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Articles
Page 69 of 155
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Citation: Arthritis Research & Therapy 2013 15:407
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A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis
Interruption of cytokine signaling, by targeting either the cytokine itself or its cellular receptor, is a mainstay in the therapy for patients with rheumatic diseases. Interleukin (IL)-33, a member of the IL-...
Citation: Arthritis Research & Therapy 2013 15:115 -
What can rheumatologists learn from translational cancer therapy?
It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation ...
Citation: Arthritis Research & Therapy 2013 15:114 -
MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc
Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more...
Citation: Arthritis Research & Therapy 2013 15:R57 -
Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women
Whereas the overall association between smoking and rheumatoid arthritis (RA) must be regarded as established, considerably less is known about how much smoking is needed to increase the risk of RA, that is, t...
Citation: Arthritis Research & Therapy 2013 15:R56 -
Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis
We sought to assess whether nailfold videocapillaroscopy (NVC) patterns are associated with levels of angiogenic factors in systemic sclerosis (SSc).
Citation: Arthritis Research & Therapy 2013 15:R55 -
Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion
Treprostinil diethanolamine is an innovative salt form of the prostacyclin analogue, treprostinil sodium, developed as an oral sustained release (SR) osmotic tablet. The availability of a formulation permittin...
Citation: Arthritis Research & Therapy 2013 15:R54 -
Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes
Synovial macrophages, which can release proinflammatory factors, are responsible for the upregulation of cartilage-breakdown proteases and play critical roles in cartilage degradation during the progression of...
Citation: Arthritis Research & Therapy 2013 15:R53 -
Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis
The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA).
Citation: Arthritis Research & Therapy 2013 15:R52 -
Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivomodels
Peroxisome proliferator-activated receptor (PPAR) agonists are widely used drugs in the treatment of diabetes and dyslipidemia. In addition to their metabolic effects, PPAR isoforms PPARα and PPARγ are also in...
Citation: Arthritis Research & Therapy 2013 15:R51 -
Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay
Autoantibodies to the Th/To antigen have been described in systemic sclerosis (SSc) and several proteins of the macromolecular Th/To complex have been reported to react with anti-Th/To antibodies. However, ant...
Citation: Arthritis Research & Therapy 2013 15:R50 -
microRNA-mediated regulation of innate immune response in rheumatic diseases
miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the...
Citation: Arthritis Research & Therapy 2013 15:210 -
Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?
Adult and juvenile dermatomyositis share the hallmark features of pathognomic skin rash and muscle inflammation, but are heterogeneous disorders with a range of additional disease features and complications. T...
Citation: Arthritis Research & Therapy 2013 15:211 -
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus
An NZB-derived genetic locus (Sle2c2) that suppresses autoantibody production in a mouse model of induced systemic lupus erythematosus contains a polymorphism in the gene encoding the G-CSF receptor. This study w...
Citation: Arthritis Research & Therapy 2013 15:R49 -
Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara
Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. The high prevalence of DM and anti-Mi-2 in Central America is thought ...
Citation: Arthritis Research & Therapy 2013 15:R48 -
B-cell targeted therapeutics in clinical development
B lymphocytes are the source of humoral immunity and are thus a critical component of the adaptive immune system. However, B cells can also be pathogenic and the origin of disease. Deregulated B-cell function ...
Citation: Arthritis Research & Therapy 2013 15(Suppl 1):S4 -
Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply
Citation: Arthritis Research & Therapy 2013 15:406 -
Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis'
Citation: Arthritis Research & Therapy 2013 15:405 -
Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?
In its widest sense, the term epigenetics describes a range of mechanisms in genome function that do not solely result from the DNA sequence itself. These mechanisms comprise DNA and chromatin modifications an...
Citation: Arthritis Research & Therapy 2013 15:209 -
Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus
β2-microglobulin (β2m) is required for the surface expression of MHC class I and class I-like proteins such as CD1d, Qa1 and neonatal Fc receptor (FcRn), all of which may impact the development of autoimmunity...
Citation: Arthritis Research & Therapy 2013 15:R47 -
Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial
Exercise training has emerged as a promising therapeutic strategy to counteract physical dysfunction in adult systemic lupus erythematosus. However, no longitudinal studies have evaluated the effects of an exe...
Citation: Arthritis Research & Therapy 2013 15:R46 -
B-cell subpopulations in humans and their differential susceptibility to depletionwith anti-CD20 monoclonal antibodies
In humans, different B-cell subpopulations can be distinguished in peripheral bloodand other tissues on the basis of differential expression of various surface markers.These different subsets correspond to dif...
Citation: Arthritis Research & Therapy 2013 15(Suppl 1):S3 -
Canonical Wnt signaling and caveolae play a role in intervertebral disc degeneration; the continuing saga of the mysterious notochordal cell
Over the past few decades small animal models mainly involving rodents and rabbits have been developed whereby needle puncture, stab incision or enzymatic approaches have been validated to create the degenerat...
Citation: Arthritis Research & Therapy 2013 15:113 -
Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy
Bone mass, bone geometry and its changes are based on trabecular and cortical bone remodeling. Whereas the effects of estrogen loss, rheumatoid arthritis (RA), glucocorticoid (GC) and bisphosphonate (BP) on tr...
Citation: Arthritis Research & Therapy 2013 15:208 -
Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathology of rheumatoid arthritis (RA), particularly as vulnerable personality types are exposed to chronic stress. Emo...
Citation: Arthritis Research & Therapy 2013 15:R45 -
Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?
Although it is generally accepted that osteoarthritis is a degenerative condition of the cartilage, other tissues such as synovium in which immunological and inflammatory reactions occur contribute to the deve...
Citation: Arthritis Research & Therapy 2013 15:112 -
Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932)
Magnetic resonance imaging (MRI) is increasingly being used in clinical trials of rheumatoid arthritis (RA) because of its superiority over x-ray radiography (XR) in detecting and monitoring change in bone ero...
Citation: Arthritis Research & Therapy 2013 15:R44 -
Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step?
Rheumatoid arthritis (RA) is associated with a similar cardiovascular risk to that in diabetes, and therefore cardiovascular risk management (CV-RM) - that is, identification and treatment of cardiovascular ri...
Citation: Arthritis Research & Therapy 2013 15:111 -
Treatment of rheumatoid arthritis in the Medicare Current Beneficiary Survey
Numerous studies across different health systems have documented that many patients with rheumatoid arthritis (RA) do not receive disease-modifying anti-rheumatic drugs (DMARDs). Relatively little is known abo...
Citation: Arthritis Research & Therapy 2013 15:R43 -
Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia
Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol c...
Citation: Arthritis Research & Therapy 2013 15:R42 -
Perspectives on epigenetic-based immune intervention for rheumatic diseases
Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide...
Citation: Arthritis Research & Therapy 2013 15:207 -
Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity
Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They intera...
Citation: Arthritis Research & Therapy 2013 15:R41 -
Further evaluation of a claims-based algorithm to determine the effectiveness of biologics for rheumatoid arthritis using commercial claims data
Citation: Arthritis Research & Therapy 2013 15:404 -
Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply
Citation: Arthritis Research & Therapy 2013 15:403 -
Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'
Citation: Arthritis Research & Therapy 2013 15:402 -
Osteopontin - a biomarker for organ damage in paediatric lupus?
A growing body of literature has demonstrated that the multifunctional glycoprotein osteopontin (OPN), has a role in type I interferon (IFN) production and may be involved in systemic lupus erythematosus (SLE)...
Citation: Arthritis Research & Therapy 2013 15:110 -
Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus
Neuropsychiatric manifestations are common in childhood-onset systemic lupus erythematosus (cSLE) and often include neurocognitive dysfunction (NCD). Functional magnetic resonance imaging (fMRI) can measure br...
Citation: Arthritis Research & Therapy 2013 15:R40 -
Erratum to: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site
Citation: Arthritis Research & Therapy 2013 15:401 -
Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease
The objective of this study was to investigate the potential role of the Toll-like receptor 7 (TLR7) signaling pathway in the pathogenesis of adult-onset Still's disease (AOSD).
Citation: Arthritis Research & Therapy 2013 15:R39 -
Kidney disease in lupus is not always 'lupus nephritis'
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the Internati...
Citation: Arthritis Research & Therapy 2013 15:108 -
The severity of experimental arthritis is independent of IL-36 receptor signaling
Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, that bind to the IL-36 receptor (IL-36R). IL-36 exerts proinflammatory effects in skin and lung and stimulates T c...
Citation: Arthritis Research & Therapy 2013 15:R38 -
Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
Detection of (subclinical) synovitis is relevant for both early diagnosis and monitoring of therapy of rheumatoid arthritis (RA). Previously, the potential of imaging (sub)clinical arthritis was demonstrated b...
Citation: Arthritis Research & Therapy 2013 15:R37 -
Enhancing the reporting and transparency of rheumatology research: a guide to reporting guidelines
Manuscripts and abstracts from biomedical journals frequently do not contain proper information for meeting required standards and serving the multiple needs of their end users. Reporting guidelines and checkl...
Citation: Arthritis Research & Therapy 2013 15:109 -
Urinary CD8+ T-cell counts discriminate between active and inactive lupus nephritis
Lupus nephritis (LN) is a severe and frequent manifestation of systemic lupus erythematosus (SLE). Early detection of initial renal manifestations and relapses during follow-up is pivotal to prevent loss of re...
Citation: Arthritis Research & Therapy 2013 15:R36 -
CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice
The ability to ameliorate murine lupus renders regulatory T cells (Treg) a promising tool for the treatment of systemic lupus erythematosus (SLE). In consideration to the clinical translation of a Treg-based i...
Citation: Arthritis Research & Therapy 2013 15:R35 -
Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?
Severe fatigue is a major health problem in fibromyalgia (FM). Obesity is common in FM, but the influence of adipokines and growth factors is not clear. The aim was to examine effects of exercise on fatigue, i...
Citation: Arthritis Research & Therapy 2013 15:R34 -
The schedule of administration of canakinumab in cryopyrin associated periodic syndrome is driven by the phenotype severity rather than the age
Interleukin-1 (IL-1) blockade is the treatment of choice of cryopyrin associated periodic syndromes (CAPS). Anti-IL-1 monoclonal antibody (canakinumab) was recently registered. However no clear data are availa...
Citation: Arthritis Research & Therapy 2013 15:R33 -
To target or not to target APRIL in systemic lupus erythematosus: that is the question!
Among the cytokines that regulate B-cell homeostasis are the TNF-like ligands B-lymphocyte stimulator (BLyS; also B-cell activation factor) and a proliferation-inducing ligand (APRIL). BLyS and APRIL share two...
Citation: Arthritis Research & Therapy 2013 15:107 -
CD154: the atherosclerotic risk factor in rheumatoid arthritis?
Atherosclerosis, now regarded as a chronic inflammatory disease of the arterial wall, and its clinical manifestations have increasingly been associated with rheumatoid arthritis (RA), supporting the notion tha...
Citation: Arthritis Research & Therapy 2013 15:206 -
Periodic knee injections of collagen tripeptide delay cartilage degeneration in rabbit experimental osteoarthritis
Collagen peptides have been reported to possess various biological activities for various cell types. The purposes of this study were, first, to examine the therapeutic effects of collagen tripeptide (Ctp) in ...
Citation: Arthritis Research & Therapy 2013 15:R32