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  1. To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) in patients with idiopathic inf...

    Authors: Antonella Notarnicola, Charlotta Preger, Susanna L. Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S. Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E. Lundberg and Cátia Fernandes-Cerqueira
    Citation: Arthritis Research & Therapy 2022 24:62
  2. Treatment of difficult-to-treat rheumatoid arthritis (D2T RA) is one of the greatest unmet needs in rheumatology. This study aims to find out preferable treatment options for a group of D2T RA patients who are...

    Authors: Sae Ochi, Koshiro Sonomoto, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:61
  3. Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly seen in the elderly that affects the whole “organ” including cartilage, subchondral bone, synovium, and muscles. An incre...

    Authors: Chong-Jie Wu, Ri-Xu Liu, Song-Wei Huan, Wang Tang, Yu-Kai Zeng, Jun-Cheng Zhang, Jie Yang, Zhen-Yan Li, Ying Zhou, Zhen-Gang Zha, Huan-Tian Zhang and Ning Liu
    Citation: Arthritis Research & Therapy 2022 24:59
  4. This study aimed to explore the clinical features of gout in adult patients with glycogen storage disease type Ia (GSD Ia).

    Authors: Na Xu, Xinxin Han, Yun Zhang, Xiaoming Huang, Weiguo Zhu, Min Shen, Wen Zhang, Chen Jialin, Min Wei, Zhengqing Qiu and Xuejun Zeng
    Citation: Arthritis Research & Therapy 2022 24:58
  5. TNF-α inhibitors are widely used in rheumatoid arthritis (RA) with varying success. Response to TNF-α inhibition may reflect the evolution of rheumatoid inflammation through fluctuating stages of TNF-α depende...

    Authors: Melanie J. Millier, Niamh C. Fanning, Christopher Frampton, Lisa K. Stamp and Paul A. Hessian
    Citation: Arthritis Research & Therapy 2022 24:57
  6. Rheumatoid arthritis (RA) is characterized by increased cardiovascular (CV) mortality. CV events are particularly high in patients with RA-specific autoimmunity, including rheumatoid factor (RF) and anti-citru...

    Authors: Hélène Gouze, Philippe Aegerter, Roula Said-Nahal, Marie Zins, Marcel Goldberg, Guillaume Morelle, Georg Schett, Maxime Breban and Maria Antonietta D’Agostino
    Citation: Arthritis Research & Therapy 2022 24:56
  7. Treatments used for rheumatoid arthritis (RA) are under investigation for their efficacy to prevent RA in at risk groups. It is therefore important to understand treatment preferences of those at risk. We syst...

    Authors: Gwenda Simons, Joshua Caplan, Rachael L. DiSantostefano, Jorien Veldwijk, Matthias Englbrecht, Karin Schölin Bywall, Ulrik Kihlbom, Karim Raza and Marie Falahee
    Citation: Arthritis Research & Therapy 2022 24:55
  8. Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease for which a lack of bacterial involvement is a key diagnostic feature to distinguish it from other symptomatically rela...

    Authors: Philipp Rausch, Meike Hartmann, John F. Baines and Philipp von Bismarck
    Citation: Arthritis Research & Therapy 2022 24:54
  9. To further improve rheumatoid arthritis (RA) treatment, it is necessary to understand each RA patient’s satisfaction and to identify the factors affecting their satisfaction. Despite the rise in medical costs ...

    Authors: Toshifumi Fujiwara, Masakazu Kondo, Hisakata Yamada, Akihisa Haraguchi, Kenjiro Fujimura, Koji Sakuraba, Satoshi Kamura, Jun-ichi Fukushi, Hisaaki Miyahara, Yasushi Inoue, Tomomi Tsuru, Toshihide Shuto, Seiji Yoshizawa, Eiichi Suematsu, Tomoya Miyamura, Masahiro Ayano…
    Citation: Arthritis Research & Therapy 2022 24:53
  10. Corticosteroid injection for knee osteoarthritis is limited by its modest duration of treatment effect. The liposome formulation of dexamethasone sodium phosphate (TLC599) was developed for the sustained relie...

    Authors: David J. Hunter, Chi-Ching Chang, James Cheng-Chung Wei, Hsiao-Yi Lin, Carl Brown, Tien-Tzu Tai, Chih-Feng Wu, Wing Chia-Ming Chuang and Sheue-Fang Shih
    Citation: Arthritis Research & Therapy 2022 24:52
  11. Although factors initiating the inflammatory response to monosodium urate crystals have been identified, the role of the gut microbiota and their metabolites on gout remains unknown. This study aimed to invest...

    Authors: Han-Ki Park and Sang Jin Lee
    Citation: Arthritis Research & Therapy 2022 24:51
  12. Systemic sclerosis (SSc), an autoimmune disease with unknown etiology and pathogenesis, is characterized by abnormal autoimmunity, vascular dysfunction, and progressive fibrosis of skin and organs. Studies hav...

    Authors: Zhuotong Zeng, Yaoyao Wang, Yangfan Xiao, Jie Zheng, Ruizhen Liu, Xinglan He, Jiangfan Yu, Bingsi Tang, Xiangning Qiu, Rui Tang, Yaqian Shi and Rong Xiao
    Citation: Arthritis Research & Therapy 2022 24:50
  13. Takayasu arteritis (TAK) is a chronic granulomatous large vessel vasculitis with multiple immune cells involved. Chemokines play critical roles in recruitment and activation of immune cells. This study aimed t...

    Authors: Xiufang Kong, Sifan Wu, Xiaojuan Dai, Wensu Yu, Jinghua Wang, Ying Sun, Zongfei Ji, Lingying Ma, Xiaomin Dai, Huiyong Chen, Lili Ma and Lindi Jiang
    Citation: Arthritis Research & Therapy 2022 24:49
  14. Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance and imbalance of immune cell subsets. Natural killer (NK) cells contribute to regulate both the innate and adaptive immune respon...

    Authors: Zhimin Lu, Yao Tian, Ziran Bai, Jiaqing Liu, Yan Zhang, Jingjing Qi, Minli Jin, Jie Zhu and Xia Li
    Citation: Arthritis Research & Therapy 2022 24:48
  15. Drug-free remission is a desirable goal in rheumatoid arthritis (RA) for both patients and clinicians. The aim of this post hoc analysis was to investigate whether clinical and magnetic resonance imaging (MRI)...

    Authors: Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan, Paul Emery, Thomas W. J. Huizinga, Yedid Elbez, Subhashis Banerjee and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2022 24:47
  16. Treatment goals for patients with systemic lupus erythematosus (SLE) include minimising disease activity and reducing the risk of flares. Although belimumab is effective at reducing disease activity and risk o...

    Authors: Sang-Cheol Bae, Damon L. Bass, Myron Chu, Paula Curtis, Richard Dimelow, Laurence Harvey, Beulah Ji, Regina Kurrasch, Saima Muzaffar, Raj Punwaney, David A. Roth, Yeong-Wook Song, Wendy Xie and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2022 24:46
  17. Synovial fibroblasts (SFs) in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of bone/cartilage as mesenchymal stem cells (MSCs). Although MSCs contr...

    Authors: Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:45
  18. Abnormal cartilage calcification is one of the pathological changes of temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that exosomes can regulate the formation of abnormal calci...

    Authors: Qian Liu, Ruoxin Wang, Shujie Hou, Feng He, Yuanjun Ma, Tao Ye, Shibin Yu, Hongwei Chen, Helin Wang and Mian Zhang
    Citation: Arthritis Research & Therapy 2022 24:44
  19. During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, half of patients with pre-existing inflammatory arthritis experience disease flares. The underlying immuno...

    Authors: Anne Sofie Sørensen, Morten Nørgaard Andersen, Kristian Juul-Madsen, Amalie Dyrelund Broksø, Cæcilie Skejø, Henrik Schmidt, Thomas Vorup-Jensen and Tue Wenzel Kragstrup
    Citation: Arthritis Research & Therapy 2022 24:43
  20. Based on clinical and genetic associations, axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) are suspected to have a linked pathogenesis. Gut dysbiosis, intrinsic to IBD, has also been obse...

    Authors: Jonas Sagard, Tor Olofsson, Elisabeth Mogard, Jan Marsal, Kristofer Andréasson, Mats Geijer, Lars Erik Kristensen, Elisabet Lindqvist and Johan K. Wallman
    Citation: Arthritis Research & Therapy 2022 24:42
  21. Hepatitis C virus (HCV) is the main etiology of cryoglobulinemia with mortality around 25%. Little is known on the changes in cryoglobulinemia mortality after the introduction of direct-acting antivirals (DAA)...

    Authors: Qianyu Guo, Jinfang Gao, Jiaoniu Duan, Ruihong Hou, Tsung-Hsueh Lu and Liyun Zhang
    Citation: Arthritis Research & Therapy 2022 24:41
  22. This study examined the time to clinically meaningful response in patients with active psoriatic arthritis treated with tofacitinib, adalimumab, or placebo switching to tofacitinib.

    Authors: Dafna D. Gladman, Laura C. Coates, Joseph Wu, Lara Fallon, Elizabeth D. Bacci, Joseph C. Cappelleri, Andrew G. Bushmakin and Philip S. Helliwell
    Citation: Arthritis Research & Therapy 2022 24:40
  23. Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc...

    Authors: Kathleen D. Kolstad, Avani Khatri, Michele Donato, Sarah E. Chang, Shufeng Li, Virginia D. Steen, Paul J. Utz, Purvesh Khatri and Lorinda Chung
    Citation: Arthritis Research & Therapy 2022 24:39
  24. Deep learning applied to ultrasound (US) can provide a feedback to the sonographer about the correct identification of scanned tissues and allows for faster and standardized measurements. The most frequently a...

    Authors: Gianluca Smerilli, Edoardo Cipolletta, Gianmarco Sartini, Erica Moscioni, Mariachiara Di Cosmo, Maria Chiara Fiorentino, Sara Moccia, Emanuele Frontoni, Walter Grassi and Emilio Filippucci
    Citation: Arthritis Research & Therapy 2022 24:38
  25. Certain circRNAs could be used as biomarkers to determine the risk of development and/or severity of systemic lupus erythematosus, and their new function in the regulation of gene expression has motivated us t...

    Authors: Xingwang Zhao, Rui Dong, Longlong Zhang, Junkai Guo, Ying Shi, Lan Ge, Juan Wang, Zhiqiang Song, Bing Ni and Yi You
    Citation: Arthritis Research & Therapy 2022 24:37
  26. Analyses of lymphoid organs are required to further elucidate the pathogenesis of inflammatory diseases like rheumatoid arthritis (RA). Yet, invasive tissue collection methods are scarcely applied, because the...

    Authors: Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas and Lisa G. M. van Baarsen
    Citation: Arthritis Research & Therapy 2022 24:36
  27. Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction o...

    Authors: Yuan-yuan Wu, Xiao-feng Li, Sha Wu, Xue-ni Niu, Su-qin Yin, Cheng Huang and Jun Li
    Citation: Arthritis Research & Therapy 2022 24:35
  28. To describe the longitudinal associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and joint structural changes in tibiofemoral compartments in patients with knee osteoarthrit...

    Authors: Jun Chang, Tianyu Chen, Yizhu Yan, Zhaohua Zhu, Weiyu Han, Yi Zhao, Benny Antony, Anita Wluka, Tania Winzenberg, Flavia Cicuttini and Changhai Ding
    Citation: Arthritis Research & Therapy 2022 24:34
  29. From this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) and (2) determine their prognostic value.

    Authors: Alexis F. Guédon, Jennifer Catano, Laure Ricard, Charlotte Laurent, Claire de Moreuil, Geoffrey Urbanski, Sophie Deriaz, Grigorios Gerotziafas, Ismail Elalamy, Alexandra Audemard, Francois Chasset, Sonia Alamowitch, Jérémie Sellam, François Maillot, Jean Jacques Boffa, Ariel Cohen…
    Citation: Arthritis Research & Therapy 2022 24:33
  30. Patients with gout frequently have low urinary pH, which is associated with the nephrolithiasis. However, the specific distribution of urinary pH and potential relationship of acidic urine pH to broader manife...

    Authors: Yuwei He, Xiaomei Xue, Robert Terkeltaub, Nicola Dalbeth, Tony R. Merriman, David B. Mount, Zhe Feng, Xinde Li, Lingling Cui, Zhen Liu, Yan Xu, Ying Chen, Hailong Li, Aichang Ji, Xiaopeng Ji, Xuefeng Wang…
    Citation: Arthritis Research & Therapy 2022 24:32
  31. To examine how female patients with RA form decisions about having children, pregnancy, and medication use.

    Authors: Nevena Rebić, Sarah Munro, Ria Garg, Glen Hazlewood, Neda Amiri, Corisande Baldwin, Stephanie Ensworth, Laurie Proulx and Mary A. De Vera
    Citation: Arthritis Research & Therapy 2022 24:31
  32. To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi).

    Authors: Maria Llop, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Eugenio de Miguel, Raquel Almodóvar, Eduardo Cuende Quintana, Jesús Sanz Sanz, Emma Beltrán, M. Dolores Ruiz Montesinos, Joan Calvet, Antoni Berenguer-Llergo and Jordi Gratacós
    Citation: Arthritis Research & Therapy 2022 24:30
  33. In patients with axial spondyloarthritis (axSpA), magnetic resonance imaging (MRI) is used to detect bone marrow edema (BME) in sacroiliac joints (SIJ) but SIJ BME are also detected in the population. Not much...

    Authors: J. Braun, X. Baraliakos, R. Bülow, C. O. Schmidt and A. Richter
    Citation: Arthritis Research & Therapy 2022 24:29
  34. Psoriasis patients developing psoriatic arthritis (PsA) are thought to go through different phases. Understanding the underlying events in these phases is crucial to diagnose PsA early. Here, we have character...

    Authors: Hannah den Braanker, Wida Razawy, Kim Wervers, Anne-Marie C. Mus, Nadine Davelaar, Marc R. Kok and Erik Lubberts
    Citation: Arthritis Research & Therapy 2022 24:28
  35. Penfluridol, isolated from an FDA-approved small-molecule drug library as an inhibitor of tumor necrosis factor α (TNFα)-stimulated NF-κB activation, is clinically used to treat chronic schizophrenia and relat...

    Authors: Yue-hong Chen, Rong-han Liu, Ya-zhou Cui, Aubryanna Hettinghouse, Wen-yu Fu, Lei Zhang, Chen Zhang and Chuan-ju Liu
    Citation: Arthritis Research & Therapy 2022 24:27
  36. Musculoskeletal (MSK) symptoms are among the commonest reasons for primary care assessments; however, few individuals will be diagnosed with an inflammatory arthritis (IA) within the following year. The purpos...

    Authors: Leticia Garcia-Montoya, Jacqueline L. Nam, Laurence Duquenne, Catalina Villota-Eraso, Andrea Di Matteo, Collette Hartley, Kulveer Mankia and Paul Emery
    Citation: Arthritis Research & Therapy 2022 24:26
  37. Intervertebral disc (IVD) herniation is characterized by annulus fibrosus failure (AF) in containing the nucleus pulposus (NP). IVD herniation involves cellular and extracellular matrix (ECM) alterations that ...

    Authors: A. L. Castro, C. Ribeiro-Machado, C. M. Oliveira, G. Q. Teixeira, C. Neidlinger-Wilke, P. Pereira, R. Vaz, M. A. Barbosa and R. M. Gonçalves
    Citation: Arthritis Research & Therapy 2022 24:25
  38. Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unkn...

    Authors: Zheni Stavre, Charles Bridgewood, Qiao Zhou, Yukiko Maeda, Ting-ting Huang, Jozsef Karman, Almas Khan, Sami Giryes, Kassem Sharif, Dennis McGonagle and Ellen M. Gravallese
    Citation: Arthritis Research & Therapy 2022 24:24
  39. Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA). In vivo, ACPAs target peptidyl-citrulline epitopes (cit-) in a variety of proteins (cit-prot-ACPAs) and derived ...

    Authors: Natalia Regine de França, Henri André Ménard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luís Eduardo Coelho Andrade and Inés Colmegna
    Citation: Arthritis Research & Therapy 2022 24:23
  40. The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, the latter experience a higher burden of disease and are affected more frequently by polyarthritis. Here, we performed an earl...

    Authors: E. Passia, M. Vis, L. C. Coates, A. Soni, I. Tchetverikov, A. H. Gerards, M. R. Kok, P. A. J. M. Vos, L. Korswagen, F. Fodili, Y. P. M. Goekoop-Ruiterman, J. van der Kaap, M. van Oosterhout and J. J. Luime
    Citation: Arthritis Research & Therapy 2022 24:22
  41. Little is known about the safety of SARS-CoV-2 vaccination in patients with rheumatic musculoskeletal disease (RMD). We evaluated the occurrence of adverse events following immunization (AEFI) in RMD patients ...

    Authors: Francesca Romana Spinelli, Ennio Giulio Favalli, Cristina Garufi, Martina Cornalba, Serena Colafrancesco, Fabrizio Conti and Roberto Caporali
    Citation: Arthritis Research & Therapy 2022 24:21
  42. Interstitial lung disease (ILD) is a common organ manifestation in systemic sclerosis (SSc) and is the leading cause of death in patients with SSc. A decline in forced vital capacity (FVC) is an indicator of I...

    Authors: Michael Kreuter, Francesco Del Galdo, Corinna Miede, Dinesh Khanna, Wim A. Wuyts, Laura K. Hummers, Margarida Alves, Nils Schoof, Christian Stock and Yannick Allanore
    Citation: Arthritis Research & Therapy 2022 24:19
  43. Synovial fluid (SF) is commonly used for diagnostic and research purposes, as it is believed to reflect the local inflammatory environment. Owing to its complex composition and especially the presence of hyalu...

    Authors: Hilde Brouwers, Johannes Hendrick von Hegedus, Enrike van der Linden, Rachid Mahdad, Margreet Kloppenburg, René Toes, Martin Giera and Andreea Ioan-Facsinay
    Citation: Arthritis Research & Therapy 2022 24:18
  44. Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear.

    Authors: Bing Wang, Hui Deng, Yao Hu, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Siyuan Wu, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang and Kexiang Yan
    Citation: Arthritis Research & Therapy 2022 24:17
  45. Although the risk of cardiovascular disease has been discussed extensively in both psoriasis (PsO) and psoriatic arthritis (PsA), very few studies have addressed the occurrence of venous thromboembolic (VTE) e...

    Authors: Tal Gazitt, Jacob Pesachov, Idit Lavi, Muna Elias, Amir Haddad, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba and Devy Zisman
    Citation: Arthritis Research & Therapy 2022 24:16
  46. The currently known risk loci could explain a small proportion of the heritability of ankylosing spondylitis (AS). Epigenetics might account for the missing heritability. We aimed to seek more novel AS-associa...

    Authors: Min Xiao, Xuqi Zheng, Xiaomin Li, Xinyu Wu, Yefei Huang, Qiujing Wei, Shuangyan Cao and Jieruo Gu
    Citation: Arthritis Research & Therapy 2022 24:15
  47. The relationship between IgG4-related disease (IgG4-RD) and the risk of malignancy is still controversial. This article focused on assessing the risk of cancer in patients with IgG4-RD by meta-analysis.

    Authors: Tingfeng Yu, Yaxian Wu, Jia Liu, Yanyan Zhuang, Xiaoyan Jin and Lingyun Wang
    Citation: Arthritis Research & Therapy 2022 24:14

    The Correspondence to this article has been published in Arthritis Research & Therapy 2022 24:122

  48. Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and...

    Authors: Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphaël Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frédéric Batteux, Jérôme Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon and Yannick Allanore
    Citation: Arthritis Research & Therapy 2022 24:13

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