Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis. Cell. 1996, 85: 307-310. 10.1016/S0092-8674(00)81109-5.
Article
CAS
PubMed
Google Scholar
Paleolog EM: The vasculature in rheumatoid arthritis: cause or consequence?. Int J Exp Pathol. 2009, 90: 249-261. 10.1111/j.1365-2613.2009.00640.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Khong T, Larsen H, Raatz Y, Paleolog E: Angiogenesis as a therapeutic target in arthritis: learning the lessons of the colorectal cancer experience. Angiogenesis. 2007, 10: 243-258. 10.1007/s10456-007-9081-1.
Article
CAS
PubMed
Google Scholar
Rooney M, Condell D, Quinlan W, Daly L, Whelan A, Feighery C, Bresnihan B: Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum. 1988, 31: 956-963. 10.1002/art.1780310803.
Article
CAS
PubMed
Google Scholar
Walsh D, Wade M, Mapp P, Blake D: Focally Regulated Endothelial Proliferation and Cell Death in Human Synovium. American Journal of Pathology. 1998, 152: 691-702.
PubMed Central
CAS
PubMed
Google Scholar
Lund-Olesen K: Oxygen tension in synovial fluids. Arthritis Rheum. 1970, 13: 769-776. 10.1002/art.1780130606.
Article
CAS
PubMed
Google Scholar
Semble EL, Turner RA, McCrickard EL: Rheumatoid arthritis and osteoarthritis synovial fluid effects on primary human endothelial cell cultures. J Rheumatol. 1985, 12: 237-241.
CAS
PubMed
Google Scholar
Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N: Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol. 1994, 152: 4149-4156.
CAS
PubMed
Google Scholar
Paleolog EM, Young S, Stark AC, McCloskey RV, Feldmann M, Maini RN: Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1258-1265. 10.1002/1529-0131(199807)41:7<1258::AID-ART17>3.0.CO;2-1.
Article
CAS
PubMed
Google Scholar
Scott BB, Zaratin PF, Colombo A, Hansbury MJ, Winkler JD, Jackson JR: Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts. J Rheumatol. 2002, 29: 230-239.
CAS
PubMed
Google Scholar
Fava RA, Olsen NJ, Spencer-Green G, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF: Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. The Journal of Experimental Medicine. 1994, 180: 341-346. 10.1084/jem.180.1.341.
Article
CAS
PubMed
Google Scholar
Shahrara S, Volin MV, Connors MA, Haines GK, Koch AE: Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue. Arthritis Research. 2002, 4: 201-208. 10.1186/ar407.
Article
PubMed Central
CAS
PubMed
Google Scholar
Koch AE, Halloran MM, Hosaka S, Shah MR, Haskell CJ, Baker SK, Panos RJ, Haines GK, Bennett GL, Pope RM, Ferrara N: Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis. Arthritis Rheum. 1996, 39: 1566-1575. 10.1002/art.1780390917.
Article
CAS
PubMed
Google Scholar
Hosaka S, Shah MR, Barquin N, Haines GK, Koch AE: Expression of basic fibroblast growth factor and angiogenin in arthritis. Pathobiology. 1995, 63: 249-256. 10.1159/000163957.
Article
CAS
PubMed
Google Scholar
Sone H, Sakauchi M, Takahashi A, Suzuki H, Inoue N, Iida K, Shimano H, Toyoshima H, Kawakami Y, Okuda Y, Matsuo K, Yamada N: Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity. Life Sci. 2001, 69: 1861-1869. 10.1016/S0024-3205(01)01264-4.
Article
CAS
PubMed
Google Scholar
Ballara S, Taylor PC, Reusch P, Marme D, Feldmann M, Maini RN, Paleolog EM: Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis & Rheumatism. 2001, 44: 2055-2064. 10.1002/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2.
Article
CAS
Google Scholar
Ikeda M, Hosoda Y, Hirose S, Okada Y, Ikeda E: Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis. J Pathol. 2000, 191: 426-433. 10.1002/1096-9896(2000)9999:9999<::AID-PATH649>3.0.CO;2-E.
Article
CAS
PubMed
Google Scholar
Williams RO, Feldmann M, Maini RN: Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA. 1992, 89: 9784-9788. 10.1073/pnas.89.20.9784.
Article
PubMed Central
CAS
PubMed
Google Scholar
Etherington PJ, Winlove P, Taylor P, Paleolog E, Miotla JM: VEGF release is associated with reduced oxygen tensions in experimental inflammatory arthritis. Clin Exp Rheumatol. 2002, 20: 799-805.
CAS
PubMed
Google Scholar
DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC: Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 2003, 48: 2461-2471. 10.1002/art.11213.
Article
CAS
PubMed
Google Scholar
Lu J, Kasama T, Kobayashi K, Yoda Y, Shiozawa F, Hanyuda M, Negishi M, Ide H, Adachi M: Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis. The Journal of Immunology. 2000, 164: 5922-5927.
Article
CAS
PubMed
Google Scholar
Sone H, Kawakami Y, Sakauchi M, Nakamura Y, Takahashi A, Shimano H, Okuda Y, Segawa T, Suzuki H, Yamada N: Neutralisation of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. Biochemical and Biophysical Research Communications. 2001, 281: 562-568. 10.1006/bbrc.2001.4395.
Article
CAS
PubMed
Google Scholar
Miotla J, Maciewicz R, Kendrew J, Feldmann M, Paleolog E: Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. Laboratory Investigation. 2002, 80: 1195-1205.
Article
Google Scholar
Clavel G, Valvason C, Yamaoka K, Lemeiter D, Laroche L, Boissier MC, Bessis N: Relationship between angiogenesis and inflammation in experimental arthritis. Eur Cytokine Netw. 2006, 17: 202-210.
CAS
PubMed
Google Scholar
Ibrahim SM, Koczan D, Thiesen HJ: Gene-expression profile of collagen-induced arthritis. J Autoimmun. 2002, 18: 159-167. 10.1006/jaut.2001.0580.
Article
PubMed
Google Scholar
Gierer P, Ibrahim S, Mittlmeier T, Koczan D, Moeller S, Landes J, Gradl G, Vollmar B: Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis. Arthritis Res Ther. 2005, 7: R868-876. 10.1186/ar1754.
Article
PubMed Central
CAS
PubMed
Google Scholar
Miller EJ: Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin. Biochemistry. 1972, 11: 4903-4909. 10.1021/bi00776a005.
Article
CAS
PubMed
Google Scholar
Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, Koch AW, Wu Y, Bagri A, Tessier-Lavigne M, Watts RJ: Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 2007, 11: 53-67. 10.1016/j.ccr.2006.10.018.
Article
CAS
PubMed
Google Scholar
Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29: e45-10.1093/nar/29.9.e45.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liem HH, Cardenas F, Tavassoli M, Poh-Fitzpatrick MB, Muller-Eberhard U: Quantitative determination of hemoglobin and cytochemical staining for peroxidase using 3,3´5,5´tetramethylbenzidine dihydrochloride, a safe substitute for benzidine. Analytical Biochemistry. 1976, 98: 388-393.
Article
Google Scholar
Veihelmann A, Szczesny G, Nolte D, Krombach F, Refior HJ, Messmer K: A novel model for the study of synovial microcirculation in the mouse knee joint in vivo. Res Exp Med (Berl). 1998, 198: 43-54. 10.1007/s004330050088.
Article
CAS
Google Scholar
Stephens RW, Ghosh P, Taylor TK, Gale CA, Swann JC, Robinson RG, Webb J: The origins and relative distribution of polysaccharides in rheumatoid and osteoarthritic fluids. Journal of Rheumatology. 1975, 2: 393-300.
CAS
PubMed
Google Scholar
Malik NM, Jin P, Raatz Y, Sumariwalla PF, Kiriakidis S, Shepard M, Feldmann M, Paleolog EM: Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis. Rheumatology (Oxford). 49: 1828-1839.
Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ: Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem. 2007, 282: 24049-24056. 10.1074/jbc.M703554200.
Article
CAS
PubMed
Google Scholar
Muz B, Khan MN, Kiriakidis S, Paleolog EM: Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. Arthritis Res Ther. 2009, 11: 201-10.1186/ar2568.
Article
PubMed Central
PubMed
Google Scholar
Rundhaug JE: Matrix metalloproteinases and angiogenesis. J Cell Mol Med. 2005, 9: 267-285. 10.1111/j.1582-4934.2005.tb00355.x.
Article
CAS
PubMed
Google Scholar
Maruyama K, Muramatsu H, Ishiguro N, Muramatsu T: Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2004, 50: 1420-1429. 10.1002/art.20175.
Article
CAS
PubMed
Google Scholar
Takada T, Toriyama K, Muramatsu H, Song XJ, Torii S, Muramatsu T: Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J Biochem. 1997, 122: 453-458. 10.1093/oxfordjournals.jbchem.a021773.
Article
CAS
PubMed
Google Scholar
Yukioka K, Inaba M, Furumitsu Y, Yukioka M, Nishino T, Goto H, Nishizawa Y, Morii H: Levels of hepatocyte growth factor in synovial fluid and serum of patients with rheumatoid arthritis and release of hepatocyte growth factor by rheumatoid synovial fluid cells. J Rheumatol. 1994, 21: 2184-2189.
CAS
PubMed
Google Scholar
Kusada J, Otsuka T, Matsui N, Hirano T, Asai K, Kato T: Immuno-reactive human epidermal growth factor (h-EGF) in rheumatoid synovial fluids. Nihon Seikeigeka Gakkai Zasshi. 1993, 67: 859-865.
CAS
PubMed
Google Scholar
Booth G, Newham P, Barlow R, Raines S, Zheng B, Han S: Gene expression profiles at different stages of collagen-induced arthritis. Autoimmunity. 2008, 41: 512-521. 10.1080/08916930802095210.
Article
CAS
PubMed
Google Scholar
La Cava A, Alviggi C, Matarese G: Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med. 2004, 82: 4-11. 10.1007/s00109-003-0492-1.
Article
CAS
PubMed
Google Scholar
Salvi R, Peclat V, So A, Busso N: Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis. Arthritis Res. 2000, 2: 504-512. 10.1186/ar132.
Article
PubMed Central
CAS
PubMed
Google Scholar
Afuwape AO, Kiriakidis S, Paleolog EM: The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histol Histopathol. 2002, 17: 961-972.
CAS
PubMed
Google Scholar
Fiedler U, Augustin HG: Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 2006, 27: 552-558. 10.1016/j.it.2006.10.004.
Article
CAS
PubMed
Google Scholar
Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U: Angiogenesis and blood vessel stability in inflammatory arthritis. Arthritis Rheum. 62: 711-721.
Izquierdo E, Canete JD, Celis R, Santiago B, Usategui A, Sanmarti R, Del Rey MJ, Pablos JL: Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy. PLoS ONE. 2009, 4: e8131-10.1371/journal.pone.0008131.
Article
PubMed Central
PubMed
Google Scholar
Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Angle N, Cheresh DA: A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008, 456: 809-813. 10.1038/nature07424.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sivakumar B, Akhavani MA, Winlove CP, Taylor PC, Paleolog EM, Kang N: Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis. J Hand Surg [Am]. 2008, 33: 49-58. 10.1016/j.jhsa.2007.09.002.
Article
Google Scholar
Levick JR: Hypoxia and acidosis in chronic inflammatory arthritis; relation to vascular supply and dynamic effusion pressure. J Rheumatol. 1990, 17: 579-582.
CAS
PubMed
Google Scholar
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 1998, 92: 735-745. 10.1016/S0092-8674(00)81402-6.
Article
CAS
PubMed
Google Scholar
Sulpice E, Plouet J, Berge M, Allanic D, Tobelem G, Merkulova-Rainon T: Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity. Blood. 2008, 111: 2036-2045. 10.1182/blood-2007-04-084269.
Article
CAS
PubMed
Google Scholar
Kim WU, Kang SS, Yoo SA, Hong KH, Bae DG, Lee MS, Hong SW, Chae CB, Cho CS: Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. J Immunol. 2006, 177: 5727-5735.
Article
CAS
PubMed
Google Scholar
Kong JS, Yoo SA, Kim JW, Yang SP, Chae CB, Tarallo V, De Falco S, Ryu SH, Cho CS, Kim WU: Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis. Arthritis Rheum. 62: 179-190.
Whitehead Institute for Biomedical Research. [http://www.genome.wi.mit.edu]