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  1. Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the periphe...

    Authors: Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus and Jordi Monfort
    Citation: Arthritis Research & Therapy 2022 24:252
  2. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13075-022-02950-3.

    Authors: Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li and Shuanke Wang
    Citation: Arthritis Research & Therapy 2022 24:250
  3. Macrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the r...

    Authors: Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen and Wenjie Zheng
    Citation: Arthritis Research & Therapy 2022 24:249

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:275

  4. Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:248

    The original article was published in Arthritis Research & Therapy 2022 24:155

  5. The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage in arthritic rats. The aim...

    Authors: Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao and Caihong Zheng
    Citation: Arthritis Research & Therapy 2022 24:247
  6. Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espirito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:246

    The original article was published in Arthritis Research & Therapy 2022 24:245

  7. We read with great interest the article by Hein et al., which described the meta-analysis study on the impact of disease-modifying anti-rheumatic drugs (DMARDs) therapy on skeletal muscle mass in rheumatoid ar...

    Authors: Hiroto Minamino, Mie Torii, Masao Katsushima, Yoshihito Fujita and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:245

    The original article was published in Arthritis Research & Therapy 2022 24:171

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:246

  8. Authors: Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
    Citation: Arthritis Research & Therapy 2022 24:244

    The original article was published in Arthritis Research & Therapy 2005 7:R1158

  9. Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.

    Authors: Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu and Chang-Fu Kuo
    Citation: Arthritis Research & Therapy 2022 24:243
  10. Clustering is an important clinical feature of Behçet’s syndrome (BS) and may have pathogenetic and therapeutic implications. Recent and previous studies on BS phenotype differ substantially in terms of method...

    Authors: Ufuk İlgen
    Citation: Arthritis Research & Therapy 2022 24:242
  11. In patients with tracheobronchial involvement, the differential diagnosis between granulomatosis with polyangiitis (GPA) and relapsing polychondritis (RP) can be challenging. The aim of this study was to descr...

    Authors: Carole Jalaber, Xavier Puéchal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel and Guillaume Chassagnon
    Citation: Arthritis Research & Therapy 2022 24:241
  12. We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immuno...

    Authors: Masanobu Ueno, Ippei Miyagawa, Yusuke Miyazaki, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:240
  13. Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang
    Citation: Arthritis Research & Therapy 2022 24:239

    The original article was published in Arthritis Research & Therapy 2022 24:237

  14. With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great apprecia...

    Authors: Zhenqian Wang and Jiawen Lu
    Citation: Arthritis Research & Therapy 2022 24:237

    The original article was published in Arthritis Research & Therapy 2021 23:108

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:239

  15. Endothelial dysfunction contributes to increased cardiovascular (CV) disease in rheumatoid arthritis (RA). Angiogenic T cells (Tang) are a key regulator of vascular function via their interaction with endothel...

    Authors: Giacomo Cafaro, Eleonora Petito, Onelia Bistoni, Emanuela Falcinelli, Sabrina Cipriani, Maria Chiara Borghi, Angelo F. Bonifacio, Elisa Giglio, Alessia Alunno, Carlo Perricone, Roberto Gerli, Paolo Gresele and Elena Bartoloni
    Citation: Arthritis Research & Therapy 2022 24:236
  16. Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 ...

    Authors: Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi and Shigeru Miyaki
    Citation: Arthritis Research & Therapy 2022 24:235
  17. Abnormal proliferation of fibroblast-like synoviocytes (FLSs) in the synovial lining layer is the primary cause of synovial hyperplasia and joint destruction in rheumatoid arthritis (RA). Currently, the relati...

    Authors: Ying Lu, Chongbo Hao, Shanshan Yu, Zuan Ma, Xuelian Fu, Mingqing Qin, Menglei Ding, Zengguang Xu and Lieying Fan
    Citation: Arthritis Research & Therapy 2022 24:234
  18. The purpose of this study was to stratify patients with rheumatoid arthritis (RA) according to the trend of disease activity by trajectory-based clustering and to identify contributing factors for treatment re...

    Authors: Bon San Koo, Seongho Eun, Kichul Shin, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Ji Seon Oh
    Citation: Arthritis Research & Therapy 2022 24:233
  19. To evaluate the impact of cardiovascular risk (CVR) on the diagnostic accuracy of the ultrasonographic (US) Halo Score in patients with suspected giant cell arteritis (GCA).

    Authors: Juan Molina-Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Julia Martínez-Barrio, Ana M. Anzola Alfaro, Javier Rivera and José María Álvaro-Gracia
    Citation: Arthritis Research & Therapy 2022 24:232
  20. Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in ...

    Authors: Dawit T. Zemedikun, Helena Lee, Krishnarajah Nirantharakumar, Karim Raza, Joht Singh Chandan, Janet M. Lord and Thomas A. Jackson
    Citation: Arthritis Research & Therapy 2022 24:231
  21. Rheumatoid arthritis (RA) is characterized by the presence of disease-specific autoreactive B cell responses, in particular those generating anti-citrullinated protein antibodies (ACPA). For many years, Epstei...

    Authors: Sanne Kroos, Arieke S. B. Kampstra, René E. M. Toes, Linda M. Slot and Hans U. Scherer
    Citation: Arthritis Research & Therapy 2022 24:230
  22. Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polyge...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang and Shun-Jen Chang
    Citation: Arthritis Research & Therapy 2022 24:229
  23. Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of ...

    Authors: Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2022 24:228
  24. X-ray images are commonly used to assess the bone destruction of rheumatoid arthritis. The purpose of this study is to propose an automatic-bone-destruction-evaluation system fully utilizing deep neural networ...

    Authors: Kazuki Miyama, Ryoma Bise, Satoshi Ikemura, Kazuhiro Kai, Masaya Kanahori, Shinkichi Arisumi, Taisuke Uchida, Yasuharu Nakashima and Seiichi Uchida
    Citation: Arthritis Research & Therapy 2022 24:227
  25. To detect dorsally located osteophytes (OP) on lateral x-ray views and to correlate their presence with the extent of structural joint damage, determined by histologic grading (cartilage damage and synovial in...

    Authors: Ilse-Gerlinde Sunk, Love Amoyo-Minar, Birgit Niederreiter, Afschin Soleiman, Franz Kainberger, Josef S. Smolen, Daniel Aletaha and Klaus Bobacz
    Citation: Arthritis Research & Therapy 2022 24:226
  26. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease progression are not well described. Previous studies demonstrated that rh...

    Authors: Megan M. Simonds, Kathleen E. Sullivan and AnneMarie C. Brescia
    Citation: Arthritis Research & Therapy 2022 24:225
  27. Authors: Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:224

    The original article was published in Arthritis Research & Therapy 2022 24:45

  28. Subchondral bone plays an important role in the pathogenesis of radiographic osteoarthritis (OA). However, the bony changes that occur in hand OA (HOA) are much less understood. This study aimed to describe th...

    Authors: Canchen Ma, Dawn Aitken, Feitong Wu, Kathryn Squibb, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2022 24:223
  29. Rheumatoid arthritis (RA) patients present with abnormal methylation patterns in their fibroblast-like synoviocytes (FLS). Given that DNA demethylation is critical for producing DNA methylation patterns, we hy...

    Authors: Akio Kawabe, Kaoru Yamagata, Shigeaki Kato, Kazuhisa Nakano, Kei Sakata, Yu-ichi Tsukada, Koichiro Ohmura, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:222
  30. Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS), a type of autologous anti-inflammatory orthobiolo...

    Authors: Alexis N. Peña, Sven D. Sommerfeld, Amy E. Anderson, Jin Han, David R. Maestas Jr, Joscelyn C. Mejias, Jennifer Woodell-May, William King, Sudipto Ganguly and Jennifer H. Elisseeff
    Citation: Arthritis Research & Therapy 2022 24:221
  31. The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease. The aim was to compare the...

    Authors: Mélissa Noack and Pierre Miossec
    Citation: Arthritis Research & Therapy 2022 24:220
  32. Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction an...

    Authors: Andrea Péter, Ágnes Balogh, Zoltán Csanádi, Katalin Dankó and Zoltan Griger
    Citation: Arthritis Research & Therapy 2022 24:219
  33. Pain is the main concern of patients with rheumatoid arthritis (RA) while reducing disease activity dominates specialist management. Disease activity assessments like the disease activity score for 28 joints w...

    Authors: Fowzia Ibrahim, Margaret Ma, David L. Scott and Ian C. Scott
    Citation: Arthritis Research & Therapy 2022 24:218
  34. To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.

    Authors: Tianxiang Fan, Shibo Chen, Muhui Zeng, Jia Li, Xiaoshuai Wang, Guangfeng Ruan, Peihua Cao, Yan Zhang, Tianyu Chen, Qianhua Ou, Qianyi Wang, Anita E. Wluka, Flavia Cicuttini, Changhai Ding and Zhaohua Zhu
    Citation: Arthritis Research & Therapy 2022 24:217
  35. Osteoarthritis (OA) is a chronic degenerative joint disease. Extracellular matrix (ECM) degradation is essential for OA progression. Previous studies have shown that circular RNAs (circRNAs) are involved in th...

    Authors: Wenzhong Que, Huili Liu and Qinqin Yang
    Citation: Arthritis Research & Therapy 2022 24:216
  36. Fibroblasts are important structural cells in synovium and play key roles in maintaining the synovial homeostasis. By single-cell RNA sequencing (scRNA-seq), subpopulation of synovium-resident cells has been r...

    Authors: Nachun Chen, Baoying Fan, Zhiyong He, Xinping Yu and Jinjun Wang
    Citation: Arthritis Research & Therapy 2022 24:215
  37. To identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore whether there are other ways to affect the progression of IDD.

    Authors: Zhenyu Wang, Yuguang Zhao, Yi Liu, Zhigang Qu, Xinming Zhuang, Qingxu Song, Haoyu Li and Jiali Leng
    Citation: Arthritis Research & Therapy 2022 24:214
  38. Patients with immune thrombocytopenia (ITP) have a risk of developing systemic lupus erythematosus (SLE). We sought to examine the clinical characteristics of patients with primary ITP who later developed SLE ...

    Authors: Soo Min Ahn, Eun-Ji Choi, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong
    Citation: Arthritis Research & Therapy 2022 24:213
  39. Tophi are lesions commonly present at sites of bone erosion in gout-affected joints. The tophus comprises a core of monosodium urate (MSU) crystals surrounded by soft tissue that contains macrophages and other...

    Authors: Dorit Naot, Bregina Pool, Ashika Chhana, Ryan Gao, Jacob T. Munro, Jillian Cornish and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2022 24:212
  40. Systemic lupus erythematosus (SLE) is a disease that can lead to damage of multiple organs and, along with certain treatments, increase the risk of developing cancer, cardiovascular disease, diabetes, osteopor...

    Authors: Baptiste Chevet, Gabriel Figueroa-Parra, Jeffrey X. Yang, Mehmet Hocaoglu, Shirley-Ann Osei-Onomah, Cassondra A. Hulshizer, Tina M. Gunderson, Divi Cornec, Kamil E. Barbour, Kurt J. Greenlund, Cynthia S. Crowson and Alí Duarte-García
    Citation: Arthritis Research & Therapy 2022 24:211
  41. Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose of this study is to investigate the potential of dersimelagon, a novel oral MC1R ag...

    Authors: Masahiro Kondo, Tsuyoshi Suzuki, Yuko Kawano, Shinji Kojima, Masahiko Miyashiro, Atsuhiro Matsumoto, Gabriela Kania, Przemysław Błyszczuk, Rebecca L. Ross, Panji Mulipa, Francesco Del Galdo, Yun Zhang and Jörg H. W. Distler
    Citation: Arthritis Research & Therapy 2022 24:210
  42. Recently, a novel humanized mouse model for systemic sclerosis (SSc) was established by transferring peripheral blood mononuclear cells (PBMC) from patients with SSc to Rag2−/−Il2rg−/− immunodeficient mice. Here,...

    Authors: Yaqing Shu, Xiaoyang Yue, Jacqueline Wax, Brigitte Kasper, Junping Yin, Xiaoqing Wang, Liang Zhang, Marjan Ahmadi, Harald Heidecke, Antje Müller, Peter Lamprecht, Xinhua Yu, Gabriela Riemekasten and Frank Petersen
    Citation: Arthritis Research & Therapy 2022 24:209
  43. Publications suggest immunomodulation co-therapy improves responder rates in uncontrolled/refractory gout patients undergoing pegloticase treatment. The MIRROR open-label trial showed a 6-month pegloticase + m...

    Authors: John K. Botson, John R. P. Tesser, Ralph Bennett, Howard M. Kenney, Paul M. Peloso, Katie Obermeyer, Yang Song, Brian LaMoreaux, Lin Zhao, Yan Xin, Jason Chamberlain, Srini Ramanathan, Michael E. Weinblatt and Jeff Peterson
    Citation: Arthritis Research & Therapy 2022 24:208
  44. Anemia is common in patients with rheumatoid arthritis (RA). Higher hemoglobin (Hb) levels may be associated with better clinical outcomes and patient-reported outcomes (PROs). To assess this hypothesis, we co...

    Authors: Andrea Rubbert-Roth, Daniel E. Furst, Stefano Fiore, Amy Praestgaard, Vivian Bykerk, Clifton O. Bingham, Christina Charles-Schoeman and Gerd Burmester
    Citation: Arthritis Research & Therapy 2022 24:207

    The Research to this article has been published in Arthritis Research & Therapy 2022 24:276

  45. Rheumatoid arthritis (RA) is a chronic autoimmune disease for which prediction of long-term prognosis from disease’s outset is not clinically feasible. The importance of immunoglobulin G (IgG) and its Fc N-glycos...

    Authors: Thomas Sénard, Irini Flouri, Frano Vučković, Garyfalia Papadaki, Panagiota Goutakoli, Aggelos Banos, Maja Pučić-Baković, Marija Pezer, George Bertsias, Gordan Lauc and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2022 24:206
  46. Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for predicting protrusion reabsorption are still unclear, which pr...

    Authors: Pengfei Yu, Feng Mao, Jingyun Chen, Xiaoying Ma, Yuxiang Dai, Guanhong Liu, Feng Dai and Jingtao Liu
    Citation: Arthritis Research & Therapy 2022 24:205
  47. This study investigated the characteristics of hypertrophic pachymeningitis (HP) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), using information from a multicenter study in Japan.

    Authors: Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Takashi Kida, Nobuyuki Yajima, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo…
    Citation: Arthritis Research & Therapy 2022 24:204
  48. To investigate the association between psychosocial vulnerability, defined as either low social support or low decision latitude at work, and disease remission at 3, 12, and 60 months in patients with rheumato...

    Authors: Louise Hedenstierna, Anna Karin Hedström, Lars Klareskog, Daniela Di Giuseppe, Lars Alfredsson, Johan Askling, Sofia Ernestam, Saedis Saevarsdottir and Lotta Ljung
    Citation: Arthritis Research & Therapy 2022 24:203
  49. To compare cardiovascular disease (CVD) rates in rheumatoid arthritis (RA) beneficiaries of the Social Security Disability Insurance (SSDI) with commercially insured RA patients.

    Authors: Iris Navarro-Millán, Fenglong Xie, Cynthia S. Crowson, Monika M. Safford, Mangala Rajan, Sebastian E. Sattui and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2022 24:202

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