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  1. Dichloroacetate (DCA) has been in clinical use for the treatment of lactacidosis and inherited mitochondrial disorders. It has potent anti-tumor effects both in vivo and in vitro, facilitating apoptosis and inhib...

    Authors: Li Bian, Elisabet Josefsson, Ing-Marie Jonsson, Margareta Verdrengh, Claes Ohlsson, Maria Bokarewa, Andrej Tarkowski and Mattias Magnusson
    Citation: Arthritis Research & Therapy 2009 11:R132
    Content type: Research article Published on:

  2. Bone marrow (BM) is an immunologically privileged site where activated autoantibody-producing B cells may survive for prolonged periods. We investigated the effect of rituximab (anti-CD20 mAb) in peripheral bl...

    Authors: Magda Nakou, Georgios Katsikas, Prodromos Sidiropoulos, George Bertsias, Eva Papadimitraki, Amalia Raptopoulou, Helen Koutala, Helen A Papadaki, Herakles Kritikos and Dimitrios T Boumpas
    Citation: Arthritis Research & Therapy 2009 11:R131
    Content type: Research article Published on:

  4. Heat shock protein 70 (Hsp70) is a well-known anti-apoptotic protein that blocks multiple steps in the stress-induced apoptotic pathway. Enhanced Hsp70 expression has previously been demonstrated in rheumatoid...

    Authors: Eun Ha Kang, Dong Jo Kim, Eun Young Lee, Yun Jong Lee, Eun Bong Lee and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2009 11:R130
    Content type: Research article Published on:

  5. The Health Assessment Questionnaire Disability Index (HAQ-DI) is a commonly used instrument to assess functional status of patients with rheumatoid arthritis (RA). Translations and adaptations of the HAQ-DI ha...

    Authors: Manathip Osiri, Jeerapat Wongchinsri, Sitthichai Ukritchon, Punchong Hanvivadhanakul, Nuntana Kasitanon and Boonjing Siripaitoon
    Citation: Arthritis Research & Therapy 2009 11:R129
    Content type: Research article Published on:

  8. Ankylosing spondylitis (AS) is a chronic rheumatic disease associated with spinal inflammation that subsequently leads to progression of structural damage and loss of function. The fully human anti-tumor necro...

    Authors: Désirée van der Heijde, David Salonen, Barbara N Weissman, Robert Landewé, Walter P Maksymowych, Hartmut Kupper, Shaila Ballal, Eric Gibson and Robert Wong
    Citation: Arthritis Research & Therapy 2009 11:R127
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:225

  9. Matrix metalloproteinases (MMPs) are known to be involved in the degradation of the nucleus pulposus (NP) during intervertebral disc (IVD) degeneration. This study investigated MMP-10 (stromelysin-2) expressio...

    Authors: Stephen M Richardson, Paul Doyle, Ben M Minogue, Kanna Gnanalingham and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2009 11:R126
    Content type: Research article Published on:

  11. The Fibromyalgia Impact Questionnaire (FIQ) is a composite disease-specific measure validated for fibromyalgia (FM), but it is rarely used in clinical practice. The objective was to develop and analyse the psy...

    Authors: Fausto Salaffi, Piercarlo Sarzi-Puttini, Rita Girolimetti, Stefania Gasparini, Fabiola Atzeni and Walter Grassi
    Citation: Arthritis Research & Therapy 2009 11:R125
    Content type: Research article Published on:

  12. We evaluated the three-year impact of adalimumab on patient-reported physical function and health-related quality-of-life (HRQOL) outcomes in patients with active ankylosing spondylitis (AS).

    Authors: Désirée M van der Heijde, Dennis A Revicki, Katherine L Gooch, Robert L Wong, Hartmut Kupper, Neesha Harnam, Chris Thompson and Joachim Sieper
    Citation: Arthritis Research & Therapy 2009 11:R124
    Content type: Research article Published on:

  13. In the present study we evaluated changes in the B cell phenotype in peripheral blood and bone marrow (BM) of patients with rheumatoid arthritis (RA) following anti-CD20 treatment using rituximab.

    Authors: Maria Rehnberg, Sylvie Amu, Andrej Tarkowski, Maria I Bokarewa and Mikael Brisslert
    Citation: Arthritis Research & Therapy 2009 11:R123
    Content type: Research article Published on:

  14. Interleukin (IL)-17 is a pro-inflammatory cytokine in rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). Since interferon (IFN)-γ inhibits Th17 cell development, IFN-γ receptor knockout (IFN-γR KO...

    Authors: Hilde Kelchtermans, Evelien Schurgers, Lies Geboes, Tania Mitera, Jo Van Damme, Jacques Van Snick, Catherine Uyttenhove and Patrick Matthys
    Citation: Arthritis Research & Therapy 2009 11:R122
    Content type: Research article Published on:

  15. Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients share many similarities with transformed cancer cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered o...

    Authors: Joana RF Abreu, Daphne de Launay, Marjolein E Sanders, Aleksander M Grabiec, Marleen G van de Sande, Paul P Tak and Kris A Reedquist
    Citation: Arthritis Research & Therapy 2009 11:R121
    Content type: Research article Published on:

  16. The Fibromyalgia Impact Questionnaire (FIQ) is a commonly used instrument in the evaluation of fibromyalgia (FM) patients. Over the last 18 years, since the publication of the original FIQ, several deficiencie...

    Authors: Robert M Bennett, Ronald Friend, Kim D Jones, Rachel Ward, Bobby K Han and Rebecca L Ross
    Citation: Arthritis Research & Therapy 2009 11:R120
    Content type: Research article Published on:

  18. Members of the ephrin system, the ephrin receptor erythropoietin-producing hepatocellular B4 (EphB4) and its specific ligand, ephrin B2, appear to be involved in the bone remodelling process. We recently showe...

    Authors: Steeve Kwan Tat, Jean-Pierre Pelletier, Nathalie Amiable, Christelle Boileau, Martin Lavigne and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2009 11:R119
    Content type: Research article Published on:

  19. Tumor necrosis factor-alpha (TNFα) plays a pivotal role in rheumatoid arthritis (RA); however, the mechanism of action of TNFα antagonists in RA is poorly defined. Immunization of DBA/1 mice with glucose-6-pho...

    Authors: Asuka Inoue, Isao Matsumoto, Yoko Tanaka, Keiichi Iwanami, Akihiro Kanamori, Naoyuki Ochiai, Daisuke Goto, Satoshi Ito and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2009 11:R118
    Content type: Research article Published on:

  20. Behçet's disease (BD) is characterized by oral and genital ulceration and is complicated by eye, skin, joint and central nervous system lesions. It has long been understood that BD has a strong genetic compone...

    Authors: Graham Wallace
    Citation: Arthritis Research & Therapy 2009 11:123
    Content type: Editorial Published on:

  22. Besides atherosclerosis and lung cancer, smoking is considered to play a major role in the pathogenesis of autoimmune diseases. It has long been known that there is a connection between rheumatoid factor-posit...

    Authors: Zsuzsanna Baka, Edit Buzás and György Nagy
    Citation: Arthritis Research & Therapy 2009 11:238
    Content type: Review Published on:

  24. T-helper (Th) lymphocytes are critically required for the pathogenesis of glucose-6-phosphate isomerase (G6PI)-induced arthritis, but neither the G6PI epitopes recognized by arthritogenic T cells nor their pat...

    Authors: Lisa Bruns, Oliver Frey, Lars Morawietz, Christiane Landgraf, Rudolf Volkmer and Thomas Kamradt
    Citation: Arthritis Research & Therapy 2009 11:R117
    Content type: Research article Published on:

  25. The view of articular cartilage as a non-regeneration organ has been challenged in recent years. The articular cartilage consists of distinct zones with different cellular and molecular phenotypes, and the sup...

    Authors: Camilla Karlsson and Anders Lindahl
    Citation: Arthritis Research & Therapy 2009 11:121
    Content type: Editorial Published on:

  26. Recent evidence suggests that uric acid (UA), regardless of crystal deposition, may play a direct pathogenic role in renal disease. We have shown that UA is an independent predictor of hypertension and cardiov...

    Authors: Dimitrios Daoussis, Vasileios Panoulas, Tracey Toms, Holly John, Ioannis Antonopoulos, Peter Nightingale, Karen MJ Douglas, Rainer Klocke and George D Kitas
    Citation: Arthritis Research & Therapy 2009 11:R116
    Content type: Research article Published on:

  27. At present, no disease-modifying osteoarthritis drugs (DMOADS) are approved by the FDA (US Food and Drug Administration); possibly partly due to inadequate trial design since efficacy demonstration requires di...

    Authors: Erik B Dam, Marco Loog, Claus Christiansen, Inger Byrjalsen, Jenny Folkesson, Mads Nielsen, Arish A Qazi, Paola C Pettersen, Patrick Garnero and Morten A Karsdal
    Citation: Arthritis Research & Therapy 2009 11:R115
    Content type: Research article Published on:

  29. Little is known about systemic B-cell activation in early rheumatoid arthritis (RA). We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis c...

    Authors: Jacques-Eric Gottenberg, Corinne Miceli-Richard, Béatrice Ducot, Philippe Goupille, Bernard Combe and Xavier Mariette
    Citation: Arthritis Research & Therapy 2009 11:R114
    Content type: Research article Published on:

  30. The aim of this study was to examine IL-17A in patients, following anti-TNF-α therapy and the effect of IL-17A on matrix turnover and cartilage degradation.

    Authors: Ellen M Moran, Ronan Mullan, Jennifer McCormick, Mary Connolly, Owen Sullivan, Oliver FitzGerald, Barry Bresnihan, Douglas J Veale and Ursula Fearon
    Citation: Arthritis Research & Therapy 2009 11:R113
    Content type: Research article Published on:

  31. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of high-titer IgG autoantibodies directed against nuclear autoantigens. Type I interferon (IFN-I) has been sho...

    Authors: Donna L Thibault, Kareem L Graham, Lowen Y Lee, Imelda Balboni, Paul J Hertzog and Paul J Utz
    Citation: Arthritis Research & Therapy 2009 11:R112
    Content type: Research article Published on:

  32. Interstitial lung disease (ILD) is a frequent manifestation of systemic sclerosis (SSc), and cytokines can contribute to the disease pathology. The aim of the current study was to identify specific changes in ...

    Authors: Katrin Schmidt, Lorena Martinez-Gamboa, Susan Meier, Christian Witt, Christian Meisel, Leif G Hanitsch, Mike O Becker, Doerte Huscher, Gerd R Burmester and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2009 11:R111
    Content type: Research article Published on:

  33. The metabolic syndrome (MetS) may contribute to the excess cardiovascular burden observed in rheumatoid arthritis (RA). The prevalence and associations of the MetS in RA remain uncertain: systemic inflammation...

    Authors: Tracey E Toms, Vasileios F Panoulas, Holly John, Karen MJ Douglas and George D Kitas
    Citation: Arthritis Research & Therapy 2009 11:R110
    Content type: Research article Published on:

  36. Infections commonly complicate the course of systemic lupus erythematosus (SLE). Our aim is to investigate the clinical predictors of major infections in patients with SLE.

    Authors: Guillermo Ruiz-Irastorza, Nerea Olivares, Ioana Ruiz-Arruza, Agustin Martinez-Berriotxoa, Maria-Victoria Egurbide and Ciriaco Aguirre
    Citation: Arthritis Research & Therapy 2009 11:R109
    Content type: Research article Published on:

  37. Glucocorticoid (GC) therapy is the main treatment for systemic lupus erythematosus (SLE). However, some patients are resistant to these agents. Abnormalities of glucocorticoid receptor (GR) seem to be related ...

    Authors: Juan Du, Min Li, Denghai Zhang, Xiaoyan Zhu, Weiwei Zhang, Wei Gu, Yinglu Feng, Xiaofeng Zhai and Changquan Ling
    Citation: Arthritis Research & Therapy 2009 11:R108
    Content type: Research article Published on:

  38. A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 resp...

    Authors: Ulrich A Walker
    Citation: Arthritis Research & Therapy 2009 11:120
    Content type: Editorial Published on:

  40. The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods...

    Authors: Alan M Jette, Christine M McDonough, Pengsheng Ni, Stephen M Haley, Ronald K Hambleton, Sippy Olarsch, David J Hunter, Young-jo Kim and David T Felson
    Citation: Arthritis Research & Therapy 2009 11:R107
    Content type: Research article Published on:

  41. The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic backgrou...

    Authors: Ghazi Chabchoub, Elif Uz, Abdellatif Maalej, Chigdem A Mustafa, Ahmed Rebai, Mouna Mnif, Zouheir Bahloul, Nadir R Farid, Tayfun Ozcelik and Hammadi Ayadi
    Citation: Arthritis Research & Therapy 2009 11:R106
    Content type: Research article Published on:

  42. Cytokines produced by spinal cord glia after peripheral injuries have a relevant role in the maintenance of pain states. Thus, while IL-1β is overexpressed in the spinal cords of animals submitted to experimen...

    Authors: Luis Constandil, Alejandro Hernández, Teresa Pelissier, Osvaldo Arriagada, Karla Espinoza, Hector Burgos and Claudio Laurido
    Citation: Arthritis Research & Therapy 2009 11:R105
    Content type: Research article Published on:

  44. Experimental streptococcal cell wall (SCW)-induced arthritis is characterized by two successive phases of the disease. The acute phase occurs early and is associated with an inflammatory process and neutrophil...

    Authors: Sylvain Perruche, Philippe Saas and Wanjun Chen
    Citation: Arthritis Research & Therapy 2009 11:R104
    Content type: Research article Published on:

  45. Radiographic progression in rheumatoid arthritis (RA) has in several studies been shown to be predicted by serological markers widely used in daily clinical practice. The objective of this longitudinal study w...

    Authors: Pernille Bøyesen, Mari Hoff, Sigrid Ødegård, Glenn Haugeberg, Silje W Syversen, Per I Gaarder, Cecilie Okkenhaug and Tore K Kvien
    Citation: Arthritis Research & Therapy 2009 11:R103
    Content type: Research article Published on:

  46. Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targe...

    Authors: Mariam Siala, Radhouane Gdoura, Hela Fourati, Markus Rihl, Benoit Jaulhac, Mohamed Younes, Jean Sibilia, Sofien Baklouti, Naceur Bargaoui, Slaheddine Sellami, Abdelghani Sghir and Adnane Hammami
    Citation: Arthritis Research & Therapy 2009 11:R102
    Content type: Research article Published on:

  47. Spondylarthropathies (SpA) are characterized by abnormal immune responses including T cell activation. Cytotoxic T lymphocyte associated molecule-4 (CTLA-4) is involved in down-regulating immune responses. A s...

    Authors: Éric Toussirot, Philippe Saas, Marina Deschamps, Fabienne Pouthier, Lucille Perrot, Sylvain Perruche, Jacqueline Chabod, Pierre Tiberghien and Daniel Wendling
    Citation: Arthritis Research & Therapy 2009 11:R101
    Content type: Research article Published on:

  48. The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from ...

    Authors: Michele Abate, Karin Gravare Silbernagel, Carl Siljeholm, Angelo Di Iorio, Daniele De Amicis, Vincenzo Salini, Suzanne Werner and Roberto Paganelli
    Citation: Arthritis Research & Therapy 2009 11:235
    Content type: Review Published on:
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