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  1. Research article

    A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRA®) to the reference product (Humira®) in patients with active rheumatoid arthritis

    This study aimed to compare efficacy and safety of test-adalimumab (CinnoRA®, CinnaGen, Iran) to the innovator product (Humira®, AbbVie, USA) in adult patients with active rheumatoid arthritis (RA).

    Ahmadreza Jamshidi, Farhad Gharibdoost, Mahdi Vojdanian, Soosan G. Soroosh, Mohsen Soroush, Arman Ahmadzadeh, Mohammad Ali Nazarinia, Mohammad Mousavi, Hadi Karimzadeh, Mohammad Reza Shakibi, Zahra Rezaieyazdi, Maryam Sahebari, Asghar Hajiabbasi, Ali Asghar Ebrahimi, Najmeh Mahjourian and Amin Mohammadinejad Rashti

    Arthritis Research & Therapy 2017 19:168

    Published on: 20 July 2017

  2. Research article

    Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously reported that C-X-C motif chemokine 10 (CXCL10; a...

    Jong-Ho Lee, Bongjun Kim, Won Jong Jin, Hong-Hee Kim, Hyunil Ha and Zang Hee Lee

    Arthritis Research & Therapy 2017 19:163

    Published on: 19 July 2017

  3. Research article

    Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

    Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of the joints, leading to bone erosion and joint dysfunction. Despite the recent successes of disease-modifying an...

    Susan MacLauchlan, Maria A. Zuriaga, José J. Fuster, Carla M. Cuda, Jennifer Jonason, Fernanda Behzadi, Jennifer Parker Duffen, G. Kenneth Haines III, Tamar Aprahamian, Harris Perlman and Kenneth Walsh

    Arthritis Research & Therapy 2017 19:166

    Published on: 19 July 2017

  4. Research article

    Impact of obesity on the response to tumor necrosis factor inhibitors in axial spondyloarthritis

    Few studies have investigated the impact of obesity on the response to tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim of our study was to investigate the impa...

    Raphael Micheroli, Monika Hebeisen, Lukas M. Wildi, Pascale Exer, Giorgio Tamborrini, Jürg Bernhard, Burkhard Möller, Pascal Zufferey, Michael J. Nissen, Almut Scherer and Adrian Ciurea

    Arthritis Research & Therapy 2017 19:164

    Published on: 19 July 2017

  5. Research article

    Sustained benefit from combined plasmapheresis and allogeneic mesenchymal stem cells transplantation therapy in systemic sclerosis

    Systemic sclerosis (SSc) is an autoimmune disease involving the skin and several internal organs. Most therapies available for this disease are symptomatic. Given the difficulty in treating SSc, we conducted t...

    Huayong Zhang, Jun Liang, Xiaojun Tang, Dandan Wang, Xuebing Feng, Fan Wang, Bingzhu Hua, Hong Wang and Lingyun Sun

    Arthritis Research & Therapy 2017 19:165

    Published on: 19 July 2017

  6. Commentary

    The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?

    Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primar...

    Marco Matucci-Cerinic, Mirko Manetti, Cosimo Bruni, Ines Chora, Silvia Bellando-Randone, Gemma Lepri, Amato De Paulis and Serena Guiducci

    Arthritis Research & Therapy 2017 19:162

    Published on: 6 July 2017

  7. Research article

    IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

    The Fc glycosylation of immunoglobulin G (IgG) is well known to associate with rheumatoid arthritis (RA) disease activity. The same may be true for other classes of Igs. In the present study, we sought to dete...

    Albert Bondt, Simone Nicolardi, Bas C. Jansen, T. Martijn Kuijper, Johanna M. W. Hazes, Yuri E. M. van der Burgt, Manfred Wuhrer and Radboud J. E. M. Dolhain

    Arthritis Research & Therapy 2017 19:160

    Published on: 5 July 2017

  8. Research article

    Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis

    The aim was to study changes in immunohistochemical expression markers of synovial and skin inflammation, clinical outcomes and magnetic resonance imaging (MRI) scores with abatacept treatment in patients with...

    Agnes Szentpetery, Eric Heffernan, Martina Gogarty, Lisa Mellerick, Janet McCormack, Muhammad Haroon, Musaab Elmamoun, Phil Gallagher, Genevieve Kelly, Aurelie Fabre, Brian Kirby and Oliver FitzGerald

    Arthritis Research & Therapy 2017 19:158

    Published on: 5 July 2017

  9. Research article

    Factors associated with initial or subsequent choice of biologic disease-modifying antirheumatic drugs for treatment of rheumatoid arthritis

    Biologic disease-modifying antirheumatic drugs (DMARDs) are increasingly used for rheumatoid arthritis (RA) treatment. However, little is known based on contemporary data about the factors associated with DMAR...

    Yinzhu Jin, Rishi J. Desai, Jun Liu, Nam-Kyong Choi and Seoyoung C. Kim

    Arthritis Research & Therapy 2017 19:159

    Published on: 5 July 2017

  10. Research article

    Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

    A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both t...

    Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky and André Struglics

    Arthritis Research & Therapy 2017 19:157

    Published on: 5 July 2017

  11. Research article

    Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

    Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease characterised by autoimmunity, vasculopathy and fibrosis. Gene expression profiling distinguishes scleroderma from normal skin,...

    Emma C. Derrett-Smith, Viktor Martyanov, Cecilia B. Chighizola, Pia Moinzadeh, Corrado Campochiaro, Korsa Khan, Tammara A. Wood, Pier Luigi Meroni, David J. Abraham, Voon H. Ong, Robert Lafyatis, Michael L. Whitfield and Christopher P. Denton

    Arthritis Research & Therapy 2017 19:156

    Published on: 4 July 2017

  12. Research article

    Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition

    Stringent remission criteria are crucial in rheumatoid arthritis (RA) assessment. Disease activity score in 28 joints (DAS28)-remission has not been included among American College of Rheumatology/European Lea...

    M. Schoels, F. Alasti, J. S. Smolen and D. Aletaha

    Arthritis Research & Therapy 2017 19:155

    Published on: 4 July 2017

  13. Research article

    Cardiovascular disease risk profiles in inflammatory joint disease entities

    Patients with inflammatory joint diseases (IJD) have increased risk of cardiovascular disease (CVD). Our aim was to compare CVD risk profiles in patients with IJD, including rheumatoid arthritis (RA), axial sp...

    Grunde Wibetoe, Eirik Ikdahl, Silvia Rollefstad, Inge C. Olsen, Kjetil Bergsmark, Tore K. Kvien, Anne Salberg, Dag Magnar Soldal, Gunnstein Bakland, Åse Lexberg, Bjørg-Tilde Fevang, Hans Christian Gulseth, Glenn Haugeberg and Anne Grete Semb

    Arthritis Research & Therapy 2017 19:153

    Published on: 3 July 2017

  14. Research article

    Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

    Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the therapeutic effect of a new s...

    Bo Ram Oh, Dong-hyeon Suh, Daekwon Bae, Nina Ha, Young Il Choi, Hyun Jung Yoo, Jin Kyun Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song

    Arthritis Research & Therapy 2017 19:154

    Published on: 3 July 2017

  15. Research article

    Fluorescence optical imaging and musculoskeletal ultrasonography in juvenile idiopathic polyarticular disease before and during antirheumatic treatment - a multicenter non-interventional diagnostic evaluation

    Valid detection of inflamed joints is essential for correct classification, therapeutic decisions, prognosis and assessment of treatment efficacy in juvenile idiopathic arthritis (JIA). Fluorescence optical im...

    Ariane Klein, Georg Werner Just, Stephanie Gabriele Werner, Prasad T. Oommen, Kirsten Minden, Ingrid Becker, Hans-Eckhard Langer, Dirk Klee and Gerd Horneff

    Arthritis Research & Therapy 2017 19:147

    Published on: 30 June 2017

  16. Research article

    Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles

    Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do n...

    Charlotte H. Hulme, Emma L. Wilson, Mandy J. Peffers, Sally Roberts, Deborah M. Simpson, James B. Richardson, Pete Gallacher and Karina T. Wright

    Arthritis Research & Therapy 2017 19:150

    Published on: 30 June 2017

  17. Review

    Animal models of rheumatoid pain: experimental systems and insights

    Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflam...

    Bradford D. Fischer, Adeshina Adeyemo, Michael E. O’Leary and Andrea Bottaro

    Arthritis Research & Therapy 2017 19:146

    Published on: 30 June 2017

  18. Commentary

    Rheumatology in the Middle East in 2017: clinical challenges and research

    The World Health Organization (WHO) has ranked musculoskeletal diseases among the top ten leading causes of disability in the Middle East. The situation in the Middle East is unique as, although seventeen coun...

    Abdulla Watad, Jamal Al-Saleh, Merav Lidar, Howard Amital and Yehuda Shoenfeld

    Arthritis Research & Therapy 2017 19:149

    Published on: 30 June 2017

  19. Research article

    Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study

    Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor a...

    Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello and Lorenzo Beretta

    Arthritis Research & Therapy 2017 19:145

    Published on: 20 June 2017

  20. Research article

    Work outcome in yet undiagnosed patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis; results of a cross-sectional study among patients with chronic low back pain

    To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain ...

    Lonneke van Hoeven, Annelies E. R. C. H. Boonen, Johanna M. W. Hazes and Angelique E. A. M. Weel

    Arthritis Research & Therapy 2017 19:143

    Published on: 17 June 2017

  21. Research article

    Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

    Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary f...

    Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick and Peter D. Katsikis

    Arthritis Research & Therapy 2017 19:144

    Published on: 17 June 2017

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