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  1. Circadian rhythms play an important role in the body and in single cells. Rhythms of molecular clocks have not been investigated in synovial fibroblasts (SF) of patients with osteoarthritis (OA) and rheumatoid...

    Authors: Stefanie Haas and Rainer H Straub
    Citation: Arthritis Research & Therapy 2012 14:R122
    Content type: Research article Published on:

  2. Rheumatoid arthritis (RA) is a chronic inflammatory disease in which prostaglandin E2 (PGE2) displays an important pathogenic role. The enzymes involved in its synthesis are highly expressed in the inflamed synov...

    Authors: Karina Roxana Gheorghe, Syed Sadique, Patrick Leclerc, Helena Idborg, Ivonne Wobst, Anca Irinel Catrina, Per-Johan Jakobsson and Marina Korotkova
    Citation: Arthritis Research & Therapy 2012 14:R121
    Content type: Research article Published on:

  3. The present study assessed the potential functions of interleukin (IL)-32α on inflammatory arthritis and endotoxin shock models using IL-32α transgenic (Tg) mice. The potential signaling pathway for the IL-32-...

    Authors: Masanori Nakayama, Yasuo Niki, Toshiki Kawasaki, Yuki Takeda, Keisuke Horiuchi, Aya Sasaki, Yasunori Okada, Kazuo Umezawa, Hiroyasu Ikegami, Yoshiaki Toyama and Takeshi Miyamoto
    Citation: Arthritis Research & Therapy 2012 14:R120
    Content type: Research article Published on:

  4. Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1β (IL-1β) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain contai...

    Authors: Kiyoshi Migita, Tomohiro Koga, Kenshi Satomura, Masahiro Izumi, Takafumi Torigoshi, Yumi Maeda, Yasumori Izumi, Yuka Jiuchi, Taiichiro Miyashita, Satoshi Yamasaki, Yoshihiro Aiba, Atsumasa Komori, Minoru Nakamura, Satoru Motokawa, Atsushi Kawakami, Tadashi Nakamura…
    Citation: Arthritis Research & Therapy 2012 14:R119
    Content type: Research article Published on:

  5. Wang and colleagues have investigated a mechanistic basis for resistance to steroid therapy in systemic lupus erythematosus patients. Their examination reveals significant differences in macrophage migration i...

    Authors: Rick Bucala
    Citation: Arthritis Research & Therapy 2012 14:118
    Content type: Editorial Published on:

  6. Anti-citrullinated peptide antibodies are found in rheumatoid arthritis (RA) patients with HLA-DRβ chains encoding the shared epitope (SE) sequence. Citrullination increases self-antigen immunogenicity, throug...

    Authors: Soi Cheng Law, Shayna Street, Chien-Hsiung Alan Yu, Christelle Capini, Sakoontalla Ramnoruth, Hendrik J Nel, Eline van Gorp, Claire Hyde, Kim Lau, Helen Pahau, Anthony W Purcell and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2012 14:R118
    Content type: Research article Published on:

  7. Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular disease (CVD), and it has been postulated that RA disease-related inflammation contributes to endothelial dysfunction. The aim ...

    Authors: Aamer Sandoo, George D Kitas, Douglas Carroll and Jet JCS Veldhuijzen van Zanten
    Citation: Arthritis Research & Therapy 2012 14:R117
    Content type: Research article Published on:

  9. Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-at...

    Authors: Elke Arts, Jaap Fransen, Heidi Lemmers, Anton Stalenhoef, Leo Joosten, Piet van Riel and Calin D Popa
    Citation: Arthritis Research & Therapy 2012 14:R116
    Content type: Research article Published on:

  10. The excess of adipose tissue in obese individuals may have immunomodulating properties and pharmacokinetic consequences. The aim of this study was to determine whether body mass index (BMI) affects response to...

    Authors: Sébastien Ottaviani, Yannick Allanore, Florence Tubach, Marine Forien, Anaïs Gardette, Blandine Pasquet, Elisabeth Palazzo, Marine Meunier, Gilles Hayem, Chantal Job-Deslandre, André Kahan, Olivier Meyer and Philippe Dieudé
    Citation: Arthritis Research & Therapy 2012 14:R115
    Content type: Research article Published on:

  11. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation of the joints and the presence of autoantibodies directed against proteins containing the non-standard arginine-derived amino ac...

    Authors: Reinout Raijmakers, Joyce JBC van Beers, Mahmoud El-Azzouny, Natasja FC Visser, Borut Božič, Ger JM Pruijn and Albert JR Heck
    Citation: Arthritis Research & Therapy 2012 14:R114
    Content type: Research article Published on:

  12. The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in cartilage as determined by immunochemical assays. The dis...

    Authors: Valeria M Dejica, John S Mort, Sheila Laverty, John Antoniou, David J Zukor, Michael Tanzer and A Robin Poole
    Citation: Arthritis Research & Therapy 2012 14:R113
    Content type: Research article Published on:

  13. In early rheumatoid arthritis (RA), low-dose oral prednisone (PDN) co-medication yields better clinical results than monotherapy with disease-modifying anti-rheumatic drugs (DMARDs). In addition, ultrasonograp...

    Authors: Carlomaurizio Montecucco, Monica Todoerti, Garifallia Sakellariou, Carlo Alberto Scirè and Roberto Caporali
    Citation: Arthritis Research & Therapy 2012 14:R112
    Content type: Research article Published on:

  14. The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship betwee...

    Authors: Mária Filková, Hana Hulejová, Klára Kuncová, Lenka Pleštilová, Lucie Andrés Cerezo, Heřman Mann, Martin Klein, Josef Zámečník, Steffen Gay, Jiří Vencovský and Ladislav Šenolt
    Citation: Arthritis Research & Therapy 2012 14:R111
    Content type: Research article Published on:

  16. Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF) in inducing and maintaining remission in patients with class III-V-lupus nephritis. Also extrarenal manifestations respond to MMF treatme...

    Authors: Sebastian Eickenberg, Eva Mickholz, Elisabeth Jung, Jerzy-Roch Nofer, Herrmann Pavenstädt and Annett M Jacobi
    Citation: Arthritis Research & Therapy 2012 14:R110
    Content type: Research article Published on:

  17. The utility of reassessing anti-cyclic citrullinated peptide (anti-CCP) antibody status later in disease in patients presenting with early undifferentiated inflammatory polyarthritis, particularly in those who...

    Authors: Marian L Burr, Sebastien Viatte, Marwan Bukhari, Darren Plant, Deborah P Symmons, Wendy Thomson and Anne Barton
    Citation: Arthritis Research & Therapy 2012 14:R109
    Content type: Research article Published on:

  18. Osteoporosis can be a complication of ankylosing spondylitis (AS), but diagnosing spinal osteoporosis can be difficult since pathologic new bone formation interferes with the assessment of the bone mineral den...

    Authors: Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten and Helena Forsblad-d'Elia
    Citation: Arthritis Research & Therapy 2012 14:R108
    Content type: Research article Published on:

  19. We used DR1 transgenic mice and covalently linked DR1 multimers to characterize analog-specific inhibitory T cells in collagen-induced arthritis (CIA). Because of the low numbers of antigen-specific T cells in...

    Authors: Masaru Kimata, David L Cullins, Monica L Brown, David D Brand, Edward F Rosloniec, Linda K Myers, John M Stuart and Andrew H Kang
    Citation: Arthritis Research & Therapy 2012 14:R107
    Content type: Research article Published on:

  20. We previously demonstrated that synovial sublining macrophages express folate receptor beta (FRβ). The aim of this study was to evaluate the efficacy of intra-articular administration of a recombinant immunoto...

    Authors: Taku Nagai, Akira Kyo, Kazuhisa Hasui, Sonshin Takao and Takami Matsuyama
    Citation: Arthritis Research & Therapy 2012 14:R106
    Content type: Research article Published on:

  21. The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mech...

    Authors: Akihiko Hiyama, Fumiyuki Arai, Daisuke Sakai, Katsuya Yokoyama and Joji Mochida
    Citation: Arthritis Research & Therapy 2012 14:R105
    Content type: Research article Published on:

  22. Both murine and human genome-wide association studies have implicated peptidyl arginine deiminase (PAD4) as a susceptibility gene in rheumatoid arthritis (RA). In addition, patients with RA commonly have autoa...

    Authors: Amanda S Rohrbach, Saskia Hemmers, Sanja Arandjelovic, Maripat Corr and Kerri A Mowen
    Citation: Arthritis Research & Therapy 2012 14:R104
    Content type: Research article Published on:

  23. Glucocorticoid (GC) therapy remains important in improving the prognosis of patients with systemic lupus erythematosus (SLE). However, some patients do not achieve an effective response with GC treatment, crea...

    Authors: Fang-Fang Wang, Li-An Zhu, Yu-Qiong Zou, Hui Zheng, Alisa Wilson, Cheng-De Yang, Nan Shen, Daniel J Wallace, Michael H Weisman, Shun-Le Chen and Liang-Jing Lu
    Citation: Arthritis Research & Therapy 2012 14:R103
    Content type: Research article Published on:

  24. Progressive fibrosis in systemic sclerosis (SSc) is linked to aberrant transforming growth factor beta (TGF-beta) signaling. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) blocks fibrogenic TGF-...

    Authors: Katja Lakota, Jun Wei, Mary Carns, Monique Hinchcliff, Jungwha Lee, Michael L Whitfield, Snezna Sodin-Semrl and John Varga
    Citation: Arthritis Research & Therapy 2012 14:R102
    Content type: Research article Published on:

  25. Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. O...

    Authors: Juan M Jimenez-Andrade and Patrick W Mantyh
    Citation: Arthritis Research & Therapy 2012 14:R101
    Content type: Research article Published on:

  26. We have previously reported that high levels of antibodies specific for native human type II collagen (anti-CII) at the time of RA diagnosis were associated with concurrent but not later signs of inflammation....

    Authors: Mohammed Mullazehi, Marius C Wick, Lars Klareskog, Ronald van Vollenhoven and Johan Rönnelid
    Citation: Arthritis Research & Therapy 2012 14:R100
    Content type: Research article Published on:

  27. The purpose of this study was to determine whether anti-tumour necrosis factor alpha (anti-TNF-α) antibody, infliximab, can inhibit T helper 17 (Th17) differentiation in uveitis patients who have Behçet's dise...

    Authors: Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie and Manabu Mochizuki
    Citation: Arthritis Research & Therapy 2012 14:R99
    Content type: Research article Published on:

  28. Autoantibodies to neutrophil cytoplasmic antigen-associated vasculitis (AAV) is characterised by inflammation of blood vessels. The introduction of immunosuppressive therapy with glucocorticoids and cyclophosp...

    Authors: Rona M Smith, Rachel B Jones and David RW Jayne
    Citation: Arthritis Research & Therapy 2012 14:210
    Content type: Review Published on:

  29. The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-α) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone t...

    Authors: Suzanne Arends, Anneke Spoorenberg, Pieternella M Houtman, Martha K Leijsma, Reinhard Bos, Cees GM Kallenberg, Henk Groen, Elisabeth Brouwer and Eveline van der Veer
    Citation: Arthritis Research & Therapy 2012 14:R98
    Content type: Research article Published on:

  30. Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are re...

    Authors: Angela Ceribelli, Micaela Fredi, Mara Taraborelli, Ilaria Cavazzana, Franco Franceschini, Marzia Quinzanini, Angela Tincani, Steven J Ross, Jason YF Chan, Brad A Pauley, Edward KL Chan and Minoru Satoh
    Citation: Arthritis Research & Therapy 2012 14:R97
    Content type: Research article Published on:

  31. Methotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that SLC19A1 is associated with the efficacy of MTX. We here examined the relationship between the efficacy of MTX and the exp...

    Authors: Misato Hashizume, Hiroto Yoshida, Keisuke Tanaka, Miho Suzuki, Isao Matsumoto, Takayuki Sumida and Masahiko Mihara
    Citation: Arthritis Research & Therapy 2012 14:R96
    Content type: Research article Published on:

  33. B cell depletion therapy is efficacious in rheumatoid arthritis (RA) patients failing on tumor necrosis factor (TNF) blocking agents. However, approximately 40% to 50% of rituximab (RTX) treated RA patients ha...

    Authors: Hennie G Raterman, Saskia Vosslamber, Sander de Ridder, Michael T Nurmohamed, Willem F Lems, Maarten Boers, Mark van de Wiel, Ben AC Dijkmans, Cornelis L Verweij and Alexandre E Voskuyl
    Citation: Arthritis Research & Therapy 2012 14:R95
    Content type: Research article Published on:

  34. We aimed to investigate whether the effect size of the systemic lupus erythematosus (SLE) risk alleles varies across European subpopulations.

    Authors: Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Gian Domenico Sebastiani, Rudolf Pullmann, Chryssa Papasteriades, Attila Kovacs, Fotini N Skopouli, Marc Bijl, Ana Suarez, Maurizio Marchini, Sergio Migliaresi, Patricia Carreira, Josep Ordi-Ros, Torsten Witte, Sarka Ruzickova…
    Citation: Arthritis Research & Therapy 2012 14:R94
    Content type: Research article Published on:

  35. Psoriatic arthritis (PsA) is an autoantibody-negative immune-mediated disease in which synovial lymphoid neogenesis (LN) occurs. We determined whether LN is associated with specific patterns of inflammatory cy...

    Authors: Raquel Celis, Núria Planell, José L Fernández-Sueiro, Raimon Sanmartí, Julio Ramírez, Isidoro González-Álvaro, José L Pablos and Juan D Cañete
    Citation: Arthritis Research & Therapy 2012 14:R93
    Content type: Research article Published on:

  36. Two major gout-causing genes have been identified, the urate transport genes SLC2A9 and ABCG2. Variation within the SLC17A1 locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of ur...

    Authors: Jade E Hollis-Moffatt, Amanda J Phipps-Green, Brett Chapman, Gregory T Jones, Andre van Rij, Peter J Gow, Andrew A Harrison, John Highton, Peter B Jones, Grant W Montgomery, Lisa K Stamp, Nicola Dalbeth and Tony R Merriman
    Citation: Arthritis Research & Therapy 2012 14:R92
    Content type: Research article Published on:

  37. Thrombin is a key factor in the stimulation of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of osteoarthritis (OA). Heme oxygenase (HO)-...

    Authors: Ju-Fang Liu, Sheng-Mou Hou, Chun-Hao Tsai, Chun-Yin Huang, Wei-Hung Yang and Chih-Hsin Tang
    Citation: Arthritis Research & Therapy 2012 14:R91
    Content type: Research article Published on:

  39. Statins (hydroxymethylglutaryl coenzyme A reductase inhibitors) are effective in reducing the risk of cardiovascular morbidity and mortality in patients with hyperlipidemia, hypertension, or type II diabetes. ...

    Authors: Rob J Vandebriel, Hilda JI De Jong, Eric R Gremmer, Olaf H Klungel, Jan-Willem Cohen Tervaert, Wout Slob, Jan Willem Van Der Laan and Henk Van Loveren
    Citation: Arthritis Research & Therapy 2012 14:R90
    Content type: Research article Published on:

  40. Rheumatoid arthritis (RA) is a multifactorial autoimmune disease in which genetic and environmental factors interact in the etiology. In this study, we investigated whether smoking and HLA-DRB1 shared-epitope (SE...

    Authors: Chun Lai Too, Abqariyah Yahya, Shahnaz Murad, Jasbir Singh Dhaliwal, Per Tobias Larsson, Nor Asiah Muhamad, Nor Aini Abdullah, Amal Nasir Mustafa, Lars Klareskog, Lars Alfredsson, Leonid Padyukov and Camilla Bengtsson
    Citation: Arthritis Research & Therapy 2012 14:R89
    Content type: Research article Published on:

  41. TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function an...

    Authors: Qiang Shu, Mohammad A Amin, Jeffrey H Ruth, Phillip L Campbell and Alisa E Koch
    Citation: Arthritis Research & Therapy 2012 14:R88
    Content type: Research article Published on:

  42. Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. Th...

    Authors: Kenji Ikuta, Yuko Waguri-Nagaya, Kae Kikuchi, Takaya Yamagami, Masahiro Nozaki, Mineyoshi Aoyama, Kiyofumi Asai and Takanobu Otsuka
    Citation: Arthritis Research & Therapy 2012 14:R87
    Content type: Research article Published on:

  43. B cell-activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) play a crucial role in B cell development, survival, and antibody production. Here we analyzed th...

    Authors: Kazuhiro Kiyama, Daisuke Kawabata, Yuji Hosono, Koji Kitagori, Naoichiro Yukawa, Hajime Yoshifuji, Koichiro Omura, Takao Fujii and Tsuneyo Mimori
    Citation: Arthritis Research & Therapy 2012 14:R86
    Content type: Research article Published on:

  44. CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, cl...

    Authors: Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper C Broen, Madelon C Vonk, Raquel Ríos-Fernández, Gerard Espinosa, Patricia Carreira, María T Camps, Maria J Castillo, Miguel A González-Gay, Emma Beltrán, María del Carmen Freire, Javier Narváez, Carlos Tolosa, Torsten Witte…
    Citation: Arthritis Research & Therapy 2012 14:R85
    Content type: Research article Published on:

  46. In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities...

    Authors: Beate Böhm, Harald Burkhardt, Steffen Uebe, Maria Apel, Frank Behrens, André Reis and Ulrike Hüffmeier
    Citation: Arthritis Research & Therapy 2012 14:R84
    Content type: Research article Published on:

  48. Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine that plays important roles in immunity and inflammation. Some studies have suggested that polymorphism in the TGFB1 gene is associated with h...

    Authors: Ying Chen, Peter T Dawes, Jon C Packham and Derek L Mattey
    Citation: Arthritis Research & Therapy 2012 14:R81
    Content type: Research article Published on:

  49. Prevalence of an abnormal Papanicolaou smear was significantly increased in lupus patients in cross-sectional studies, associated with a higher prevalence of high-risk human papillomavirus (HPV) infection. The...

    Authors: Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li and Lai-Shan Tam
    Citation: Arthritis Research & Therapy 2012 14:R80
    Content type: Research article Published on:

  50. Myositis specific autoantibodies are associated with unique clinical subsets and are useful biomarkers in polymyositis/dermatomyositis (PM/DM). A 120 kD protein recognized by certain patients with DM was ident...

    Authors: Minoru Satoh, Jason YF Chan, Steven J Ross, Yi Li, Yoshioki Yamasaki, Hidehiro Yamada, Monica Vazquez-del Mercado, Marcelo H Petri, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Reyes, Eric S Sobel, Westley H Reeves, Angela Ceribelli and Edward KL Chan
    Citation: Arthritis Research & Therapy 2012 14:R79
    Content type: Research article Published on:
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Arthritis Research & Therapy

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