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Rheumatoid arthritis and risk factors for low bone mineral density
Arthritis Res Thervolume 6, Article number: 89 (2004)
To study the influence of gender, menopausal status, smoking, previous nonvertebral fractures, hormone replacement use, disease duration and glucorticoid use for low bone mineral density (BMD) in rheumatoid arthritis patients.
A cross-sectional study in 177 patients (164 females and 13 males). BMD was assessed in the spine and femoral neck in a DXA Norland XR26. Low BMD was defined as Z score < -1 compared with our normal population. Student's t test, logistic regression, stepwise logistic regression and multiple logistic regression were calculated.
When risk factors for low BMD were analyzed in an age-adjusted and sex-adjusted model, disease duration and glucorticoid use appeared as significant risk factors for low BMD. In a multivariate analysis, disease duration longer than 5 years appears as independently significant for low femoral neck BMD. Related to glucorticoid use, only more than 10 g cummulative dose was independently significant for low BMD both in the spine and femoral neck.