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  1. Content type: Research article

    Adult-onset Still’s disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more promine...

    Authors: François Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke and Marie-Elise Truchetet

    Citation: Arthritis Research & Therapy 2019 21:53

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  2. Content type: Research article

    Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The ...

    Authors: Gracijela Bozovic, Rille Pullerits, Arne Ståhl, Kristina Ydström, Daniel Wenger, Jan Marsal, Pontus Thulin and Kristofer Andréasson

    Citation: Arthritis Research & Therapy 2019 21:52

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  3. Content type: Research article

    MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from...

    Authors: Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard and Jörg Tost

    Citation: Arthritis Research & Therapy 2019 21:51

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  4. Content type: Research article

    Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate ...

    Authors: M. C. P. Cleophas, T. O. Crişan, V. Klück, N. Hoogerbrugge, R. T. Netea-Maier, C. A. Dinarello, M. G. Netea and L. A. B. Joosten

    Citation: Arthritis Research & Therapy 2019 21:50

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  5. Content type: Research article

    Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased i...

    Authors: Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole Orzechowski, Sarah Arron and Michael L. Whitfield

    Citation: Arthritis Research & Therapy 2019 21:49

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    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:81

  6. Content type: Research article

    We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA).

    Authors: Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou and David W. Ray

    Citation: Arthritis Research & Therapy 2019 21:47

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  7. Content type: Research article

    Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut. Rats transgenic for HLA-B27 and human β2-mi...

    Authors: Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia and Maxime Breban

    Citation: Arthritis Research & Therapy 2019 21:46

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  8. Content type: Research

    Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addres...

    Authors: Ingiäld Hafström, Sofia Ajeganova, Kristina Forslind and Björn Svensson

    Citation: Arthritis Research & Therapy 2019 21:45

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  9. Content type: Research article

    This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadeniti...

    Authors: Mu Wang, Panpan Zhang, Wei Lin, Yunyun Fei, Hua Chen, Jing Li, Li Zhang, Wenjie Zheng, Yongze Li, Xiaofeng Zeng, Jiaxin Zhou, Yamin Lai, Xiaowei Liu, Huadan Xue, Yueying Cui, Lian Zhou…

    Citation: Arthritis Research & Therapy 2019 21:44

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  10. Content type: Research article

    An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4+) B cells and plasma cells are implicated in the pathogenesis of GPA. We...

    Authors: A. Al-Soudi, M. E. Doorenspleet, R. E. Esveldt, L. T. Burgemeister, A. E. Hak, B. J. H. van den Born, S. W. Tas, R. F. van Vollenhoven, P. L. Klarenbeek and N. de Vries

    Citation: Arthritis Research & Therapy 2019 21:43

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  11. Content type: Research article

    The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hyp...

    Authors: Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W. N. Ueng, Chuen-Yung Yang, Tsung-Ting Tsai and Po-Liang Lai

    Citation: Arthritis Research & Therapy 2019 21:42

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  12. Content type: Research article

    Spondyloarthritis (SpA) has a significant impact on patients’ quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility an...

    Authors: Helen Hoi Lun Tsang, Jason Pui Yin Cheung, Carlos King Ho Wong, Prudence Wing Hang Cheung, Chak Sing Lau and Ho Yin Chung

    Citation: Arthritis Research & Therapy 2019 21:41

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  13. Content type: Research article

    Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with...

    Authors: Shijun He, Xing Liu, Zemin Lin, Yuting Liu, Lei Gu, Hu Zhou, Wei Tang and Jianping Zuo

    Citation: Arthritis Research & Therapy 2019 21:40

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  14. Content type: Research article

    Autophagy has emerged as a key mechanism in the survival and function of T and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid arthritis (RA). To investigate whether the re...

    Authors: M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti…

    Citation: Arthritis Research & Therapy 2019 21:39

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  15. Content type: Research article

    Ixekizumab improves signs/symptoms of psoriatic arthritis (PsA). We present an integrated analysis of baseline disease burden and post-baseline outcomes in ixekizumab-treated patients with enthesitis or dactyl...

    Authors: Dafna D. Gladman, Ana-Maria Orbai, Uta Klitz, James Cheng-Chung Wei, Gaia Gallo, Julie Birt, Suchitrita Rathmann, David Shrom and Helena Marzo-Ortega

    Citation: Arthritis Research & Therapy 2019 21:38

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  16. Content type: Editorial

    While many of intricacies of the mammalian circadian rhythm remain unknown, the role that this physiological clock plays in our everyday lives and within the global ecosystem is clearly evident. However, only ...

    Authors: Roman J. Krawetz

    Citation: Arthritis Research & Therapy 2019 21:37

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    The Research article to this article has been published in Arthritis Research & Therapy 2019 21:5

  17. Content type: Research article

    A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman et al., J Scleroderma Relat Disord 2:115-20, 2017), while for their evaluation, classification and ca...

    Authors: J. Blagojevic, S. Bellando-Randone, G. Abignano, J. Avouac, L. Cometi, L. Czirják, C. P. Denton, O. Distler, M. Frerix, S. Guiducci, D. Huscher, V. K. Jaeger, V. Lóránd, B. Maurer, S. Nihtyanova, G. Riemekasten…

    Citation: Arthritis Research & Therapy 2019 21:35

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  18. Content type: Research article

    Endothelial activation and damage is commonly observed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is related to development of atherosclerosis and cardiovascular dise...

    Authors: Laura Atehortúa, Mauricio Rojas, Gloria Vásquez, Carlos H. Muñoz-Vahos, Adriana Vanegas-García, Rafael Andrés Posada-Duque and Diana Castaño

    Citation: Arthritis Research & Therapy 2019 21:34

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  19. Content type: Research article

    Individuals with rheumatoid arthritis (RA) are at risk of developing cardiovascular disease (CVD), but patient perceptions of CVD are not routinely assessed. We performed a systematic literature review to eval...

    Authors: Olivia R. Ghosh-Swaby and Bindee Kuriya

    Citation: Arthritis Research & Therapy 2019 21:33

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  20. Content type: Protocol

    Spondyloarthritis comprises a group of inflammatory diseases, characterised by inflammation within axial joints and/or peripheral arthritis, enthesitis and dactylitis. An increasing number of biologic treatmen...

    Authors: Ernest Choy, Xenofon Baraliakos, Frank Behrens, Salvatore D’Angelo, Kurt de Vlam, Bruce W. Kirkham, Mikkel Østergaard, Georg A. Schett, Michael Rissler, Kamel Chaouche-Teyara and Chiara Perella

    Citation: Arthritis Research & Therapy 2019 21:32

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  21. Content type: Research article

    Childhood Takayasu’s arteritis (c-TA) is scarcely reported but is characterized by devastating morbidity and mortality. This study aims to investigate the clinical course of c-TA and prognostic factors associa...

    Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou

    Citation: Arthritis Research & Therapy 2019 21:31

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    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:55

  22. Content type: Research article

    The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the app...

    Authors: Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada and Koichi Akashi

    Citation: Arthritis Research & Therapy 2019 21:30

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  23. Content type: Research article

    Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the A...

    Authors: A. J. Feuerherm, E. A. Dennis and B. Johansen

    Citation: Arthritis Research & Therapy 2019 21:29

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  24. Content type: Research article

    Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. ...

    Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Leendert A. Trouw, Holger Bang, Gerard Collée, Leroy R. Lard, Sofia Ramiro, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude

    Citation: Arthritis Research & Therapy 2019 21:28

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  25. Content type: Research article

    A high prevalence of periodontitis has been reported in rheumatoid arthritis (RA) patients, although the strength of this association, its temporal link and the possible relationship between the severity of pe...

    Authors: Beatriz Rodríguez-Lozano, Jerián González-Febles, Jorge Luis Garnier-Rodríguez, Shashi Dadlani, Sagrario Bustabad-Reyes, Mariano Sanz, Fernando Sánchez-Alonso, Carlos Sánchez-Piedra, Enrique González-Dávila and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2019 21:27

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  26. Content type: Research article

    Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune effectors, is of importance. Specifically, monocytes...

    Authors: Alejandro Gómez-Aristizábal, Rajiv Gandhi, Nizar N. Mahomed, K. Wayne Marshall and Sowmya Viswanathan

    Citation: Arthritis Research & Therapy 2019 21:26

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  27. Content type: Research article

    In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (H...

    Authors: Kim Wervers, Jolanda J. Luime, Ilja Tchetverikov, Andreas H. Gerards, Marc R. Kok, Cathelijne W. Y. Appels, Wiebo L. van der Graaff, Johannes H. L. M. van Groenendael, Lindy-Anne Korswagen, Josien J. Veris-van Dieren, Johanna M. W. Hazes and Marijn Vis

    Citation: Arthritis Research & Therapy 2019 21:25

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  28. Content type: Research article

    To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity of Takayasu arteritis (TA).

    Authors: Ling-Ying Ma, Chao-Lun Li, Li-Li Ma, Xiao-Meng Cui, Xiao-Min Dai, Ying Sun, Hui-Yong Chen, Bei-Jian Huang and Lin-Di Jiang

    Citation: Arthritis Research & Therapy 2019 21:24

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  29. Content type: Research article

    This study aimed to assess the minimal clinically important differences (MCIDs) for the modified Rodnan skin score (mRSS) using combined data from the Scleroderma Lung Studies (I and II).

    Authors: Dinesh Khanna, Philip J. Clements, Elizabeth R. Volkmann, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Michael D. Roth, Oliver Distler and Donald P. Tashkin

    Citation: Arthritis Research & Therapy 2019 21:23

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  30. Content type: Research article

    To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MR...

    Authors: Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe and Arnaud Constantin

    Citation: Arthritis Research & Therapy 2019 21:22

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  31. Content type: Research article

    The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthriti...

    Authors: Miriam Frenken, Christoph Schleich, Ralph Brinks, Daniel Benjamin Abrar, Christine Goertz, Matthias Schneider, Benedikt Ostendorf and Philipp Sewerin

    Citation: Arthritis Research & Therapy 2019 21:21

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  32. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the affiliation of Ari Polachek.

    Authors: Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman and Lihi Eder

    Citation: Arthritis Research & Therapy 2019 21:20

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    The original article was published in Arthritis Research & Therapy 2017 19:189

  33. Content type: Research article

    The aim of this study was to investigate whether vitamin D plays a protective role in podocyte injury induced by autoantibodies purified from the serum of patients with lupus nephritis (LN) via reducing aberra...

    Authors: Qi Yu, Yingjin Qiao, Dongwei Liu, Fengxun Liu, Congcong Gao, Jiayu Duan, Lulu Liang, Xueqi Di, Yi Yuan, Yukui Gao, Siwan Cui, Yilu Qin, Tianfang Li, Zhaohui Zheng and Zhangsuo Liu

    Citation: Arthritis Research & Therapy 2019 21:19

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  34. Content type: Research article

    Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-...

    Authors: Sabine Trellu, Alice Courties, Stéphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum and Jérémie Sellam

    Citation: Arthritis Research & Therapy 2019 21:18

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  35. Content type: Research article

    Obesity is over-represented in patients with psoriatic arthritis (PsA) and associated with higher disease activity, poorer effect of treatment and increased cardiovascular morbidity. Studies on the effects of ...

    Authors: Eva Klingberg, Annelie Bilberg, Sofia Björkman, Martin Hedberg, Lennart Jacobsson, Helena Forsblad-d’Elia, Hans Carlsten, Björn Eliasson and Ingrid Larsson

    Citation: Arthritis Research & Therapy 2019 21:17

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  36. Content type: Research article

    Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease and in experimental m...

    Authors: Samra Sardar, Alish Kerr, Daniëlle Vaartjes, Emilie Riis Moltved, Edita Karosiene, Ramneek Gupta and Åsa Andersson

    Citation: Arthritis Research & Therapy 2019 21:16

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  37. Content type: Review

    Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyl...

    Authors: Zoltán Szekanecz, Hennie G. Raterman, Zsófia Pethő and Willem F. Lems

    Citation: Arthritis Research & Therapy 2019 21:15

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  38. Content type: Research article

    Ultrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD) techniques to demonstrate increased blood flow and vascularizatio...

    Authors: Yasushi Kondo, Katsuya Suzuki, Yumiko Inoue, Koumei Sakata, Chihiro Takahashi, Masaru Takeshita, Yoshiaki Kassai, Takahiro Miyazaki, Rimpei Morita, Yasuo Niki, Yuko Kaneko, Hidekata Yasuoka, Kunihiro Yamaoka, Akihiko Yoshimura and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2019 21:14

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  39. Content type: Research article

    Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ ...

    Authors: Ravi K. Narang, Ruth Topless, Murray Cadzow, Greg Gamble, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:13

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  40. Content type: Research

    The objective was to determine if dose reduction is non-inferior to full-dose TNFi to maintain low disease activity (LDA) in patients already in remission with TNFi, in axial spondyloarthritis.

    Authors: Jordi Gratacós, Caridad Pontes, Xavier Juanola, Jesús Sanz, Ferran Torres, Cristina Avendaño, Antoni Vallano, Gonzalo Calvo, Eugenio de Miguel and Raimon Sanmartí

    Citation: Arthritis Research & Therapy 2019 21:11

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  41. Content type: Research article

    Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an innate-immune receptor found in blood. Its presence reflects innate immune cell activation. We sought to investigate plasma sTREM-1 leve...

    Authors: Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria and Yair Molad

    Citation: Arthritis Research & Therapy 2019 21:10

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  42. Content type: Research article

    Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps ...

    Authors: Qiongyi Hu, Hui Shi, Ting Zeng, Honglei Liu, Yutong Su, Xiaobing Cheng, Junna Ye, Yufeng Yin, Mengru Liu, Hui Zheng, Xinyao Wu, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Yue Sun, Jialin Teng…

    Citation: Arthritis Research & Therapy 2019 21:9

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  43. Content type: Research article

    In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical...

    Authors: Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Maple Fung, Scott Baumgartner and Fernando Perez-Ruiz

    Citation: Arthritis Research & Therapy 2019 21:8

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  44. Content type: Research article

    A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healin...

    Authors: Nicoletta Del Papa, Gabriele Di Luca, Romina Andracco, Eleonora Zaccara, Wanda Maglione, Francesca Pignataro, Antonina Minniti and Claudio Vitali

    Citation: Arthritis Research & Therapy 2019 21:7

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  45. Content type: Research article

    Fibroblast-like synoviocytes (FLS) and CCR7 effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, wh...

    Authors: Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko and Christine Beeton

    Citation: Arthritis Research & Therapy 2019 21:6

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  46. Content type: Research article

    The circadian clock plays a crucial role in regulating physiology and is important for maintaining immune homeostasis and responses to inflammatory stimuli. Inflammatory arthritis often shows diurnal variation...

    Authors: Laura E. Hand, Suzanna H. Dickson, Anthony J. Freemont, David W. Ray and Julie E. Gibbs

    Citation: Arthritis Research & Therapy 2019 21:5

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    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:37

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