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  1. Research article

    Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

    Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α prod...

    Goh Murayama, Nanako Furusawa, Asako Chiba, Ken Yamaji, Naoto Tamura and Sachiko Miyake

    Arthritis Research & Therapy 2017 19:234

    Published on: 19 October 2017

  2. Research article

    Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

    The interaction of circulating microparticles (MPs) with immune cells in systemic lupus erythematosus (SLE) is sparsely investigated. We examined the ability of MPs from SLE patients to induce production of re...

    Line Kjær Winberg, Søren Jacobsen and Claus H. Nielsen

    Arthritis Research & Therapy 2017 19:230

    Published on: 17 October 2017

  3. Research article

    Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study

    Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess wh...

    Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang and Jeffrey R. Curtis

    Arthritis Research & Therapy 2017 19:228

    Published on: 17 October 2017

  4. Research article

    Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis

    Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence probably due to atherosclerosis...

    Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Smastuen, Stefan Agewall, Torstein Lyberg, Nicoletta Ronda, Knut Mikkelsen, Gunnbjorg Hjeltnes and Ivana Hollan

    Arthritis Research & Therapy 2017 19:232

    Published on: 17 October 2017

  5. Research article

    Incretins in patients with rheumatoid arthritis

    The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin...

    Beatriz Tejera-Segura, Raquel López-Mejías, María Jesús Domínguez-Luis, Antonia M. de Vera-González, Alejandra González-Delgado, Begoña Ubilla, José M. Olmos, José L. Hernández, Miguel A. González-Gay and Iván Ferraz-Amaro

    Arthritis Research & Therapy 2017 19:229

    Published on: 17 October 2017

  6. Research article

    Fluorescence optical imaging in pediatric patients with inflammatory and non-inflammatory joint diseases: a comparative study with ultrasonography

    Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wri...

    Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick and Jens Klotsche

    Arthritis Research & Therapy 2017 19:233

    Published on: 17 October 2017

  7. Research article

    A new bioassay for measuring the strength of IL-6/STAT3 signal inhibition by tocilizumab in patients with rheumatoid arthritis

    Interleukin-6 (IL-6) transduces signals via phosphorylation of STAT3 (pSTAT3). Tocilizumab (TCZ) is an IL-6 receptor blocker, which, when administered intravenously every 4 weeks, efficiently ameliorates rheum...

    Shuntaro Saito, Katsuya Suzuki, Keiko Yoshimoto, Yuko Kaneko, Yoshihiro Matsumoto, Kunihiro Yamaoka and Tsutomu Takeuchi

    Arthritis Research & Therapy 2017 19:231

    Published on: 17 October 2017

  8. Research article

    Behçet’s disease risk association fine-mapped on the IL23RIL12RB2 intergenic region in Koreans

    Behçet’s disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23RIL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in ...

    Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang and Yeong Wook Song

    Arthritis Research & Therapy 2017 19:227

    Published on: 10 October 2017

  9. Research article

    Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice

    With expanding therapeutic possibilities for treatment of psoriatic arthritis (PsA) it will be increasingly important to determine residual disease and define when to adjust treatment. The rationale behind tre...

    Leonieke J. J. van Mens, Marleen G. H. van de Sande, Inka A. Fluri, Sadaf Atiqi, Arno W. R. van Kuijk and Dominique L. P. Baeten

    Arthritis Research & Therapy 2017 19:226

    Published on: 10 October 2017

  10. Research article

    T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

    A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that is critical for the development of autoimmunity. However, t...

    Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B. Harley, Yuanjia Tang and Nan Shen

    Arthritis Research & Therapy 2017 19:225

    Published on: 5 October 2017

  11. Research article

    Clinical features of IgG4-related periaortitis/periarteritis based on the analysis of 179 patients with IgG4-related disease: a case–control study

    Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic condition characterized by high serum immunoglobulin G4 (IgG4) concentration and IgG4-bearing plasma cell infiltration in affected org...

    Makiko Ozawa, Yasunari Fujinaga, Junpei Asano, Akira Nakamura, Takayuki Watanabe, Tetsuya Ito, Takashi Muraki, Hideaki Hamano and Shigeyuki Kawa

    Arthritis Research & Therapy 2017 19:223

    Published on: 4 October 2017

  12. Research article

    Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)

    Although one study showed minimal progression of erosions in patients with rheumatoid arthritis (RA) one year after TNFα inhibition therapy, no studies have investigated very early bone changes after initiatio...

    Tomohiro Shimizu, Hyo Jin Choi, Ursula Heilmeier, Matthew Tanaka, Andrew J. Burghardt, Jingshan Gong, Nattagan Chanchek, Thomas M. Link, Jonathan Graf, John B. Imboden and Xiaojuan Li

    Arthritis Research & Therapy 2017 19:222

    Published on: 4 October 2017

  13. Research article

    The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

    Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs)...

    Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines III, Christina L. Bloomfield and Carla M. Cuda

    Arthritis Research & Therapy 2017 19:224

    Published on: 4 October 2017

  14. Research article

    Ultrasound of the hand is sufficient to detect subclinical inflammation in rheumatoid arthritis remission: a post hoc longitudinal study

    Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remissio...

    Hilde Berner Hammer, Tore K. Kvien and Lene Terslev

    Arthritis Research & Therapy 2017 19:221

    Published on: 4 October 2017

  15. Research article

    Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology

    Infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (RA). However, studies investigating this hypothesis in RA show conflicti...

    Natalia Sherina, Hulda S. Hreggvidsdottir, Camilla Bengtsson, Monika Hansson, Lena Israelsson, Lars Alfredsson and Karin Lundberg

    Arthritis Research & Therapy 2017 19:219

    Published on: 30 September 2017

  16. Research article

    Further Treatment Intensification in Undifferentiated and Rheumatoid Arthritis Patients Already in Low Disease Activity has Limited Benefit towards Physical Functioning

    It is recommended to optimise treatment as long as a predefined treatment target is not met, but should the aim be remission if patients are in low disease activity (LDA)? The aim of this study was to assess i...

    Sytske Anne Bergstra, Otto Olivas, Gülşah Akdemir, Naghmeh Riyazi, Gerard Collée, Johannes H. L. M. van Groenendael, Robert B. M. Landewé and Cornelia F. Allaart

    Arthritis Research & Therapy 2017 19:220

    Published on: 30 September 2017

  17. Research article

    Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

    Targeted proteomics, which involves quantitative analysis of targeted proteins using selected reaction monitoring (SRM) mass spectrometry, has emerged as a new methodology for discovery of clinical biomarkers....

    Jun Ishizaki, Ayako Takemori, Koichiro Suemori, Takuya Matsumoto, Yoko Akita, Ken-ei Sada, Yukio Yuzawa, Koichi Amano, Yoshinari Takasaki, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, Masaki Yasukawa, Nobuaki Takemori and Hitoshi Hasegawa

    Arthritis Research & Therapy 2017 19:218

    Published on: 29 September 2017

  18. Research article

    S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

    Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow mo...

    Niels A. J. Cremers, Martijn H. J. van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J. W. Geven, Arjen B. Blom and Peter L. E. M. van Lent

    Arthritis Research & Therapy 2017 19:217

    Published on: 29 September 2017

  19. Research article

    A somatization comorbidity phenotype impacts response to therapy in rheumatoid arthritis: post-hoc results from the certolizumab pegol phase 4 PREDICT trial

    Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to ce...

    Jeffrey R. Curtis, Christopher Herrem, ’Matladi N. Ndlovu, Cathy O’Brien and Yusuf Yazici

    Arthritis Research & Therapy 2017 19:215

    Published on: 29 September 2017

  20. Research article

    Patient-provider discordance between global assessments of disease activity in rheumatoid arthritis: a comprehensive clinical evaluation

    Discordance between patients with rheumatoid arthritis (RA) and their rheumatology health care providers is a common and important problem. The objective of this study was to perform a comprehensive clinical e...

    Divya N. Challa, Zoran Kvrgic, Andrea L. Cheville, Cynthia S. Crowson, Tim Bongartz, Thomas G. Mason II, Eric L. Matteson, Clement J. Michet Jr, Scott T. Persellin, Daniel E. Schaffer, Theresa L. Wampler Muskardin, Kerry Wright and John M. Davis III

    Arthritis Research & Therapy 2017 19:212

    Published on: 26 September 2017

  21. Research article

    Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis

    Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthy control subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging ...

    Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki and Zoltán Szekanecz

    Arthritis Research & Therapy 2017 19:213

    Published on: 26 September 2017

  22. Research article

    HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

    Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyro...

    Yu-Yon Kim, Ki Tae Park, Sun Young Jang, Kyu Hang Lee, Joo-Yun Byun, Kwee Hyun Suh, Young-Mi Lee, Young Hoon Kim and Kwang Woo Hwang

    Arthritis Research & Therapy 2017 19:211

    Published on: 26 September 2017

  23. Research article

    Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

    A recent systematic review identified four candidate serum-soluble bone-turnover biomarkers (dickkopf-1, Dkk-1; macrophage-colony stimulating factor, M-CSF; matrix metalloproteinase-3, MMP-3; osteoprotegerin, ...

    Deepak R. Jadon, Raj Sengupta, Alison Nightingale, Hui Lu, Juliet Dunphy, Amelia Green, James T. Elder, Rajan P. Nair, Eleanor Korendowych, Mark A. Lindsay and Neil J. McHugh

    Arthritis Research & Therapy 2017 19:210

    Published on: 21 September 2017

  24. Editorial

    Inflammasome lights up in systemic sclerosis

    Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement depen...

    John Henderson and Steven O’Reilly

    Arthritis Research & Therapy 2017 19:205

    Published on: 18 September 2017

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