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46 result(s) for 'nci' within Arthritis Research & Therapy

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  1. The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different ...

    Authors: Balint Farkas, Ferenc Boldizsar, Oktavia Tarjanyi, Anna Laszlo, Simon M Lin, Gabor Hutas, Beata Tryniszewska, Aaron Mangold, Gyorgy Nagyeri, Holly L Rosenzweig, Alison Finnegan, Katalin Mikecz and Tibor T Glant
    Citation: Arthritis Research & Therapy 2009 11:R21
    Content type: Research article Published on:

  2. B cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE), so the safety and activity of anti-B cell immunotherapy with the humanized anti-CD22 antibody epratuzumab was evaluated...

    Authors: Thomas Dörner, Joerg Kaufmann, William A Wegener, Nick Teoh, David M Goldenberg and Gerd R Burmester
    Citation: Arthritis Research & Therapy 2006 8:R74
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:406

  3. The objective of the study was to evaluate the efficacy and safety of upadacitinib over 84 weeks in Japanese patients with active rheumatoid arthritis (RA) and an inadequate response to conventional synthetic ...

    Authors: Hideto Kameda, Tsutomu Takeuchi, Kunihiro Yamaoka, Motohiro Oribe, Mitsuhiro Kawano, Masayuki Yokoyama, Aileen L. Pangan, Yuko Konishi, Sebastian Meerwein and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2021 23:9
    Content type: Research article Published on:

  4. Engagement of the homotypic cell-to-cell adhesion molecule cadherin-11 on rheumatoid arthritis (RA) synovial fibroblasts with a chimeric molecule containing the cadherin-11 extracellular binding domain stimula...

    Authors: Erika H Noss, Gerald FM Watts, Davide Zocco, Tracy L Keller, Malcolm Whitman, Carl P Blobel, David M Lee and Michael B Brenner
    Citation: Arthritis Research & Therapy 2015 17:126
    Content type: Research article Published on:

  5. Patients with active rheumatoid arthritis who had failed at least one disease-modifying anti-rheumatic drug (DMARD) were treated with adalimumab (ADA) in the ReAct study with the option to continue treatment f...

    Authors: Gerd R Burmester, Marco Matucci-Cerinic, Xavier Mariette, Francisco Navarro-Blasco, Sonja Kary, Kristina Unnebrink and Hartmut Kupper
    Citation: Arthritis Research & Therapy 2014 16:R24
    Content type: Research article Published on:

  6. The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice with mutations in the Shp1 gene develop inflammatory skin disease and...

    Authors: Adrienn Markovics, Daniel M. Toth, Tibor T. Glant and Katalin Mikecz
    Citation: Arthritis Research & Therapy 2020 22:160
    Content type: Research article Published on:

  7. Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate  their effects by decreasing the methylation status...

    Authors: Yulia S. Kehayova, J. Mark Wilkinson, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2023 25:83
    Content type: Research Published on:

  8. Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humani...

    Authors: William P Kennedy, J Abraham Simon, Carolyn Offutt, Priscilla Horn, Ann Herman, Michael J Townsend, Meina T Tang, Jane L Grogan, Frank Hsieh and John C Davis
    Citation: Arthritis Research & Therapy 2014 16:467
    Content type: Research article Published on:

  9. Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to ...

    Authors: Hans-Peter Tony, Gerd Burmester, Hendrik Schulze-Koops, Mathias Grunke, Joerg Henes, Ina Kötter, Judith Haas, Leonore Unger, Svjetlana Lovric, Marion Haubitz, Rebecca Fischer-Betz, Gamal Chehab, Andrea Rubbert-Roth, Christof Specker, Jutta Weinerth, Julia Holle…
    Citation: Arthritis Research & Therapy 2011 13:R75
    Content type: Research article Published on:

  10. Folate receptor beta (FRβ) is only detectable in placenta and limited to some hematopoietic cells of myeloid lineage in healthy people. Studies have indicated that FRβ is over-expressed in activated macrophage...

    Authors: Yang Feng, Jiayin Shen, Emily D Streaker, Michael Lockwood, Zhongyu Zhu, Philip S Low and Dimiter S Dimitrov
    Citation: Arthritis Research & Therapy 2011 13:R59
    Content type: Research article Published on:

  12. Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthrit...

    Authors: Zihao Qu, Jiawei Huang, Fangkun Yang, Jianqiao Hong, Wei Wang and Shigui Yan
    Citation: Arthritis Research & Therapy 2020 22:118
    Content type: Research article Published on:

  13. Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently, a naturally occurring CD4+CD25+ T-cell subset that is anergic and also suppressive has been shown t...

    Authors: Tamas Bardos, Matyas Czipri, Csaba Vermes, Alison Finnegan, Katalin Mikecz and Jian Zhang
    Citation: Arthritis Res Ther 2003 5:R106
    Content type: Research article Published on:

  14. The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties.

    Authors: Jeffrey H Ruth, Christy C Park, M Asif Amin, Charles Lesch, Hubert Marotte, Shiva Shahrara and Alisa E Koch
    Citation: Arthritis Research & Therapy 2010 12:R118
    Content type: Research article Published on:

  15. Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for de novo vessel formation and p...

    Authors: Takeo Isozaki, M Asif Amin, Ali S Arbab, Alisa E Koch, Christine M Ha, Gautam Edhayan, G Kenneth Haines III and Jeffrey H Ruth
    Citation: Arthritis Research & Therapy 2014 16:R68
    Content type: Research article Published on:

  16. Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs...

    Authors: Abby Brumwell, Guillaume Aubourg, Juhel Hussain, Eleanor Parker, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2022 24:189
    Content type: Research Published on:

  17. Ankylosing spondylitis (AS) is unique in its pathology where inflammation commences at the entheses before progressing to an osteoproliferative phenotype generating excessive bone formation that can result in ...

    Authors: Katelin R Haynes, Allison R Pettit, Ran Duan, Hsu-Wen Tseng, Tibor T Glant, Matthew A Brown and Gethin P Thomas
    Citation: Arthritis Research & Therapy 2012 14:R253
    Content type: Research article Published on:

  18. Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, howeve...

    Authors: Nicolas Delaleu, Cuong Q Nguyen, Kidane M Tekle, Roland Jonsson and Ammon B Peck
    Citation: Arthritis Research & Therapy 2013 15:R174
    Content type: Research article Published on:

  19. Cutaneous lupus erythematosus (CLE) is a chronic disease characterized by disfigurement and a relapsing course. Thalidomide has proven its efficacy in refractory cutaneous lupus disease, although it is not exe...

    Authors: Josefina Cortés-Hernández, Gabriela Ávila, Miquel Vilardell-Tarrés and Josep Ordi-Ros
    Citation: Arthritis Research & Therapy 2012 14:R265
    Content type: Research article Published on:

  20. Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety for the treatment of rheumatoid arthritis (RA) in randomized, controlled trials of up to 52 weeks’ duration. How...

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada
    Citation: Arthritis Research & Therapy 2020 22:47
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:155

  21. Notochordal cells (NCs) pattern aneural and avascular intervertebral discs (IVDs), and their disappearance, is associated with onset of IVD degeneration. This study induced and characterized the maturation of ...

    Authors: Devina Purmessur, Clare C Guterl, Samuel K Cho, Marisa C Cornejo, Ying W Lam, Bryan A Ballif, Damien M Laudier and James C Iatridis
    Citation: Arthritis Research & Therapy 2013 15:R122
    Content type: Research article Published on:

  22. Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis. In human adult articular cartilage, FGF2 mediates ant...

    Authors: Xin Li, Howard S An, Michael Ellman, Frank Phillips, Eugene J Thonar, Daniel K Park, Ranjith K Udayakumar and Hee-Jeong Im
    Citation: Arthritis Research & Therapy 2008 10:R48
    Content type: Research article Published on:

  23. Lupus animal model has shown that arsenic trioxide (ATO), a treatment of acute promyelocytic leukaemia, could be effective in SLE. This is the first clinical study to determine the safety and efficacy of a sho...

    Authors: Mohamed Hamidou, Antoine Néel, Joel Poupon, Zahir Amoura, Mikael Ebbo, Jean Sibilia, Jean-Francois Viallard, Benjamin Gaborit, Christelle Volteau, Jean Benoit Hardouin, Eric Hachulla and François Rieger
    Citation: Arthritis Research & Therapy 2021 23:70
    Content type: Research article Published on:

  24. Subcutaneous tocilizumab (TCZ SC) is approved globally for giant cell arteritis (GCA). This phase Ib study investigated the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of intravenous (...

    Authors: Christophe Schmitt, Laura Brockwell, Mylène Giraudon, Mauro Zucchetto, Lisa Christ, Bettina Bannert, Thomas Daikeler and Peter M. Villiger
    Citation: Arthritis Research & Therapy 2022 24:133
    Content type: Research Published on:

  25. We present here an extensive study of differential gene expression in the initiation, acute and chronic phases of murine autoimmune arthritis with the use of high-density oligonucleotide arrays interrogating t...

    Authors: Vyacheslav A Adarichev, Csaba Vermes, Anita Hanyecz, Katalin Mikecz, Eric G Bremer and Tibor T Glant
    Citation: Arthritis Res Ther 2004 7:R196
    Content type: Research article Published on:

  28. Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 prod...

    Authors: Gautam Edhayan, Ray A. Ohara, W. Alex Stinson, M. Asif Amin, Takeo Isozaki, Christine M. Ha, G. Kenneth Haines III, Rachel Morgan, Phillip L. Campbell, Ali S. Arbab, Sean C. Friday, David A. Fox and Jeffrey H. Ruth
    Citation: Arthritis Research & Therapy 2016 18:87
    Content type: Research article Published on:

  29. Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma...

    Authors: Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko and Christine Beeton
    Citation: Arthritis Research & Therapy 2016 18:103
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:122

  30. Hyperimmune caprine serum (HICS) is a novel biological therapy with potential benefit for skin in established diffuse cutaneous systemic sclerosis. Here we report multiplex protein analysis of blood samples fr...

    Authors: Niamh Quillinan, Kristina E. N. Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq and Christopher P. Denton
    Citation: Arthritis Research & Therapy 2017 19:45
    Content type: Research article Published on:

  31. Multiple myeloma, a cancer of plasma cells, is associated with excessive tumor-induced, osteoclast-mediated bone destruction. Hypercalcemia remains the most frequent metabolic complication of myeloma in patien...

    Authors: Babatunde O Oyajobi
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  34. Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human ...

    Authors: Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy and Hee-Jeong Im
    Citation: Arthritis Research & Therapy 2011 13:R130
    Content type: Research article Published on:

  35. Psoriasis and psoriatic arthritis (PsA) increase cardiovascular disease (CVD) risk, but surrogate markers for CVD in these disorders are inadequate. Because the presence of sacroiliitis may portend more severe...

    Authors: Shawn Rose, Jenny Dave, Corina Millo, Haley B Naik, Evan L Siegel and Nehal N Mehta
    Citation: Arthritis Research & Therapy 2014 16:R161
    Content type: Research article Published on:

  36. Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In...

    Authors: Mukundan Attur, Xin Duan, Lei Cai, Tianzhen Han, Weili Zhang, Eric D. Tycksen, Jonathan Samuels, Robert H. Brophy, Steven B. Abramson and Muhammad Farooq Rai
    Citation: Arthritis Research & Therapy 2021 23:104
    Content type: Research article Published on:

  37. Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease, and kidney involvement with SLE, a.k.a. lupus nephritis (LN), is a frequent and severe complication of SLE that increases patient mo...

    Authors: Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan and Michael A Kennedy
    Citation: Arthritis Research & Therapy 2011 13:R199
    Content type: Research article Published on:

  39. Treatments for rheumatoid arthritis (RA) are associated with complex changes in lipids and lipoproteins that may impact cardiovascular (CV) risk. The objective of this study was to examine lipid and lipoprotei...

    Authors: Katherine P. Liao, Pamela Rist, Jon Giles, Leah Santacroce, Margery A. Connelly, Robert J. Glynn, Paul Ridker, Ahmed Tawakol, Joan Bathon and Daniel H. Solomon
    Citation: Arthritis Research & Therapy 2024 26:123
    Content type: Research Published on:

  40. Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...

    Authors: Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning and Xu-jie Zhou
    Citation: Arthritis Research & Therapy 2021 23:279
    Content type: Research article Published on:

  41. Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no animal scleroderma esophagus models and esophageal sm...

    Authors: Jaclyn N. Taroni, Viktor Martyanov, Chiang-Ching Huang, J. Matthew Mahoney, Ikuo Hirano, Brandon Shetuni, Guang-Yu Yang, Darren Brenner, Barbara Jung, Tammara A. Wood, Swati Bhattacharyya, Orit Almagor, Jungwha Lee, Arlene Sirajuddin, John Varga, Rowland W. Chang…
    Citation: Arthritis Research & Therapy 2015 17:194
    Content type: Research article Published on:

  42. Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess wh...

    Authors: Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2017 19:228
    Content type: Research article Published on:

  43. In addition to activated T cells, the immune checkpoint inhibitor “V domain-containing Ig suppressor of T-cell activation” (VISTA) is expressed by myeloid cell types, including macrophages and neutrophils. The...

    Authors: Sabrina Ceeraz, Susan K. Eszterhas, Petra A. Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti and Roy A. Fava
    Citation: Arthritis Research & Therapy 2017 19:270
    Content type: Research article Published on:

  44. We evaluated the safety of current treatment regimens for patients with RA and HBV in a large US cohort.

    Authors: Mary Jane Burton, Jeffrey R Curtis, Shuo Yang, Lang Chen, Jasvinder A Singh, Ted R Mikuls, Kevin L Winthrop and John W Baddley
    Citation: Arthritis Research & Therapy 2015 17:136
    Content type: Research article Published on:

  45. The lacrimal gland (LG) of the CD25-/- model of Sjögren’s syndrome (SS) has high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific contribution of these cytokines to the onset and se...

    Authors: Fang Bian, Flavia L Barbosa, Rosa M Corrales, Flavia SA Pelegrino, Eugene A Volpe, Stephen C Pflugfelder and Cintia S de Paiva
    Citation: Arthritis Research & Therapy 2015 17:53
    Content type: Research article Published on:

  46. To assess the comparative effectiveness of febuxostat and allopurinol in reducing serum urate (sUA) levels in a real-world U.S. managed care setting.

    Authors: Jasvinder A Singh, Kasem S Akhras and Aki Shiozawa
    Citation: Arthritis Research & Therapy 2015 17:120
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2015 17:236

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Arthritis Research & Therapy

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