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  1. Content type: Research article

    Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no...

    Authors: Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter and Philip S. Low

    Citation: Arthritis Research & Therapy 2019 21:143

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  2. Content type: Research article

    To describe the disease course of patients with early arthritis without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort. To determine baseline predictors of ...

    Authors: Gaël Mouterde, Nathalie Rincheval, Cédric Lukas, Claire Daien, Alain Saraux, Philippe Dieudé, Jacques Morel and Bernard Combe

    Citation: Arthritis Research & Therapy 2019 21:140

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  3. Content type: Research article

    (a) To describe the prevalence and incidence of peripheral arthritis during 5 years of follow-up in recent axial spondyloarthritis (axSpA), (b) to evaluate factors associated with their appearance and (c) to a...

    Authors: Clementina López-Medina, Maxime Dougados, Adeline Ruyssen-Witrand and Anna Moltó

    Citation: Arthritis Research & Therapy 2019 21:139

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  4. Content type: Research article

    Treatment persistence is an important consideration when selecting a therapy for chronic conditions such as rheumatoid arthritis (RA). We assessed the long-term persistence of abatacept or a tumor necrosis fac...

    Authors: Denis Choquette, Louis Bessette, Evo Alemao, Boulos Haraoui, Roelien Postema, Jean-Pierre Raynauld and Louis Coupal

    Citation: Arthritis Research & Therapy 2019 21:138

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  5. Content type: Research article

    Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the clinical distinction between HA20 and Behçet’s disease (BD...

    Authors: Naomi Tsuchida, Yohei Kirino, Yutaro Soejima, Masafumi Onodera, Katsuhiro Arai, Eiichiro Tamura, Takashi Ishikawa, Toshinao Kawai, Toru Uchiyama, Shigeru Nomura, Daisuke Kobayashi, Masataka Taguri, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake…

    Citation: Arthritis Research & Therapy 2019 21:137

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  6. Content type: Research article

    Activated T and B cells participate in the development and progression of Sjögren’s syndrome (SS). Metformin, a first-line anti-diabetic drug, exerts anti-inflammatory and immunomodulatory effects by activatin...

    Authors: Ji-Won Kim, Sung-Min Kim, Jin-Sil Park, Sun-Hee Hwang, JeongWon Choi, Kyung-Ah Jung, Jun-Geol Ryu, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Arthritis Research & Therapy 2019 21:136

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  7. Content type: Review

    The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have p...

    Authors: Daniel E. Furst and James S. Louie

    Citation: Arthritis Research & Therapy 2019 21:135

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  8. Content type: Research article

    We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is k...

    Authors: Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu and Yusheng Qiu

    Citation: Arthritis Research & Therapy 2019 21:134

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  9. Content type: Review

    Advances in genomic technology have enabled a greater understanding of the genetics of common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory bowel disease (IBD) and psoriasis. The s...

    Authors: Jessica M. Whyte, Jonathan J. Ellis, Matthew A. Brown and Tony J. Kenna

    Citation: Arthritis Research & Therapy 2019 21:133

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  10. Content type: Research article

    There is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and...

    Authors: Charlotte Proudman, Susan E. Lester, David A. Gonzalez-Chica, Tiffany K. Gill, Nicola Dalbeth and Catherine L. Hill

    Citation: Arthritis Research & Therapy 2019 21:132

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  11. Content type: Research

    Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients with T cell lymphopenia are more susceptible to life-threatening infections. However, the pathogenesi...

    Authors: Lu Zhang, Qisheng Xia, Wenli Li, Qinglin Peng, Hanbo Yang, Xin Lu and Guochun Wang

    Citation: Arthritis Research & Therapy 2019 21:131

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  12. Content type: Research article

    Sandoz etanercept (SDZ ETN; GP2015) is an etanercept biosimilar with equivalent efficacy and comparable safety and immunogenicity to reference etanercept (ETN) in patients with moderate-to-severe chronic plaqu...

    Authors: Janusz Jaworski, Marco Matucci-Cerinic, Hendrik Schulze-Koops, Maya H. Buch, Eugeniusz J. Kucharz, Yannick Allanore, Arthur Kavanaugh, Philip Young and Goran Babic

    Citation: Arthritis Research & Therapy 2019 21:130

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  13. Content type: Research article

    Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc). Here, we firstly investigated the correlation between skin ...

    Authors: Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shunsuke Miura, Tetsuo Toyama, Asako Yoshizaki, Hayakazu Sumida, Yoshihide Asano, Koji Oba and Shinichi Sato

    Citation: Arthritis Research & Therapy 2019 21:129

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  14. Content type: Research article

    There is substantial evidence that patients with ankylosing spondylitis (AS) have high response rates to tumour necrosis factor inhibitors (TNFi), a low likelihood of successful treatment termination, but yet ...

    Authors: Ulf Lindström, Tor Olofsson, Sara Wedrén, Ilia Qirjazo and Johan Askling

    Citation: Arthritis Research & Therapy 2019 21:128

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  15. Content type: Research article

    To examine whether metformin use was associated with knee cartilage volume loss over 4 years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.

    Authors: Yuanyuan Wang, Sultana Monira Hussain, Anita E. Wluka, Yuan Z. Lim, François Abram, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Flavia M. Cicuttini

    Citation: Arthritis Research & Therapy 2019 21:127

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  16. Content type: Research article

    To evaluate the performance of the extended modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) incorporating information from anteroposterior (AP) lumbar radiographs as compared to the conventional mSA...

    Authors: Maria Llop, Valeria Rios Rodriguez, Imke Redeker, Joachim Sieper, Hildrun Haibel, Martin Rudwaleit and Denis Poddubnyy

    Citation: Arthritis Research & Therapy 2019 21:126

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  17. Content type: Research article

    To describe the 6-year safety and efficacy of etanercept (ETN) in children with extended oligoarticular juvenile idiopathic arthritis (eoJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA)

    Authors: Ivan Foeldvari, Tamàs Constantin, Jelena Vojinović, Gerd Horneff, Vyacheslav Chasnyk, Joke Dehoorne, Violeta Panaviene, Gordana Sušić, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Irina Nikishina, Brigitte Bader-Meunier, Luciana Breda, Pavla Doležalová…

    Citation: Arthritis Research & Therapy 2019 21:125

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  18. Content type: Research article

    Infrapatellar fat pad (IFP) has recently emerged as a potential source of inflammation in knee arthropathies. It has been proposed to be one source of adipocytokines, fatty acids (FA), and FA-derived lipid med...

    Authors: Anne-Mari Mustonen, Reijo Käkelä, Petri Lehenkari, Johanna Huhtakangas, Sanna Turunen, Antti Joukainen, Tommi Kääriäinen, Tommi Paakkonen, Heikki Kröger and Petteri Nieminen

    Citation: Arthritis Research & Therapy 2019 21:124

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  19. Content type: Research article

    Numerous preclinical studies have revealed a critical role of cysteine-rich 61 (Cyr61) in the pathogenesis of rheumatoid arthritis (RA). But there is little literature discussing the clinical value of circulat...

    Authors: Yong Fan, Xinlei Yang, Juan Zhao, Xiaoying Sun, Wenhui Xie, Yanrong Huang, Guangtao Li, Yanjie Hao and Zhuoli Zhang

    Citation: Arthritis Research & Therapy 2019 21:123

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  20. Content type: Research article

    To evaluate the long-term efficacy, safety and immunogenicity of continuing LBEC0101; the etanercept (ETN) biosimilar; or switching from the ETN reference product (RP) to LBEC0101 in patients with rheumatoid a...

    Authors: Min-Chan Park, Hiroaki Matsuno, Jinseok Kim, Sung-Hwan Park, Sang-Heon Lee, Yong-Beom Park, Yun Jong Lee, Sang-Il Lee, Won Park, Dong Hyuk Sheen, Jung-Yoon Choe, Chan-Bum Choi, Seung-Jae Hong, Chang-Hee Suh, Shin-Seok Lee, Hoon-Suk Cha…

    Citation: Arthritis Research & Therapy 2019 21:122

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  21. Content type: Research article

    Disease-modifying antirheumatic drug (DMARD)-free remission, the sustained absence of synovitis after DMARD cessation, is increasingly achievable, especially in autoantibody-negative rheumatoid arthritis (RA)....

    Authors: Debbie M. Boeters, Leonie E. Burgers, Eric H. Sasso, Tom W. J. Huizinga and Annette H. M. van der Helm – van Mil

    Citation: Arthritis Research & Therapy 2019 21:121

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  22. Content type: Research article

    Conditioned pain modulation (CPM) is impaired in people with chronic pain such as knee osteoarthritis (KOA). The purpose of this randomized, controlled clinical trial was to investigate whether strong electroa...

    Authors: Zheng-tao Lv, Lin-lin Shen, Bing Zhu, Zhao-qing Zhang, Chao-yang Ma, Guo-fu Huang, Jing Yin, Ling-ling Yu, Si-yi Yu, Ming-qiao Ding, Jing Li, Xiao-cui Yuan, Wei He, Xiang-hong Jing and Man Li

    Citation: Arthritis Research & Therapy 2019 21:120

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  23. Content type: Research article

    To assess increased sacroiliac joint (SIJ) uptake on 18F-NaF PET/CT and to compare with MRI for inflammation and with CT scan for structural damages in a population of 23 patients with spondyloarthritis (SpA).

    Authors: Marie Raynal, Fehd Bouderraoui, Remy Ouichka, Julian Melchior, Olivier Morel, Alain Blum, Isabelle Chary-Valckenaere, Willy Ngueyon Sime, Véronique Roch, Walter Maksymowych, Robert G. Lambert, Pierre Olivier and Damien Loeuille

    Citation: Arthritis Research & Therapy 2019 21:119

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  24. Content type: Research article

    The efficacy and safety of apremilast were assessed in patients with psoriatic arthritis (PsA) in three phase III clinical trials with similar designs (PALACE 1, 2, and 3).

    Authors: Arthur Kavanaugh, Dafna D. Gladman, Christopher J. Edwards, Georg Schett, Benoit Guerette, Nikolay Delev, Lichen Teng, Maria Paris and Philip J. Mease

    Citation: Arthritis Research & Therapy 2019 21:118

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  25. Content type: Research article

    Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegat...

    Authors: Stefano Alivernini, Dario Bruno, Barbara Tolusso, Laura Bui, Luca Petricca, Maria Rita Gigante, Domenico Birra, Anna Laura Fedele, Giusy Peluso, Francesco Federico, Gianfranco Ferraccioli and Elisa Gremese

    Citation: Arthritis Research & Therapy 2019 21:116

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  26. Content type: Research article

    To study the impact of treatment strategy on achieving and sustaining disease-modifying antirheumatic drug (DMARD)-free remission in patients with rheumatoid arthritis (RA).

    Authors: L. E. Burgers, J. A. van der Pol, T. W. J. Huizinga, C. F. Allaart and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2019 21:115

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  27. Content type: Correction

    Following publication of the original article [1], the authors noticed that two corrections were not implemented during the production process.

    Authors: Kosuke Ebina, Motomu Hashimoto, Wataru Yamamoto, Toru Hirano, Ryota Hara, Masaki Katayama, Akira Onishi, Koji Nagai, Yonsu Son, Hideki Amuro, Keiichi Yamamoto, Yuichi Maeda, Koichi Murata, Sadao Jinno, Tohru Takeuchi, Makoto Hirao…

    Citation: Arthritis Research & Therapy 2019 21:114

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    The original article was published in Arthritis Research & Therapy 2019 21:91

  28. Content type: Research article

    The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with bone fragility are unclear. We aimed to investigate the association between BMLs, bone mineral density (B...

    Authors: Seiya Ota, Daisuke Chiba, Eiji Sasaki, Gentaro Kumagai, Yuji Yamamoto, Shigeyuki Nakaji, Eiichi Tsuda and Yasuyuki Ishibashi

    Citation: Arthritis Research & Therapy 2019 21:113

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  29. Content type: Research article

    Mesenchymal stem cells (MSCs) have the ability to differentiate into different types of cells of the mesenchymal lineage, such as osteocytes, chondrocytes, and adipocytes. It is also known that under inflammat...

    Authors: Jose Ramon Lamas, Benjamin Fernandez-Gutierrez, Arkaitz Mucientes, Fernando Marco, Yaiza Lopiz, Juan Angel Jover, Lydia Abasolo and Luis Rodríguez-Rodríguez

    Citation: Arthritis Research & Therapy 2019 21:112

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  30. Content type: Research article

    Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in the treatment of moderate-to-severe psoriasis (PsO)...

    Authors: A. Deodhar, P. J. Mease, I. B. McInnes, X. Baraliakos, K. Reich, A. Blauvelt, C. Leonardi, B. Porter, A. Das Gupta, A. Widmer, L. Pricop and T. Fox

    Citation: Arthritis Research & Therapy 2019 21:111

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  31. Content type: Research article

    Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier int...

    Authors: Helena Tydén, Christian Lood, Andreas Jönsen, Birgitta Gullstrand, Robin Kahn, Petrus Linge, Sunil B. Kumaraswamy, Björn Dahlbäck and Anders A. Bengtsson

    Citation: Arthritis Research & Therapy 2019 21:110

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  32. Content type: Research article

    To investigate the expression of peptidylarginine deiminases (PADIs) during macrophage differentiation and its role in inflammatory responses.

    Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu

    Citation: Arthritis Research & Therapy 2019 21:108

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  33. Content type: Research article

    Interferons (IFNs) are considered to be key molecules in the pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III IFNs in a large cohort of patients with systemic lupus ...

    Authors: Vilija Oke, Iva Gunnarsson, Jessica Dorschner, Susanna Eketjäll, Agneta Zickert, Timothy B. Niewold and Elisabet Svenungsson

    Citation: Arthritis Research & Therapy 2019 21:107

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  34. Content type: Research article

    Autologous hematopoietic stem cell transplantation (aHSCT) is performed in patients with aggressive forms of systemic sclerosis (SSc). The profile of B cell reconstitution after aHSCT is not fully understood. ...

    Authors: Michael Gernert, Hans-Peter Tony, Eva Christina Schwaneck, Ottar Gadeholt and Marc Schmalzing

    Citation: Arthritis Research & Therapy 2019 21:106

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  35. Content type: Research article

    Lupus nephritis (LN) is a representative manifestation in systemic lupus erythematosus (SLE). Some studies have shown that myeloid-derived suppressor cells (MDSCs) play a vital role in the regulation of the SL...

    Authors: Dan Li, Guoping Shi, Jiali Wang, Dongya Zhang, Yuchen Pan, Huan Dou and Yayi Hou

    Citation: Arthritis Research & Therapy 2019 21:105

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  36. Content type: Research article

    There is limited evidence supporting the long-term effect of a foot care package that includes footwear for people with gout. The aim of this study was to investigate the effectiveness of a footwear interventi...

    Authors: Mike Frecklington, Nicola Dalbeth, Peter McNair, Trish Morpeth, Alain C. Vandal, Peter Gow and Keith Rome

    Citation: Arthritis Research & Therapy 2019 21:104

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  37. Content type: Research article

    Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic s...

    Authors: Tomoaki Higuchi, Kae Takagi, Akiko Tochimoto, Yuki Ichimura, Takanari Norose, Yasuhiro Katsumata, Ikuko Masuda, Hisashi Yamanaka, Toshiro Morohoshi and Yasushi Kawaguchi

    Citation: Arthritis Research & Therapy 2019 21:103

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  38. Content type: Research article

    Clinical guidelines recommend pneumococcal and tetanus vaccinations in patients with rheumatoid arthritis (RA). Baricitinib is an oral, selective Janus kinase (JAK) 1/JAK 2 inhibitor and is approved for the tr...

    Authors: Kevin L. Winthrop, Clifton O. Bingham III, Wendy J. Komocsar, John Bradley, Maher Issa, Rena Klar and Cynthia E. Kartman

    Citation: Arthritis Research & Therapy 2019 21:102

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  39. Content type: Research article

    Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, pl...

    Authors: Peter C. Taylor, Didier Saurigny, Jiri Vencovsky, Tsutomu Takeuchi, Tadashi Nakamura, Galina Matsievskaia, Barbara Hunt, Thomas Wagner and Bernard Souberbielle

    Citation: Arthritis Research & Therapy 2019 21:101

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  40. Content type: Research article

    Ultrasound (US) is sensitive for detecting joint and tendon inflammation in patients with rheumatoid arthritis (RA). So far, which grade of abnormalities on US corresponds to clinical manifestations is unclear...

    Authors: Xiaoying Sun, Xuerong Deng, Wenhui Xie, Liujun Wang, Yu Wang and Zhuoli Zhang

    Citation: Arthritis Research & Therapy 2019 21:100

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  41. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Table 2.

    Authors: Yoshiya Tanaka, Kazuteru Wada, Yoshinori Takahashi, Owen Hagino, Hubert van Hoogstraten, Neil M. H. Graham and Hideto Kameda

    Citation: Arthritis Research & Therapy 2019 21:99

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    The original article was published in Arthritis Research & Therapy 2019 21:79

  42. Content type: Research article

    To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data.

    Authors: Hiromu Ito, Shinjiro Tominari, Yasuharu Tabara, Takeo Nakayama, Moritoshi Furu, Tomotoshi Kawata, Masayuki Azukizawa, Kazuya Setoh, Takahisa Kawaguchi, Fumihiko Matsuda and Shuichi Matsuda

    Citation: Arthritis Research & Therapy 2019 21:98

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  43. Content type: Research article

    Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain, and the treatment of IDD is costly and relatively ineffective. Dysregulation of microRNAs (miRNAs) has been repo...

    Authors: Qi Yang, Xiao-Peng Guo, Yan-Li Cheng and Yang Wang

    Citation: Arthritis Research & Therapy 2019 21:97

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  44. Content type: Research article

    Systemic sclerosis (SSc) can lead to ischemic complications such as digital ulcers (DUs). The aim of the study was to find predictors of DUs by clinical and new imaging methods.

    Authors: S. Friedrich, S. Lüders, A. M. Glimm, S. G. Werner, G. Schmittat, G. R. Burmester, M. Backhaus, G. Riemekasten and S. Ohrndorf

    Citation: Arthritis Research & Therapy 2019 21:96

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  45. Content type: Research article

    Systemic sclerosis (SSc) is an autoimmune disease associated with immune abnormalities and widespread vascular lesions, including increased intimal and medial thickness. These changes may be reflected in early...

    Authors: Rania M. Gamal, Hanan Sayed M. Abozaid, Mohmed Zidan, Mohamed Aboel-Kassem F. Abdelmegid, Mohmed Raouf Abdel-Razek, Sahar Abdel-Rahman Alsayed, Amr F. Mourad, Nashwa Mostafa A. Azoz, Lobna Abdel-Wahid Mohram and Daniel E. Furst

    Citation: Arthritis Research & Therapy 2019 21:95

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  46. Content type: Research article

    Impaired vascular pathophysiology and increased cardiovascular (CV) mortality are associated with rheumatoid arthritis (RA). To date, no genomic analysis of RA- and RA treatment-related vascular pathophysiolog...

    Authors: Szilárd Póliska, Timea Besenyei, Edit Végh, Attila Hamar, Anita Pusztai, Andrea Váncsa, Nóra Bodnár, Szilvia Szamosi, Mária Csumita, György Kerekes, Zoltán Szabó, Zoltán Nagy, Gabriella Szűcs, Sándor Szántó, Gábor Zahuczky, László Nagy…

    Citation: Arthritis Research & Therapy 2019 21:94

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  47. Content type: Research article

    Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with differen...

    Authors: Hai Qin Xie, Wei Wei Zhang, De Sheng Sun, Xiang Mei Chen, Shu Fang Yuan, Zheng Hua Gong and Li Liu

    Citation: Arthritis Research & Therapy 2019 21:93

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  48. Content type: Research article

    The aim of this study is to evaluate the retention rates and reasons for discontinuation for seven biological disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting of patients with rheumatoid...

    Authors: Kosuke Ebina, Motomu Hashimoto, Wataru Yamamoto, Toru Hirano, Ryota Hara, Masaki Katayama, Akira Onishi, Koji Nagai, Yonsu Son, Hideki Amuro, Keiichi Yamamoto, Yuichi Maeda, Koichi Murata, Sadao Jinno, Tohru Takeuchi, Makoto Hirao…

    Citation: Arthritis Research & Therapy 2019 21:91

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    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:114

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