Mitchell P: Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism. Nature. 1961, 191: 144-148. 10.1038/191144a0.
Article
CAS
PubMed
Google Scholar
Semenza GL: Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. J Clin Invest. 2001, 108: 39-40.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gendron A, Kouassi E, Nuara S, Cossette C, D'Angelo G, Geadah D, du Souich P, Teitelbaum J: Transient middle cerebral artery occlusion influence on systemic oxygen homeostasis and erythropoiesis in Wistar rats. Stroke. 2004, 35: 1979-1984. 10.1161/01.STR.0000133691.07945.f2.
Article
CAS
PubMed
Google Scholar
Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS: Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001, 15: 2865-2876.
PubMed Central
CAS
PubMed
Google Scholar
Goshima J, Goldberg VM, Caplan AI: The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop Relat Res. 1991, 269: 274-283.
PubMed
Google Scholar
Pechak DG, Kujawa MJ, Caplan AI: Morphology of bone development and bone remodeling in embryonic chick limbs. Bone. 1986, 7: 459-472. 10.1016/8756-3282(86)90005-0.
Article
CAS
PubMed
Google Scholar
Brighton CT, Heppenstall RB: Oxygen tension in zones of the epiphyseal plate, the metaphysis and diaphysis. An in vitro and in vivo study in rats and rabbits. J Bone Joint Surg Am. 1971, 53: 719-728.
CAS
PubMed
Google Scholar
Lund-Olesen K: Oxygen tension in synovial fluids. Arthritis Rheum. 1970, 13: 769-776. 10.1002/art.1780130606.
Article
CAS
PubMed
Google Scholar
Silver IA: Measurement of pH and ionic composition of pericellular sites. Philos Trans R Soc Lond B Biol Sci. 1975, 271: 261-272. 10.1098/rstb.1975.0050.
Article
CAS
PubMed
Google Scholar
Treuhaft PS, DJ MC: Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum. 1971, 14: 475-484. 10.1002/art.1780140407.
Article
CAS
PubMed
Google Scholar
Lafont JE, Talma S, Murphy CL: Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype. Arthritis Rheum. 2007, 56: 3297-3306. 10.1002/art.22878.
Article
CAS
PubMed
Google Scholar
Lafont JE, Talma S, Hopfgarten C, Murphy CL: Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. J Biol Chem. 2008, 283: 4778-4786. 10.1074/jbc.M707729200.
Article
CAS
PubMed
Google Scholar
Domm C, Schunke M, Christesen K, Kurz B: Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage. 2002, 10: 13-22. 10.1053/joca.2001.0477.
Article
CAS
PubMed
Google Scholar
Bargahi A, Rabbani-Chadegani A: Angiogenic inhibitor protein fractions derived from shark cartilage. Biosci Rep. 2008, 28: 15-21. 10.1042/BSR20070029.
Article
CAS
PubMed
Google Scholar
Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995, 92: 5510-5514. 10.1073/pnas.92.12.5510.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M: Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J Biol Chem. 2003, 278: 11032-11040. 10.1074/jbc.M208681200.
Article
CAS
PubMed
Google Scholar
Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N: Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun. 2001, 287: 808-813. 10.1006/bbrc.2001.5659.
Article
CAS
PubMed
Google Scholar
Provot S, Schipani E: Fetal growth plate: a developmental model of cellular adaptation to hypoxia. Ann N Y Acad Sci. 2007, 1117: 26-39. 10.1196/annals.1402.076.
Article
CAS
PubMed
Google Scholar
Pfander D, Cramer T, Schipani E, Johnson RS: HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci. 2003, 116: 1819-1826. 10.1242/jcs.00385.
Article
CAS
PubMed
Google Scholar
Stewart AJ, Houston B, Farquharson C: Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. J Cell Physiol. 2006, 206: 435-440. 10.1002/jcp.20481.
Article
CAS
PubMed
Google Scholar
Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E: Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004, 131: 2497-2508. 10.1242/dev.01138.
Article
CAS
PubMed
Google Scholar
Gelse K, Pfander D, Obier S, Knaup KX, Wiesener M, Hennig FF, Swoboda B: The role of HIF-1alpha for the integrity of articular cartilage in murine knee joints. Arthritis Res Ther. 2008, 10: R111-10.1186/ar2508.
Article
PubMed Central
PubMed
Google Scholar
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P: 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003, 3: 363-375. 10.1016/S1535-6108(03)00077-1.
Article
CAS
PubMed
Google Scholar
Falchuk KH, Goetzl EJ, Kulka JP: Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med. 1970, 49: 223-231. 10.1016/S0002-9343(70)80078-X.
Article
CAS
PubMed
Google Scholar
Adams MA: The mechanical environment of chondrocytes in articular cartilage. Biorheology. 2006, 43: 537-545.
PubMed
Google Scholar
Glowacki J, Trepman E, Folkman J: Cell shape and phenotypic expression in chondrocytes. Proc Soc Exp Biol Med. 1983, 172: 93-98.
Article
CAS
PubMed
Google Scholar
Mark von der K, Gauss V, Mark von der H, Muller P: Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. 1977, 267: 531-532. 10.1038/267531a0.
Article
PubMed
Google Scholar
Watt FM: Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture. J Cell Sci. 1988, 89: 373-378.
PubMed
Google Scholar
Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayr F, Zimmer R, Bartnik E: Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum. 2006, 54: 3533-3544. 10.1002/art.22174.
Article
CAS
PubMed
Google Scholar
Urban JP: The chondrocyte: a cell under pressure. Br J Rheumatol. 1994, 33: 901-908. 10.1093/rheumatology/33.10.901.
Article
CAS
PubMed
Google Scholar
Lane Smith R, Trindade MC, Ikenoue T, Mohtai M, Das P, Carter DR, Goodman SB, Schurman DJ: Effects of shear stress on articular chondrocyte metabolism. Biorheology. 2000, 37: 95-107.
CAS
PubMed
Google Scholar
Smith RL, Carter DR, Schurman DJ: Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Clin Orthop Relat Res. 2004, 427 (Suppl): S89-95.
PubMed
Google Scholar
Monfort J, Garcia-Giralt N, Lopez-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ: Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. Arthritis Res Ther. 2006, 8: R149-10.1186/ar2042.
Article
PubMed Central
PubMed
Google Scholar
Gibson JS, Milner PI, White R, Fairfax TP, Wilkins RJ: Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis. Pflugers Arch. 2008, 455: 563-573. 10.1007/s00424-007-0310-7.
Article
CAS
PubMed
Google Scholar
Murphy CL, Sambanis A: Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. Tissue Eng. 2001, 7: 791-803. 10.1089/107632701753337735.
Article
CAS
PubMed
Google Scholar
Murphy CL, Polak JM: Control of human articular chondrocyte differentiation by reduced oxygen tension. J Cell Physiol. 2004, 199: 451-459. 10.1002/jcp.10481.
Article
CAS
PubMed
Google Scholar
Adesida AB, Grady LM, Khan WS, Hardingham TE: The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Arthritis Res Ther. 2006, 8: R61-10.1186/ar1929.
Article
PubMed Central
PubMed
Google Scholar
Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL: Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone. 2005, 37: 313-322. 10.1016/j.bone.2005.04.040.
Article
CAS
PubMed
Google Scholar
Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E: HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007, 134: 3917-3928. 10.1242/dev.008441.
Article
CAS
PubMed
Google Scholar
De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH: Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003, 174: 101-109. 10.1159/000071150.
Article
PubMed
Google Scholar
Kuznetsov SA, Mankani MH, Gronthos S, Satomura K, Bianco P, Robey PG: Circulating skeletal stem cells. J Cell Biol. 2001, 153: 1133-1140. 10.1083/jcb.153.5.1133.
Article
PubMed Central
CAS
PubMed
Google Scholar
De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP: Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001, 44: 1928-1942. 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P.
Article
CAS
PubMed
Google Scholar
Murphy JM, Fink DJ, Hunziker EB, Barry FP: Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003, 48: 3464-3474. 10.1002/art.11365.
Article
PubMed
Google Scholar
Ponticiello MS, Schinagl RM, Kadiyala S, Barry FP: Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy. J Biomed Mater Res. 2000, 52: 246-255. 10.1002/1097-4636(200011)52:2<246::AID-JBM2>3.0.CO;2-W.
Article
CAS
PubMed
Google Scholar
Adachi N, Ochi M: [Regenerative medicine for rheumatoid arthritis – current status and problems]. Nippon Rinsho. 2005, 63 (Suppl 1): 666-671.
PubMed
Google Scholar
Kanichai M, Ferguson D, Prendergast PJ, Campbell VA: Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha. J Cell Physiol. 2008, 216: 708-715. 10.1002/jcp.21446.
Article
CAS
PubMed
Google Scholar
Lennon DP, Edmison JM, Caplan AI: Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol. 2001, 187: 345-355. 10.1002/jcp.1081.
Article
CAS
PubMed
Google Scholar
Mueller MB, Tuan RS: Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum. 2008, 58: 1377-1388. 10.1002/art.23370.
Article
PubMed Central
CAS
PubMed
Google Scholar
de Crombrugghe B, Lefebvre V, Nakashima K: Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol. 2001, 13: 721-727. 10.1016/S0955-0674(00)00276-3.
Article
CAS
PubMed
Google Scholar
Khan WS, Adesida AB, Hardingham TE: Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. Arthritis Res Ther. 2007, 9: R55-10.1186/ar2211.
Article
PubMed Central
PubMed
Google Scholar
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001, 292: 468-472. 10.1126/science.1059796.
Article
CAS
PubMed
Google Scholar
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem. 2004, 279: 38458-38465. 10.1074/jbc.M406026200.
Article
CAS
PubMed
Google Scholar
Mahon PC, Hirota K, Semenza GL: FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001, 15: 2675-2686. 10.1101/gad.924501.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 2002, 16: 1466-1471. 10.1101/gad.991402.
Article
PubMed Central
CAS
PubMed
Google Scholar
Harwood R, Grant ME, Jackson DS: Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases. Biochem J. 1974, 144: 123-130.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hofbauer KH, Gess B, Lohaus C, Meyer HE, Katschinski D, Kurtz A: Oxygen tension regulates the expression of a group of pro-collagen hydroxylases. Eur J Biochem. 2003, 270: 4515-4522. 10.1046/j.1432-1033.2003.03846.x.
Article
CAS
PubMed
Google Scholar
Terkhorn SP, Bohensky J, Shapiro IM, Koyama E, Srinivas V: Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. J Cell Physiol. 2007, 210: 257-265. 10.1002/jcp.20873.
Article
CAS
PubMed
Google Scholar
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J: HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J. 2003, 22: 4082-4090. 10.1093/emboj/cdg392.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fang J, Yan L, Shing Y, Moses MA: HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis. Cancer Res. 2001, 61: 5731-5735.
CAS
PubMed
Google Scholar
Zhang W, Petrovic JM, Callaghan D, Jones A, Cui H, Howlett C, Stanimirovic D: Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol. 2006, 174: 63-73. 10.1016/j.jneuroim.2006.01.014.
Article
CAS
PubMed
Google Scholar