Skip to main content

Articles

Page 2 of 137

  1. Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains ...

    Authors: Kieran Murray, Matthew Turk, Yousef Alammari, Francis Young, Phil Gallagher, Tajvur Saber, Ursula Fearon and Douglas J. Veale

    Citation: Arthritis Research & Therapy 2021 23:25

    Content type: Research article

    Published on:

  2. Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, whic...

    Authors: Chunyi Zhang, Congcong Gao, Xueqi Di, Siwan Cui, Wenfang Liang, Wenbo Sun, Menghui Yao, Shengyun Liu and Zhaohui Zheng

    Citation: Arthritis Research & Therapy 2021 23:24

    Content type: Research article

    Published on:

  3. Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are c...

    Authors: Wenchao Zhang, Lin Qi, Ruiqi Chen, Jieyu He, Zhongyue Liu, Wanchun Wang, Chao Tu and Zhihong Li

    Citation: Arthritis Research & Therapy 2021 23:23

    Content type: Review

    Published on:

  4. Systemic sclerosis starts with an early phase characterized by Raynaud’s phenomenon, puffy fingers/hands, autoantibodies, and a scleroderma nailfold microscopic pattern. Alterations in the nailfold microscopic...

    Authors: Khalid Daoudi, Brigit E. Kersten, Cornelia H. M. van den Ende, Frank H. J. van den Hoogen, Madelon C. Vonk and Chris L. de Korte

    Citation: Arthritis Research & Therapy 2021 23:22

    Content type: Research article

    Published on:

  5. Systemic sclerosis (SSc) is an acquired autoimmune disorder characterized by excessive accumulation of collagen and progressive tissue fibrosis. Although interstitial lung disease (ILD) complicates the majorit...

    Authors: Yiqun Li, Jing Huang, Chaojun Hu, Jiaxin Zhou, Dong Xu, Yong Hou, Chanyuan Wu, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng, Changzheng Liu, Qian Wang and Yan Zhao

    Citation: Arthritis Research & Therapy 2021 23:21

    Content type: Research article

    Published on:

  6. Scarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case-control study aims to survey the prevalence of scarring alopecia during the ...

    Authors: Yirong Xiang, Mengtao Li, Hui Luo, Yanhong Wang, Xinwang Duan, Cheng Zhao, Feng Zhan, Zhenbiao Wu, Hongbin Li, Min Yang, Jian Xu, Wei Wei, Lijun Wu, Hanxiao You, Junyan Qian, Xiaoxi Yang…

    Citation: Arthritis Research & Therapy 2021 23:20

    Content type: Research article

    Published on:

  7. Mixed connective tissue disease (MCTD) is a rare condition that is distinguished by the presence of specific U1-RNP antibodies. Information about its etiopathology and diagnostics is still unclear. miRNAs such...

    Authors: Barbara Stypińska, Aleksandra Lewandowska, Anna Felis-Giemza, Marzena Olesińska and Agnieszka Paradowska-Gorycka

    Citation: Arthritis Research & Therapy 2021 23:19

    Content type: Research article

    Published on:

  8. Granulomatosis with polyangiitis (GPA) causes a recurring inflammation in nose and paranasal sinuses that clinically resembles chronic rhinosinusitis (CRS) of other aetiologies. While sinonasal inflammation is...

    Authors: Sigrun Skaar Holme, Karin Kilian, Heidi B. Eggesbø, Jon Magnus Moen and Øyvind Molberg

    Citation: Arthritis Research & Therapy 2021 23:18

    Content type: Research article

    Published on:

  9. T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target. However, its role in autoimmu...

    Authors: Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang and Qinglin Peng

    Citation: Arthritis Research & Therapy 2021 23:15

    Content type: Research article

    Published on:

  10. Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrenc...

    Authors: Olivier Espitia, Gauthier Blonz, Geoffrey Urbanski, Cédric Landron, Jérôme Connault, Christian Lavigne, Pascal Roblot, François Maillot, Alexandra Audemard-Verger, Mathieu Artifoni, Cécile Durant, Béatrice Guyomarch, Mohamed Hamidou, Julie Magnant and Christian Agard

    Citation: Arthritis Research & Therapy 2021 23:14

    Content type: Research article

    Published on:

  11. Associations between rheumatoid arthritis (RA) and effect of treatment at the tissue levels are poorly understood. We investigated the scope of released extracellular matrix (ECM) metabolites as a consequence ...

    Authors: Patryk J. Drobinski, Anne C. Bay-Jensen, Morten A. Karsdal, Samra Sardar and Anne S. Siebuhr

    Citation: Arthritis Research & Therapy 2021 23:13

    Content type: Research article

    Published on:

  12. This study measured the magnitude and determinants of clinical and radiological progression in patients with hand osteoarthritis (HOA) over a 2-year prospective follow-up to gain a greater understanding of the...

    Authors: Audrey Neuprez, Jean-François Kaux, Médéa Locquet, Charlotte Beaudart and Jean-Yves Reginster

    Citation: Arthritis Research & Therapy 2021 23:12

    Content type: Research article

    Published on:

  13. Treat-to-target (T2T) is a widely accepted strategy for patients with rheumatoid arthritis (RA). It recommends attaining a goal of at least low disease activity (LDA) within 6 months; otherwise, the current th...

    Authors: Lucie Nekvindová, Jiří Vencovský, Karel Pavelka, Pavel Horák, Zlatuše Křístková and Jakub Závada

    Citation: Arthritis Research & Therapy 2021 23:11

    Content type: Research article

    Published on:

  14. Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease d...

    Authors: David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2021 23:10

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:73

  15. The objective of the study was to evaluate the efficacy and safety of upadacitinib over 84 weeks in Japanese patients with active rheumatoid arthritis (RA) and an inadequate response to conventional synthetic ...

    Authors: Hideto Kameda, Tsutomu Takeuchi, Kunihiro Yamaoka, Motohiro Oribe, Mitsuhiro Kawano, Masayuki Yokoyama, Aileen L. Pangan, Yuko Konishi, Sebastian Meerwein and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2021 23:9

    Content type: Research article

    Published on:

  16. Placebo-controlled clinical trials have demonstrated the efficacy of tocilizumab (TCZ) for remission maintenance and glucocorticoid sparing in patients with giant cell arteritis (GCA). However, limited data ex...

    Authors: Sebastian Unizony, Timothy J. McCulley, Robert Spiera, Jinglan Pei, Paris N. Sidiropoulos, Jennie H. Best, Christine Birchwood, Andrey Pavlov and John H. Stone

    Citation: Arthritis Research & Therapy 2021 23:8

    Content type: Research article

    Published on:

  17. There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent ...

    Authors: Xiaokang Dong, Yuqian Li, Lulu Zhang, Xiaotian Liu, Runqi Tu, Yikang Wang, Ruiying Li, Linlin Li, Jian Hou, Zhenxing Mao, Wenqian Huo and Chongjian Wang

    Citation: Arthritis Research & Therapy 2021 23:7

    Content type: Research article

    Published on:

  18. Although treatments have been proposed for calcinosis cutis (CC) in patients with systemic sclerosis (SSc), a standardized and validated method for CC burden quantification is necessary to enable valid clinica...

    Authors: Anita C. Chandrasekaran, Zhicheng Fu, Reid Kraniski, F. Perry Wilson, Shannon Teaw, Michelle Cheng, Annie Wang, Shangping Ren, Imran M. Omar and Monique E. Hinchcliff

    Citation: Arthritis Research & Therapy 2021 23:6

    Content type: Research article

    Published on:

  19. CD40-CD40L is a key co-stimulatory pathway for B cell activation. As such, its blockade can inhibit pathogenic B cell responses in autoimmune diseases, such as Sjogren’s syndrome (SjS) and systemic lupus eryth...

    Authors: John Marken, Sujatha Muralidharan and Natalia V. Giltiay

    Citation: Arthritis Research & Therapy 2021 23:5

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:36

  20. Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral scler...

    Authors: April Hartley, Sarah A. Hardcastle, Monika Frysz, Jon Parkinson, Lavinia Paternoster, Eugene McCloskey, Kenneth E. S. Poole, Muhammad K. Javaid, Mo Aye, Katie Moss, Martin Williams, Jon H. Tobias and Celia L. Gregson

    Citation: Arthritis Research & Therapy 2021 23:4

    Content type: Research article

    Published on:

  21. Baricitinib is an oral selective inhibitor of Janus kinase (JAK)1 and JAK2 that has proved effective and well tolerated in the treatment of rheumatoid arthritis (RA) in an extensive programme of clinical studi...

    Authors: Paul Emery, Patrick Durez, Axel J. Hueber, Inmaculada de la Torre, Esbjörn Larsson, Thorsten Holzkämper and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2021 23:3

    Content type: Review

    Published on:

  22. Rheumatoid arthritis (RA) patients have an increased cardiovascular (CV) risk. Here, we aimed to investigate whether gender and age are contributing to the misclassification of CV risk in RA patients.

    Authors: Daphne C. Rohrich, Eline H. M. van de Wetering, Alexander J. Rennings, Elke E. Arts, Inger L. Meek, Alfons A. den Broeder, Jaap Fransen and Calin D. Popa

    Citation: Arthritis Research & Therapy 2021 23:2

    Content type: Research article

    Published on:

  23. The multi-biomarker disease activity (MBDA) test measures 12 serum protein biomarkers to quantify disease activity in RA patients. A newer version of the MBDA score, adjusted for age, sex, and adiposity, has b...

    Authors: Jeffrey R. Curtis, Michael E. Weinblatt, Nancy A. Shadick, Cecilie H. Brahe, Mikkel Østergaard, Merete Lund Hetland, Saedis Saevarsdottir, Megan Horton, Brent Mabey, Darl D. Flake II, Rotem Ben-Shachar, Eric H. Sasso and T. W. Huizinga

    Citation: Arthritis Research & Therapy 2021 23:1

    Content type: Research article

    Published on:

  24. Prevalence and outcomes of coronavirus disease (COVID)-19 in relation to immunomodulatory medications are still unknown. The aim of the study is to investigate the impact of glucocorticoids and immunosuppressi...

    Authors: Ennio Giulio Favalli, Serena Bugatti, Catherine Klersy, Martina Biggioggero, Silvia Rossi, Orazio De Lucia, Francesca Bobbio-Pallavicini, Antonella Murgo, Silvia Balduzzi, Roberto Caporali and Carlomaurizio Montecucco

    Citation: Arthritis Research & Therapy 2020 22:290

    Content type: Research article

    Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ellis Niemantsverdriet, Erik B. van den Akker, Debbie M. Boeters, Susan J. F. van den Eeden, Annemieke Geluk and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:289

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2020 22:266

  26. Preference assessments of patients with rheumatoid arthritis can support clinical therapeutic decisions for including biologic and targeted synthetic medicines to use. This study assesses patient preferences f...

    Authors: Karin Schölin Bywall, Ulrik Kihlbom, Mats Hansson, Marie Falahee, Karim Raza, Eva Baecklund and Jorien Veldwijk

    Citation: Arthritis Research & Therapy 2020 22:288

    Content type: Research article

    Published on:

  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Changmin Choi, Wooseong Jeong, Byeongzu Ghang, Yonggeun Park, Changlim Hyun, Moonjae Cho and Jinseok Kim

    Citation: Arthritis Research & Therapy 2020 22:287

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2020 22:275

  28. Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously reported that the lncRNA HOTAIR plays a central role in the ...

    Authors: Christopher W. Wasson, Rebecca L. Ross, Rebecca Wells, Clarissa Corinaldesi, Ioanna Ch. Georgiou, Natalia A. Riobo-Del Galdo and Francesco Del Galdo

    Citation: Arthritis Research & Therapy 2020 22:286

    Content type: Research article

    Published on:

  29. To investigate the association between blood biomarkers and disease activity of Takayasu’s arteritis (TAK) in a follow-up cohort.

    Authors: Jing Li, Yahong Wang, Yanhong Wang, Ying Wang, Yunjiao Yang, Jiuliang Zhao, Mengtao Li, Xinping Tian and Xiaofeng Zeng

    Citation: Arthritis Research & Therapy 2020 22:285

    Content type: Research article

    Published on:

  30. Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multip...

    Authors: Marta Novella-Navarro, Chamaida Plasencia, Carolina Tornero, Victoria Navarro-Compán, José L. Cabrera-Alarcón, Diana Peiteado-López, Laura Nuño, Irene Monjo-Henry, Karen Franco-Gómez, Alejandro Villalba and Alejandro Balsa

    Citation: Arthritis Research & Therapy 2020 22:284

    Content type: Research article

    Published on:

  31. Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions. An important function of HS...

    Authors: Sara Shamdani, Sandrine Chantepie, Camille Flageollet, Nadia Henni-Chebra, Yohann Jouan, Florent Eymard, Eric Hay, Martine Cohen-Solal, Dulce Papy-Garcia, Xavier Chevalier and Patricia Albanese

    Citation: Arthritis Research & Therapy 2020 22:283

    Content type: Research article

    Published on:

  32. Rheumatoid arthritis (RA) patients have increased risk for cardiovascular disease (CVD). Accurate CVD risk prediction could improve care for RA patients. Our goal is to develop and validate a biomarker-based m...

    Authors: Jeffrey R. Curtis, Fenglong Xie, Cynthia S. Crowson, Eric H. Sasso, Elena Hitraya, Cheryl L. Chin, Richard D. Bamford, Rotem Ben-Shachar, Alexander Gutin, Darl D. Flake II, Brent Mabey and Jerry S. Lanchbury

    Citation: Arthritis Research & Therapy 2020 22:282

    Content type: Research article

    Published on:

  33. The discovery and development of new medicines requires high-throughput screening of possible therapeutics in a specific model of the disease. Infrared thermal imaging (IRT) is a modern assessment method with ...

    Authors: Zeynab Nosrati, Marta Bergamo, Cristina Rodríguez-Rodríguez, Katayoun Saatchi and Urs O. Häfeli

    Citation: Arthritis Research & Therapy 2020 22:281

    Content type: Research article

    Published on:

  34. In knee osteoarthritis (OA), pain is the most frequent and dominant symptom. However, which factors other than radiological changes contribute to the symptoms is unresolved. The aims of this study were to iden...

    Authors: Kazuya Nigoro, Hiromu Ito, Tomotoshi Kawata, Kohei Nishitani, Yasuharu Tabara, Fumihiko Matsuda, Shu Narumiya and Shuichi Matsuda

    Citation: Arthritis Research & Therapy 2020 22:280

    Content type: Research article

    Published on:

  35. Osteoclasts are the only cells that perform bone resorption. Noncoding RNAs (ncRNAs) are crucial epigenetic regulators of osteoclast biological behaviors ranging from osteoclast differentiation to bone resorpt...

    Authors: Li Duan, Yujie Liang, Xiao Xu, Jifeng Wang, Xingfu Li, Deshun Sun, Zhiqin Deng, Wencui Li and Daping Wang

    Citation: Arthritis Research & Therapy 2020 22:279

    Content type: Review

    Published on:

  36. To compare the patients’ and physician’s global assessment of disease activity in Behçet’s syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance.

    Authors: Alberto Floris, Gerard Espinosa, Luisa Serpa Pinto, Nikolaos Kougkas, Andrea Lo Monaco, Giuseppe Lopalco, Ida Orlando, George Bertsias, Luca Cantarini, Ricard Cervera, João Correia, Marcello Govoni, Florenzo Iannone, Alessandro Mathieu, Piergiorgio Neri, Ana Martins Silva…

    Citation: Arthritis Research & Therapy 2020 22:278

    Content type: Research article

    Published on:

  37. The forefoot is a preferential location for joint and tendon sheath inflammation in rheumatoid arthritis (RA). It also contains bursae, of which the intermetatarsal bursae have a synovial lining. Some small im...

    Authors: Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil and Monique Reijnierse

    Citation: Arthritis Research & Therapy 2020 22:277

    Content type: Research article

    Published on:

  38. Sustained DMARD-free remission (SDFR) is increasingly achievable. The pathogenesis underlying SDFR development is unknown and patient characteristics at diagnosis poorly explain whether SDFR will be achieved. ...

    Authors: M. Verstappen, E. Niemantsverdriet, X. M. E. Matthijssen, S. le Cessie and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:276

    Content type: Research article

    Published on:

  39. Interleukin-6 (IL-6) is involved in fibroblast-like synoviocyte (FLS) activation and promotes pannus formation and bone and cartilage destruction in rheumatoid arthritis (RA). Cysteine-rich 61 (Cyr61) protein ...

    Authors: Changmin Choi, Wooseong Jeong, Byeongzu Ghang, Yonggeun Park, Changlim Hyun, Moonjae Cho and Jinseok Kim

    Citation: Arthritis Research & Therapy 2020 22:275

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:287

  40. Circulating IgA anti-citrullinated protein antibodies (ACPA) associate with more active disease, but a previous study implied that salivary IgA ACPA is related to a less severe disease. Therefore, we aimed to ...

    Authors: Karin Roos Ljungberg, Emil Börjesson, Klara Martinsson, Jonas Wetterö, Alf Kastbom and Anna Svärd

    Citation: Arthritis Research & Therapy 2020 22:274

    Content type: Research article

    Published on:

  41. Although vascular endothelial growth factor-A (VEGF)-induced angiogenesis has been reported to play an important role in the pathogenesis of rheumatoid arthritis (RA), serious side effects, mainly grade 2–3 hy...

    Authors: Kai Lu, O. Hans Iwenofu, Rita Mitra, Xiaokui Mo, Partha Sarathi Dasgupta and Sujit Basu

    Citation: Arthritis Research & Therapy 2020 22:273

    Content type: Research article

    Published on:

  42. To report on the characteristics and long-term course of rheumatic manifestations in Schnitzler syndrome (SchS).

    Authors: Christelle Darrieutort-Laffite, Catherine Ansquer, Hélène Aubert, Françoise Kraeber-Bodéré, Agathe Masseau, Christian Agard, Mohamed Hamidou, Claire Bernier, Jean-Marie Berthelot, Benoit Le Goff, Sébastien Barbarot and Antoine Néel

    Citation: Arthritis Research & Therapy 2020 22:272

    Content type: Research article

    Published on:

  43. Intra-articular glucocorticoid (GC) injections are widely used as a symptomatic treatment for osteoarthritis (OA). However, there are also concerns about their potentially harmful effects, and their detailed e...

    Authors: Antti Pemmari, Tiina Leppänen, Mari Hämäläinen, Teemu Moilanen, Katriina Vuolteenaho and Eeva Moilanen

    Citation: Arthritis Research & Therapy 2020 22:271

    Content type: Research article

    Published on:

  44. Intervertebral disc degeneration (IDD) is the most common cause of low-back pain. Accumulating evidence indicates that the expression profiling of noncoding RNAs (ncRNAs), including microRNAs (miRNAs), circula...

    Authors: Hao-Yu Guo, Ming-Ke Guo, Zhong-Yuan Wan, Fang Song and Hai-Qiang Wang

    Citation: Arthritis Research & Therapy 2020 22:270

    Content type: Review

    Published on:

  45. Osteogenic differentiation is an essential process for bone regeneration involving bone marrow mesenchymal stem cells (BMSCs). BMSC-secreted extracellular vesicles (EVs) enriched with microRNAs (miRs) have vit...

    Authors: Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li and Shuanke Wang

    Citation: Arthritis Research & Therapy 2020 22:269

    Content type: Research article

    Published on:

  46. The positivity of anti-citrullinated protein/peptide antibodies (ACPAs) is a clinically useful diagnostic and prognostic marker in rheumatoid arthritis (RA). However, the significance of ACPA titer and its flu...

    Authors: Koichi Murata, Hiromu Ito, Motomu Hashimoto, Kosaku Murakami, Ryu Watanabe, Masao Tanaka, Wataru Yamamoto and Shuichi Matsuda

    Citation: Arthritis Research & Therapy 2020 22:268

    Content type: Research article

    Published on:

  47. Cryoglobulins (CG) are immunoglobulins which precipitate at low temperature. The analysis of IgG subclass composition of CG is poorly reported. The aim of this study was to determine the subclasses of IgG-cont...

    Authors: Marie N. Kolopp-Sarda, Pedro Ming Azevedo and Pierre Miossec

    Citation: Arthritis Research & Therapy 2020 22:267

    Content type: Research article

    Published on:

  48. Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthrit...

    Authors: Ellis Niemantsverdriet, Erik B. van den Akker, Debbie M. Boeters, Susan J. F. van den Eeden, Annemieke Geluk and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:266

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:289

Annual Journal Metrics