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  1. Methotrexate (MTX) induces macrophage apoptosis in vitro, but there is not much evidence for increased synovial macrophage apoptosis in MTX-treated patients. Macrophage apoptosis is reported, however, during clin...

    Authors: Susan ZY Lo, James H Steer and David A Joyce
    Citation: Arthritis Research & Therapy 2011 13:R24
    Content type: Research article Published on:

  2. Transforming growth factor beta (TGFβ) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and ex...

    Authors: Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, Philippe Galéra and Karim Boumédiene
    Citation: Arthritis Research & Therapy 2011 13:R23
    Content type: Research article Published on:

  3. We tested the hypothesis that there exist relationships between the onset of early stage radiographically defined knee osteoarthritis (OA), pain and changes in biomarkers of joint metabolism.

    Authors: Muneaki Ishijima, Taiji Watari, Kiyohito Naito, Haruka Kaneko, Ippei Futami, Kaori Yoshimura-Ishida, Akihito Tomonaga, Hideyo Yamaguchi, Tetsuro Yamamoto, Isao Nagaoka, Hisashi Kurosawa, Robin A Poole and Kazuo Kaneko
    Citation: Arthritis Research & Therapy 2011 13:R22
    Content type: Research article Published on:

  4. CD4+ T cells express K2P5.1 (TWIK-related acid-sensitive potassium channel 2 (TASK2); KCNK5), a member of the two-pore domain potassium channel family, which has been shown to influence T cell effector functions....

    Authors: Stefan Bittner, Nicole Bobak, Martin Feuchtenberger, Alexander M Herrmann, Kerstin Göbel, Raimund W Kinne, Anker J Hansen, Thomas Budde, Christoph Kleinschnitz, Oliver Frey, Hans-Peter Tony, Heinz Wiendl and Sven G Meuth
    Citation: Arthritis Research & Therapy 2011 13:R21
    Content type: Research article Published on:

  5. The objective of this study was to compare the clinical usefulness of the new anti-double-stranded DNA nucleosome-complexed enzyme-linked immunosorbent assay (Anti-dsDNA-NcX ELISA), which is based on dsDNA-loa...

    Authors: Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer and Falk Hiepe
    Citation: Arthritis Research & Therapy 2011 13:R26
    Content type: Research article Published on:

  6. In this study, we sought to determine the diagnostic value and clinical laboratory associations of autoantibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in systemic...

    Authors: Fidan Barkhudarova, Cornelia Dähnrich, Anke Rosemann, Udo Schneider, Winfried Stöcker, Gerd-Rüdiger Burmester, Karl Egerer, Wolfgang Schlumberger, Falk Hiepe and Robert Biesen
    Citation: Arthritis Research & Therapy 2011 13:R20
    Content type: Research article Published on:

  7. The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers.

    Authors: Rasmus K Madsen, Torbjörn Lundstedt, Jon Gabrielsson, Carl-Johan Sennbro, Gerd-Marie Alenius, Thomas Moritz, Solbritt Rantapää-Dahlqvist and Johan Trygg
    Citation: Arthritis Research & Therapy 2011 13:R19
    Content type: Research article Published on:

  8. Systemic sclerosis (SSc) is characterized by fibrosis and microvascular abnormalities including dysregulated angiogenesis. Chemokines, in addition to their chemoattractant properties, have the ability to modul...

    Authors: Bradley J Rabquer, Pei-Suen Tsou, Yong Hou, Eshwar Thirunavukkarasu, G Kenneth Haines 3rd, Ann J Impens, Kristine Phillips, Bashar Kahaleh, James R Seibold and Alisa E Koch
    Citation: Arthritis Research & Therapy 2011 13:R18
    Content type: Research article Published on:

  9. Follistatin-like protein 1 (FSTL1) is a proinflammation mediator implicated in arthritis in rodent animal models. The present study is aimed at assessing FSTL1 levels in systemic autoimmune diseases and correl...

    Authors: Dawei Li, Yuji Wang, Nanwei Xu, Qianghua Wei, Min Wu, Xiaofeng Li, Ping Zheng, Sai Sun, Yuli Jin, Gailian Zhang, Ruomin Liao and Ping Zhang
    Citation: Arthritis Research & Therapy 2011 13:R17
    Content type: Research article Published on:

  10. The aim of the present study was to compare bone mineral density (BMD) and body composition (BC) measurements as well as identify risk factors for low BMD and osteoporotic fractures in postmenopausal women wit...

    Authors: Paulo G Pedreira, Marcelo M Pinheiro and Vera L Szejnfeld
    Citation: Arthritis Research & Therapy 2011 13:R16
    Content type: Research article Published on:

  11. Rheumatoid arthritis (RA) is now suspected to be driven by pathogenic Th17 cells that secrete interleukin (IL)-17 and can be regulated by IL-4. A single-nucleotide polymorphism (SNP), I50V, in the coding regio...

    Authors: Susan K Wallis, Laura A Cooney, Judith L Endres, Min Jie Lee, Jennifer Ryu, Emily C Somers and David A Fox
    Citation: Arthritis Research & Therapy 2011 13:R15
    Content type: Research article Published on:

  12. In a murine model, interleukin (IL)-17 plays a critical role in the pathogenesis of arthritis. There are controversies, however, regarding whether IL-17 is a proinflammatory mediator in rheumatoid arthritis (R...

    Authors: Hiroshi Ito, Hidehiro Yamada, Toshiko N Shibata, Hirofumi Mitomi, So Nomoto and Shoichi Ozaki
    Citation: Arthritis Research & Therapy 2011 13:R14
    Content type: Research article Published on:

  13. Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue...

    Authors: Sarah Khalifé and Muhammad Zafarullah
    Citation: Arthritis Research & Therapy 2011 13:102
    Content type: Editorial Published on:

  14. We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals...

    Authors: Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2011 13:R13
    Content type: Research article Published on:

  15. Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proport...

    Authors: Adrian Cortes and Matthew A Brown
    Citation: Arthritis Research & Therapy 2011 13:101
    Content type: Commentary Published on:

  17. Juvenile idiopathic arthritis (JIA) is an umbrella term for all chronic childhood arthropathies and can be divided into seven subtypes. It includes the enthesitis related arthritis (ERA) subtype which displays...

    Authors: Anne Hinks, Paul Martin, Edward Flynn, Steve Eyre, Jon Packham, Anne Barton, Jane Worthington and Wendy Thomson
    Citation: Arthritis Research & Therapy 2011 13:R12
    Content type: Research article Published on:

  18. Cytochrome P-450 2E1 (CYP2E1) is an important member of the CYP superfamily, which is involved in the metabolism and activation of many low molecular weight toxic compounds. We tried to investigate the possibl...

    Authors: Ling-hong Liao, Hao Zhang, Man-Po Lai, Shun-Le Chen, Madeline Wu and Nan Shen
    Citation: Arthritis Research & Therapy 2011 13:R11
    Content type: Research article Published on:

  19. Rheumatoid arthritis (RA) improves during pregnancy and flares after delivery. It has been hypothesized that high levels of the complement factor mannose-binding lectin (MBL) are associated with a favourable d...

    Authors: Fleur E van de Geijn, Yaël A de Man, Manfred Wuhrer, Sten P Willemsen, André M Deelder, Johanna MW Hazes and Radboud JEM Dolhain
    Citation: Arthritis Research & Therapy 2011 13:R10
    Content type: Research article Published on:

  20. Inadequate clearance of apoptotic cells by macrophages is one of the reasons for the breakdown of self-tolerance. Class A scavenger receptors, macrophage receptor with collagenous structure (MARCO) and scaveng...

    Authors: Xiao-wei Chen, Yan Shen, Chuan-yin Sun, Feng-xia Wu, Yi Chen and Cheng-de Yang
    Citation: Arthritis Research & Therapy 2011 13:R9
    Content type: Research article Published on:

  21. Recent evidence suggests that intervertebral disc (IVD) cells derived from degenerative tissue are unable to respond to physiologically relevant mechanical stimuli in the 'normal' anabolic manner, but instead ...

    Authors: Hamish TJ Gilbert, Judith A Hoyland, Anthony J Freemont and Sarah J Millward-Sadler
    Citation: Arthritis Research & Therapy 2011 13:R8
    Content type: Research article Published on:

  22. With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in ...

    Authors: Eliza K Pontifex, Danielle M Gerlag, Martina Gogarty, Marjolein Vinkenoog, Adrian Gibbs, Ilse Burgman, Ursula Fearon, Barry Bresnihan, Paul Peter Tak, Robin G Gibney, Douglas J Veale and Oliver FitzGerald
    Citation: Arthritis Research & Therapy 2011 13:R7
    Content type: Research article Published on:

  23. Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H2 to PGE2. mPGES-1 plays a key r...

    Authors: Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask and Mohit Kapoor
    Citation: Arthritis Research & Therapy 2011 13:R6
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2011 13:402

  26. Both cardiovascular disease and osteoporosis are important causes of morbidity and mortality in the elderly. The co-occurrence of cardiovascular disease and osteoporosis prompted us to review the evidence of a...

    Authors: Debby den Uyl, Mike T Nurmohamed, Lilian HD van Tuyl, Hennie G Raterman and Willem F Lems
    Citation: Arthritis Research & Therapy 2011 13:R5
    Content type: Research article Published on:

  27. In this study, we aimed to investigate ultrasonographic (US) changes suggestive of gouty arthritis in the hyaline cartilage, joints and tendons from asymptomatic individuals with hyperuricemia.

    Authors: Carlos Pineda, Luis M Amezcua-Guerra, Carla Solano, Pedro Rodriguez-Henríquez, Cristina Hernández-Díaz, Angelica Vargas, Fritz Hofmann and Marwin Gutiérrez
    Citation: Arthritis Research & Therapy 2011 13:R4
    Content type: Research article Published on:

  28. Increased levels of genes in the type I interferon (IFN) pathway have been observed in patients with systemic sclerosis (SSc), or scleroderma. How type I IFN regulates the dermal fibroblast and its participati...

    Authors: Sandeep K Agarwal, Minghua Wu, Christopher K Livingston, Donald H Parks, Maureen D Mayes, Frank C Arnett and Filemon K Tan
    Citation: Arthritis Research & Therapy 2011 13:R3
    Content type: Research article Published on:

  29. The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren's syndrome (pSS). Plasma cells producing these autoantibodies are ...

    Authors: Ewa A Szyszko, Karl A Brokstad, Gunnvor Øijordsbakken, Malin V Jonsson, Roland Jonsson and Kathrine Skarstein
    Citation: Arthritis Research & Therapy 2011 13:R2
    Content type: Research article Published on:

  30. Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affe...

    Authors: Gwenyth R Wallen, Kimberly R Middleton, Migdalia V Rivera-Goba and Barbara B Mittleman
    Citation: Arthritis Research & Therapy 2011 13:R1
    Content type: Research article Published on:

  31. Adiponectin has been implicated in the pathogenesis of osteoarthritis (OA). We studied the effects of adiponectin on the OA cartilage homeostasis.

    Authors: Eun Ha Kang, Yun Jong Lee, Tae Kyun Kim, Chong Bum Chang, Jin-Haeng Chung, Kichul Shin, Eun Young Lee, Eun Bong Lee and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2010 12:R231
    Content type: Research article Published on:

  32. Aggrecanase cleavage at the 392Glu-393Ala bond in the interglobular domain (IGD) of aggrecan, releasing N-terminal 393ARGS fragments, is an early key event in arthritis and joint injuries. We determined whether s...

    Authors: Staffan Larsson, Martin Englund, André Struglics and L Stefan Lohmander
    Citation: Arthritis Research & Therapy 2010 12:R230
    Content type: Research article Published on:

  33. Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...

    Authors: Jonathan B Catterall, Thomas V Stabler, Carl R Flannery and Virginia B Kraus
    Citation: Arthritis Research & Therapy 2010 12:R229
    Content type: Research article Published on:

  34. Chemerin is a chemotactic peptide which directs leukocytes expressing the chemokine-like receptor ChemR23 towards sites of inflammation. ChemR23 is a G protein-coupled receptor which binds several different li...

    Authors: Vivian Berg, Baldur Sveinbjörnsson, Signy Bendiksen, Jan Brox, Khaled Meknas and Yngve Figenschau
    Citation: Arthritis Research & Therapy 2010 12:R228
    Content type: Research article Published on:

  35. Regulatory factor X-box 1 (RFX1) can interact with DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1), and RFX1 down-regulation contributes to DNA hypomethylation and histone H3 hyperacetylation...

    Authors: Ming Zhao, Xiaoyan Wu, Qing Zhang, Shuangyan Luo, Gongping Liang, Yuwen Su, Yixin Tan and Qianjin Lu
    Citation: Arthritis Research & Therapy 2010 12:R227
    Content type: Research article Published on:

  36. We aimed to assess the incidence and hospitalization rate of hip and "minor" fragility fractures in the Italian population.

    Authors: Umberto Tarantino, Antonio Capone, Marco Planta, Michele D'Arienzo, Giulia Letizia Mauro, Angelo Impagliazzo, Alessandro Formica, Francesco Pallotta, Vittorio Patella, Antonio Spinarelli, Ugo Pazzaglia, Guido Zarattini, Mauro Roselli, Giuseppina Montanari, Giuseppe Sessa, Marco Privitera…
    Citation: Arthritis Research & Therapy 2010 12:R226
    Content type: Research article Published on:

  37. The burden of disability, analgesia, and health services use associated with knee pain and osteoarthritis (OA) in developing countries is relatively unknown, despite a high proportion of these populations requ...

    Authors: Jianhao Lin, Marlene Fransen, Xiaozheng Kang, Hu Li, Yan Ke, Zhiqiang Wang, Yuqing Zhang and Steve Su
    Citation: Arthritis Research & Therapy 2010 12:R225
    Content type: Research article Published on:

  38. Rheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases (MMPs) implicated in homeostasis of the extracellular matrix...

    Authors: Samuel García, Jerónimo Forteza, Carlos López-Otin, Juan J Gómez-Reino, Antonio González and Carmen Conde
    Citation: Arthritis Research & Therapy 2010 12:R224
    Content type: Research article Published on:

  39. There are conflicting data on the natural history and clinical significance of bone marrow lesions (BMLs). The aims of this study were to describe the natural history of MRI-detected BMLs at the knee using a q...

    Authors: Dawn Dore, Stephen Quinn, Changhai Ding, Tania Winzenberg, Guangju Zhai, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2010 12:R223
    Content type: Research article Published on:

  40. Recent evidence suggests that bone marrow lesions (BMLs) play a pivotal role in knee osteoarthritis (OA). The aims of this study were to determine: 1) whether baseline BML presence and/or severity predict site...

    Authors: Dawn Dore, Ashleigh Martens, Stephen Quinn, Changhai Ding, Tania Winzenberg, Guangju Zhai, Jean-Pierre Pelletier, Johanne Martel-Pelletier, François Abram, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2010 12:R222
    Content type: Research article Published on:

  41. The human monoclonal antibody adalimumab is known to induce an anti-globulin response in some adalimumab-treated patients. Antibodies against adalimumab (AAA) are associated with non-response to treatment. Imm...

    Authors: Geertje M Bartelds, Els de Groot, Michael T Nurmohamed, Margreet HL Hart, Peter H van Eede, Carla A Wijbrandts, Jakob BA Crusius, Ben AC Dijkmans, Paul Peter Tak, Lucien Aarden and Gerrit J Wolbink
    Citation: Arthritis Research & Therapy 2010 12:R221
    Content type: Research article Published on:

  42. Sjögren's syndrome (SS) involves a chronic, progressive inflammation primarily of the salivary and lacrimal glands leading to decreased levels of saliva and tears resulting in dry mouth and dry eye diseases. S...

    Authors: Cuong Q Nguyen, Hongen Yin, Byung Ha Lee, Wendy C Carcamo, John A Chiorini and Ammon B Peck
    Citation: Arthritis Research & Therapy 2010 12:R220
    Content type: Research article Published on:

  43. Rheumatoid arthritis (RA) frequently involves the loss of tolerance to citrullinated antigens, which may play a role in pathogenicity. Citrullinated fibrinogen is commonly found in inflamed synovial tissue and...

    Authors: Joyce JBC van Beers, Reinout Raijmakers, Lou-Ella Alexander, Judith Stammen-Vogelzangs, Angelique MC Lokate, Albert JR Heck, Richard BM Schasfoort and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2010 12:R219
    Content type: Research article Published on:

  44. Rheumatoid arthritis (RA) is associated with increased morbidity and mortality due to cardiovascular disease, and this occurs early in the disease process. The metabolic syndrome (MetS) may contribute to the e...

    Authors: Hanh-Hung Dao, Quan-Trung Do and Junichi Sakamoto
    Citation: Arthritis Research & Therapy 2010 12:R218
    Content type: Research article Published on:

  45. The aim of this study was to determine whether mycophenolate mofetil (MMF) pharmacokinetics (PK) under combined MMF and prednisone remission-maintenance therapy can predict systemic lupus erythematosus (SLE) c...

    Authors: Sarah Djabarouti, Dominique Breilh, Pierre Duffau, Estibaliz Lazaro, Carine Greib, Olivier Caubet, Marie-Claude Saux, Jean-Luc Pellegrin and Jean-François Viallard
    Citation: Arthritis Research & Therapy 2010 12:R217
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2011 13:401

  46. Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been ...

    Authors: Edward Roddy and Michael Doherty
    Citation: Arthritis Research & Therapy 2010 12:223
    Content type: Review Published on:

  49. The Second Kitasato Symposium: New Prospects for Cytokines brought together researchers and rheumatologists to consider the essential role of cytokines in health and their contributions to autoimmunity. Topics...

    Authors: Gerd R Burmester, Peter E Lipsky and Thomas Dörner
    Citation: Arthritis Research & Therapy 2010 12:301
    Content type: Meeting report Published on:
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Arthritis Research & Therapy

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