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  1. Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of sy...

    Authors: Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies and C. Thomas Appleton
    Citation: Arthritis Research & Therapy 2024 26:73
    Content type: Research Published on:

  3. Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we aim to investigate the role of TfR1 in OA progression and its underly...

    Authors: Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang and Xingzhi Jing
    Citation: Arthritis Research & Therapy 2024 26:71
    Content type: Research Published on:

  4. Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself.

    Authors: Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette and Niek de Vries
    Citation: Arthritis Research & Therapy 2024 26:70
    Content type: Research Published on:

  5. To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease.

    Authors: Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič and Tadej Avčin
    Citation: Arthritis Research & Therapy 2024 26:69
    Content type: Research Published on:

  6. To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sjögren’s disease (SjD).

    Authors: Lisa Christ, Seraphina Kissling, Axel Finckh, Benjamin A. Fisher, Sabine Adler, Britta Maurer, Burkhard Möller and Florian Kollert
    Citation: Arthritis Research & Therapy 2024 26:68
    Content type: Research Published on:

  7. To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP).

    Authors: Jun Li, Liying Peng, Lijun Wu, Yufang Ding, Xinwang Duan, Jian Xu, Wei Wei, Zhen Chen, Cheng Zhao, Min Yang, Nan Jiang, Shangzhu Zhang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng…
    Citation: Arthritis Research & Therapy 2024 26:67
    Content type: Research Published on:

  8. CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for understanding molecular pathways driving cartilage diseases. However, primary chondrocytes a...

    Authors: Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong and Goncalo Barreto
    Citation: Arthritis Research & Therapy 2024 26:66
    Content type: Research Published on:

  9. Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnan...

    Authors: Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg, Tansim Akhter, Dag Leonard, Lars Rönnblom, Sofia Pihl, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majczuk Sennström, Agneta Zickert…
    Citation: Arthritis Research & Therapy 2024 26:65
    Content type: Research Published on:

  10. Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to...

    Authors: Chen Cheng, Hao Yang, Chan Yang, Juan Xie, Jinshen Wang, Luping Cheng, Jianfu He, Honglian Li, Haoxing Yuan, Fangfang Guo, Minmin Li and Shuwen Liu
    Citation: Arthritis Research & Therapy 2024 26:64
    Content type: Research Published on:

  11. Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between lupus flares and elevated risks of adverse pregnancy outcomes (APOs), securing remissi...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:63
    Content type: Research Published on:

  12. Primary Sjogren’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, with the possibility of manifestations across multiple organs. Antibody-producing B cells have...

    Authors: Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li and Liyun Zou
    Citation: Arthritis Research & Therapy 2024 26:62
    Content type: Research Published on:

  13. Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoi...

    Authors: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed and Per-Johan Jakobsson
    Citation: Arthritis Research & Therapy 2024 26:61
    Content type: Research Published on:

  15. The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.

    Authors: Na Li, Liufu Cui, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Gary Tse, Nan Zhang, Xuemei Yang, Wenqi Xu, Shouling Wu and Tong Liu
    Citation: Arthritis Research & Therapy 2024 26:59
    Content type: Research Published on:

  16. The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants.

    Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu and Min Shen
    Citation: Arthritis Research & Therapy 2024 26:58
    Content type: Research Published on:

  17. Patients with Rheumatoid Arthritis (RA) have a higher prevalence of comorbidities compared to the general population. However, the implications of multimorbidity on therapeutic response and treatment retention...

    Authors: Jerusalem Calvo-Gutiérrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Montesino, Manuel Pombo-Suarez, Inmaculada Ros-Vilamajo, Fernando Sánchez-Alonso and Isabel Castrejón
    Citation: Arthritis Research & Therapy 2024 26:57
    Content type: Research Published on:

  18. Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like synoviocytes in RA (RA-FLSs-Exos) play a role in the development of RA, and ci...

    Authors: Guoqing Li, Yuxuan Fang, Nan Xu, Yimin Ding and Dan Liu
    Citation: Arthritis Research & Therapy 2024 26:56
    Content type: Research Published on:

  19. IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obli...

    Authors: Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2024 26:55
    Content type: Research Published on:

  20. Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus ne...

    Authors: Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, Betty Diamond…
    Citation: Arthritis Research & Therapy 2024 26:54
    Content type: Research Published on:

  21. Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they re...

    Authors: Akshay Pandey, Mamta Singla, Ana Geller, Stuart B. Goodman and Nidhi Bhutani
    Citation: Arthritis Research & Therapy 2024 26:53
    Content type: Research Published on:

  22. Henoch–Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regu...

    Authors: Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau and Tu Anh Tran
    Citation: Arthritis Research & Therapy 2024 26:52
    Content type: Research Published on:

  23. Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of c...

    Authors: Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema and Hani El-Gabalawy
    Citation: Arthritis Research & Therapy 2024 26:51
    Content type: Correspondence Published on:

  24. Capacity to work is impacted by psoriatic arthritis (PsA). Our objective was to describe the course of work productivity and leisure activity in patients with PsA treated with biologic (b) and targeted synthet...

    Authors: Laure Gossec, Brittany Humphries, Megan Rutherford, Vanessa Taieb, Damon Willems and William Tillett
    Citation: Arthritis Research & Therapy 2024 26:50
    Content type: Review Published on:

  25. We report long-term, end-of-study program safety outcomes from 25 randomized clinical trials (RCTs) in adult patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA) [includ...

    Authors: Atul Deodhar, Andrew Blauvelt, Mark Lebwohl, Meghan Feely, Andris Kronbergs, Nadezhda Eberhart, Danting Zhu, Elsa Inman, Elsie Grace, Thorsten Holzkaemper, Proton Rahman, Helena Marzo-Ortega, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb and Sergio Schwartzman
    Citation: Arthritis Research & Therapy 2024 26:49
    Content type: Research Published on:

  26. Previous studies have shown conflicting evidence regarding the incidence of cancer in patients with systemic lupus erythematosus (SLE) compared with that in healthy individuals. Calcineurin inhibitors (CNIs) s...

    Authors: Kunihiro Ichinose, Shuntaro Sato, Takashi Igawa, Momoko Okamoto, Ayuko Takatani, Yushiro Endo, Sosuke Tsuji, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Nobuyuki Yajima…
    Citation: Arthritis Research & Therapy 2024 26:48
    Content type: Research Published on:

  27. Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been e...

    Authors: Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung and Wonhee Jang
    Citation: Arthritis Research & Therapy 2024 26:47
    Content type: Research Published on:

  28. Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pe...

    Authors: Mira Sandersfeld, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz and Christoph Daniel
    Citation: Arthritis Research & Therapy 2024 26:46
    Content type: Research Published on:

  29. Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both alcohol consumption and serum urate or gout in sep...

    Authors: Min H Chuah, Megan P Leask, Ruth K Topless, Gregory D Gamble, Nicholas A Sumpter, Lisa K Stamp, Tony R Merriman and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2024 26:45
    Content type: Research Published on:

  30. Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from...

    Authors: Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser and Ruth Fritsch-Stork
    Citation: Arthritis Research & Therapy 2024 26:44
    Content type: Research Published on:

  31. Sjögren’s disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and ...

    Authors: Mehrnaz Maleki-Fischbach, Liudmila Kastsianok, Matthew Koslow and Edward D. Chan
    Citation: Arthritis Research & Therapy 2024 26:43
    Content type: Review Published on:

  32. Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health. However, it remains unclear whether DAS...

    Authors: N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil and H. W. van Steenbergen
    Citation: Arthritis Research & Therapy 2024 26:42
    Content type: Research Published on:

  33. Although cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an animal model of cervical disc degeneration and discogenic neck pain i...

    Authors: Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao and Binhui Chen
    Citation: Arthritis Research & Therapy 2024 26:41
    Content type: Research Published on:

  35. Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang
    Citation: Arthritis Research & Therapy 2024 26:39
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:206

  36. Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function is a more sensitive predictor of central nervous system damage, and abn...

    Authors: Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2024 26:38
    Content type: Research Published on:

  37. The etiology of giant cell arteritis (GCA) and its predictors are incompletely understood. Previous studies have indicated reduced risk of future development of GCA in individuals with obesity and/or diabetes ...

    Authors: Karin Wadström, Lennart T. H. Jacobsson, Aladdin J. Mohammad, Kenneth J. Warrington, Eric L. Matteson and Carl Turesson
    Citation: Arthritis Research & Therapy 2024 26:37
    Content type: Research Published on:

  38. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This ...

    Authors: Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu and Youhua Wang
    Citation: Arthritis Research & Therapy 2024 26:36
    Content type: Research Published on:

  39. Whether rheumatoid arthritis patients have an increased risk of cervical cancer remains controversial, and further research is needed on this clinical question. This study aims to investigate the association b...

    Authors: Minxian Xu, Huan Chen, Tao Tan, Kaihong Xie, Hui Xie and Qing Li
    Citation: Arthritis Research & Therapy 2024 26:35
    Content type: Research Published on:

  40. Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan
    Citation: Arthritis Research & Therapy 2024 26:34
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:151

  41. Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation in primary osteoarthritis (OA), a common age-associated joint disease. EV subpopulati...

    Authors: Anne-Mari Mustonen, Mari Palviainen, Laura Säisänen, Lauri Karttunen, Sylvain Tollis, Amir Esrafilian, Jusa Reijonen, Petro Julkunen, Pia R-M Siljander, Heikki Kröger, Jussi Mäki, Jari Arokoski and Petteri Nieminen
    Citation: Arthritis Research & Therapy 2024 26:33
    Content type: Research Published on:

  42. PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, a...

    Authors: Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich and Adam Mor
    Citation: Arthritis Research & Therapy 2024 26:32
    Content type: Research Published on:

  43. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the ...

    Authors: Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng and Richard Bucala
    Citation: Arthritis Research & Therapy 2024 26:31
    Content type: Research Published on:

  44. To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relation...

    Authors: Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath and David J. Hunter
    Citation: Arthritis Research & Therapy 2024 26:30
    Content type: Research Published on:

  45. Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonar...

    Authors: Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo and Xiaoxia Zuo
    Citation: Arthritis Research & Therapy 2024 26:29
    Content type: Research Published on:

  46. To early recognise and improve the prognosis of children systemic lupus erythematosus (cSLE)-associated pancreatitis by summarising and analysing clinical features and prognosis data from 12 cases.

    Authors: Dan Zhang, Jianming Lai, Gaixiu Su, Jia Zhu, Min, Kang, Ming Li, Yingjie Xu and Li Meng
    Citation: Arthritis Research & Therapy 2024 26:28
    Content type: Research Published on:

  47. Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in DERMatomyositis) study is the first large randomised, placebo-con...

    Authors: Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Csörgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V. Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi and Todd Levine
    Citation: Arthritis Research & Therapy 2024 26:27
    Content type: Research Published on:

  48. Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than those with o...

    Authors: Jingwei Hong, Hui Cheng, Ping Wang, Yanzhi Wu, Saisai Lu, Yan Zhou, Xiao bing Wang and Xiaofang Zhu
    Citation: Arthritis Research & Therapy 2024 26:26
    Content type: Research Published on:

  49. Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent pr...

    Authors: Kwanghoon Lee, Soheil Niku, Sonya J. Koo, Ernest Belezzuoli and Monica Guma
    Citation: Arthritis Research & Therapy 2024 26:25
    Content type: Review Published on:

  50. Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological fact...

    Authors: Yuchang Fei, Huan Yu, Yulun Wu and Shanshan Gong
    Citation: Arthritis Research & Therapy 2024 26:24
    Content type: Research Published on:
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Arthritis Research & Therapy

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