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  1. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining a balance between the proliferation and apoptosis of rheumatoid arthritis synovial fibr...

    Authors: Xiaonan Zhang, Xiaoyu He, Ming Zhang, Tianyu Wu, Xiaojie Liu, Yan Zhang, Zhuobei Xie, Saisai Liu, Tian Xia, Yuanyuan Wang, Fang Wei, Hongtao Wang and Changhao Xie
    Citation: Arthritis Research & Therapy 2023 25:238
  2. While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolonged joint immobilization can cause multiple complications. A better understanding how ...

    Authors: Donghao Gan, Xiaowan Jin, Xiangpeng Wang, Chu Tao, Qinnan Yan, Qingyun Jia, Shaochuan Huo, Di Chen, Qing Yao and Guozhi Xiao
    Citation: Arthritis Research & Therapy 2023 25:237
  3. Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α. This study ai...

    Authors: Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim and Jang-Soo Chun
    Citation: Arthritis Research & Therapy 2023 25:236
  4. To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA).

    Authors: Zhuolun Wang, Xinjie Wang, Liangliang Liu, Xiongtian Guo, Haiyan Zhang, Jianbing Yin, Rengui Lin, Yan Shao and Daozhang Cai
    Citation: Arthritis Research & Therapy 2023 25:235

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:250

  5. Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate diff...

    Authors: Aleš Kvasnička, David Friedecký, Radana Brumarová, Markéta Pavlíková, Kateřina Pavelcová, Jana Mašínová, Lenka Hasíková, Jakub Závada, Karel Pavelka, Pavel Ješina and Blanka Stibůrková
    Citation: Arthritis Research & Therapy 2023 25:234
  6. PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies. Ne...

    Authors: Jing Li, Jun Cui, Li Wu, Ya-bing Liu and Qi Wang
    Citation: Arthritis Research & Therapy 2023 25:233
  7. Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in humans. Cur...

    Authors: Jacob Kenny, Benjamin H. Mullin, William Tomlinson, Brett Robertson, Jinbo Yuan, Weiwei Chen, Jinmin Zhao, Nathan J. Pavlos, John P. Walsh, Scott G. Wilson, Jennifer Tickner, Grant Morahan and Jiake Xu
    Citation: Arthritis Research & Therapy 2023 25:232
  8. The objective of this study was to investigate the relation between swelling and tenderness of individual finger joints and grip force in patients with early rheumatoid arthritis (RA).

    Authors: Maria Rydholm, Ankita Sharma, Lennart Jacobsson and Carl Turesson
    Citation: Arthritis Research & Therapy 2023 25:231
  9. Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is characterized by synovial inflammation and condylar cartilage degradation. We are urged ...

    Authors: Xin Liu, Huimin Li, Yaping Feng, Huilin Guo, Yingjie Li, Jin Ke and Xing Long
    Citation: Arthritis Research & Therapy 2023 25:230
  10. Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the treatment of osteoarthritis (OA).

    Authors: Chenfei Huang, Yuechao Zhao, Shengchen Lin, Lin Li, Xuan Guo, Sebastian Yumiseba, Jeng-dar Yang, Robert Hariri, Qian Ye, Shuyang He and Adrian Kilcoyne
    Citation: Arthritis Research & Therapy 2023 25:229
  11. Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone-disease of unknown origin. The National Pediatric Rheumatologic Database (NPRD) collects long-term data of children and adolescents with rh...

    Authors: Christiane Reiser, Jens Klotsche, Toni Hospach, Georg Heubner, Daniel Windschall, Ralf Trauzeddel, Nadine Groesch, Martina Niewerth, Kirsten Minden and Hermann Girschick
    Citation: Arthritis Research & Therapy 2023 25:228
  12. Identifying axial spondyloarthritis (axSpA) activity early and accurately is essential for treating physicians to adjust treatment plans and guide clinical decisions promptly. The current literature is mostly ...

    Authors: Peijin Xin, Qizheng Wang, Ruixin Yan, Yongye Chen, Yupeng Zhu, Enlong Zhang, Cui Ren and Ning Lang
    Citation: Arthritis Research & Therapy 2023 25:227
  13. Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab ...

    Authors: Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar Díaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa and Hector Corominas
    Citation: Arthritis Research & Therapy 2023 25:226
  14. This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in relation to disea...

    Authors: K Kielbassa, L Van der Weele, AE Voskuyl, N de Vries, E Eldering and TW Kuijpers
    Citation: Arthritis Research & Therapy 2023 25:225
  15. Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machine learning (ML). We applied various ML algorithms to compare the clusters of comorbidi...

    Authors: Daniel H. Solomon, Hongshu Guan, Fredrik D. Johansson, Leah Santacroce, Wendi Malley, Lin Guo and Heather Litman
    Citation: Arthritis Research & Therapy 2023 25:224
  16. To establish refined risk prediction models for mortality in patients with microscopic polyangiitis (MPA) by using comprehensive clinical characteristics.

    Authors: Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Daisuke Nishioka, Ryu Watanabe, Takaho Gon, Atsushi Manabe, Mikihito Shoji, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2023 25:223
  17. To determine the prevalence of sustained remission/low disease activity (LDA) in patients with rheumatoid arthritis (RA) after discontinuation of tumor necrosis factor inhibitors (TNFi), separately in inductio...

    Authors: Michael M. Ward, Nima Madanchi, Ali Yazdanyar, Nehal R. Shah and Florina Constantinescu
    Citation: Arthritis Research & Therapy 2023 25:222
  18. The induction direction of interferon (IFN)-α in T-cell phenotype and function varies depending on the activation state of the cell and the time of stimulation. To assess the effects of elevated IFN-α on regul...

    Authors: Shihan Yu, Jia Gu, Rui Wang, Seunghyun Lee, Yu Shan, Jiakai Wang, Yini Sun and Xiaoxue Ma
    Citation: Arthritis Research & Therapy 2023 25:221
  19. The differential diagnosis between adult-onset Still’s disease (AOSD) and sepsis has always been a challenge. In this study, a machine learning model for differential diagnosis of AOSD and sepsis was developed...

    Authors: Dongmei Zhou, Jingzhi Xie, Jiarui Wang, Juan Zong, Quanquan Fang, Fei Luo, Ting Zhang, Hua Ma, Lina Cao, Hanqiu Yin, Songlou Yin and Shuyan Li
    Citation: Arthritis Research & Therapy 2023 25:220
  20. Prior research has revealed a heightened prevalence of neoplasms in individuals diagnosed with rheumatoid arthritis (RA). The primary objective of this study is to delve into the causal association between RA ...

    Authors: Mingyi Yang, Yani Su, Ke Xu, Jiale Xie, Pengfei Wen, Lin Liu, Zhi Yang and Peng Xu
    Citation: Arthritis Research & Therapy 2023 25:219
  21. This article has been retracted. Please see the Retraction Notice for more detail:

    Authors: Nadira Ruzehaji, Jerome Avouac, Muriel Elhai, Maxime Frechet, Camelia Frantz, Barbara Ruiz, Joerg H. Distler and Yannick Allanore
    Citation: Arthritis Research & Therapy 2023 25:218
  22. The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerbation of rheumatoid arthritis (RA) through the promotion of synovitis and cartilage dam...

    Authors: Dong Guo, Haoyan Pan, Xueying Lu, Zhong Chen, Laixi Zhou, Shuxin Chen, Jin Huang, Xinzhi Liang, Zhisheng Xiao, Hua Zeng, Yan Shao, Weizhong Qi, Denghui Xie and Chuangxin Lin
    Citation: Arthritis Research & Therapy 2023 25:217
  23. Intradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is often associated with disc degeneration. Several in vivo studies have demonstrated the reg...

    Authors: Takahiro Hasegawa, Koji Akeda, Junichi Yamada, Koki Kawaguchi, Norihiko Takegami, Tatsuhiko Fujiwara, Takahiro Natsume, Koichiro Ide, Yukihiro Matsuyama and Akihiro Sudo
    Citation: Arthritis Research & Therapy 2023 25:216
  24. Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction. Btk inhibito...

    Authors: Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru and Akihiro Ishizu
    Citation: Arthritis Research & Therapy 2023 25:215
  25. This study sought to evaluate the efficacy and safety of tofacitinib in patients with rheumatoid arthritis with distinct treatment histories.

    Authors: John Tesser, Ahmet Gül, Ewa Olech, Kurt Oelke, Tatjana Lukic, Kenneth Kwok and Abbas Ebrahim
    Citation: Arthritis Research & Therapy 2023 25:214
  26. Cardiovascular (CV) risk estimation calculators for the general population underperform in patients with rheumatoid arthritis (RA). The purpose of this study was to identify relevant protein biomarkers that co...

    Authors: Joan M. Bathon, Michael Centola, Xiaoqian Liu, Zhicheng Jin, Weihua Ji, Nicholas S. Knowlton, Iván Ferraz-Amaro, Qin Fu, Jon T. Giles, Mary Chester Wasko, C. Michael Stein and Jennifer E. Van Eyk
    Citation: Arthritis Research & Therapy 2023 25:213
  27. Systemic sclerosis (SSc), with unclear pathophysiology, is a paradigmatic rheumatic disease of immunity dysfunction-driven multi-organ inflammation and ultimate fibrosis. Pathogenesis breakthroughs are urgentl...

    Authors: Dianyu Cao, Jina Zheng, Zheng Li, Yong Yu, Zengrui Chen and Qiang Wang
    Citation: Arthritis Research & Therapy 2023 25:212
  28. Rheumatoid arthritis is a chronic systemic autoimmune disease that involves transformation of the lining of synovial joints into an invasive and destructive tissue. Synovial fibroblasts become transformed, inv...

    Authors: Shane Bruckner, Vittoria M. Capria, Braden Zeno, Binnaz Leblebicioglu, Kanu Goyal, William K. Vasileff, Hisham Awan, William L. Willis, Latha P. Ganesan and Wael N. Jarjour
    Citation: Arthritis Research & Therapy 2023 25:211
  29. Authors: Marta Valero, Carlos Sanchez-Piedra, Mercedes Freire, Maria Colazo, Noemi Busquets, Erardo Merino-Ibarra, Carlos Rodriguez-Lozano, Sara Manrique, Cristina Campos, Fernando Sanchez-Alonso and Isabel Castrejon
    Citation: Arthritis Research & Therapy 2023 25:210

    The original article was published in Arthritis Research & Therapy 2023 25:86

  30. The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare the risk of bronchiectasis between individuals with systemic sclerosis and those without...

    Authors: Bumhee Yang, Bo-Guen Kim, Kyungdo Han, Jin-Hyung Jung, Ji Hyoun Kim, Dong Won Park, Sang-Heon Kim, Eung-Gook Kim, Jang Won Sohn, Ho Joo Yoon, Hayoung Choi and Hyun Lee
    Citation: Arthritis Research & Therapy 2023 25:209
  31. To compare the 10-year structural and functional prognosis between patients in sustained remission versus patients in sustained low disease activity (LDA) in early rheumatoid arthritis (RA).

    Authors: Adeline Ruyssen-Witrand, Gregory Guernec, Julia Dupont, Diane Lapuyade, Frédéric Lioté, Olivier Vittecoq, Yannick Degboé and Arnaud Constantin
    Citation: Arthritis Research & Therapy 2023 25:207
  32. Circular RNAs are involved in autoimmune disease pathogenesis. Our previous study indicated that circPTPN22 is involved in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthrit...

    Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang
    Citation: Arthritis Research & Therapy 2023 25:206

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:39

  33. In European axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) clinical registries, we aimed to investigate commonalities and differences in (1) set-up, clinical data collection; (2) data availabili...

    Authors: Louise Linde, Lykke M. Ørnbjerg, Simon H. Rasmussen, Thorvardur Jon Love, Anne Gitte Loft, Jakub Závada, Jiří Vencovský, Karin Laas, Dan Nordstrom, Tuulikki Sokka-Isler, Bjorn Gudbjornsson, Gerdur Gröndal, Florenzo Iannone, Roberta Ramonda, Pasoon Hellamand, Eirik K. Kristianslund…
    Citation: Arthritis Research & Therapy 2023 25:205
  34. Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate. Existing resea...

    Authors: Junmei Zhang, Li Sun, XinWei Shi, Shipeng Li, Cuihua Liu, Xiaoqing Li, Meiping Lu, Jianghong Deng, Xiaohua Tan, Wanzhen Guan, Guomin Li, Xinran Wen, Ping Liu and Caifeng Li
    Citation: Arthritis Research & Therapy 2023 25:204
  35. IL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between IL-37 genetic variants, IL-37 plasma levels, and various clinical phases...

    Authors: Lucie Andres Cerezo, Adéla Navrátilová, Hana Hulejová, Markéta Pavlíková, Jakub Závada, Karel Pavelka, Ladislav Šenolt and Blanka Stiburkova
    Citation: Arthritis Research & Therapy 2023 25:203
  36. TNF-α inhibitor (TNFi) serum trough levels have previously been found to be related to disease activity in axial spondyloarthritis (axSpA). However, most research regarding serum trough levels has been conduct...

    Authors: Liseth de Wolff, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma and Anneke Spoorenberg
    Citation: Arthritis Research & Therapy 2023 25:202
  37. Serum exosomes play important roles in intercellular communication and are promising biomarkers of several autoimmune diseases. However, the biological functions and potential clinical importance of long non-c...

    Authors: Li Xue, Biao Wang, Xueyi Li, Jianhong Zhu, Wei Wang, Fang Huang, Xiaofei Wang, Yaofeng Jin, Chaoliang Xiong, Li Tao, Ke Xu, Jing Wang, Ying Guo, Jing Xu, Xin Yang, Na Wang…
    Citation: Arthritis Research & Therapy 2023 25:201
  38. In systemic lupus erythematosus (SLE), autoreactive B cells are thought to develop by-passing immune checkpoints and contribute to its pathogenesis. Toll-like receptor (TLR) 7 and 9 signaling have been implica...

    Authors: Ken Yasaka, Tomohide Yamazaki, Hiroko Sato, Tsuyoshi Shirai, Minkwon Cho, Koji Ishida, Koyu Ito, Tetsuhiro Tanaka, Kouetsu Ogasawara, Hideo Harigae, Tomonori Ishii and Hiroshi Fujii
    Citation: Arthritis Research & Therapy 2023 25:200
  39. Giant cell arteritis (GCA) is primarily treated with glucocorticoids (GCs), which have substantial toxicity. Tocilizumab, an interleukin-6-receptor inhibitor (IL-6Ri), showed beneficial effects in GCA, leading...

    Authors: Wolfgang A. Schmidt, Bhaskar Dasgupta, Jennifer Sloane, Angeliki Giannelou, Yuqing Xu, Sebastian H. Unizony, Sarah L. Mackie, Miguel A. Gonzalez-Gay, Robert Spiera, Kenneth J. Warrington, Peter M. Villiger, Michael C. Nivens, Bolanle Akinlade, Yong Lin, Frank Buttgereit and John H. Stone
    Citation: Arthritis Research & Therapy 2023 25:199
  40. The clinical value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in assessing relapsing polychondritis (RP) with airway involvement remains controversial. This study ai...

    Authors: Jing-Wei Yi, Jun-Feng Huang, Peng Hou, Zi-Kai Lin, Jin-Sheng Lin, Si-Yan Lin, Min Wang, Shi-Yue Li and Xin-Lu Wang
    Citation: Arthritis Research & Therapy 2023 25:198
  41. Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) b...

    Authors: Yu-Hsiu Chen, Xin Zhang, David Attarian and Virginia Byers Kraus
    Citation: Arthritis Research & Therapy 2023 25:197
  42. Upadacitinib (UPA) is a selective JAK inhibitor recently approved for the treatment of psoriatic arthritis (PsA). In this post-approval study, we aimed to evaluate the effectiveness and safety of UPA over 24 w...

    Authors: Michele Maria Luchetti Gentiloni, Valentino Paci, Antonio Carletto, Alen Zabotti, Roberta Ramonda, Maria Sole Chimenti, Lorenzo Dagna, Nicoletta Luciano, Anna Piccinelli, Ivan Giovannini, Giovanni Striani, Nicola Boffini, Gilda Sandri, Niccolò Possemato, Ilenia Pantano, Devis Benfaremo…
    Citation: Arthritis Research & Therapy 2023 25:196
  43. β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association bet...

    Authors: Katsuhiko Yoneda, Yo Ueda, Kenji Tanimura, Hisashi Arase, Hideto Yamada and Jun Saegusa
    Citation: Arthritis Research & Therapy 2023 25:195
  44. Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting on syndesmophyte formation in AS are not we...

    Authors: Yulong Tang, Kai Yang, Qingmei Liu, Yanyun Ma, Hao Zhu, Kunhai Tang, Chengchun Geng, Jiangnan Xie, Dachun Zhuo, Wenyu Wu, Li Jin, Wenze Xiao, Jiucun Wang, Qi Zhu and Jing Liu
    Citation: Arthritis Research & Therapy 2023 25:194
  45. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and bone destruction. The mechanisms of dendritic cell (DC) and T c...

    Authors: Zhandong Wang, Jinlong Zhang, Fangyu An, Jie Zhang, Xiangrui Meng, Shiqing Liu, Ruoliu Xia, Gang Wang and Chunlu Yan
    Citation: Arthritis Research & Therapy 2023 25:193
  46. Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for...

    Authors: Lorena Rodriguez-Martinez, Cristina García-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro and Antonio González
    Citation: Arthritis Research & Therapy 2023 25:192
  47. While many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this improvement or worsening. In our unique RA pregnancy cohort that includes a p...

    Authors: Matthew Wright, Mette Kiel Smed, J. Lee Nelson, Jørn Olsen, Merete Lund Hetland, Nicholas P. Jewell, Vibeke Zoffmann and Damini Jawaheer
    Citation: Arthritis Research & Therapy 2023 25:191
  48. As current therapies for canine osteoarthritis (OA) provide mainly symptomatic improvement and fail to address the complex pathology of the disease, mesenchymal stem cells (MSCs) offer a promising biological a...

    Authors: Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Lore Van Hecke, Koen Chiers, Leen Van Brantegem, Gabriele Braun, Klaus Hellmann, Nathalie de Bouvre, Nathalie Van Bruaene, Tine De Ryck, Luc Duchateau, Bernadette Van Ryssen, Kathelijne Peremans, Jimmy H. Saunders…
    Citation: Arthritis Research & Therapy 2023 25:190

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