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  1. Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotid...

    Authors: Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, In Seol Yoo, Chan Keol Park and Seong Wook Kang

    Citation: Arthritis Research & Therapy 2020 22:116

    Content type: Research article

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  2. In clinical practice, temporary interruption of rheumatoid arthritis (RA) therapy is common for various reasons including side effects, non-compliance, or necessity for surgery. To characterize temporary inter...

    Authors: Paul Emery, Yoshiya Tanaka, Tracy Cardillo, Douglas Schlichting, Terence Rooney, Scott Beattie, Cameron Helt and Josef S. Smolen

    Citation: Arthritis Research & Therapy 2020 22:115

    Content type: Research article

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    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:166

  3. Several lines of evidence suggest that the pathobiont Porphyromonas gingivalis is involved in the development and/or progression of auto-inflammatory diseases. This bacterium produces cysteine proteases, such as ...

    Authors: Hsin-Yi Peng, Shih-Yao Chen, Shih-Hong Siao, Jinghua Tsai Chang, Ting-Yin Xue, Yi-Hsuan Lee, Ming-Shiou Jan, Gregory J. Tsay and Moncef Zouali

    Citation: Arthritis Research & Therapy 2020 22:114

    Content type: Research article

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  4. Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinou...

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Holly Richendrfer, Tannin A. Schmidt and Khaled A. Elsaid

    Citation: Arthritis Research & Therapy 2020 22:113

    Content type: Research article

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  5. Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies ...

    Authors: Na Liu, Dejie Fu, Junjun Yang, Pingju Liu, Xiongbo Song, Xin Wang, Rui Li, Zhenlan Fu, Jiajia Chen, Xiaoyuan Gong, Cheng Chen and Liu Yang

    Citation: Arthritis Research & Therapy 2020 22:112

    Content type: Research article

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  6. Systemic sclerosis (SSc) or scleroderma is an intractable autoimmune disorder that affects multiple organs. The objectives were to investigate clinical correlations of serum calpain activity and high mobility ...

    Authors: Ji-Na Zheng, Yang Li, Yue-Mei Yan, Yong Yu, Wen-Qi Shao and Qiang Wang

    Citation: Arthritis Research & Therapy 2020 22:110

    Content type: Research article

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Joo Youn Lee, Jin Kyun Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2020 22:109

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2016 18:264

  8. To identify potential biomarkers to distinguish adult-onset Still’s disease (AOSD) from sepsis.

    Authors: Tomohiro Koga, Remi Sumiyoshi, Kaori Furukawa, Shuntaro Sato, Kiyoshi Migita, Toshimasa Shimizu, Masataka Umeda, Yushiro Endo, Shoichi Fukui, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Fumiaki Nonaka…

    Citation: Arthritis Research & Therapy 2020 22:108

    Content type: Research article

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  9. Pathogenesis and aetiology of systemic sclerosis (SSc) are currently unclear, thus rendering disease prognosis, diagnosis and treatment challenging. The aim of this study was to use paired skin biopsy samples ...

    Authors: Paraskevi Chairta, Paschalis Nicolaou, Kleitos Sokratous, Christine Galant, Frédéric Houssiau, Anastasis Oulas, George M. Spyrou, Marta E. Alarcon-Riquelme, Bernard R. Lauwerys and Kyproula Christodoulou

    Citation: Arthritis Research & Therapy 2020 22:107

    Content type: Research article

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  10. The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis ...

    Authors: Yun-Jeong Song, In Ah. Choi, Françoise Meylan, M. Kristen Demoruelle, Taylor Farley, Arianne C. Richard, Eric Hawley, John Botson, Yoo Jin Hong, Eun Young Lee, Sabina R. Mian, Bartlett C. Hamilton, Geoffrey M. Thiele, Ted R. Mikuls, Naveen Gara, Chris D. Ward…

    Citation: Arthritis Research & Therapy 2020 22:106

    Content type: Research article

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  11. Calprotectin (S100A8/S100A9 protein) is known as a damage-associated molecular pattern (DAMP) protein and reflects mainly neutrophil activation. Serum calprotectin levels might be a good alternative to acute-p...

    Authors: Matthias Jarlborg, Delphine S. Courvoisier, Céline Lamacchia, Laura Martinez Prat, Michael Mahler, Chelsea Bentow, Axel Finckh, Cem Gabay and Michael J. Nissen

    Citation: Arthritis Research & Therapy 2020 22:105

    Content type: Research article

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  12. Soluble urate has been shown to serve as an antioxidant, especially in the central nervous system. Although there are intriguing data suggesting that low levels of serum urate are associated with worse outcome...

    Authors: Woo-Joong Kim, Hye Ri Kim, Jung Soo Song and Sang Tae Choi

    Citation: Arthritis Research & Therapy 2020 22:104

    Content type: Research article

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  13. Large vessels could be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to clarify the clinical features and evaluate the treatment efficacy for IgG4-RD with aortitis/periaortitis...

    Authors: Linyi Peng, Panpan Zhang, Jieqiong Li, Zheng Liu, Hui Lu, Liang Zhu, Xiaorong Wang, Fei Teng, Xuemei Li, Huifang Guo, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng and Fengchun Zhang

    Citation: Arthritis Research & Therapy 2020 22:103

    Content type: Research article

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  14. Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway act...

    Authors: Christel Wilkinson, Robert B. Henderson, Angela R. Jones-Leone, Shaun M. Flint, Mark Lennon, Roger A. Levy, Beulah Ji, Damon L. Bass and David Roth

    Citation: Arthritis Research & Therapy 2020 22:102

    Content type: Research article

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  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Debbie M. Boeters and Annette H. M. van der Helm–van Mil

    Citation: Arthritis Research & Therapy 2020 22:101

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:55

  16. Overlapping Sjogren’s syndrome (SS) is not uncommon in rheumatoid arthritis (RA) and considered as a probable detrimental factor of RA. But data on the impact of overlapping SS on RA therapeutic response is li...

    Authors: Huijuan Zhang, Haoze Zhang, Dai Gao, Wenhui Xie, Yan Geng and Zhuoli Zhang

    Citation: Arthritis Research & Therapy 2020 22:100

    Content type: Research article

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  17. Due to the lack of research on the pathological mechanism of temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in the clinic. In recent years, microRNAs (miRs) have bee...

    Authors: Shixing Ma, Aobo Zhang, Xiaole Li, Shizhou Zhang, Shaopeng Liu, Haoming Zhao, Shichao Wu, Lei Chen, Chuan Ma and Huaqiang Zhao

    Citation: Arthritis Research & Therapy 2020 22:99

    Content type: Research article

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  18. Fluorescence optical imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in p...

    Authors: Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun, Tore Kristian Kvien, Till Uhlig, Sarah Ohrndorf and Ida Kristin Haugen

    Citation: Arthritis Research & Therapy 2020 22:98

    Content type: Research article

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  19. To systematically review the impact of tapering targeted therapies (bDMARDs or JAKis) on the risk of serious infections and severe adverse events (SAEs) in patients with rheumatoid arthritis (RA) or axial spon...

    Authors: D. Vinson, L. Molet-Benhamou, Y. Degboé, A. den Broeder, F. Ibrahim, C. Pontes, R. Westhovens, J. Závada, T. Pham, T. Barnetche, A. Constantin and A. Ruyssen-Witrand

    Citation: Arthritis Research & Therapy 2020 22:97

    Content type: Research article

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  20. Studies have demonstrated that rheumatoid arthritis (RA) patients who achieve low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs). The aim of this stu...

    Authors: Stéphanie Dierckx, Tatiana Sokolova, Bernard R. Lauwerys, Aleksandra Avramovska, Laurent Meric de Bellefon, Adrien Nzeusseu Toukap, Maria Stoenoiu, Frédéric A. Houssiau and Patrick Durez

    Citation: Arthritis Research & Therapy 2020 22:96

    Content type: Research article

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  21. CD4+ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the curre...

    Authors: Jonatan Tuncel, Jens Holmberg, Sabrina Haag, Malin Hultqvist Hopkins, Lena Wester-Rosenlöf, Stefan Carlsen, Peter Olofsson and Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2020 22:95

    Content type: Research article

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  22. The objective of this study was to compare in real life the occurrence of anterior uveitis in patients with spondyloarthritis (SpA), including psoriatic arthritis (PsA), treated with the soluble-receptor etane...

    Authors: Gisèle Khoury, Jacques Morel, Bernard Combe and Cédric Lukas

    Citation: Arthritis Research & Therapy 2020 22:94

    Content type: Research article

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  23. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this ...

    Authors: Taehyeung Kim, Sang-Cheol Bae and Changwon Kang

    Citation: Arthritis Research & Therapy 2020 22:93

    Content type: Research article

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  24. Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both d...

    Authors: Caroline van Durme, Bart Spaetgens, Johanna Driessen, Johannes Nielen, Manuel Sastry, Annelies Boonen and Frank de Vries

    Citation: Arthritis Research & Therapy 2020 22:92

    Content type: Research article

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  25. Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been...

    Authors: Alessandra Tesser, Luciana Martins de Carvalho, Paula Sandrin-Garcia, Alessia Pin, Serena Pastore, Andrea Taddio, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella and Alberto Tommasini

    Citation: Arthritis Research & Therapy 2020 22:91

    Content type: Research article

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  26. In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk est...

    Authors: Grunde Wibetoe, Joseph Sexton, Eirik Ikdahl, Silvia Rollefstad, George D. Kitas, Piet van Riel, Sherine Gabriel, Tore K. Kvien, Karen Douglas, Aamer Sandoo, Elke E. Arts, Solveig Wållberg-Jonsson, Solbritt Rantapää Dahlqvist, George Karpouzas, Patrick H. Dessein, Linda Tsang…

    Citation: Arthritis Research & Therapy 2020 22:90

    Content type: Research article

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  27. Pain persists in a moderate number of patients following hip or knee replacement surgery. Persistent pain may subsequently lead to the prolonged consumption of analgesics after surgery and expose patients to t...

    Authors: Tuomas Jaakko Rajamäki, Pia A. Puolakka, Aki Hietaharju, Teemu Moilanen and Esa Jämsen

    Citation: Arthritis Research & Therapy 2020 22:89

    Content type: Research article

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  28. Foxp3 is a marker for regulatory T cells (Treg cells), but recent studies have shown the plasticity and heterogeneity of CD4+Foxp3+ T cells. This study aimed to examine the phenotype and function of circulating C...

    Authors: Hironari Hanaoka, Tetsuya Nishimoto, Yuka Okazaki, Tsutomu Takeuchi and Masataka Kuwana

    Citation: Arthritis Research & Therapy 2020 22:88

    Content type: Research article

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  29. Missing clinical outcome data are a common occurrence in longitudinal studies. Data quality in clinical audit is a particular cause for concern. The relationship between departmental levels of missing clinical...

    Authors: Mark Yates, Katie Bechman, Elaine M. Dennison, Alexander J. MacGregor, Jo Ledingham, Sam Norton and James B. Galloway

    Citation: Arthritis Research & Therapy 2020 22:87

    Content type: Research article

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  30. Gout has been associated with a higher risk for coronary heart disease (CHD) and stroke in some prior studies. Few studies have assessed the association of gout with incident heart failure (HF).

    Authors: Lisandro D. Colantonio, Kenneth G. Saag, Jasvinder A. Singh, Ligong Chen, Richard J. Reynolds, Angelo Gaffo, Timothy B. Plante, Jeffrey R. Curtis, S. Louis Bridges Jr., Emily B. Levitan, Ninad S. Chaudhary, George Howard, Monika M. Safford, Paul Muntner and Marguerite Ryan Irvin

    Citation: Arthritis Research & Therapy 2020 22:86

    Content type: Research article

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  31. Citation: Arthritis Research & Therapy 2020 22:85

    Content type: Letter

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:280

  32. Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement of serum urate at a single time point. Further, the combined effect of serum urate and sy...

    Authors: Shanshan Li, Liufu Cui, Jin Cheng, Rong Shu, Shuohua Chen, Uyen-Sa Nguyen, Devyani Misra, Shouling Wu and Xiang Gao

    Citation: Arthritis Research & Therapy 2020 22:84

    Content type: Research article

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  33. Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reducti...

    Authors: Kelly A. Kimmerling, Sara J. Oswald, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Chia-Lung Wu and Farshid Guilak

    Citation: Arthritis Research & Therapy 2020 22:83

    Content type: Research article

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  34. Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of ...

    Authors: Ruben Queiro, Juan D. Cañete, María Montoro, Susana Gómez and Ana Cábez

    Citation: Arthritis Research & Therapy 2020 22:82

    Content type: Research article

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  35. To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.

    Authors: Arnd Heiligenhaus, Jens Klotsche, Martina Niewerth, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas and Kirsten Minden

    Citation: Arthritis Research & Therapy 2020 22:81

    Content type: Research article

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  36. Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and it...

    Authors: Yuya Fujita, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Haruki Matsumoto, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2020 22:80

    Content type: Research article

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  37. Anti-TNF treatment may be useful for the treatment of patients with refractory juvenile dermatomyositis (JDM). The aim of this study was to describe the use of infliximab and adalimumab therapy in juvenile der...

    Authors: Raquel Campanilho-Marques, Claire T. Deakin, Stefania Simou, Charalampia Papadopoulou, Lucy R. Wedderburn and Clarissa A. Pilkington

    Citation: Arthritis Research & Therapy 2020 22:79

    Content type: Research article

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  38. For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for per...

    Authors: Csaba Oláh, Noa Schwartz, Christopher Denton, Zsófia Kardos, Chaim Putterman and Zoltán Szekanecz

    Citation: Arthritis Research & Therapy 2020 22:78

    Content type: Review

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  39. Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is ...

    Authors: Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park and Mi-La Cho

    Citation: Arthritis Research & Therapy 2020 22:77

    Content type: Research article

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  40. Fibrotic diseases are characterized by tissue overgrowth, hardening, and/or scarring because of the excessive production, deposition, and contraction of the extracellular matrix (ECM). However, the detailed me...

    Authors: Yosuke Kanno, En Shu, Hirofumi Niwa, Hiroyuki Kanoh and Mariko Seishima

    Citation: Arthritis Research & Therapy 2020 22:76

    Content type: Research article

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  41. Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological damage and mortality. In this regard, understanding the pathology of SCIRI and preventing its development are of great clinic value.

    Authors: Ran Li, Kunchi Zhao, Qing Ruan, Chunyang Meng and Fei Yin

    Citation: Arthritis Research & Therapy 2020 22:75

    Content type: Research article

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  42. The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are invo...

    Authors: Geng Wang, Tae-Hwan Kim, Zhixiu Li, Adrian Cortes, Kwangwoo Kim, So-Young Bang, Paul Leo, Matthew A. Brown and Huji Xu

    Citation: Arthritis Research & Therapy 2020 22:74

    Content type: Research article

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  43. Interleukin (IL)-16 is a T cell chemoattractant produced by peripheral mononuclear cells. We investigated whether IL-16 plays a pro- or an anti-inflammatory role in antineutrophil cytoplasmic antibody-associat...

    Authors: Taejun Yoon, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: Arthritis Research & Therapy 2020 22:73

    Content type: Research article

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  44. Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treat...

    Authors: Takahiko Sugihara, Hitoshi Hasegawa, Haruhito A. Uchida, Hajime Yoshifuji, Yoshiko Watanabe, Eisuke Amiya, Yasuhiro Maejima, Masanori Konishi, Yohko Murakawa, Noriyoshi Ogawa, Shunsuke Furuta, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka…

    Citation: Arthritis Research & Therapy 2020 22:72

    Content type: Research article

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  45. To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).

    Authors: Gabriella Giancane, Joost F. Swart, Elio Castagnola, Andreas H. Groll, Gerd Horneff, Hans-Iko Huppertz, Daniel J. Lovell, Tom Wolfs, Troels Herlin, Pavla Dolezalova, Helga Sanner, Gordana Susic, Flavio Sztajnbok, Despoina Maritsi, Tamas Constantin, Veronika Vargova…

    Citation: Arthritis Research & Therapy 2020 22:71

    Content type: Research article

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  46. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Sarilumab is a human monoclonal antibody that binds membrane-bound and soluble IL-6 receptor-α ...

    Authors: Cem Gabay, Gerd R. Burmester, Vibeke Strand, Jérôme Msihid, Moshe Zilberstein, Toshio Kimura, Hubert van Hoogstraten, Susan H. Boklage, Jonathan Sadeh, Neil M. H. Graham and Anita Boyapati

    Citation: Arthritis Research & Therapy 2020 22:70

    Content type: Research article

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  47. Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature, but the pathogenesis of JDM and the etiology of its IFN signature remain unknown. The Mendelian auto...

    Authors: Hanna Kim, Fatima Gunter-Rahman, John A. McGrath, Esther Lee, Adriana A. de Jesus, Ira N. Targoff, Yan Huang, Terrance P. O’Hanlon, Wanxia L. Tsai, Massimo Gadina, Frederick W. Miller, Raphaela Goldbach-Mansky and Lisa G. Rider

    Citation: Arthritis Research & Therapy 2020 22:69

    Content type: Research article

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  48. Hemorrhagic arthritis (HA) is a common disease of the musculoskeletal system caused by hemorrhage in the joints, leading to damages in the synovium and cartilage. Pure platelet-rich plasma (P-PRP) has been rec...

    Authors: Yulun Xue, Xinlin Su, Miao Jiang, Ziqiang Yu, Huilin Yang, Ling Qin, Peter V. Giannoudis and Jiong Jiong Guo

    Citation: Arthritis Research & Therapy 2020 22:68

    Content type: Research article

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  49. The relationship between physical joint examination (PE) and MRI-detected inflammation in early inflammatory arthritis has mostly been studied in the hands. Physical examination of MTP joints is considered dif...

    Authors: Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:67

    Content type: Research article

    Published on:

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