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Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study

Arthritis Research & Therapy volume 14, Article number: R215 (2012) Cite this article

Abstract

Introduction

Literature data suggest that sleep disturbances are prevalent among patients with ankylosing spondylitis (AS) and have a close correlation with pain. Other studies indicate that sleep disturbances are constantly accompanied by depression and anxiety in AS, but their interrelations are poorly understood. This study was designed to evaluate sleep disturbances and their association with demographic variables, pain, disease-specific variables, functional status, covering depression and anxiety in AS patients.

Methods

The 314 patients with AS and age- and sex-matched controls took part in the study, completed a battery of questionnaires, and participated in long-term follow-up. Blood samples were taken to measure C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR). The association among sleep, pain, disease activity, functional status, depression, and anxiety were assessed by using Pearson/Spearman correlations and multiple regression analysis.

Results

The Pittsburgh Sleep Quality Index (PSQI) score of the Chinese version was significantly higher in the AS group than in the control group (P = 0.020). Of the 314 patients with AS, 184 (58.6%) had a high risk for sleep disturbances. The PSQI score was associated with age, years of education, ESR, CRP, overall assessment of health, pain, morning stiffness, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), depression, and anxiety (all P < 0.001), but were not associated with disease duration, fingertip-to-floor distance, and Bath Ankylosing Spondylitis Metrology Index (BASMI) (P > 0.05). In hierarchic multiple regression analysis, the medical and psychological variables contributed significantly to the variance in sleep-disturbances scores, adding an additional 23.9% to the overall R2 beyond that accounted for by demographic variables (R-square, 8.5%), resulting in a final R2 of 42.6%. Multiple stepwise regression analysis revealed that anxiety was the maximal statistical contribution in predicting sleep disturbances (standardized coefficients, 0.287).

Conclusions

The prevalence of sleep disturbances in AS patients is higher than it is generally thought to be. Depression, anxiety, nocturnal pain, and total back pain are the major contributors of sleep disturbances in AS.

Introduction

Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects approximately 0.36% of the Chinese population [1]. It has a negative effect on all aspects of a patient's life: physically, psychologically, and socially. Sleep disturbances are often reported in rheumatic diseases and are considered to be multifactorial. Some studies document poor quality of sleep in rheumatoid arthritis (RA), osteoarthritis (OA), systemic lupus erythematosus (SLE), fibromyalgia, Sjögren's syndrome, and spondyloarthritis (SpA) [2–7]. Currently, the pathophysiology of sleep disturbances is ill defined, and it is likely to be underreported by AS patients. One possible reason for the lack of therapeutic success in sleep disturbances is the very limited research conducted on the frequency and correlates of sleep disturbances in patients with AS.

Sleep disturbances reduce an individual's quality of life by seriously impairing cognition, mood, and physical symptoms of diseases. A cross-sectional study investigating the effects of sleep deprivation on cognition and work performance of residents and interns in Korea reported severe sleep deprivation (average night sleep, less than 4 hours) was associated with a higher level of stress, more-frequent attention deficit, and difficulty in learning [8]. In a very large sample of 5,877 participants aged between 15 and 54 years, reduced quantity of sleep seemed to be associated with difficulties in coping with stressful life events [9]. Sleep also plays an important role in learning processes and memory consolidation; poor sleep usually is associated with decreased academic performance and reduced neurobehavioral functioning [10]. Moreover, a number of longitudinal studies [11–13] indicate that insomnia or poor sleep is a risk factor for major depression and anxiety. Presumably, effects of poor sleep on cognition and mood are due to reducing cerebral blood flow and metabolic rate in the thalamus, prefrontal and parietal cortices, and elevating the activity of the stress systems (the autonomic sympathoadrenal system and the hypothalamic-pituitary-adrenal system) [14, 15]. Furthermore, sleep alterations increase the pathologic significance of any disease and reduce general well-being [16, 17]. Clinical studies reported that sleep problems are inversely associated with the pain threshold at all sites, suggesting a defect in central pain processing [2]. Martin [18] suggested a cause-and-effect relation between sleep dysfunction, psychological effects, and musculoskeletal function changes; the greatest effect of sleep disturbances would be a reduction in high-intensity physical exercise tolerance. Therefore, poor sleep could cause a negative impact on exercise and rehabilitation of AS patients. Few studies have been conducted to explore the relation among sleep and physical and psychological symptoms.

Although, the prevalence, type, and severity of sleep complaints in an AS population have been difficult to judge, it has been reported to occur in 15.4% to 80% of patients with AS, reflecting divergent definitions of sleep disturbance and instruments of measure. Hultgren et al. [19] studied 43 male and 27 female patients with AS, completed a sleep questionnaire, and the results were compared with earlier findings in 3,558 persons randomly selected from the general population. Too little sleep was reported by 80.8% of the female and 50.0% of the male patients, compared with 28.8% and 21.8%, respectively, in the reference group. Another study [7] assessed the sleep quality of patients with spondyloarthropathy (SpA) with the PSQI in Canada; 69% of the sample were classified as poor sleepers, and worse functional status was associated with poorer sleep quality, longer sleep latency, shorter sleep duration, and poorer sleep efficiency. A recent study [20] of sleep disturbance, assessed by the fourth item of the Hamilton anxiety scale, was found in 15.4% of 110 patients with AS. Although sleep complaints are commonly reported in rheumatism, little is known in persons with AS. Moreover, it is unclear whether the severity of AS is directly related to poor sleep quality. Specifically, given the considerable adverse effects of sleep disturbances on clinical outcomes, identifying the factors associated with poor sleep is an important goal. Studies addressing this issue have had some limitations: small sample size, inclusion of patients with SpA, and lack of comprehensive assessment of sleep quality and physical and psychological status.

The objective of this study were (1) to determine the prevalence of sleep disturbances and their association with demographic variables, disease-specific variables, and other variables that can have an impact on sleep; and (2) to evaluate the statistical contribution in predicting sleep disturbances in AS patients.

Methods

For long-term follow-up, patients were recruited from two rheumatology clinics and departments in the Chinese PLA General Hospital, and the healthy controls were recruited from three communities. All patients met the 1984 modified New York classification criteria for AS [21]. The 102 age- and sex-matched healthy controls (84 men, 18 women) were included in this case-control study. Controls were group matched by age groups (15 to 20 years, 21 to 25 years, 26 to 30 years, and 30 years and older), meaning that the proportion of controls in each age group was identical to the proportion of patients in each age group. The patients and controls who had malignancy, fibromyalgia, serious infections or systemic diseases, and other chronic diseases were excluded from the study. The study was approved by the Chinese PLA General Hospital ethics committee, and all participants gave their written informed consent, according to the Declaration of Helsinki.

Demographic characteristics, age, years of education, occupation, marital status, disease duration, and duration of morning stiffness were documented for each patient. The patients were subjected to a detailed investigation including hemogram, liver, and kidney-function tests, to exclude other diseases that may cause sleep disturbances. Sleep quality was assessed by using the Chinese version of the PSQI; depressive symptoms, with Zung self-rating depression scale (SDS), and anxiety symptoms with the Zung self-rating anxiety scale (SAS). Overall assessment of health score in AS patients was determined from a visual analogue scale (VAS), recording from 0 cm (none) to 10 cm (very severe); the pain score by visual analogue scale (VAS, 0 to 10 cm), included nocturnal pain (last week/spine/at night due to AS) and total back pain (last week/spine/due to AS). The disease activity was evaluated by the BASDAI, CRP, ESR, and duration of morning stiffness; the functional state was assessed by BASFI, metrologic measurements by fingertip-to-floor distance, and BASMI. The PSQI, SDS, and SAS were used in healthy controls to assess sleep, depression, and anxiety respectively.

Sleep quality

Sleep during the month preceding the evaluation was examined by using the PSQI, which includes 19 questions completed by the subject. These 19 items were broken down into the following seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorders, use of hypnotics, and daytime dysfunction. Sleep latency is assessed by two questions rated according to time to fall asleep. Sleep duration by one question rated 4 on a Likert scale from >7 to <5 hours, and sleep efficiency by hours asleep divided by total of hours in bed. Use of hypnotics and poor daytime functioning are rated by a 4-point Likert scale (not during the past month, less than once per week, once or twice per week, 3 or more times per week). Sleep disorders were assessed with nine questions focused on waking up in the middle of the night or early in the morning, getting up to go to the toilet, difficulty breathing properly, coughing or snoring loudly, being too cold, being too hot, having nightmares, experiencing pain, or other reasons for disturbed sleep. Each question is rated with a 4-point Likert scale (not during the past month, less than once per week, once or twice per week, 3 or more times per week). Subjective sleep is evaluated with one question rated by a 4-point Likert scale from very good to very bad. The seven components were each scored from 0 (no difficulty) to 3 (severe difficulty), and summed, to give an overall score ranging from 0 to 21. Participants were dichotomized into a poor-sleep group if the PSQI was >7.0 and a good-sleep group if the PSQI was ≤7.0 [22].

Depressive symptoms

The depression levels of the patients were evaluated by using the SDS. This scale consists of 20 questions that examine the somatic, affective, and psychological symptoms associated with depression. Each question is scored between 1 and 4 (rarely, sometimes, frequently, and always). The total score varies between 20 and 80. Higher scores reflected more-severe depression. A score of 50 to 69 shows the existence of depression, and a score of 70 or higher means extreme depression [23].

Anxiety symptoms

The revised SAS was used to evaluate the level of anxiety-related symptoms during the last week before the survey. This self-administered test has 20 questions, with 15 items worded toward increasing anxiety levels and five questions worded toward decreasing anxiety levels. Each question was scored on a scale of 1 to 4 (rarely, sometimes, frequently, and always). The scores ranged between 20 and 80. A score of 50 to 69 shows the existence of anxiety, and a score of 70 or higher means extreme anxiety [24].

Data analysis

Descriptive statistics were used for assessing the parameters related to disease. The differences in terms of variables that are studied in patients who are grouped as experiencing poor sleep and good sleep, according to the PSQI, were evaluated with independent sample Mann-Whitney U test and a t test. The relations between the sleep and the other evaluation parameters were examined with Spearman rank correlation analysis. Hierarchic multiple regression analysis was chosen to analyze the contribution of demographic, medical, and psychological variables to sleep disturbances. Stepwise multiple regression analysis was designed to find the most powerful predictor of sleep disturbances. Statistical analysis was performed by using SPSS 17.0, and the level of significance was set at P < 0.05.

Results

Patient characteristics

Of the 318 AS patients who agreed to participate in this study, 314 (98.7%) returned their completed questionnaires, and four patients were no longer interested and/or had no time to participate.

Demographic and clinical characteristics of the patients are given in Table 1. The 314 consecutive patients with AS (234 men, 80 women) were included in the study. The mean age of patients was 27.6 ± 8.3 years, and the mean disease duration was 6.1 ± 4.9 years. The mean PSQI, SDS, and SAS scores of patients were 6.6 ± 3.6, 47.3 ± 10.5, and 48.4 ± 8.1, respectively.

Table 1 Demographic and disease-related characteristics of patients with ankylosing spondylitis
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Sleep-disturbances parameters

As shown in Table 2, components of PSQI include subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorders, use of hypnotics, and daytime dysfunction. The seven components were each scored from 0 (no difficulty) to 3 (severe difficulty). When the score of the components was ≥2, the component was regarded as indicating sleep disturbance. We found that poor subjective sleep quality was 22.3%, sleep latency was 22.9%, sleep duration was 13.4%, habitual sleep efficiency was 25.6%, sleep disorders was 30%, use of hypnotics was 2.9%, and daytime dysfunction was 57.6% in patients with AS. The most prominent sleep disturbance was daytime dysfunction. Despite the high incidence of sleep disturbance in AS patients, they rarely use hypnotics.

Table 2 Descriptive statistics on the components of PSQI in cases
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Mann-Whitney U test and t test

The prevalence of poor sleep was 35.4%, and the mean total PSQI score was 6.62 ± 3.62 in participants, compared with 22.9% and 5.50 ± 2.51, respectively, in the control group. The total PSQI score of patients with AS was significantly higher than that of the control participants (6.62 ± 3.62 versus 5.50 ± 2.51; P = 0.020), and four of the seven components of PSQI in AS patients were significantly different from controls: sleep latency, sleep duration, habitual sleep efficiency, and sleep disorders (see Table 3).

Table 3 Comparison of the components of PSQI in cases and controls
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The Mann-Whitney U test and a t test were performed between patients who were good and poor sleepers (see Table 4). Poor-sleep patients with had significantly higher levels of morning stiffness, BASFI, overall poor assessment of health, nocturnal pain, total back pain, BASDAI, ESR, CRP, SDS, and SAS (P < 0.05) than did good-sleep patients. With regard to age, years of education, disease duration, fingertip-to-floor distance, and BASMI score, no statistically significant differences were found between the two groups (P > 0.05)

Table 4 Comparison between poor and good sleepers (sorted by P value)
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Bivariate associations

As shown in Table 5, Spearman rank correlation coefficients were computed to identify correlates of components of PSQI, demographic, clinical, and psychogenic variables in our sample of AS patients. PSQI and almost all components of the PSQI score were associated with age, years of education, ESR, CRP, morning stiffness, overall assessment of health, nocturnal pain, total back pain. The BASDAI, BASFI, SDS, and SAS (P < 0.001), were not associated with disease duration, fingertip-to-floor distance, and BASMI (P > 0.05). In these, sleep scores was moderately related to depression scores (rho, 0.467), nocturnal pain (rho, 0.487), total back pain (rho, 0.485), BASDAI (rho, 0.479), overall assessment of health (rho, 0.386), and BASFI (rho, 0.312), and highly related to anxiety scores (rho, 0.522).

Table 5 Correlation coefficients between components of PSQI, demographic, clinical, and psychogenic variables (Spearman rho)
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Hierarchic multiple regression analysis

The results of the hierarchic multiple regression analyses are shown in Table 6.

Table 6 Hierarchic multiple regression analysis of demographic, medical, and psychological variables in relation to PSQI
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Model 1 (demographic model) tests the contribution of demographic variables to sleep disturbances.

Model 2 (medical variables model) tests the contributions of medical and physiological variables to sleep disturbances after controlling for the demographic variables.

Model 3 (psychological model) describes the extent to which psychological variables contribute to sleep disturbances after controlling for the demographic variables. Models 1 through 3 are the results of hierarchic regression analyses, which are usually done in research to determine the importance of predictor variables once other predictor variables have already been entered into the equation.

Model 4 is the standard regression analysis in which all of the variables were entered simultaneously into the model to assess the relative contributions of these variables to sleep disturbances. This model takes into account the interrelations between predictor variables as well as the effects of predictor variables on the outcome variable (sleep disturbances). The first model testing the contributions of demographic variables to sleep disturbances was found to be statistically significant (R2 = 0.85). In this model, years of education (P = 0.011) contributed significantly to sleep disturbances. The addition of medical variables (model 2) resulted in a significant increase in the R2 value (R2 = 0.32). In this model, Nocturnal pain (P = 0.012) and BASDAI (P = 0.005) contributed significantly to sleep disturbances. Inclusion of psychological variables also significantly added to the demographic set (R2 = 0.324). In this model, SDS (P = 0.004) and SAS (P = 0.000) contributed significantly to sleep disturbances. The medical and psychological variables explained an additional 23.9% of the variance in sleep disturbances. In the final full model (standard multiple regression analysis), in which all of the variables were entered simultaneously, only nocturnal pain (P = 0.009), SDS (P = 0.008), and SAS scores (P = 0.000) remained as significant determinants of sleep disturbances. The full model could explain 42.6% of the total variance in sleep disturbances.

Multiple stepwise regression analysis

The results of the stepwise multiple regression analyses are shown in Table 7. The SDS score (B = 0.059; P = 0.004), SAS score (B = 0.128; P = 0.000), nocturnal pain (B = 0.235; P = 0.013), and total back pain (B = 0.210; P = 0.044) were found to be significantly associated with sleep disturbances. The R2 = 39.5 indicated that 39.5% variation of sleep disturbances could be explained by depression, nocturnal pain, and total back pain. None of the factors significantly influenced sleep disturbances (age, gender, years of education, occupation, marital status, ESR, CRP, disease duration, morning stiffness, fingertip-to-floor distance, BASMI, BASDAI, or BASFI). The stepwise multiple regression analyses revealed that anxiety was the maximal statistical contribution in predicting back pain (standardized coefficients of 0.287).

Table 7 Stepwise multiple regression analysis of demographic, physiological, medical, and psychological variables in relation to PSQI
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Discussion

The current study is, to our knowledge, the largest to evaluate sleep disorders in AS patients. The relation between sleep disturbances and physical and psychological problems were described by the following six aspects.

Characteristics of sleep in AS patients

Significant sleep disturbance was much more common in AS patients than in the control group. PSQI is a standard index for assessing sleep quality and is widely used in both clinical settings and public health practice. The prevalence of poor sleep was 35.4%, and the mean total PSQI score was 6.62 ± 3.62 in participants, compared with 22.9% and 5.50 ± 2.51, respectively, in the control group. This prevalence was lower than those reported, 54.1% and 64.5% of sleep disturbance, respectively, in other studies of AS patients [20, 25].

Among seven components of PSQI, the most prominent component of sleep disturbances was daytime dysfunction. In total, 57.6% of participants reported various degrees of daytime dysfunction, including excessive daytime sleepiness, fatigue, and changes in mood. In another study in patients with AS [20], 66.4% experienced severe fatigue, and a positive relation was established between fatigue and sleep problems. These changes are reflected in patient reports of difficulty in concentrating, increased forgetfulness, an inability to make decisions, and falling asleep at the wheel of a motor vehicle. Those with moderate to severe cases of the disorder are at a higher risk of having a motor vehicle accident and may also have difficulties at work or school [26].

Another prominent component of PSQI was use of sleep medication. Despite the high incidence of sleep disturbance in AS patients, they rarely use hypnotics. The main reasons for impairment of chronic sleep disturbance were not paid attention to by patients, such as daytime sleepiness, fatigue, negative mood, and recognition [8–13]. Moreover, patients worry that long-term use of sleep medication could increase the risks of development of tolerance and dependence. Intervention for and prevention of sleep disturbances are becoming increasingly important. Recent studies [27, 28] concluded that nonpharmacologic interventions are clinically effective for sleep disturbance, including sleep-hygiene education, bright-light therapy, and cognitive and behavioral therapies.

Sleep and pain

Pain is one of the most common symptoms of AS. However, it is a chicken-and-egg problem to determine the direction of causation between pain and sleep disturbance. Some studies [29–31] demonstrated an apparent bidirectionality in the relation between pain causing sleep dysfunction and sleep dysfunction aggravating pain. This cross-sectional study demonstrates a strong association between not only sleep disturbance and pain (nocturnal pain, total back pain), but also the components of PSQI (subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorders, use of sleep medications, daytime dysfunction) and pain in AS patients.

These findings are consistent with a previous study [32] showing an association between sleep disturbance and clinical pain severity among RA patients. The mechanism of interaction between sleep disturbance and pain, so far not determined, could be understood with two factors. First, from the perspective of neurobiology, sleep disruption, fragmentation, or restriction produces hyperalgesia and can interfere with analgesic treatments involving opioidergic and serotonergic mechanisms of action [33–36]. Second, from the perspective of psychology, sleep disturbance lowers the pain threshold and amplifies the pain signals, resulting in increased attention to pain, and more negative pain-focused emotions and cognitions [3]. Thus, patients experience increased pain by hyperalgesia, reduced activity levels, and further disrupted sleep in a positive-feedback-loop pattern.

Sleep and disease activity

A close relation exists between sleep quality and disease activity in AS patients. In the current study, analyses were performed between patients who were good and poor sleepers; poor-sleep patients had significantly higher levels of morning stiffness, BASDAI, ESR, and CRP compared with good sleepers (P < 0.05). These findings indicate that sleep quality of AS patients is closely related to disease activity. CRP could directly and/or indirectly affect sleep quality. Some evidence [37–40] stems from studies that indicate that poor sleep is associated with inflammatory responses, indicated by increased CRP. Okun et al. [40] evaluated cross-sectional relations between self-reported sleep and three inflammatory markers (interleukin-6, tumor necrosis factor-α, and CRP) in community-dwelling nonpregnant women. Findings showed that poor sleep continuity and quality were related to high levels of CRP. Furthermore, Lee et al. [2] examining the association between disease activity, sleep, and pain sensitivity in rheumatoid arthritis, found that CRP was strongly associated with the pain threshold. Speculating from this result, we suspect that the CRP could indirectly affect sleep quality via a decreased pain threshold.

Tumor necrosis factor (TNF) plays an important role in AS and sleep regulation. Several observations [41, 42] strongly implicated TNF in the pathogenesis of AS, and elevated serum levels of TNF correlate with disease activity [43]. TNF-inhibitor therapies, such as thalidomide [44], etanercept [45], and infliximab [46], have been demonstrated to be effective in the treatment of AS. Moreover, TNF-α has been determined to be an important sleep-promoting substance [47, 48]. Chennaoui et al. [47] reported that total sleep deprivation in young healthy men is associated with significant sleepiness, decrements in psychomotor performance, and increased secretion of the proinflammatory cytokine TNF-α. The similar results of sleep deprivation led to elevated levels of TNF-α had been obtained in another experiment [48]. In turn, many of the symptoms induced by sleep loss (for example, sleepiness, fatigue, poor cognition, and enhanced sensitivity to pain) can be elicited by injection of exogenous IL-1 or TNF [49]. Further study was done recently by Rudwaleit et al. [50], and the results indicated that the TNF inhibitor, adalimumab, improved sleep and sleep quality in patients with active AS.

Sleep and depression

Sleep problems were the chief complaints of depression and anxiety; early awakening is the main disturbance of a depression disorder; and difficulty falling asleep is present in anxiety disorder. In the present study, analyses were performed between patients who were good and poor sleepers. Poor-sleep patients had significantly higher levels of SDS scores compared with good sleepers.

Sleep disturbances in relation to a depressed mood have been examined in the general population. Sayar et al. [51] reported that pain intensity, anxiety, and depression correlated significantly with poorer sleep quality. At the multivariate level, depression was found to be the only significant factor correlating with the quality of sleep, and the model explained 34% of the variance. In 2005, Costa et al. [52] compared systemic lupus erythematosus patients with healthy controls and insomniacs and concluded that only depressed mood was a significant independent determinant of global sleep quality.

The relation between sleep complaints and depressed mood is consistent with findings from another study of SLE [4]. Hultgren et al. [19] reported that depression was independently associated with three of the sleep parameters (quality, duration, and efficiency), whereas perceived stress contributed to global sleep quality. In this study, the association between depression and sleep disturbances was evident and significant on bivariate analysis, but did not remain significant on logistic regression analyses.

Sleep and anxiety

To our knowledge, this is the first study to examine anxiety correlates of sleep problems in AS. Poor-sleep patients had significantly higher levels of SAS scores compared with those of good sleepers. Bivariate analyses indicated a significant relation between anxiety and sleep disturbances. The relation of sleep and anxiety, rarely has been studied separately, apparently less than that of sleep and depression. A number of studies [53–55] indicated that sleep problems usually were associated with depression and anxiety. However, anxiety was divided into trait-anxiety and state-anxiety in a study by Augner [56], who reported that subjective sleep quality was strongly negatively correlated with trait-anxiety, which is ingrained in a person's personality. Further study might indicate whether state-anxiety, characterized as a temporary change in a person's emotional state due to an outside factor, is correlated with sleep quality.

Statistical contribution in predicting sleep disturbances

A number of studies [13, 57–60] indicated that poor sleep or insomnia or both are risk factors for major depression. Gregory et al. [57] reported that sleep problems predict symptoms of depression at 10 years. Riemann et al. [59] also reported that insomnia symptoms for a period of more than 2 weeks predict an increased risk for developing depression within the following 3 years. A few studies [13, 60, 61], usually included in surveys of sleep and depression, found that poor sleep or insomnia could predict anxiety. In turn, little research exists on the role of depression and/or anxiety in sleep disturbances. In our hierarchic multiple regression analysis, the medical and psychological variables contributed significantly to the variance in sleep-disturbances scores, adding an additional 23.9% to the overall R2 beyond that accounted for by demographic variables (R2 , 8.5%), resulting in a final R2 of 42.6%. Multiple stepwise regression analysis revealed that anxiety was the maximal statistical contribution in predicting sleep disturbances. It is worth mentioning that Jansson and Lindblom [11] conducted a population-based study providing prospective evidence that individuals liable to anxiety may be at particularly high risk of postevent sleep disturbances, at least during the first months after the event.

Conclusions

In summary, half of the patients with AS are reported to have sleep disturbances, and multidimensional assessments have provided better understanding for the specific aspects of sleep. The factors that contributed to poor sleep in the study were overall assessment of health, pain, disease activity, BASFI, depression, and anxiety, even though it was observed that anxiety was the maximal statistical contribution in predicting sleep disturbances. Sleep dysfunction is importantly related to AS physical and psychological symptoms and deserves more attention in both research and clinical practice. Results highlight the high co-occurrence of sleep and AS problems, emphasizing the need for assessment and intervention of sleep disturbance in this population.

Abbreviations

AS:

ankylosing spondylitis

BASDAI:

Bath Ankylosing Spondylitis Disease Activity Index

BASFI:

Bath Ankylosing Spondylitis Functional Index

BASMI:

Bath Ankylosing Spondylitis Metrology Index

CRP:

C-reactive protein

ESR:

erythrocyte sedimentation rate

PSQI:

Pittsburgh sleep quality index

SAS:

self-rating anxiety scale

SDS:

self-rating depression scale

TNF:

tumor necrosis factor.

References

  1. Jin JY, Han SL, Li KP, Zhu J, Zhang JL, Liao YH, Guan X, Wang XR, Huang F: Epidemiological investigation of back pain and spondyloarthritis in Shougang resident communities. Chin J Intern. 2010, 49: 832-835.

    Google Scholar 

  2. Lee YC, Chibnik LB, Lu B, Wasan AD, Edwards RR, Fossel AH, Helfgott SM, Solomon DH, Clauw DJ, Karlson EW: The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther. 2009, 11: R160-10.1186/ar2842. Epub 2009 Oct 29

    PubMed Central  Article  PubMed  Google Scholar 

  3. Vitiello MV, Rybarczyk B, Von Korff M, Stepanski EJ: Cognitive behavioral therapy for insomnia improves sleep and decreases pain in older adults with co-morbid insomnia and osteoarthritis. J Clin Sleep Med. 2009, 5: 355-362.

    PubMed Central  PubMed  Google Scholar 

  4. Chandrasekhara PK, Jayachandran NV, Rajasekhar L, Thomas J, Narsimulu G: The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus. Mod Rheumatol. 2009, 19: 407-415. 10.1007/s10165-009-0185-x.

    Article  PubMed  Google Scholar 

  5. Roizenblatt S, Neto NS, Tufik S: Sleep disorders and fibromyalgia. Curr Pain Headache Rep. 2011, 15: 347-357. 10.1007/s11916-011-0213-3.

    Article  PubMed  Google Scholar 

  6. George A, Pope JE: The minimally important difference (MID) for patient-reported outcomes including pain, fatigue, sleep and the health assessment questionnaire disability index (HAQ-DI) in primary Sjögren's syndrome. Clin Exp Rheumatol. 2011, 29: 248-253.

    CAS  PubMed  Google Scholar 

  7. Da Costa D, Zummer M, Fitzcharles MA: Determinants of sleep problems in patients with spondyloarthropathy. Musculoskeletal Care. 2009, 7: 143-161. 10.1002/msc.155.

    Article  PubMed  Google Scholar 

  8. Kim HJ, Kim JH, Park KD, Choi KG, Lee HW: A survey of sleep deprivation patterns and their effects on cognitive functions of residents and interns in Korea. Sleep Med. 2011, 12: 390-396. 10.1016/j.sleep.2010.09.010.

    Article  PubMed  Google Scholar 

  9. Vincent N, Cox B, Clara I: Are personality dimensions associated with sleep length in a large nationally representative sample?. Compr Psychiatry. 2009, 50: 158-163. 10.1016/j.comppsych.2008.07.007.

    Article  PubMed  Google Scholar 

  10. Curcio G, Ferrara M, De Gennaro L: Sleep loss, learning capacity and academic performance. Sleep Med Rev. 2006, 10: 323-337. 10.1016/j.smrv.2005.11.001.

    Article  PubMed  Google Scholar 

  11. Jansson-Fröjmark M, Lindblom K: A bidirectional relationship between anxiety and depression, and insomnia? A prospective study in the general population. J Psychosom Res. 2008, 64: 443-449. 10.1016/j.jpsychores.2007.10.016.

    Article  PubMed  Google Scholar 

  12. Neckelmann D, Mykletun A, Dahl AA: Chronic insomnia as a risk factor for developing anxiety and depression. Sleep. 2007, 30: 873-880.

    PubMed Central  PubMed  Google Scholar 

  13. Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR: Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007, 30: 274-280.

    PubMed  Google Scholar 

  14. Meerlo P, Sgoifo A, Suchecki D: Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Med Rev. 2008, 12: 197-210. 10.1016/j.smrv.2007.07.007.

    Article  PubMed  Google Scholar 

  15. Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R, Wagner H, Thorne D, Popp K, Rowland L, Welsh A, Balwinski S, Redmond D: Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res. 2000, 9: 335-352. 10.1046/j.1365-2869.2000.00225.x.

    CAS  Article  PubMed  Google Scholar 

  16. Berger AM, Mitchell SA: Modifying cancer-related fatigue by optimizing sleep quality. J Natl Compr Cancer Netw. 2008, 6: 3-13.

    Google Scholar 

  17. Simpson N, Dinges DF: Sleep and inflammation. Nutr Rev. 2007, 65: S244-252. 10.1301/nr.2007.dec.S244-S252.

    Article  PubMed  Google Scholar 

  18. Martin BJ: Effect of sleep deprivation on tolerance of prolonged exercise. Eur J Appl Physiol Occup Physiol. 1981, 47: 345-354. 10.1007/BF02332962.

    CAS  Article  PubMed  Google Scholar 

  19. Hultgren S, Broman JE, Gudbjörnsson B, Hetta J, Lindqvist U: Sleep disturbances in outpatients with ankylosing spondylitis: a questionnaire study with gender implications. Scand J Rheumatol. 2000, 29: 365-369. 10.1080/030097400447561.

    CAS  Article  PubMed  Google Scholar 

  20. Aissaoui N, Rostom S, Hakkou J, Berrada Ghziouel K, Bahiri R, Abouqal R, Hajjaj-Hassouni N: Fatigue in patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status, and sleep disturbance. Rheumatol Int. 2011

    Google Scholar 

  21. Van der Linden S, Valkenburg HA, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368. 10.1002/art.1780270401.

    CAS  Article  PubMed  Google Scholar 

  22. Xianchen Liu, Maoqin Tang, Lei Hu, Aizhen Wang, Hongxin Wu, Guifang Zhao, Chunni Gao, Wanshun Li: Reliability and validity of the Pittsburgh sleep quality index. Clin J Psychiatry. 1996, 29: 103-107.

    Google Scholar 

  23. Zung WW: A self-rating depression scale. Arch Gen Psychiatry. 1965, 12: 63-70. 10.1001/archpsyc.1965.01720310065008.

    CAS  Article  PubMed  Google Scholar 

  24. Zung WW: A rating instrument for anxiety disorders. Psychosomatics. 1971, 12: 371-379.

    CAS  Article  PubMed  Google Scholar 

  25. Günaydin R, Göksel Karatepe A, Ceşmeli N, Kaya T: Fatigue in patients with ankylosing spondylitis: relationships with disease-specific variables, depression, and sleep disturbance. Clin Rheumatol. 2009, 28: 1045-1051. 10.1007/s10067-009-1204-1.

    Article  PubMed  Google Scholar 

  26. Jackson ML, Howard ME, Barnes M: Cognition and daytime functioning in sleep-related breathing disorders. Prog Brain Res. 2011, 190: 53-68.

    Article  PubMed  Google Scholar 

  27. Joshi S: Nonpharmacologic therapy for insomnia in the elderly. Clin Geriatr Med. 2008, 24: 107-119. 10.1016/j.cger.2007.08.005.

    Article  PubMed  Google Scholar 

  28. Morin CM, Vallières A, Guay B, Ivers H, Savard J, Mérette C, Bastien C, Baillargeon L: Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA. 2009, 301: 2005-2015. 10.1001/jama.2009.682.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  29. Kundermann B, Krieg JC, Schreiber W, Lautenbacher S: The effect of sleep deprivation on pain. Pain Res Manag. 2004, 9: 25-32.

    PubMed  Google Scholar 

  30. Smith MT, Haythornthwaite JA: How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Med Rev. 2004, 8: 119-132. 10.1016/S1087-0792(03)00044-3.

    Article  PubMed  Google Scholar 

  31. Hakki Onen S, Alloui A, Jourdan D, Eschalier A, Dubray C: Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat. Brain Res. 2001, 900: 261-267. 10.1016/S0006-8993(01)02320-4.

    CAS  Article  PubMed  Google Scholar 

  32. Wolfe F, Michaud K, Li T: Sleep disturbance in patients with rheumatoid arthritis: evaluation by medical outcomes study and visual analog sleep scales. J Rheumatol. 2006, 33: 1942-1951.

    PubMed  Google Scholar 

  33. Haack M, Sanchez E, Mullington JM: Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007, 30: 1145-1152.

    PubMed Central  PubMed  Google Scholar 

  34. Smith MT, Edwards RR, McCann UD, Haythornthwaite JA: The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep. 2007, 30: 494-505.

    PubMed  Google Scholar 

  35. Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T: Sleep loss and REM sleep loss are hyperalgesic. Sleep. 2006, 29: 145-151.

    PubMed  Google Scholar 

  36. Lautenbacher S, Kundermann B, Krieg JC: Sleep deprivation and pain perception. Sleep Med Rev. 2006, 10: 357-369. 10.1016/j.smrv.2005.08.001.

    Article  PubMed  Google Scholar 

  37. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, Somers VK: Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation. 2002, 105: 2462-2464. 10.1161/01.CIR.0000018948.95175.03.

    CAS  Article  PubMed  Google Scholar 

  38. Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM: Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004, 43: 678-683. 10.1016/j.jacc.2003.07.050.

    CAS  Article  PubMed  Google Scholar 

  39. Liukkonen T, Räsänen P, Ruokonen A, Laitinen J, Jokelainen J, Leinonen M, Meyer-Rochow VB, Timonen M: C-reactive protein levels and sleep disturbances: observations based on the Northern Finland 1966 Birth Cohort study. Psychosom Med. 2007, 69: 756-761. 10.1097/PSY.0b013e318157cb96.

    CAS  Article  PubMed  Google Scholar 

  40. Okun ML, Coussons-Read M, Hall M: Disturbed sleep is associated with increased C-reactive protein in young women. Brain Behav Immun. 2009, 23: 351-354. 10.1016/j.bbi.2008.10.008.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  41. Braun J, Bollow M, Neure L, Seipelt E, Seyrekbasan F, Herbst H, Eggens U, Distler A, Sieper J: Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum. 1995, 38: 499-505. 10.1002/art.1780380407.

    CAS  Article  PubMed  Google Scholar 

  42. Francois RJ, Neure L, Sieper J, Braun J: Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor alpha in two patients with early disease and transforming growth factor beta in three more advanced cases. Ann Rheum Dis. 2006, 65: 713-720. 10.1136/ard.2005.037465.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  43. Lange U, Teichmann J, Stracke H: Correlation between plasma TNFα, IGF-1, biochemical markers of bone metabolism, markers of inflammation/disease activity, and clinical manifestations in ankylosing spondylitis. Eur J Med Res. 2000, 5: 507-511.

    CAS  PubMed  Google Scholar 

  44. Deng XH, Huang F, Zhang JL, Zhang J, Zhang YM: Thalidomide successfully maintains remission in ankylosing spondylitis after discontinuing etanercept treatment. Chin J Rhematol. 2009, 13: 765-768.

    Google Scholar 

  45. Davis JC, van der Heijde DM, Braun J, Dougados M, Cush J, Clegg D, Inman RD, Kivitz A, Zhou L, Solinger A, Tsuji W: Sustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks. Ann Rheum Dis. 2005, 64: 1557-1562. 10.1136/ard.2004.035105.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  46. Baraliakos X, Listing J, Rudwaleit M, Brandt J, Sieper J, Braun J: Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumour necrosis factor alpha antibody infliximab. Ann Rheum Dis. 2005, 64: 1462-1466. 10.1136/ard.2004.033472.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  47. Chennaoui M, Sauvet F, Drogou C, Van Beers P, Langrume C, Guillard M, Gourby B, Bourrilhon C, Florence G, Gomez-Merino D: Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men. Cytokine. 2011, 56: 318-324. 10.1016/j.cyto.2011.06.002.

    CAS  Article  PubMed  Google Scholar 

  48. Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF: Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol. 2001, 107: 165-170. 10.1067/mai.2001.112270.

    CAS  Article  PubMed  Google Scholar 

  49. Krueger JM: The role of cytokines in sleep regulation. Curr Pharm Des. 2008, 14: 3408-3416. 10.2174/138161208786549281.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  50. Rudwaleit M, Gooch K, Michel B, Herold M, Thörner A, Wong R, Kron M, Chen N, Kupper H: Adalimumab improves sleep and sleep quality in patients with active ankylosing spondylitis. J Rheumatol. 2011, 38: 79-86. 10.3899/jrheum.100213.

    Article  PubMed  Google Scholar 

  51. Sayar K, Arikan M, Yontem T: Sleep quality in chronic pain patients. Can J Psychiatry. 2002, 47: 844-848.

    PubMed  Google Scholar 

  52. Costa DD, Bernatsky S, Dritsa M, Clarke AE, Dasgupta K, Keshani A, Pineau C: Determinants of sleep quality in women with systemic lupus erythematosus. Arthritis Rheum. 2005, 53: 272-278. 10.1002/art.21069.

    Article  PubMed  Google Scholar 

  53. Fernandez-Mendoza J, Calhoun SL, Bixler EO, Karataraki M, Liao D, Vela-Bueno A, Jose Ramos-Platon M, Sauder KA, Basta M, Vgontzas AN: Sleep misperception and chronic insomnia in the general population: role of objective sleep duration and psychological profiles. Psychosom Med. 2011, 73: 88-97. 10.1097/PSY.0b013e3181fe365a.

    PubMed Central  Article  PubMed  Google Scholar 

  54. Casimir GJ, Jean-Louis G, Butler S, Zizi F, Nunes J, Brady L: Perceived insomnia, anxiety, and depression among older Russian immigrants. Psychol Rep. 2010, 106: 589-597. 10.2466/pr0.106.2.589-597.

    CAS  Article  PubMed  Google Scholar 

  55. Ostacoli L, Saini A, Ferini-Strambi L, Castronovo V, Sguazzotti E, Picci RL, Toje M, Gorzegno G, Capogna S, Dongiovanni V, Dogliotti L, Furlan PM, Berruti A: Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy. Qual Life Res. 2010, 19: 531-537. 10.1007/s11136-010-9614-8.

    Article  PubMed  Google Scholar 

  56. Augner C: Associations of subjective sleep quality with depression score, anxiety, physical symptoms and sleep onset latency in students. Cent Eur J Public Health. 2011, 19: 115-117.

    PubMed  Google Scholar 

  57. Gregory AM, Rijsdijk FV, Lau JY, Dahl RE, Eley TC: The direction of longitudinal associations between sleep problems and depression symptoms: a study of twins aged 8 and 10 years. Sleep. 2009, 32: 189-199.

    PubMed Central  PubMed  Google Scholar 

  58. Buysse DJ, Angst J, Gamma A, Ajdacic V, Eich D, Rössler W: Prevalence, course, and comorbidity of insomnia and depression in young adults. Sleep. 2008, 31: 473-480.

    PubMed Central  PubMed  Google Scholar 

  59. Riemann D, Voderholzer U: Primary insomnia: a risk factor to develop depression?. J Affect Disord. 2003, 76: 255-259. 10.1016/S0165-0327(02)00072-1.

    Article  PubMed  Google Scholar 

  60. Gregory AM, O'Connor TG: Sleep problems in childhood: a longitudinal study of developmental change and association with behavioral problems. J Am Acad Child Adolesc Psychiatry. 2002, 41: 964-971. 10.1097/00004583-200208000-00015.

    Article  PubMed  Google Scholar 

  61. Gregory AM, Caspi A, Eley TC, Moffitt TE, Oconnor TG, Poulton R: Prospective longitudinal associations between persistent sleep problems in childhood and anxiety and depression disorders in adulthood. J Abnorm Child Psychol. 2005, 33: 157-163. 10.1007/s10802-005-1824-0.

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors thank the patients for their participation in this study. We thank all personnel from the rheumatology clinic and department in Chinese PLA General Hospital for their technical and logistic contributions to this work, and we also thank Yulang Zhuo, MD (College of Public Health, Zhengzhou University, China) for his invaluable help in data collation and entry.

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    Authors and Affiliations

    1. Department of Rheumatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

      Yan Li, Shengli Zhang, Jian Zhu, Xuna Du & Feng Huang

    2. Department of Child and Adolescent Health, College of Public Health, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China

      Yan Li

    3. Department of Rheumatology, Fuzhou General Hospital of Nanjing Military Command, 156 Xi'erhuan North Road, Fuzhou, 350025, China

      Shengli Zhang

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    1. Yan Li
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    Correspondence to Feng Huang.

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    The authors declare that they have no competing interests.

    Authors' contributions

    YL, SZ, and FH have contributed substantially in the processes of study design, data acquisition, and analysis and interpretation of data. XD contributed to the statistical analyses of the data. JZ has been involved in revising the manuscript critically for its important intellectual concept and also gave the final approval for its publication. All authors read and approved the final manuscript.

    Yan Li, Shengli Zhang contributed equally to this work.

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    Li, Y., Zhang, S., Zhu, J. et al. Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study. Arthritis Res Ther 14, R215 (2012). https://doi.org/10.1186/ar4054

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    • DOI: https://doi.org/10.1186/ar4054

    Keywords

    • Ankylose Spondylitis
    • Sleep Disturbance
    • Sleep Quality
    • Poor Sleep
    • Pittsburgh Sleep Quality Index

    Arthritis Research & Therapy

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