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  1. Content type: Research article

    To investigate the association between the extent of tapering tumor necrosis factor inhibitor (TNFi) and the likelihood of achieving inactive disease in patients with axial spondyloarthritis (axSpA)

    Authors: Jun Won Park, Hyoun-Ah Kim, Kichul Shin, Yong-Beom Park, Tae-Hwan Kim, Yeong Wook Song and Eun Young Lee

    Citation: Arthritis Research & Therapy 2019 21:163

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  2. Content type: Research article

    To address whether the use of methotrexate (MTX) and biological disease-modifying anti-rheumatic drugs (bDMARDs) impacts bone structure and biomechanical properties in patients with psoriatic arthritis (PsA).

    Authors: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2019 21:162

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  3. Content type: Research article

    Thrombocytopenia is a manifestation associated with primary antiphospholipid syndrome (PAPS), and many studies have stressed the leading role played by platelets in the pathogenesis of antiphospholipid syndrom...

    Authors: C. Barbati, L. Stefanini, T. Colasanti, E. Cipriano, A. Celia, G. Gabriele, M. Vomero, F. Ceccarelli, F. R. Spinelli, A. Finucci, M. Speziali, G. Orso, D. P. E. Margiotta, F. Conti, F. Violi, A. Afeltra…

    Citation: Arthritis Research & Therapy 2019 21:161

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  4. Content type: Research article

    To examine the feasibility, preference, and satisfaction of an interactive voice response (IVR) system versus a customized smartphone application (StudyBuddy) to capture gout flares

    Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, David Redden, Lang Chen, Cooper Filby, Jeffrey R. Curtis, Ted R. Mikuls and Kenneth G. Saag

    Citation: Arthritis Research & Therapy 2019 21:160

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  5. Content type: Research article

    Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The prostaglandin E2 receptor EP2/EP4 signaling...

    Authors: Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqué, Schafiq Nabhani and David M. Kofler

    Citation: Arthritis Research & Therapy 2019 21:159

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  6. Content type: Research article

    People with hand-related rheumatoid arthritis (RA) experience problems performing activities of daily living (ADL). Compensatory strategies to improve ADL ability have shown effective. Similarly, hand exercise...

    Authors: Karen Ellegaard, Cecilie von Bülow, Alice Røpke, Cecilie Bartholdy, Inge Skovby Hansen, Signe Rifbjerg-Madsen, Marius Henriksen and Eva Ejlersen Wæhrens

    Citation: Arthritis Research & Therapy 2019 21:158

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  7. Content type: Research article

    Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which ...

    Authors: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge and Sandra G. Heil

    Citation: Arthritis Research & Therapy 2019 21:157

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  8. Content type: Research article

    GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arth...

    Authors: Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune and Jessica B. Duis

    Citation: Arthritis Research & Therapy 2019 21:156

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  9. Content type: Research article

    Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and ...

    Authors: Abena A. Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard and Hannah L. F. Cooper

    Citation: Arthritis Research & Therapy 2019 21:155

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  10. Content type: Research article

    Our objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA).

    Authors: L. K. Brekke, B.-T. S. Fevang, A. P. Diamantopoulos, J. Assmus, E. Esperø and C. G. Gjesdal

    Citation: Arthritis Research & Therapy 2019 21:154

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  11. Content type: Research article

    Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats—suggesting it may be a potent drug for rheumatoid arthritis (RA) t...

    Authors: Jian-Da Ma, Jun Jing, Jun-Wei Wang, Tao Yan, Qian-Hua Li, Ying-Qian Mo, Dong-Hui Zheng, Jin-Long Gao, Ky-Anh Nguyen and Lie Dai

    Citation: Arthritis Research & Therapy 2019 21:153

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  12. Content type: Research article

    The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become recognized by their incorporation into the 2013 ACR/EULAR classification criteria. Clear prognostic and phenotypic association...

    Authors: Claudio Corallo, Sara Cheleschi, Maurizio Cutolo, Stefano Soldano, Antonella Fioravanti, Nila Volpi, Daniela Franci, Ranuccio Nuti and Nicola Giordano

    Citation: Arthritis Research & Therapy 2019 21:152

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  13. Content type: Research article

    Tumor necrosis factor (TNF) inhibitors (TNF-i) are effective in the treatment of entero-Behcet’s disease (BD). However, there is no objective tool for assessment of disease activity in entero-BD; therefore, it...

    Authors: Ippei Miyagawa, Kazuhisa Nakano, Shigeru Iwata, Shingo Nakayamada, Kazuyoshi Saito, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Akio Kawabe, Yusuke Miyazaki and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2019 21:151

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  14. Content type: Research article

    Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent va...

    Authors: Nicola Dalbeth, Christopher Frampton, Maple Fung, Scott Baumgartner, Savvas Nicolaou and Hyon K. Choi

    Citation: Arthritis Research & Therapy 2019 21:150

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  15. Content type: Research article

    Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic an...

    Authors: Colin Shepherd, Abigail E. Reese, Louise N. Reynard and John Loughlin

    Citation: Arthritis Research & Therapy 2019 21:149

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  16. Content type: Research article

    Sensory disturbances in fibromyalgia extend beyond nociception. It has been proposed that imbalance in the mutual competition between painful input and non-painful sensory activity may, to a significant extent...

    Authors: Jesus Pujol, Daniel Ramos-López, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort and Joan Deus

    Citation: Arthritis Research & Therapy 2019 21:148

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  17. Content type: Research article

    To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin...

    Authors: John A. Reynolds, Tracy A. Briggs, Gillian I. Rice, Sathya Darmalinggam, Vincent Bondet, Ellen Bruce, Mumtaz Khan, Sahena Haque, Hector Chinoy, Ariane L. Herrick, Eoghan M. McCarthy, Leo Zeef, Andrew Hayes, Darragh Duffy, Ben Parker and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2019 21:147

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  18. Content type: Research article

    Obesity is a leading risk factor for osteoarthritis (OA). In contrast, calorie restriction (CR) may lessen OA due to improved systemic inflammatory status and reduced weight-bearing. The aim of this study was ...

    Authors: Lauren B. Radakovich, Angela J. Marolf, Lauren A. Culver and Kelly S. Santangelo

    Citation: Arthritis Research & Therapy 2019 21:145

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  19. Content type: Research article

    Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblast...

    Authors: Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa Hülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner and Elena Neumann

    Citation: Arthritis Research & Therapy 2019 21:144

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  20. Content type: Research article

    Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no...

    Authors: Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter and Philip S. Low

    Citation: Arthritis Research & Therapy 2019 21:143

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  21. Content type: Research article

    The aim of this study was to compare radiographic progression in patients with ankylosing spondylitis (AS) treated for up to 2 years with secukinumab (MEASURE 1) with a historical cohort of biologic-naïve pati...

    Authors: J. Braun, H. Haibel, M. de Hooge, R. Landewé, M. Rudwaleit, T. Fox, A. Readie, H. B. Richards, B. Porter, R. Martin, D. Poddubnyy, J. Sieper and D. van der Heijde

    Citation: Arthritis Research & Therapy 2019 21:142

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  22. Content type: Research article

    To assess the risks of malignancies, infections and autoimmune diseases in patients with rheumatoid arthritis (RA) treated with abatacept compared with other biologic (b) disease-modifying antirheumatic drugs ...

    Authors: Gulsen Ozen, Sofia Pedro, Rebecca Schumacher, Teresa A. Simon and Kaleb Michaud

    Citation: Arthritis Research & Therapy 2019 21:141

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  23. Content type: Research article

    To describe the disease course of patients with early arthritis without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort. To determine baseline predictors of ...

    Authors: Gaël Mouterde, Nathalie Rincheval, Cédric Lukas, Claire Daien, Alain Saraux, Philippe Dieudé, Jacques Morel and Bernard Combe

    Citation: Arthritis Research & Therapy 2019 21:140

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  24. Content type: Research article

    (a) To describe the prevalence and incidence of peripheral arthritis during 5 years of follow-up in recent axial spondyloarthritis (axSpA), (b) to evaluate factors associated with their appearance and (c) to a...

    Authors: Clementina López-Medina, Maxime Dougados, Adeline Ruyssen-Witrand and Anna Moltó

    Citation: Arthritis Research & Therapy 2019 21:139

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  25. Content type: Research article

    Treatment persistence is an important consideration when selecting a therapy for chronic conditions such as rheumatoid arthritis (RA). We assessed the long-term persistence of abatacept or a tumor necrosis fac...

    Authors: Denis Choquette, Louis Bessette, Evo Alemao, Boulos Haraoui, Roelien Postema, Jean-Pierre Raynauld and Louis Coupal

    Citation: Arthritis Research & Therapy 2019 21:138

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  26. Content type: Research article

    Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the clinical distinction between HA20 and Behçet’s disease (BD...

    Authors: Naomi Tsuchida, Yohei Kirino, Yutaro Soejima, Masafumi Onodera, Katsuhiro Arai, Eiichiro Tamura, Takashi Ishikawa, Toshinao Kawai, Toru Uchiyama, Shigeru Nomura, Daisuke Kobayashi, Masataka Taguri, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake…

    Citation: Arthritis Research & Therapy 2019 21:137

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  27. Content type: Research article

    Activated T and B cells participate in the development and progression of Sjögren’s syndrome (SS). Metformin, a first-line anti-diabetic drug, exerts anti-inflammatory and immunomodulatory effects by activatin...

    Authors: Ji-Won Kim, Sung-Min Kim, Jin-Sil Park, Sun-Hee Hwang, JeongWon Choi, Kyung-Ah Jung, Jun-Geol Ryu, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Arthritis Research & Therapy 2019 21:136

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  28. Content type: Review

    The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have p...

    Authors: Daniel E. Furst and James S. Louie

    Citation: Arthritis Research & Therapy 2019 21:135

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  29. Content type: Research article

    We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is k...

    Authors: Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu and Yusheng Qiu

    Citation: Arthritis Research & Therapy 2019 21:134

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  30. Content type: Review

    Advances in genomic technology have enabled a greater understanding of the genetics of common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory bowel disease (IBD) and psoriasis. The s...

    Authors: Jessica M. Whyte, Jonathan J. Ellis, Matthew A. Brown and Tony J. Kenna

    Citation: Arthritis Research & Therapy 2019 21:133

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  31. Content type: Research article

    There is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and...

    Authors: Charlotte Proudman, Susan E. Lester, David A. Gonzalez-Chica, Tiffany K. Gill, Nicola Dalbeth and Catherine L. Hill

    Citation: Arthritis Research & Therapy 2019 21:132

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  32. Content type: Research

    Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients with T cell lymphopenia are more susceptible to life-threatening infections. However, the pathogenesi...

    Authors: Lu Zhang, Qisheng Xia, Wenli Li, Qinglin Peng, Hanbo Yang, Xin Lu and Guochun Wang

    Citation: Arthritis Research & Therapy 2019 21:131

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  33. Content type: Research article

    Sandoz etanercept (SDZ ETN; GP2015) is an etanercept biosimilar with equivalent efficacy and comparable safety and immunogenicity to reference etanercept (ETN) in patients with moderate-to-severe chronic plaqu...

    Authors: Janusz Jaworski, Marco Matucci-Cerinic, Hendrik Schulze-Koops, Maya H. Buch, Eugeniusz J. Kucharz, Yannick Allanore, Arthur Kavanaugh, Philip Young and Goran Babic

    Citation: Arthritis Research & Therapy 2019 21:130

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  34. Content type: Research article

    Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc). Here, we firstly investigated the correlation between skin ...

    Authors: Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shunsuke Miura, Tetsuo Toyama, Asako Yoshizaki, Hayakazu Sumida, Yoshihide Asano, Koji Oba and Shinichi Sato

    Citation: Arthritis Research & Therapy 2019 21:129

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  35. Content type: Research article

    There is substantial evidence that patients with ankylosing spondylitis (AS) have high response rates to tumour necrosis factor inhibitors (TNFi), a low likelihood of successful treatment termination, but yet ...

    Authors: Ulf Lindström, Tor Olofsson, Sara Wedrén, Ilia Qirjazo and Johan Askling

    Citation: Arthritis Research & Therapy 2019 21:128

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  36. Content type: Research article

    To examine whether metformin use was associated with knee cartilage volume loss over 4 years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.

    Authors: Yuanyuan Wang, Sultana Monira Hussain, Anita E. Wluka, Yuan Z. Lim, François Abram, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Flavia M. Cicuttini

    Citation: Arthritis Research & Therapy 2019 21:127

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  37. Content type: Research article

    To evaluate the performance of the extended modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) incorporating information from anteroposterior (AP) lumbar radiographs as compared to the conventional mSA...

    Authors: Maria Llop, Valeria Rios Rodriguez, Imke Redeker, Joachim Sieper, Hildrun Haibel, Martin Rudwaleit and Denis Poddubnyy

    Citation: Arthritis Research & Therapy 2019 21:126

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  38. Content type: Research article

    To describe the 6-year safety and efficacy of etanercept (ETN) in children with extended oligoarticular juvenile idiopathic arthritis (eoJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA)

    Authors: Ivan Foeldvari, Tamàs Constantin, Jelena Vojinović, Gerd Horneff, Vyacheslav Chasnyk, Joke Dehoorne, Violeta Panaviene, Gordana Sušić, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Irina Nikishina, Brigitte Bader-Meunier, Luciana Breda, Pavla Doležalová…

    Citation: Arthritis Research & Therapy 2019 21:125

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  39. Content type: Research article

    Infrapatellar fat pad (IFP) has recently emerged as a potential source of inflammation in knee arthropathies. It has been proposed to be one source of adipocytokines, fatty acids (FA), and FA-derived lipid med...

    Authors: Anne-Mari Mustonen, Reijo Käkelä, Petri Lehenkari, Johanna Huhtakangas, Sanna Turunen, Antti Joukainen, Tommi Kääriäinen, Tommi Paakkonen, Heikki Kröger and Petteri Nieminen

    Citation: Arthritis Research & Therapy 2019 21:124

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  40. Content type: Research article

    Numerous preclinical studies have revealed a critical role of cysteine-rich 61 (Cyr61) in the pathogenesis of rheumatoid arthritis (RA). But there is little literature discussing the clinical value of circulat...

    Authors: Yong Fan, Xinlei Yang, Juan Zhao, Xiaoying Sun, Wenhui Xie, Yanrong Huang, Guangtao Li, Yanjie Hao and Zhuoli Zhang

    Citation: Arthritis Research & Therapy 2019 21:123

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  41. Content type: Research article

    To evaluate the long-term efficacy, safety and immunogenicity of continuing LBEC0101; the etanercept (ETN) biosimilar; or switching from the ETN reference product (RP) to LBEC0101 in patients with rheumatoid a...

    Authors: Min-Chan Park, Hiroaki Matsuno, Jinseok Kim, Sung-Hwan Park, Sang-Heon Lee, Yong-Beom Park, Yun Jong Lee, Sang-Il Lee, Won Park, Dong Hyuk Sheen, Jung-Yoon Choe, Chan-Bum Choi, Seung-Jae Hong, Chang-Hee Suh, Shin-Seok Lee, Hoon-Suk Cha…

    Citation: Arthritis Research & Therapy 2019 21:122

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  42. Content type: Research article

    Disease-modifying antirheumatic drug (DMARD)-free remission, the sustained absence of synovitis after DMARD cessation, is increasingly achievable, especially in autoantibody-negative rheumatoid arthritis (RA)....

    Authors: Debbie M. Boeters, Leonie E. Burgers, Eric H. Sasso, Tom W. J. Huizinga and Annette H. M. van der Helm – van Mil

    Citation: Arthritis Research & Therapy 2019 21:121

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  43. Content type: Research article

    Conditioned pain modulation (CPM) is impaired in people with chronic pain such as knee osteoarthritis (KOA). The purpose of this randomized, controlled clinical trial was to investigate whether strong electroa...

    Authors: Zheng-tao Lv, Lin-lin Shen, Bing Zhu, Zhao-qing Zhang, Chao-yang Ma, Guo-fu Huang, Jing Yin, Ling-ling Yu, Si-yi Yu, Ming-qiao Ding, Jing Li, Xiao-cui Yuan, Wei He, Xiang-hong Jing and Man Li

    Citation: Arthritis Research & Therapy 2019 21:120

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  44. Content type: Research article

    To assess increased sacroiliac joint (SIJ) uptake on 18F-NaF PET/CT and to compare with MRI for inflammation and with CT scan for structural damages in a population of 23 patients with spondyloarthritis (SpA).

    Authors: Marie Raynal, Fehd Bouderraoui, Remy Ouichka, Julian Melchior, Olivier Morel, Alain Blum, Isabelle Chary-Valckenaere, Willy Ngueyon Sime, Véronique Roch, Walter Maksymowych, Robert G. Lambert, Pierre Olivier and Damien Loeuille

    Citation: Arthritis Research & Therapy 2019 21:119

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  45. Content type: Research article

    The efficacy and safety of apremilast were assessed in patients with psoriatic arthritis (PsA) in three phase III clinical trials with similar designs (PALACE 1, 2, and 3).

    Authors: Arthur Kavanaugh, Dafna D. Gladman, Christopher J. Edwards, Georg Schett, Benoit Guerette, Nikolay Delev, Lichen Teng, Maria Paris and Philip J. Mease

    Citation: Arthritis Research & Therapy 2019 21:118

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  46. Content type: Research article

    Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegat...

    Authors: Stefano Alivernini, Dario Bruno, Barbara Tolusso, Laura Bui, Luca Petricca, Maria Rita Gigante, Domenico Birra, Anna Laura Fedele, Giusy Peluso, Francesco Federico, Gianfranco Ferraccioli and Elisa Gremese

    Citation: Arthritis Research & Therapy 2019 21:116

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  47. Content type: Research article

    To study the impact of treatment strategy on achieving and sustaining disease-modifying antirheumatic drug (DMARD)-free remission in patients with rheumatoid arthritis (RA).

    Authors: L. E. Burgers, J. A. van der Pol, T. W. J. Huizinga, C. F. Allaart and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2019 21:115

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  48. Content type: Correction

    Following publication of the original article [1], the authors noticed that two corrections were not implemented during the production process.

    Authors: Kosuke Ebina, Motomu Hashimoto, Wataru Yamamoto, Toru Hirano, Ryota Hara, Masaki Katayama, Akira Onishi, Koji Nagai, Yonsu Son, Hideki Amuro, Keiichi Yamamoto, Yuichi Maeda, Koichi Murata, Sadao Jinno, Tohru Takeuchi, Makoto Hirao…

    Citation: Arthritis Research & Therapy 2019 21:114

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    The original article was published in Arthritis Research & Therapy 2019 21:91

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