foell and Susanne M Benseler
    Citation: Arthritis Research & Therapy 2013 15:R64
    Content type: Research article Published on:

  41. Early systemic sclerosis (SSc) is characterized by Raynaud's phenomenon together with scleroderma marker autoantibodies and/or a scleroderma pattern at capillaroscopy and no other distinctive feature of SSc. P...

    Authors: Gabriele Valentini, Antonella Marcoccia, Giovanna Cuomo, Serena Vettori, Michele Iudici, Francesco Bondanini, Carlo Santoriello, Aldo Ciani, Domenico Cozzolino, Giovanni Maria De Matteis, Salvatore Cappabianca, Filiberto Vitelli and Alberto Spanò
    Citation: Arthritis Research & Therapy 2013 15:R63
    Content type: Research article Published on:

  42. The aim of this study was to determine the factors, including markers of bone resorption and bone formation, which determine catabolic and anabolic periarticular bone changes in patients with rheumatoid arthri...

    Authors: Sophie Aschenberg, Stephanie Finzel, Sarah Schmidt, Sebastian Kraus, Klaus Engelke, Matthias Englbrecht, Jürgen Rech and Georg Schett
    Citation: Arthritis Research & Therapy 2013 15:R62
    Content type: Research article Published on:

  43. Spondyloarthritis (SpA), an interrelated group of rheumatic diseases, has been suggested to be triggered by bacterial infections prior to the development of an autoimmune response that causes inflammation of t...

    Authors: Thomas Gelsing Carlsen, Astrid Hjelholt, Anne Grethe Jurik, Berit Schiøttz-Christensen, Anna Zejden, Gunna Christiansen, Bent Deleuran and Svend Birkelund
    Citation: Arthritis Research & Therapy 2013 15:R61
    Content type: Research article Published on:

  44. Signals from the epidermal growth factor receptor (EGFR) have typically been considered to provide catabolic activities in articular cartilage, and accordingly have been suggested to have a causal role in oste...

    Authors: John B Shepard, Jae-Wook Jeong, Nita J Maihle, Sean O'Brien and Caroline N Dealy
    Citation: Arthritis Research & Therapy 2013 15:R60
    Content type: Research article Published on:

  47. This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (...

    Authors: Joost F Swart, Sytze de Roock and Nico M Wulffraat
    Citation: Arthritis Research & Therapy 2013 15:213
    Content type: Review Published on:

  48. Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to t...

    Authors: Julie Barsalou, Timothy J Bradley and Earl D Silverman
    Citation: Arthritis Research & Therapy 2013 15:212
    Content type: Review Published on:

  49. Current therapies for articular cartilage defects fail to achieve qualitatively sufficient tissue regeneration, possibly because of a mismatch between the speed of cartilage rebuilding and the resorption of de...

    Authors: David Pretzel, Stefanie Linss, Hannes Ahrem, Michaela Endres, Christian Kaps, Dieter Klemm and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2013 15:R59
    Content type: Research article Published on:

  50. Adenosine, acting through the A2A receptor, promotes tissue matrix production in the skin and the liver and induces the development of dermal fibrosis and cirrhosis in murine models. Since expression of A2A recep...

    Authors: Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska and Bruce N Cronstein
    Citation: Arthritis Research & Therapy 2013 15:R58
    Content type: Research article Published on:
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