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  1. Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituxim...

    Authors: Francesca Faustini, Nicky Dunn, Nastya Kharlamova, Malin Ryner, Annette Bruchfeld, Vivianne Malmström, Anna Fogdell-Hahn and Iva Gunnarsson

    Citation: Arthritis Research & Therapy 2021 23:211

    Content type: Research article

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  2. First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) have a fourfold increased risk of developing RA. The Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire was develo...

    Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2021 23:210

    Content type: Research article

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  3. Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease ...

    Authors: Helga Westerlind, Ida Palmqvist, Saedis Saevarsdottir, Lars Alfredsson, Lars Klareskog and Daniela Di Giuseppe

    Citation: Arthritis Research & Therapy 2021 23:209

    Content type: Research article

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  4. Trabecular bone texture analysis (TBTA) has been identified as an imaging biomarker that provides information on trabecular bone changes due to knee osteoarthritis (KOA). Consequently, it is important to condu...

    Authors: Ahmad Almhdie-Imjabbar, Pawel Podsiadlo, Richard Ljuhar, Rachid Jennane, Khac-Lan Nguyen, Hechmi Toumi, Simo Saarakkala and Eric Lespessailles

    Citation: Arthritis Research & Therapy 2021 23:208

    Content type: Review

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  5. Clinical research projects often use traditional methods in which data collection and signing informed consent forms rely on patients’ visits to the research institutes. However, during challenging times when ...

    Authors: L. Boekel, F. Hooijberg, E. H. Vogelzang, P. L. Klarenbeek, W. H. Bos, S. W. Tas and G. J. Wolbink

    Citation: Arthritis Research & Therapy 2021 23:207

    Content type: Review

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  6. Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biolog...

    Authors: D. A. M. Thuy Trang, Koichi Okamura, Takahito Suto, Hideo Sakane, Yukio Yonemoto, Takahito Nakajima, Yoshito Tsushima and Hirotaka Chikuda

    Citation: Arthritis Research & Therapy 2021 23:206

    Content type: Research article

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  7. Circulating fibrocytes are an important source of fibroblasts and myofibroblasts, which are involved in fibrotic processes, including systemic sclerosis (SSc).

    Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Stefano Soldano

    Citation: Arthritis Research & Therapy 2021 23:205

    Content type: Research article

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  8. To evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc).

    Authors: Roger Hesselstrand, Jörg H. W. Distler, Gabriela Riemekasten, Dirk M. Wuttge, Marie Törngren, Helén C. Nyhlén, Fredrik Andersson, Helena Eriksson, Birgitta Sparre, Helén Tuvesson and Oliver Distler

    Citation: Arthritis Research & Therapy 2021 23:204

    Content type: Research article

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  9. Systemic lupus erythematosus (SLE) is a heterogeneous systemic autoimmune condition for which there are limited licensed therapies. Clinical trial design is challenging in SLE due at least in part to imperfect...

    Authors: John A. Reynolds, Jennifer Prattley, Nophar Geifman, Mark Lunt, Caroline Gordon and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2021 23:203

    Content type: Research article

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  10. Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic proc...

    Authors: M. Badii, O. I. Gaal, M. C. Cleophas, V. Klück, R. Davar, E. Habibi, S. T. Keating, B. Novakovic, M. M. Helsen, N. Dalbeth, L. K. Stamp, D. Macartney-Coxson, A. J. Phipps-Green, H. G. Stunnenberg, C. A. Dinarello, T. R. Merriman…

    Citation: Arthritis Research & Therapy 2021 23:202

    Content type: Research article

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  11. The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and autoantibodies could be involved in the pat...

    Authors: Sofia Ajeganova, Maria L. E. Andersson, Johan Frostegård and Ingiäld Hafström

    Citation: Arthritis Research & Therapy 2021 23:201

    Content type: Research article

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  12. Oxylipins are biological lipids that have been implicated in inflammation. We previously found that certain oxylipins correlated with clinical manifestations in psoriatic arthritis (PsA) patients. Here, we com...

    Authors: Roxana Coras, Arthur Kavanaugh, Angela Kluzniak, Dustina Holt, Amy Weilgosz, Armando Aaron, Oswald Quehenberger, Christopher Ritchlin and Monica Guma

    Citation: Arthritis Research & Therapy 2021 23:200

    Content type: Research article

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  13. Targeting TNFα is beneficial in many autoimmune and inflammatory diseases, including rheumatoid arthritis. However, the response to each of the existing TNFα inhibitors (TNFis) can be patient- and/or disease-d...

    Authors: Ching-Huang Ho, Andrea A. Silva, Beverly Tomita, Hui-Ying Weng and I-Cheng Ho

    Citation: Arthritis Research & Therapy 2021 23:199

    Content type: Research article

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  14. Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clini...

    Authors: Junyu Liang, Heng Cao, Yinuo Liu, Bingjue Ye, Yiduo Sun, Yini Ke, Ye He, Bei Xu and Jin Lin

    Citation: Arthritis Research & Therapy 2021 23:198

    Content type: Research article

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  15. To compare the efficacy and safety of tofacitinib and baricitinib in patients with RA in a real-world setting.

    Authors: Naoki Iwamoto, Shuntaro Sato, Shota Kurushima, Toru Michitsuji, Shinya Nishihata, Momoko Okamoto, Yoshika Tsuji, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Takahisa Suzuki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Keita Fujikawa, Takashi Igawa…

    Citation: Arthritis Research & Therapy 2021 23:197

    Content type: Research article

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  16. Hypertension occurred in 30–80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical charact...

    Authors: Sun Ying, Wu Sifan, Wang Yujiao, Chen Rongyi, Huang Qingrong, Ma Lili, Chen Huiyong and Jiang Lindi

    Citation: Arthritis Research & Therapy 2021 23:196

    Content type: Research article

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  17. Citation: Arthritis Research & Therapy 2021 23:195

    Content type: Letter

    Published on:

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:183

    The Research article to this article has been published in Arthritis Research & Therapy 2021 23:96

  18. Effector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and are involved in the pathogenesis of ANCA-associated vasculitis (AAV). The diversity of effector me...

    Authors: Zhonghua Liao, Jiale Tang, Liying Luo, Shuanglinzi Deng, Lisa Luo, Fangyuan Wang, Xiangning Yuan, Xinyue Hu, Juntao Feng and Xiaozhao Li

    Citation: Arthritis Research & Therapy 2021 23:194

    Content type: Research article

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  19. HLA-B27/human β2m transgenic rats (B27-rats) develop an inflammatory disorder resembling spondyloarthritis (SpA) with dysregulated IL-10/IL-17 production by regulatory T cells (Treg). Treg plays a major role i...

    Authors: L. M. Araujo, Q. Jouhault, I. Fert, I. Bouiller, G. Chiocchia and M. Breban

    Citation: Arthritis Research & Therapy 2021 23:193

    Content type: Research article

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  20. Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA). We aimed to assess and compare the incidence of AU in axSpA patients treated with anti-TNF or anti-IL17A.

    Authors: Damien Roche, Martin Badard, Laurent Boyer, Pierre Lafforgue and Thao Pham

    Citation: Arthritis Research & Therapy 2021 23:192

    Content type: Research article

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  21. We sought to examine the disease course of High Disease Activity Status (HDAS) patients and their different disease patterns in a real-world longitudinal cohort. Disease resolution till Lupus Low Disease Activ...

    Authors: Alberta Hoi, Rachel Koelmeyer, Julie Bonin, Ying Sun, Amy Kao, Oliver Gunther, Hieu T. Nim and Eric Morand

    Citation: Arthritis Research & Therapy 2021 23:191

    Content type: Research article

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  22. The interleukin-23p19-subunit inhibitor guselkumab effectively treats signs and symptoms of psoriatic arthritis (PsA). We evaluated the effect of guselkumab on fatigue.

    Authors: Proton Rahman, Philip J. Mease, Philip S. Helliwell, Atul Deodhar, Laure Gossec, Arthur Kavanaugh, Alexa P. Kollmeier, Elizabeth C. Hsia, Bei Zhou, Xiwu Lin, May Shawi, Chetan S. Karyekar and Chenglong Han

    Citation: Arthritis Research & Therapy 2021 23:190

    Content type: Research article

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  23. The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether they associat...

    Authors: Marit Stockfelt, Anna-Carin Lundell, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Jonathan Aldridge, Kerstin Andersson, Kaj Blennow…

    Citation: Arthritis Research & Therapy 2021 23:189

    Content type: Research article

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  24. The risk of severe COVID-19 and its determinants remain largely unknown in patients with autoimmune and inflammatory rheumatic diseases. The objective of this study was to assess the prevalence of COVID-19 inf...

    Authors: Renaud Felten, Marc Scherlinger, Aurélien Guffroy, Vincent Poindron, Alain Meyer, Margherita Giannini, Anne-Sophie Korganow, Christelle Sordet, Emmanuel Chatelus, Rose-Marie Javier, Aurore Meyer, Luc Pijnenburg, Jean-François Kleinmann, Jacques-Eric Gottenberg, Jean Sibilia, Thierry Martin…

    Citation: Arthritis Research & Therapy 2021 23:188

    Content type: Research article

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  25. Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeleta...

    Authors: Brian J. Andonian, Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2021 23:187

    Content type: Research article

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  26. MicroRNAs (miRNAs) are short single-stranded RNAs that play a role in the post-transcriptional regulation of gene expression. Their deregulation can be associated with various diseases, such as cancer, neurode...

    Authors: Jana Bohatá, Veronika Horváthová, Markéta Pavlíková and Blanka Stibůrková

    Citation: Arthritis Research & Therapy 2021 23:186

    Content type: Research article

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  27. To investigate whether baseline monosodium urate (MSU) burden estimated by ultrasound (US) predicts the achievement of the 2016 remission criteria for gout after 12 months.

    Authors: Edoardo Cipolletta, Jacopo Di Battista, Marco Di Carlo, Andrea Di Matteo, Fausto Salaffi, Walter Grassi and Emilio Filippucci

    Citation: Arthritis Research & Therapy 2021 23:185

    Content type: Research article

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  28. The new concept of difficult-to-treat rheumatoid arthritis (D2T RA) refers to RA patients who remain symptomatic after several lines of treatment, resulting in a high patient and economic burden. During a hack...

    Authors: Marianne A. Messelink, Nadia M. T. Roodenrijs, Bram van Es, Cornelia A. R. Hulsbergen-Veelken, Sebastiaan Jong, L. Malin Overmars, Leon C. Reteig, Sander C. Tan, Tjebbe Tauber, Jacob M. van Laar, Paco M. J. Welsing and Saskia Haitjema

    Citation: Arthritis Research & Therapy 2021 23:184

    Content type: Research article

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  29. Citation: Arthritis Research & Therapy 2021 23:183

    Content type: Letter

    Published on:

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:195

    The Research article to this article has been published in Arthritis Research & Therapy 2021 23:96

  30. Tapering or stopping biological disease-modifying anti-rheumatic drugs has been proposed for patients with rheumatoid arthritis (RA) in remission, but it frequently results in high rates of recurrence. This st...

    Authors: Sang Youn Jung, Jung Hee Koh, Ki-Jo Kim, Yong-Wook Park, Hyung-In Yang, Sung Jae Choi, Jisoo Lee, Chan-Bum Choi and Wan-Uk Kim

    Citation: Arthritis Research & Therapy 2021 23:182

    Content type: Research article

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  31. Clinical data collection requires correct and complete data sets in order to perform correct statistical analysis and draw valid conclusions. While in randomized clinical trials much effort concentrates on dat...

    Authors: Lisa Lindner, Anja Weiß, Andreas Reich, Siegfried Kindler, Frank Behrens, Jürgen Braun, Joachim Listing, Georg Schett, Joachim Sieper, Anja Strangfeld and Anne C. Regierer

    Citation: Arthritis Research & Therapy 2021 23:181

    Content type: Research article

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  32. Glucocorticoids (GC) modulate several regulators involved in the pathogenesis of bone changes in rheumatoid arthritis (RA). Trabecular bone score (TBS) allows the indirect assessment of bone quality. The aim o...

    Authors: Addolorata Corrado, Cinzia Rotondo, Angiola Mele, Daniela Cici, Nicola Maruotti, Eliana Sanpaolo, Ripalta Colia and Francesco Paolo Cantatore

    Citation: Arthritis Research & Therapy 2021 23:180

    Content type: Research article

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  33. Autoreactive B cells are well recognized as key participants in the pathogenesis of systemic lupus erythematosus (SLE). However, elucidating the particular subset of B cells in producing anti-dsDNA antibodies ...

    Authors: Kittikorn Wangriatisak, Chokchai Thanadetsuntorn, Thamonwan Krittayapoositpot, Chaniya Leepiyasakulchai, Thanitta Suangtamai, Pintip Ngamjanyaporn, Ladawan Khowawisetsut, Prasong Khaenam, Chavachol Setthaudom, Prapaporn Pisitkun and Patchanee Chootong

    Citation: Arthritis Research & Therapy 2021 23:179

    Content type: Research article

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  34. We developed a model to predict remissions in patients treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs) and to identify important clinical features associated with remission using explain...

    Authors: Bon San Koo, Seongho Eun, Kichul Shin, Hyemin Yoon, Chaelin Hong, Do-Hoon Kim, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Ji Seon Oh

    Citation: Arthritis Research & Therapy 2021 23:178

    Content type: Research article

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  35. To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).

    Authors: Jin Kyun Park, Sehui Shon, Hyun Jung Yoo, Dong-Hyeon Suh, Daekwon Bae, Jieun Shin, Jae Hyun Jun, Nina Ha, Hyeseung Song, Young Il Choi, Thomas Pap and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2021 23:177

    Content type: Research article

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  36. To evaluate the effectiveness of bazedoxifene in preventing bone loss in patients with rheumatoid arthritis (RA) receiving low-dose glucocorticoids (GCs).

    Authors: Soo-Kyung Cho, Hyoungyoung Kim, Jiyoung Lee, Eunwoo Nam, Seunghun Lee, Yun Young Choi and Yoon-Kyoung Sung

    Citation: Arthritis Research & Therapy 2021 23:176

    Content type: Research article

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  37. Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by specific vascular and obstetric manifestations and by antiphospholipid antibodies (aPL) positivity. Microvascular damage in the...

    Authors: Giorgia Ferrari, Emanuele Gotelli, Sabrina Paolino, Giampaola Pesce, Luca Nanni, Barbara Maria Colombo, Greta Pacini, Carlotta Schenone, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Maurizio Cutolo

    Citation: Arthritis Research & Therapy 2021 23:175

    Content type: Research article

    Published on:

  38. Electronic health records (EHRs) offer a wealth of observational data. Machine-learning (ML) methods are efficient at data extraction, capable of processing the information-rich free-text physician notes in EH...

    Authors: T. D. Maarseveen, M. P. Maurits, E. Niemantsverdriet, A. H. M. van der Helm-van Mil, T. W. J. Huizinga and R. Knevel

    Citation: Arthritis Research & Therapy 2021 23:174

    Content type: Research article

    Published on:

  39. The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to...

    Authors: Maja Špiritović, Barbora Heřmánková, Sabína Oreská, Hana Štorkánová, Olga Růžičková, Lucia Vernerová, Martin Klein, Kateřina Kubínová, Hana Šmucrová, Adéla Rathouská, Petr Česák, Martin Komarc, Václav Bunc, Karel Pavelka, Ladislav Šenolt, Heřman Mann…

    Citation: Arthritis Research & Therapy 2021 23:173

    Content type: Research article

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  40. The pathogenesis of lupus nephritis (LN) remains not fully understood. In this study, we aimed to explore the pathogenic roles of autoantibodies against human renal glomerular endothelial cells (HRGEC) in LN p...

    Authors: Ya-Chiao Hu, I-Jung Tsai, Hui-Yao Hsu, Bor-Luen Chiang and Yao-Hsu Yang

    Citation: Arthritis Research & Therapy 2021 23:171

    Content type: Research article

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  41. Early diffuse cutaneous systemic sclerosis (dcSSc) has the highest case fatality among rheumatic diseases. We report baseline characteristics, current immunosuppressive therapies, progression of skin and inter...

    Authors: Sara Jaafar, Alain Lescoat, Suiyuan Huang, Jessica Gordon, Monique Hinchcliff, Ami A. Shah, Shervin Assassi, Robyn Domsic, Elana J. Bernstein, Virginia Steen, Sabrina Elliott, Faye Hant, Flavia V. Castelino, Victoria K. Shanmugam, Chase Correia, John Varga…

    Citation: Arthritis Research & Therapy 2021 23:170

    Content type: Research article

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  42. Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this stud...

    Authors: Anna Eberhard, Stefan Bergman, Thomas Mandl, Tor Olofsson, Maria Rydholm, Lennart Jacobsson and Carl Turesson

    Citation: Arthritis Research & Therapy 2021 23:169

    Content type: Research article

    Published on:

  43. Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conduc...

    Authors: Michelle L. M. Mulder, Tamara W. van Hal, Mark H. Wenink, Hans J. P. M. Koenen, Frank H. J. van den Hoogen, Elke M. G. J. de Jong, Juul M. P. A. van den Reek and Johanna E. Vriezekolk

    Citation: Arthritis Research & Therapy 2021 23:168

    Content type: Review

    Published on:

  44. To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) in a randomized, double-blind, placebo-controlled clin...

    Authors: Miao Miao, Xian Xiao, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Ruijun Zhang, Jiali Chen, Xiaoying Zhang, Bo Huang, Yuebo Jin, Xiaolin Sun, Jing He and Zhanguo Li

    Citation: Arthritis Research & Therapy 2021 23:167

    Content type: Research article

    Published on:

  45. To investigate whether methotrexate treatment may affect the susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    Authors: Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss and Georg Schett

    Citation: Arthritis Research & Therapy 2021 23:166

    Content type: Research article

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  46. Enthesitis is a hallmark of spondyloarthritis (SpA) with a substantial impact on quality of life. Reports of treatment effectiveness across individual enthesitis sites in real-world patients with axial SpA (ax...

    Authors: Michael J. Nissen, Burkhard Möller, Adrian Ciurea, Ruediger B. Mueller, Patrick Zueger, Martin Schulz, Fabiana Ganz, Almut Scherer, Eleftherios Papagiannoulis and Thomas Hügle

    Citation: Arthritis Research & Therapy 2021 23:165

    Content type: Research article

    Published on:

  47. Rheumatoid arthritis (RA) is a chronic, autoimmune disorder characterized by joint inflammation and pain. In patients with RA, metabolomic approaches, i.e., high-throughput profiling of small-molecule metaboli...

    Authors: Benjamin Hur, Vinod K. Gupta, Harvey Huang, Kerry A. Wright, Kenneth J. Warrington, Veena Taneja, John M. Davis III and Jaeyun Sung

    Citation: Arthritis Research & Therapy 2021 23:164

    Content type: Research article

    Published on:

  48. Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3...

    Authors: M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane and Erika Darrah

    Citation: Arthritis Research & Therapy 2021 23:163

    Content type: Research article

    Published on:

  49. A variety of chronic inflammatory diseases are linked to ischemic heart disease (IHD); however, this association is less well studied in patients with Behçet’s syndrome (BS). The primary objective of this stud...

    Authors: Chun-Yu Lin, Hung-An Chen, Chun-Hsin Wu, Yu-Jih Su, Tsai-Ching Hsu and Chung-Yuan Hsu

    Citation: Arthritis Research & Therapy 2021 23:161

    Content type: Research article

    Published on:

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