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  1. CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of CD38+ NK cells and the effect of C3G on RA.

    Authors: Hongxing Wang, Shutong Li, Guoqing Zhang, Hui Wu and Xiaotian Chang

    Citation: Arthritis Research & Therapy 2019 21:220

    Content type: Research article

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  2. The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis ...

    Authors: Zixuan Pan, Alberto M. Marra, Nicola Benjamin, Christina A. Eichstaedt, Norbert Blank, Eduardo Bossone, Antonio Cittadini, Gerry Coghlan, Christopher P. Denton, Oliver Distler, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Panagiota Xanthouli, Hanns-Martin Lorenz and Ekkehard Grünig

    Citation: Arthritis Research & Therapy 2019 21:217

    Content type: Research article

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  3. The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responder...

    Authors: Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson…

    Citation: Arthritis Research & Therapy 2019 21:216

    Content type: Research article

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  4. Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a multifactorial origin. While several disease-related ...

    Authors: Casper Webers, Laura Vanhoof, Carsten Leue, Annelies Boonen and Sebastian Köhler

    Citation: Arthritis Research & Therapy 2019 21:215

    Content type: Research article

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  5. The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis ...

    Authors: Philip G. Conaghan, Mikkel Østergaard, Orrin Troum, Michael A. Bowes, Gwenael Guillard, Bethanie Wilkinson, Zhiyong Xie, John Andrews, Amy Stein, Douglass Chapman and Andrew Koenig

    Citation: Arthritis Research & Therapy 2019 21:214

    Content type: Research article

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  6. Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensat...

    Authors: Jun Long, Xiaobo Wang, Xianfa Du, Hehai Pan, Jianru Wang, Zemin Li, Hui Liu, Xudong Li and Zhaomin Zheng

    Citation: Arthritis Research & Therapy 2019 21:213

    Content type: Research article

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  7. Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lympho...

    Authors: Ann-Christin Pecher, Felix Kettemann, Elisa Asteriti, Hannes Schmid, Silke Duerr-Stoerzer, Hildegard Keppeler, Joerg Christoph Henes, Reinhild Klein, Clemens Hinterleitner, Kathy-Ann Secker, Corina Schneidawind, Lothar Kanz and Dominik Schneidawind

    Citation: Arthritis Research & Therapy 2019 21:212

    Content type: Research article

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  8. To estimate and compare the burdens of opportunistic infections and herpes zoster in real-world practice among patients with various systemic rheumatic diseases.

    Authors: Chung-Yuan Hsu, Chi-Hua Ko, Jiun-Ling Wang, Tsai-Ching Hsu and Chun-Yu Lin

    Citation: Arthritis Research & Therapy 2019 21:211

    Content type: Research article

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  9. This study investigates the association between exposure to urate-lowering drugs (ULDs) and progression and recovery from chronic kidney disease (CKD).

    Authors: Ting-Ting Chung, Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Meng-Jiun Chiou, Wen-Ching Lan, Jung-Sheng Chen, Wen-Yi Tseng, Ao-Ho Hsieh and Lian-Chin Wang

    Citation: Arthritis Research & Therapy 2019 21:210

    Content type: Research article

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  10. Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies.

    Authors: Anne-Marie Glimm, Lisa Ines Sprenger, Ida Kristin Haugen, Ulrich Mansmann, Sandra Hermann, Thomas Häupl, Paula Hoff, Gerd-Rüdiger Burmester, Marina Backhaus, Lien Le and Sarah Ohrndorf

    Citation: Arthritis Research & Therapy 2019 21:209

    Content type: Research article

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  11. If TNF inhibitors are initiated in the early stages of psoriatic arthritis, this could potentially modulate disease and therefore allow us to discontinue the TNF inhibitor after achieving remission.

    Authors: Henriëtte M. Y. de Jong, Leonieke J. J. van Mens, Michael T. Nurmohamed, Marc R. Kok, Arno W. R. van Kuijk, Dominique L. P. Baeten and Marleen G. H. van de Sande

    Citation: Arthritis Research & Therapy 2019 21:208

    Content type: Research article

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  12. To investigate the incidence of pneumocystis pneumonia (PCP) and its risk factors in patients with rheumatic disease receiving non-high-dose steroid treatment, along with the risks and benefits of PCP prophyla...

    Authors: Jun Won Park, Jeffrey R. Curtis, Min Jung Kim, Hajeong Lee, Yeong Wook Song and Eun Bong Lee

    Citation: Arthritis Research & Therapy 2019 21:207

    Content type: Research article

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  13. Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sen...

    Authors: Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs and Raymond P. Boot-Handford

    Citation: Arthritis Research & Therapy 2019 21:206

    Content type: Research article

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  14. Neuropsychiatric systemic lupus erythaematosus (NP-SLE) is one of the major manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely unknown. The abnormal activation of the type I ...

    Authors: Jing Zeng, Xinyu Meng, Ping Zhou, Zhihua Yin, Qinglian Xie, Hong Zou, Nan Shen, Zhizhong Ye and Yuanjia Tang

    Citation: Arthritis Research & Therapy 2019 21:205

    Content type: Research article

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  15. Rheumatoid arthritis (RA) is associated with an increased risk of morbidity and mortality, when compared with general population, largely due to enhanced atherosclerotic disease. In this work, we aimed at asse...

    Authors: Piero Ruscitti, Paola Cipriani, Vasiliki Liakouli, Daniela Iacono, Ilenia Pantano, Domenico Paolo Emanuele Margiotta, Luca Navarini, Giulia Maria Destro Castaniti, Nicola Maruotti, Gerardo Di Scala, Licia Picciariello, Francesco Caso, Sara Bongiovanni, Rosa Daniela Grembiale, Fabiola Atzeni, Raffaele Scarpa…

    Citation: Arthritis Research & Therapy 2019 21:204

    Content type: Research article

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  16. Excessive cartilage degradation is a known characteristic of osteoarthritis (OA). Biochemical markers, such as uCTX-II, have been shown to be associated with disease severity, yet the tissue origin of CTX-II h...

    Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis and Morten A. Karsdal

    Citation: Arthritis Research & Therapy 2019 21:203

    Content type: Research article

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  17. To determine the effect of riociguat, an oral, selective soluble guanylate cyclase stimulator, on the net digital ulcer (DU) burden in systemic sclerosis (SSc).

    Authors: Vivek Nagaraja, Cathie Spino, Erica Bush, Pei-Suen Tsou, Robyn T. Domsic, Robert Lafyatis, Tracy Frech, Jessica K. Gordon, Virginia D. Steen and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2019 21:202

    Content type: Research article

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  18. Intervertebral disc degeneration (IDD) has a complicated and enigmatic pathogenic process. Accumulating evidence shows that long non-coding RNAs (LncRNAs) play a role in the pathogenesis of IDD. This study aim...

    Authors: Shengfeng Zhan, Kun Wang, Yu Song, Shuai Li, Huipeng Yin, Rongjin Luo, Zhiwei Liao, Xinghuo Wu, Yukun Zhang and Cao Yang

    Citation: Arthritis Research & Therapy 2019 21:201

    Content type: Research article

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  19. Low doses of febuxostat or benzbromarone are widely used in Asian countries, but lacking studies to compare the efficacy and safety of the two urate-lowering drugs.

    Authors: Nan Liang, Mingshu Sun, Ruixia Sun, Ting Xu, Lingling Cui, Can Wang, Lidan Ma, Xiaoyu Cheng, Xiaomei Xue, Wenyan Sun, Xuan Yuan, Hui Zhang, Hailong Li, Yuwei He, Aichang Ji, Xinjiang Wu…

    Citation: Arthritis Research & Therapy 2019 21:200

    Content type: Research article

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  20. Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid ...

    Authors: Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro and Koichi Akashi

    Citation: Arthritis Research & Therapy 2019 21:198

    Content type: Research article

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  21. The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA).

    Authors: Johanna Callhoff, Thomas Dietrich, Mariya Chubrieva, Jens Klotsche and Angela Zink

    Citation: Arthritis Research & Therapy 2019 21:197

    Content type: Research article

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  22. To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS).

    Authors: Hsin-Hua Chen, Wen-Cheng Chao, Yi-Hsing Chen, Tsu-Yi Hsieh, Kuo-Lung Lai, Yi-Ming Chen, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng and Ching-Heng Lin

    Citation: Arthritis Research & Therapy 2019 21:196

    Content type: Research article

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  23. Structural variations such as copy number variations (CNVs) have a functional impact on various human traits. This study profiled genome-wide CNVs in Korean patients with rheumatoid arthritis (RA) to investiga...

    Authors: Ki-Nam Gu, So-Young Bang, Hye-Soon Lee, Youngho Park, Ju-Yeon Kang, Ji-Soong Kim, Bora Nam, Hyun-Seung Yoo, Jung-Min Shin, Yeon-Kyung Lee, Tae-Han Lee, Sehwan Chun, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim…

    Citation: Arthritis Research & Therapy 2019 21:195

    Content type: Research article

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  24. Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.

    Authors: Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang and Feng Zhang

    Citation: Arthritis Research & Therapy 2019 21:194

    Content type: Research article

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  25. Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. In this study, we explored the effect of the natural compo...

    Authors: Baofeng Chen, Hongmei Li, Guochun Ou, Long Ren, Xiaohong Yang and Mei Zeng

    Citation: Arthritis Research & Therapy 2019 21:193

    Content type: Research article

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  26. Predicting which patients with hip osteoarthritis are more likely to show disease progression is important for healthcare professionals. Therefore, the aim of this review was to assess which factors are predic...

    Authors: C. H. Teirlinck, D. M. J. Dorleijn, P. K. Bos, J. B. M. Rijkels-Otters, S. M. A. Bierma-Zeinstra and P. A. J. Luijsterburg

    Citation: Arthritis Research & Therapy 2019 21:192

    Content type: Review

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  27. Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1–6), and serves as an important mediator in inflammation. Previous studies have demonstrat...

    Authors: Chie Miyabe, Yoshishige Miyabe, Jun Nagai, Noriko N. Miura, Naohito Ohno, Jerold Chun, Ryoji Tsuboi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka and Toshihiro Nanki

    Citation: Arthritis Research & Therapy 2019 21:191

    Content type: Research article

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  28. To evaluate the safety and efficacy of intravenous golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) aged < 65 years and those ≥ 65 years who were enrolled in the GO-FURTHER study.

    Authors: John Tesser, Shelly Kafka, Raphael J. DeHoratius, Stephen Xu, Elizabeth C. Hsia and Anthony Turkiewicz

    Citation: Arthritis Research & Therapy 2019 21:190

    Content type: Research article

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  29. In clinical practice, discrimination between central nervous system (CNS) infections in patients with systemic lupus erythematosus (SLE) and neuropsychiatric lupus erythematosus (NPSLE) could be urgent and cri...

    Authors: Mengdi Jiang, Xiaochun Shi, Xin Gao, Jingwen Niu, Xiaomin Hu, Lidan Zhao and Xuan Zhang

    Citation: Arthritis Research & Therapy 2019 21:189

    Content type: Research article

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  30. Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced ...

    Authors: C. G. Fenton, C. L. Doig, S. Fareed, A. Naylor, A. P. Morrell, O. Addison, C. Wehmeyer, C. D. Buckley, M. S. Cooper, G. G. Lavery, K. Raza and R. S. Hardy

    Citation: Arthritis Research & Therapy 2019 21:188

    Content type: Research article

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  31. The purpose of the present study was to demonstrate whether alcohol consumption could predict spinal structural damage in axial spondyloarthritis (axSpA) in a prospective cohort study.

    Authors: Hong Ki Min, Jennifer Lee, Ji Hyeon Ju, Sung-Hwan Park and Seung-Ki Kwok

    Citation: Arthritis Research & Therapy 2019 21:187

    Content type: Research article

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  32. Previous studies suggest that regulatory microRNAs (miRs) may modulate neuro-inflammatory processes. The purpose of the present study was to examine the role of miR-17 following intervertebral disc herniation.

    Authors: Eivind Hasvik, Tiril Schjølberg, Daniel Pitz Jacobsen, Anne Julsrud Haugen, Lars Grøvle, Elina Iordanova Schistad and Johannes Gjerstad

    Citation: Arthritis Research & Therapy 2019 21:186

    Content type: Research article

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  33. Following publication of the original article [1], it was brought to our attention that the fifth author’s name was incorrectly published. The original article [1] is corrected.

    Authors: Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena and Chandra Mohan

    Citation: Arthritis Research & Therapy 2019 21:185

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2019 21:176

  34. Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previou...

    Authors: Sho Sendo, Jun Saegusa, Hirotaka Yamada, Keisuke Nishimura and Akio Morinobu

    Citation: Arthritis Research & Therapy 2019 21:184

    Content type: Research article

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  35. The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level.

    Authors: Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman and Peter C. Taylor

    Citation: Arthritis Research & Therapy 2019 21:183

    Content type: Research article

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  36. Patients with rheumatoid arthritis (RA) experience extra-articular manifestations including osteoporosis and muscle wasting, which closely associate with severity of disease. Whilst therapeutic glucocorticoids...

    Authors: C. G. Fenton, J. M. Webster, C. S. Martin, S. Fareed, C. Wehmeyer, H. Mackie, R. Jones, A. P. Seabright, J. W. Lewis, Y. C. Lai, C. S. Goodyear, S. W Jones, M. S. Cooper, G. G. Lavery, R. Langen, K. Raza…

    Citation: Arthritis Research & Therapy 2019 21:182

    Content type: Research article

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  37. Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sic...

    Authors: Lara A. Aqrawi, Hilde Kanli Galtung, Eduarda M. Guerreiro, Reidun Øvstebø, Bernd Thiede, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Kathrine Skarstein and Janicke Liaaen Jensen

    Citation: Arthritis Research & Therapy 2019 21:181

    Content type: Research article

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  38. The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.

    Authors: X. Guillot, N. Tordi, C. Laheurte, L. Pazart, C. Prati, P. Saas and D. Wendling

    Citation: Arthritis Research & Therapy 2019 21:180

    Content type: Research article

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  39. Comparison of two doses of bio-optimized Curcuma longa extract (BCL) in the management of symptomatic knee osteoarthritis (OA).

    Authors: Y. Henrotin, M. Malaise, R. Wittoek, K. de Vlam, J.-P. Brasseur, F. P. Luyten, Q. Jiangang, M. Van den Berghe, R. Uhoda, J. Bentin, T. De Vroey, L. Erpicum, A. F. Donneau and Y. Dierckxsens

    Citation: Arthritis Research & Therapy 2019 21:179

    Content type: Research article

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  40. A specific subset of psoriasis patients is characterized by subclinical inflammatory changes. These patients frequently present with arthralgia and have a higher risk to develop psoriatic arthritis (PsA). We h...

    Authors: Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2019 21:178

    Content type: Research article

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  41. The impact of smoking on TNF inhibition (TNFi) therapy is unclear. We examined the effect of smoking on all-cause and cause-specific TNFi discontinuation in axial spondyloarthritis (axSpA).

    Authors: Sizheng Steven Zhao, Kazuki Yoshida, Gareth T. Jones, David M. Hughes, Stephen J. Duffield, Sara K. Tedeschi, Houchen Lyu, Robert J. Moots, Daniel H. Solomon and Nicola J. Goodson

    Citation: Arthritis Research & Therapy 2019 21:177

    Content type: Research article

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  42. This study evaluates the utility of urinary pro-thrombotic molecules such as tissue factor (TF), anti-thrombotic molecules such as tissue factor pathway inhibitor (TFPI), and fibrinolytic molecules such as pla...

    Authors: Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena and Chandra Mohan

    Citation: Arthritis Research & Therapy 2019 21:176

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:185

  43. Primary Sjögren syndrome (pSS) is characterized by T and B cell infiltration of exocrine glands. The cysteine protease cathepsin S (CatS) is crucially involved in MHCII processing and T cell stimulation, and e...

    Authors: Patrick Hargreaves, Douglas Daoudlarian, Michel Theron, Fabrice A. Kolb, Marianne Manchester Young, Bernhard Reis, Andre Tiaden, Bettina Bannert, Diego Kyburz and Tobias Manigold

    Citation: Arthritis Research & Therapy 2019 21:175

    Content type: Research article

    Published on:

  44. Rheumatoid arthritis (RA) is known to cause secondary osteoporosis and fragility fractures. This study aimed to identify biomarkers predictive of bone mineral density (BMD) change at three anatomical sites in ...

    Authors: T. Tomizawa, H. Ito, K. Murata, M. Hashimoto, M. Tanaka, K. Murakami, K. Nishitani, M. Azukizawa, A. Okahata, K. Doi, M. Saito, M. Furu, M. Hamaguchi, T. Mimori and S. Matsuda

    Citation: Arthritis Research & Therapy 2019 21:174

    Content type: Research article

    Published on:

  45. To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials.

    Authors: ZeYu Huang, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen and Virginia Byers Kraus

    Citation: Arthritis Research & Therapy 2019 21:173

    Content type: Review

    Published on:

  46. Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in ...

    Authors: Andrew D. Eustace, Emily F. McNaughton, Sophie King, Oksana Kehoe, Andreas Kungl, Derek Mattey, Angela H. Nobbs, Neil Williams and Jim Middleton

    Citation: Arthritis Research & Therapy 2019 21:172

    Content type: Research article

    Published on:

  47. Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destructio...

    Authors: Fen Wang, Jijie Liu, Xiaolei Chen, Xinpeng Zheng, Ning Qu, Bing Zhang and Chun Xia

    Citation: Arthritis Research & Therapy 2019 21:171

    Content type: Research article

    Published on:

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