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  1. Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to systematically analyse the phenotype, cytokine profile and frequency of interleukin-17 (IL-17) pro...

    Authors: Leigh D Church, Andrew D Filer, Esther Hidalgo, Katherine A Howlett, Andrew MC Thomas, Stephen Rapecki, Dagmar Scheel-Toellner, Christopher D Buckley and Karim Raza
    Citation: Arthritis Research & Therapy 2010 12:R184
    Content type: Research article Published on:

  2. The 30-day case-fatality rate after acute myocardial infarction (MI) for rheumatoid arthritis (RA) patients is twice that of the general population. This study compared the frequency and timeliness of early re...

    Authors: Sharon Van Doornum, Caroline Brand, Vijaya Sundararajan, Andrew E Ajani and Ian P Wicks
    Citation: Arthritis Research & Therapy 2010 12:R183
    Content type: Research article Published on:

  3. Oestrogen depletion may influence onset and/or progression of osteoarthritis. We investigated in an ovariectomized mouse model the impact of oestrogen loss and oestrogen supplementation on articular cartilage ...

    Authors: Yvonne H Sniekers, Harrie Weinans, Gerjo JVM van Osch and Johannes PTM van Leeuwen
    Citation: Arthritis Research & Therapy 2010 12:R182
    Content type: Research article Published on:

  6. The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advan...

    Authors: Hans LA Nienhuis, Karina de Leeuw, Johan Bijzet, Jasper J van Doormaal, Arie M van Roon, Andries J Smit, Reindert Graaff, Cees GM Kallenberg and Marc Bijl
    Citation: Arthritis Research & Therapy 2010 12:R181
    Content type: Research article Published on:

  7. The objective of the present study was to assess heritability of clinical and radiographic features of hand osteoarthritis (OA) in affected patients and their siblings.

    Authors: Mariko L Ishimori, Roy D Altman, Myles J Cohen, Jinrui Cui, Xiuqing Guo, Jerome I Rotter and Michael H Weisman
    Citation: Arthritis Research & Therapy 2010 12:R180
    Content type: Research article Published on:

  8. Validity of biomarkers may be affected if studies do not include certain features in their design. We evaluated whether translational research studies of potential biomarkers incorporated design features impor...

    Authors: Maria G Tektonidou and Michael M Ward
    Citation: Arthritis Research & Therapy 2010 12:R179
    Content type: Research article Published on:

  9. In this study, we investigate the efficacy of repairing an osteochondral defect in rabbit knee joints by administering bevacizumab, a humanized monoclonal anti-vascular endothelial growth factor (VEGF) antibody.

    Authors: Toshihiro Nagai, Masato Sato, Toshiharu Kutsuna, Mami Kokubo, Goro Ebihara, Naoshi Ohta and Joji Mochida
    Citation: Arthritis Research & Therapy 2010 12:R178
    Content type: Research article Published on:

  10. In a previous issue of the journal, Becker and colleagues present efficacy and safety data from a large study comparing febuxostat to allopurinol. The study showed non-inferiority of febuxostat 40 mg/day in lo...

    Authors: Jasvinder A Singh
    Citation: Arthritis Research & Therapy 2010 12:136
    Content type: Editorial Published on:

  11. The Work Productivity and Activity Impairment (WPAI) questionnaire is a well validated instrument to measure impairments in work and activities. However, its validation among patients with rheumatoid arthritis...

    Authors: Wei Zhang, Nick Bansback, Annelies Boonen, Adam Young, Amitabh Singh and Aslam H Anis
    Citation: Arthritis Research & Therapy 2010 12:R177
    Content type: Research article Published on:

  13. Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...

    Authors: Stephen Eyre, Anne Hinks, John Bowes, Edward Flynn, Paul Martin, Anthony G Wilson, Ann W Morgan, Paul Emery, Sophia Steer, Lynne J Hocking, David M Reid, Pille Harrison, Paul Wordsworth, Wendy Thomson, Jane Worthington and Anne Barton
    Citation: Arthritis Research & Therapy 2010 12:R175
    Content type: Research article Published on:

  14. TNFAIP3 interacting protein 1, TNIP1 (ABIN-1) is involved in inhibition of nuclear factor-κB (NF-κB) activation by interacting with TNF alpha-induced protein 3, A20 (TNFAIP3), an established susceptibility gene t...

    Authors: Aya Kawasaki, Satoshi Ito, Hiroshi Furukawa, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Makio Kusaoi, Jun Ohashi, Robert R Graham, Kunio Matsuta, Timothy W Behrens, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida and Naoyuki Tsuchiya
    Citation: Arthritis Research & Therapy 2010 12:R174
    Content type: Research article Published on:

  16. Joint effusion is frequently associated with osteoarthritis (OA) flare-up and is an important marker of therapeutic response. This study aimed at developing and validating a fully automated system based on mag...

    Authors: Wei Li, François Abram, Jean-Pierre Pelletier, Jean-Pierre Raynauld, Marc Dorais, Marc-André d'Anjou and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2010 12:R173
    Content type: Research article Published on:

  17. The purpose of the present study was to determine the prevalence of cystic lesions and cyst-like bursitides in subjects with frequent knee pain and to assess their relation to radiographic osteoarthritis (OA) ...

    Authors: Daichi Hayashi, Frank W Roemer, Zineb Dhina, C Kent Kwoh, Michael J Hannon, Carolyn Moore and Ali Guermazi
    Citation: Arthritis Research & Therapy 2010 12:R172
    Content type: Research article Published on:

  18. In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupu...

    Authors: Yanice Mendez-Fernandez and Amy Major
    Citation: Arthritis Research & Therapy 2010 12:139
    Content type: Editorial Published on:

  19. Rheumatoid arthritis (RA) is a multi-organ inflammatory disorder associated with high cardiovascular morbidity and mortality. We sought to assess cardiac involvement using a comprehensive cardiac magnetic reso...

    Authors: Yasuyuki Kobayashi, Jon T Giles, Masaharu Hirano, Isamu Yokoe, Yasuo Nakajima, Joan M Bathon, Joao AC Lima and Hitomi Kobayashi
    Citation: Arthritis Research & Therapy 2010 12:R171
    Content type: Research article Published on:

  20. The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolym...

    Authors: Ling-dong Quan, P Edward Purdue, Xin-ming Liu, Michael D Boska, Subodh M Lele, Geoffrey M Thiele, Ted R Mikuls, Huanyu Dou, Steven R Goldring and Dong Wang
    Citation: Arthritis Research & Therapy 2010 12:R170
    Content type: Research article Published on:

  21. This study describes the results of the Belgian 'MabThera In Rheumatoid Arthritis (MIRA)' registry: effectiveness, safety and evaluation of the current retreatment practice on the background of the Belgian rei...

    Authors: Bert Vander Cruyssen, Patrick Durez, Rene Westhovens, Marie-Joelle Kaiser, Ilse Hoffman and Filip De Keyser
    Citation: Arthritis Research & Therapy 2010 12:R169
    Content type: Research article Published on:

  22. Joint fluid in patients with Lyme arthritis often contains high levels of CCL4 and CCL2, which are chemoattractants for monocytes and some T cells, and CXCL9 and CXCL10, which are chemoattractants for CD4+ and...

    Authors: Junghee J Shin, Klemen Strle, Lisa J Glickstein, Andrew D Luster and Allen C Steere
    Citation: Arthritis Research & Therapy 2010 12:R168
    Content type: Research article Published on:

  23. Accumulation of advanced glycation end products (AGEs) in joints contributes to the pathogenesis of cartilage damage in osteoarthritis (OA). We aim to explore the potential chondroprotective effects of resvera...

    Authors: Feng-Cheng Liu, Li-Feng Hung, Wan-Lin Wu, Deh-Ming Chang, Chuan-Yueh Huang, Jenn-Haung Lai and Ling-Jun Ho
    Citation: Arthritis Research & Therapy 2010 12:R167
    Content type: Research article Published on:

  24. The objective of the present study was to examine the association of baseline demographic and clinical characteristics with sequentially obtained measurements of forced vital capacity (FVC), expressed as a per...

    Authors: Shervin Assassi, Roozbeh Sharif, Robert E Lasky, Terry A McNearney, Rosa M Estrada-Y-Martin, Hilda Draeger, Deepthi K Nair, Marvin J Fritzler, John D Reveille, Frank C Arnett and Maureen D Mayes
    Citation: Arthritis Research & Therapy 2010 12:R166
    Content type: Research article Published on:

  25. Where risk factors have been identified in knee and hip osteoarthritis (OA), with few exceptions, no prevention strategies have proven beneficial. The major risk factors for knee OA are advanced age, injury an...

    Authors: Charles R Ratzlaff and Matthew H Liang
    Citation: Arthritis Research & Therapy 2010 12:215
    Content type: Review Published on:

  26. High mobility group box 1 (HMGB1) is released by necrotic cells or secreted in response to inflammatory stimuli. Extracellular HMGB1 may act as a pro-inflammatory cytokine in rheumatoid arthritis. We have rece...

    Authors: Isabel García-Arnandis, Maria Isabel Guillén, Francisco Gomar, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Maria José Alcaraz
    Citation: Arthritis Research & Therapy 2010 12:R165
    Content type: Research article Published on:

  27. Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of thi...

    Authors: Nicola Dalbeth, Bregina Pool, Timothy Smith, Karen E Callon, Maria Lobo, William J Taylor, Peter B Jones, Jillian Cornish and Fiona M McQueen
    Citation: Arthritis Research & Therapy 2010 12:R164
    Content type: Research article Published on:

  29. The purpose of this study was to evaluate the effects of risedronate (Ris) in the modulation of bone formation in rats with glucocorticoid (GC)-induced osteoporosis by histomorphometric, immunohistochemical an...

    Authors: Maria Teresa Valenti, Sandro Giannini, Luca Donatelli, Mirko Zanatta, Francesco Bertoldo, Stefania Sella, Maria Teresa Vilei, Elena Ossi, Giuseppe Realdi, Vincenzo Lo Cascio and Luca Dalle Carbonare
    Citation: Arthritis Research & Therapy 2010 12:R163
    Content type: Research article Published on:

  30. Understanding the relationship between patient-reported osteoarthritis (OA) severity and other patient-reported outcomes in the real-world clinical setting can provide a basis for appropriate patient managemen...

    Authors: Alesia B Sadosky, Andrew G Bushmakin, Joseph C Cappelleri and David R Lionberger
    Citation: Arthritis Research & Therapy 2010 12:R162
    Content type: Research article Published on:

  31. Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentia...

    Authors: Caroline Schmutz, Alison Cartwright, Helen Williams, Oliver Haworth, John HH Williams, Andrew Filer, Mike Salmon, Christopher D Buckley and Jim Middleton
    Citation: Arthritis Research & Therapy 2010 12:R161
    Content type: Research article Published on:

  33. A significant role for IFNα in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFNα monoclonal antibodies are in progress in this disease. In other autoimmune di...

    Authors: Mary K Crow
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  36. Disease severity in collagen-induced arthritis (CIA) is commonly assessed by clinical scoring of paw swelling and histological examination of joints. Although this is an accurate approach, it is also labour-in...

    Authors: Sylvie Seeuws, Peggy Jacques, Jens Van Praet, Michael Drennan, Julie Coudenys, Tine Decruy, Ellen Deschepper, Lien Lepescheux, Philippe Pujuguet, Line Oste, Nick Vandeghinste, Reginald Brys, Gust Verbruggen and Dirk Elewaut
    Citation: Arthritis Research & Therapy 2010 12:R160
    Content type: Research article Published on:

  38. The glucocorticoid receptor (GR) plays an important regulatory role in the immune system. Four polymorphisms in the GR gene are associated with differences in glucocorticoid (GC) sensitivity; the minor alleles...

    Authors: Manon JM van Oosten, Radboud JEM Dolhain, Jan W Koper, Elisabeth FC van Rossum, Marieke Emonts, Khik H Han, Jacques MGW Wouters, Johanne MW Hazes, Steven WJ Lamberts and Richard A Feelders
    Citation: Arthritis Research & Therapy 2010 12:R159
    Content type: Research article Published on:

  39. In this study we aimed to investigate whether there are indications of premature atherosclerosis, as measured by endothelial dependent flow-mediated dilation (ED-FMD) and intima media thickness (IMT), in patie...

    Authors: Anna Södergren, Kjell Karp, Kurt Boman, Catharina Eriksson, Elisabet Lundström, Torgny Smedby, Lisbet Söderlund, Solbritt Rantapää-Dahlqvist and Solveig Wållberg-Jonsson
    Citation: Arthritis Research & Therapy 2010 12:R158
    Content type: Research article Published on:

  40. Predicting complications of diseases such as rheumatoid arthritis (RA) as well as the efficacy and toxicity of drugs used to treat the disease based on an understanding of genetic differences is leading to the...

    Authors: Bruce N Cronstein
    Citation: Arthritis Research & Therapy 2010 12:134
    Content type: Editorial Published on:

  41. Aberrant immune responses play a pivotal role in the processes that cause inflammation and joint damage in patients with rheumatoid arthritis (RA). Polyclonal B cell activation and the production of autoantibo...

    Authors: Claudia Mauri and Elizabeth C Jury
    Citation: Arthritis Research & Therapy 2010 12:133
    Content type: Editorial Published on:

  42. Laser Doppler imaging (LDI) is a relatively new method for assessing the functional aspect of superficial skin blood flow in systemic sclerosis (SSc) and Raynaud's phenomenon. The present study investigated th...

    Authors: Marcelo JU Correa, Luis EC Andrade and Cristiane Kayser
    Citation: Arthritis Research & Therapy 2010 12:R157
    Content type: Research article Published on:

  43. Known biomarkers of Gaucher-disease activity are platelets, chitotriosidase, angiotensin-converting enzyme (ACE), tartrate-resistant acid phosphatase (TRAP) and ferritin. The aim of this study was to retrospec...

    Authors: Jérôme Stirnemann, Nadia Belmatoug, Corine Vincent, Olivier Fain, Bruno Fantin and France Mentré
    Citation: Arthritis Research & Therapy 2010 12:R156
    Content type: Research article Published on:

  44. The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a tran...

    Authors: Patrick Merky, Tsvetelina Batsalova, Robert Bockermann, Balik Dzhambazov, Bettina Sehnert, Harald Burkhardt and Johan Bäcklund
    Citation: Arthritis Research & Therapy 2010 12:R155
    Content type: Research article Published on:

  45. Although osteoporosis has been reported to be more common in patients with rheumatoid arthritis (RA), little is known whether the risk of osteoporotic fractures in these patients differs by age, sex, and anato...

    Authors: Seo Young Kim, Sebastian Schneeweiss, Jun Liu, Gregory W Daniel, Chun-Lan Chang, Katie Garneau and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2010 12:R154
    Content type: Research article Published on:

  46. Our objective was to determine the frequency of and factors associated with prevalent vertebral compression fractures in female systemic lupus erythematosus (SLE) patients attending rheumatologists in western ...

    Authors: Katarina Almehed, Szabolcs Hetényi, Claes Ohlsson, Hans Carlsten and Helena Forsblad-d'Elia
    Citation: Arthritis Research & Therapy 2010 12:R153
    Content type: Research article Published on:

  47. Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage...

    Authors: Miriam Bellido, Laura Lugo, Jorge A Roman-Blas, Santos Castañeda, Jose R Caeiro, Sonia Dapia, Emilio Calvo, Raquel Largo and Gabriel Herrero-Beaumont
    Citation: Arthritis Research & Therapy 2010 12:R152
    Content type: Research article Published on:

  48. Sex differences in the prevalence, incidence, and severity of osteoarthritis (OA) have long been known. Some differences in the evaluation of this issue across studies may be related to differences in study de...

    Authors: Mehrnaz Maleki-Fischbach and Joanne M Jordan
    Citation: Arthritis Research & Therapy 2010 12:212
    Content type: Review Published on:
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Arthritis Research & Therapy

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