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  1. In contrast to other chronic rheumatic musculoskeletal diseases such as rheumatoid arthritis, comorbidities in axial spondyloarthritis (axSpA) and their impact on disease outcomes are less well studied. The ai...

    Authors: Imke Redeker, Johanna Callhoff, Falk Hoffmann, Ursula Marschall, Hildrun Haibel, Joachim Sieper, Angela Zink and Denis Poddubnyy

    Citation: Arthritis Research & Therapy 2020 22:210

    Content type: Research article

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  2. To examine the relation between inflammatory potential of diet and incident knee osteoarthritis (OA) and the role of BMI in the association of interest.

    Authors: Qiang Liu, James R. Hebert, Nitin Shivappa, Jianjun Guo, Ke Tao, Chao Zeng, Guanghua Lei, Jianhao Lin and Yuqing Zhang

    Citation: Arthritis Research & Therapy 2020 22:209

    Content type: Research article

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  3. Predictive biomarkers of progression in knee osteoarthritis are sought to enable clinical trials of structure-modifying drugs. A peripheral blood leukocyte (PBL) inflammatory gene signature, MRI-based bone mar...

    Authors: Mukundan Attur, Svetlana Krasnokutsky, Hua Zhou, Jonathan Samuels, Gregory Chang, Jenny Bencardino, Pamela Rosenthal, Leon Rybak, Janet L. Huebner, Virginia B. Kraus and Steven B. Abramson

    Citation: Arthritis Research & Therapy 2020 22:208

    Content type: Research article

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  4. Limited information exists about the very early forms of psoriatic arthritis. In particular, differences and responsiveness of patient-reported outcomes (PROs) in very early as compared to established PsA have...

    Authors: Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2020 22:207

    Content type: Research article

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  5. Diabetes is common in patients with rheumatoid arthritis (RA). Interleukin (IL)-6 is implicated in both the pathogenesis of RA and in glucose homeostasis; this post hoc analysis investigated the effects of IL-...

    Authors: Mark C. Genovese, Gerd R. Burmester, Owen Hagino, Karthinathan Thangavelu, Melitza Iglesias-Rodriguez, Gregory St John, Miguel A. González-Gay, Thomas Mandrup-Poulsen and Roy Fleischmann

    Citation: Arthritis Research & Therapy 2020 22:206

    Content type: Research article

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  6. The CAMERA-II trial compared two tight-control, treat-to-target strategies, initiating methotrexate with prednisone (MTX+pred) or MTX with placebo (MTX+plac), in early RA-patients. The multi-biomarker disease ...

    Authors: M. S. Jurgens, M. Safy-Khan, M. J. H. de Hair, J. W. J. Bijlsma, P. M. J. Welsing, J. Tekstra, F. P. J. G. Lafeber, E. H. Sasso and J. W. G. Jacobs

    Citation: Arthritis Research & Therapy 2020 22:205

    Content type: Research article

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  7. Knee osteoarthritis (OA) is a common disabling disease involving the entire joint tissue, and its onset and progression are affected by many factors. However, the current number of studies investigating the re...

    Authors: Xuequan Han, Junqi Cui, Kai Xie, Xu Jiang, Zihao He, Jingke Du, Linyang Chu, Xinhua Qu, Songtao Ai, Qi Sun, Liao Wang, Haishan Wu, Weituo Zhang, Zhifeng Yu and Mengning Yan

    Citation: Arthritis Research & Therapy 2020 22:203

    Content type: Research article

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  8. A role for the type II arginine methyltransferase PRMT5 in various human diseases has been identified. In this study, the potential mechanism underlying the involvement of PRMT5 in the pathological process lea...

    Authors: Yonghui Dong, Ping Wang, Yongguang Yang, Jincheng Huang, Zhipeng Dai, Wendi Zheng, Zhen Li, Zheng Yao, Hongjun Zhang and Jia Zheng

    Citation: Arthritis Research & Therapy 2020 22:201

    Content type: Research article

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  9. The disruption of metabolic events and changes to nutrient and oxygen availability due to sustained inflammation in RA increases the demand of bioenergetic and biosynthetic processes within the damaged tissue....

    Authors: Jing Xu, Congshan Jiang, Yongsong Cai, Yuanxu Guo, Xipeng Wang, Jiaxiang Zhang, Jiawen Xu, Ke Xu, Wenhua Zhu, Si Wang, Fujun Zhang, Manman Geng, Yan Han, Qilan Ning, Peng Xu, Liesu Meng…

    Citation: Arthritis Research & Therapy 2020 22:200

    Content type: Research article

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  10. Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100...

    Authors: Arjen B. Blom, Martijn H. van den Bosch, Esmeralda N. Blaney Davidson, Johannes Roth, Thomas Vogl, Fons A. van de Loo, Marije Koenders, Peter M. van der Kraan, Edwin J. Geven and Peter L. van Lent

    Citation: Arthritis Research & Therapy 2020 22:199

    Content type: Research article

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  11. Sleep disturbances, fatigue, and anxiety/depression in psoriatic arthritis (PsA) may be influenced by skin and musculoskeletal manifestations. All of these in turn affect the psychosocial impact of disease. Th...

    Authors: Glenn Haugeberg, Mari Hoff, Arthur Kavanaugh and Brigitte Michelsen

    Citation: Arthritis Research & Therapy 2020 22:198

    Content type: Research article

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  12. Ultrasound is a useful tool to evaluate and quantify skin lesions. Few studies have assessed the criterion validity of skin ultrasound in systemic sclerosis (SSc). The aims of the study were to investigate ski...

    Authors: Chen Chen, Yi Cheng, Xiaoxia Zhu, Yehua Cai, Yu Xue, Ning Kong, Yiyun Yu, Dandan Xuan, Shucong Zheng, Xue Yang, Zaihua Zhu, Tianyi Zhao, Weiguo Wan, Hejian Zou and Minrui Liang

    Citation: Arthritis Research & Therapy 2020 22:197

    Content type: Research article

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  13. The mechanisms by which only some rheumatoid arthritis (RA) patients respond favorably to TNF blockade are still poorly characterized. The goal of this study was to identify biological features that explain th...

    Authors: Antonio Julià, Gabriela Ávila, Raquel Celis, Raimon Sanmartí, Julio Ramírez, Sara Marsal and Juan D. Cañete

    Citation: Arthritis Research & Therapy 2020 22:196

    Content type: Research article

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  14. To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to the second TNFi in axial spondyloarthritis (axSpA).

    Authors: Santiago Rodrigues Manica, Alexandre Sepriano, Fernando Pimentel-Santos, Nélia Gouveia, Anabela Barcelos, Jaime C. Branco, Miguel Bernardes, Raquel Miriam Ferreira, Elsa Vieira-Sousa, Sofia Barreira, Filipe Vinagre, Raquel Roque, Helena Santos, Nathalie Madeira, João Rovisco, Alexandra Daniel…

    Citation: Arthritis Research & Therapy 2020 22:195

    Content type: Research article

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  15. Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining ...

    Authors: Li Duan, Yujie Liang, Xiao Xu, Yin Xiao and Daping Wang

    Citation: Arthritis Research & Therapy 2020 22:194

    Content type: Review

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  16. The development of autoantibodies in patients with rheumatoid arthritis (RA) has potential as a marker of treatment response. This analysis assessed the association of an autoantibody response to carbamylated ...

    Authors: Pedro López-Romero, Lorena Martinez-Gamboa, Holger Bang, Inmaculada de la Torre, Thorsten Holzkämper and Eugen Feist

    Citation: Arthritis Research & Therapy 2020 22:193

    Content type: Research article

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  17. To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and heal...

    Authors: A. Schmidt, A. M. Glimm, I. K. Haugen, P. Hoff, G. Schmittat, G. R. Burmester, J. Klotsche and S. Ohrndorf

    Citation: Arthritis Research & Therapy 2020 22:192

    Content type: Research article

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  18. Although hydroxychloroquine (HCQ) is a mainstay of treatment for patients with systemic lupus erythematosus (SLE), ocular toxicity can result from accumulated exposure. As the longevity of patients with SLE im...

    Authors: Ruth Fernandez-Ruiz, Nicole Bornkamp, Mimi Y. Kim, Anca Askanase, Anna Zezon, Chung-E Tseng, H. Michael Belmont, Amit Saxena, Jane E. Salmon, Michael Lockshin, Jill P. Buyon and Peter M. Izmirly

    Citation: Arthritis Research & Therapy 2020 22:191

    Content type: Research article

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  19. Ovarian toxicity is a dreaded complication of cyclophosphamide (CYC). With the use of lower cumulative doses of intravenous CYC (modified NIH regimens) and availability of better markers of ovarian toxicity, t...

    Authors: Shefali Khanna Sharma, Siddharth Jain, Pooja Bahl, Pragna Potturi, Manish Rathi, Shankar Naidu, Naresh Sachdeva, Varun Dhir and Sanjay Jain

    Citation: Arthritis Research & Therapy 2020 22:189

    Content type: Research article

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  20. Phase III clinical trials of the tumour necrosis factor inhibitors SB4, SB2, and SB5 (biosimilars to etanercept, infliximab, and adalimumab, respectively) have demonstrated efficacy in moderate-to-severe rheum...

    Authors: Josef S. Smolen, Young Mo Kang, Wan-Hee Yoo, Paul Emery, Michael E. Weinblatt, Edward C. Keystone, Mark C. Genovese, Gihyun Myung, Inyoung Baek and Jeehoon Ghil

    Citation: Arthritis Research & Therapy 2020 22:188

    Content type: Research article

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  21. This study aimed to investigate the relationship between radiological severity, as assessed by the individual grades and grouped grades (grades “0 and 1” and “2 to 4”) of the Kellgren-Lawrence scale (K&Ls), an...

    Authors: Isadora Cristina Ribeiro, Arlete Maria Valente Coimbra, Beatriz Lavras Costallat and Ibsen Bellini Coimbra

    Citation: Arthritis Research & Therapy 2020 22:187

    Content type: Research article

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  22. Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocy...

    Authors: Tobias Schmidt, Elisabet Berthold, Sabine Arve-Butler, Birgitta Gullstrand, Anki Mossberg, Fredrik Kahn, Anders A. Bengtsson, Bengt Månsson and Robin Kahn

    Citation: Arthritis Research & Therapy 2020 22:186

    Content type: Research article

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  23. Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not bee...

    Authors: Pattarin Tangtanatakul, Chisanu Thumarat, Nusara Satproedprai, Punna Kunhapan, Tassamonwan Chaiyasung, Siriwan Klinchanhom, Yong-Fei Wang, Wei Wei, Jeerapat Wongshinsri, Direkrit Chiewchengchol, Pongsawat Rodsaward, Pintip Ngamjanyaporn, Thanitta Suangtamai, Surakameth Mahasirimongkol, Prapaporn Pisitkun and Nattiya Hirankarn

    Citation: Arthritis Research & Therapy 2020 22:185

    Content type: Research article

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  24. Endoplasmic reticulum (ER) stress is closely related with the pathological progression of rheumatoid arthritis (RA), and fibroblast-like synoviocytes (FLSs) are known as its resistance against ER stress-induce...

    Authors: Xiaomei Yang, Qingwei Guo, Tingting Feng, Qiqi Lu, Luna Ge, Jihong Pan, Kehong Bi, Li Qiao, Lei Tian, Tianhua Xie, Chengfang Yao, Guanhua Song and Lin Wang

    Citation: Arthritis Research & Therapy 2020 22:184

    Content type: Research article

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  25. Autologous hematopoietic stem cell transplantation (aHSCT) is a treatment option for a selected group of systemic sclerosis (SSc) patients with good available evidence but can be associated with considerable m...

    Authors: Michael Gernert, Hans-Peter Tony, Eva Christina Schwaneck, Matthias Fröhlich and Marc Schmalzing

    Citation: Arthritis Research & Therapy 2020 22:183

    Content type: Research article

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  26. The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese.

    Authors: Minh Duc Do, Thao Phuong Mai, Anh Duy Do, Quang Dinh Nguyen, Nghia Hieu Le, Linh Gia Hoang Le, Vu Anh Hoang, Anh Ngoc Le, Hung Quoc Le, Pascal Richette, Matthieu Resche-Rigon and Thomas Bardin

    Citation: Arthritis Research & Therapy 2020 22:182

    Content type: Research article

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  27. To determine the feasibility and validity of using wearable activity trackers to test associations between gout flares with physical activity and sleep.

    Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, Lang Chen, Cooper Filby, Ted R. Mikuls, Jeffrey R. Curtis and Kenneth Saag

    Citation: Arthritis Research & Therapy 2020 22:181

    Content type: Research article

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  28. Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum an...

    Authors: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski and M. Trojanowska

    Citation: Arthritis Research & Therapy 2020 22:179

    Content type: Research article

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  29. Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the t...

    Authors: Masahiro Tachibana, Yukio Yonemoto, Koichi Okamura, Takahito Suto, Hideo Sakane, Tetsuya Kaneko, Trang Thuy Dam, Chisa Okura, Tsuyoshi Tajika, Yoshito Tsushima and Hirotaka Chikuda

    Citation: Arthritis Research & Therapy 2020 22:178

    Content type: Research article

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  30. The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Xenofon Baraliakos, Vibeke Strand, Philip J. Mease, Maarten de Wit, Torkell Ellingsen, Inger Marie J. Hansen, Jamie Kirkham, George A. Wells, Peter Tugwell, Lara Maxwell, Maarten Boers, Kenneth Egstrup and Robin Christensen

    Citation: Arthritis Research & Therapy 2020 22:177

    Content type: Review

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  31. Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for r...

    Authors: Jin Kyun Park, Yu Jin Jang, Bo Ram Oh, Jieun Shin, Daekwon Bae, Nina Ha, Young il Choi, Gi Soo Youn, Jinseu Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2020 22:176

    Content type: Research article

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  32. Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5 years of their SLE diagnosis, although it is not uncommon for LN to develop at later time points. Here we evaluat...

    Authors: Kunihiro Ichinose, Mineaki Kitamura, Shuntaro Sato, Keita Fujikawa, Yoshiro Horai, Naoki Matsuoka, Masahiko Tsuboi, Fumiaki Nonaka, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Mami Tamai, Hideki Nakamura…

    Citation: Arthritis Research & Therapy 2020 22:175

    Content type: Research article

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  33. The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin, and mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce the inhibitory signaling to regulate immu...

    Authors: Yuya Fujita, Tomoyuki Asano, Haruki Matsumoto, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2020 22:174

    Content type: Research article

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  34. Infiltration of immune cells into the kidney is one of the key features of lupus nephritis (LN). The presence of immune cells in the urine may be used as a non-invasive biomarker of LN. Here, we aimed to analy...

    Authors: Jihye Kim, Jung Sun Lee, Heounjeong Go, Joon Seo Lim, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong

    Citation: Arthritis Research & Therapy 2020 22:173

    Content type: Research article

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  35. Several metabolomics studies have shed substantial light on the pathophysiological pathways underlying multiple diseases including systemic lupus erythematosus (SLE). This review takes stock of our current und...

    Authors: Ting Zhang and Chandra Mohan

    Citation: Arthritis Research & Therapy 2020 22:172

    Content type: Review

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  36. Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rare...

    Authors: Lorenzo Ramos-Mucci, Behzad Javaheri, Rob van ‘t Hof, George Bou-Gharios, Andrew A. Pitsillides, Eithne Comerford and Blandine Poulet

    Citation: Arthritis Research & Therapy 2020 22:171

    Content type: Research article

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  37. Rheumatoid arthritis (RA) is classified as seropositive or seronegative, depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti-citrullinated protein antibodies (ACPA), comm...

    Authors: Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid and Karin Lundberg

    Citation: Arthritis Research & Therapy 2020 22:170

    Content type: Research article

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  38. Patients with gout have arterial dysfunction and systemic inflammation, even during intercritical episodes, which may be markers of future adverse cardiovascular outcomes. We conducted a prospective observatio...

    Authors: Michael Toprover, Binita Shah, Cheongeun Oh, Talia F. Igel, Aaron Garza Romero, Virginia C. Pike, Fatmira Curovic, Daisy Bang, Deana Lazaro, Svetlana Krasnokutsky, Stuart D. Katz and Michael H. Pillinger

    Citation: Arthritis Research & Therapy 2020 22:169

    Content type: Research article

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  39. Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively. While both cell types appear morphologically similar, cont...

    Authors: Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi

    Citation: Arthritis Research & Therapy 2020 22:168

    Content type: Research article

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  40. The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lym...

    Authors: Kevin M.-C. Lee, Zihao Zhang, Adrian Achuthan, Andrew J. Fleetwood, Julia E. Smith, John A. Hamilton and Andrew D. Cook

    Citation: Arthritis Research & Therapy 2020 22:123

    Content type: Research article

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  41. To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis.

    Authors: Stefan Vordenbäumen, Ralph Brinks, Patrick Schriek, Angelika Lueking, Jutta G. Richter, Petra Budde, Peter Schulz-Knappe, Hans-Dieter Zucht, Johanna Callhoff and Matthias Schneider

    Citation: Arthritis Research & Therapy 2020 22:167

    Content type: Research article

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  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Paul Emery, Yoshiya Tanaka, Tracy Cardillo, Douglas Schlichting, Terence Rooney, Scott Beattie, Cameron Helt and Josef S. Smolen

    Citation: Arthritis Research & Therapy 2020 22:166

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2020 22:115

  43. Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively dele...

    Authors: Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane and Wei Yao

    Citation: Arthritis Research & Therapy 2020 22:165

    Content type: Research article

    Published on:

  44. Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.

    Authors: Naomi Schlesinger, N. Lawrence Edwards, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2020 22:164

    Content type: Research article

    Published on:

  45. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic

    Citation: Arthritis Research & Therapy 2020 22:162

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2020 22:36

  46. Systemic lupus erythematosus (SLE) is associated with increased risk of cancer and the mechanism remains unclear. Here, we examined the level of auto-antibodies and disease activity index scores in SLE patient...

    Authors: Jinyan Guo, Zhigang Ren, Jianhao Li, Tianfang Li, Shengyun Liu and Zujiang Yu

    Citation: Arthritis Research & Therapy 2020 22:159

    Content type: Research article

    Published on:

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