Disease features and outcomes among US lupus patients of Hispanic origin and their Mestizo counterpart in Latina America
© Ugarte-Gil et al.; licensee BioMed Central Ltd. 2014
Published: 18 September 2014
Systemic lupus erythematosus (SLE) US Hispanic patients with a large Amerindian ancestral background have been found to have poor outcomes. Similar observations have been made in the mixed population of Latin America. We are now comparing and contrasting selected sociodemographic and clinical features and outcomes of lupus patients from these two groups.
SLE US Hispanic patients (European and Amerindian ancestry) from the LUMINA cohort (Lupus in Minorities: Nature vs. Nurture) and Latin American Mestizo patients from the GLADEL cohort (Grupo LatinoAmericano De Estudio de Lupus (Latin American Group for the Study of Lupus)) constitute the study population. Only patients who fulfilled four of the 1997 ACR criteria were included. Diagnosis time was time to the fourth criterion. Demographic and clinical data from these patients were extracted. When the ascertainment method for a specific variable was different in both cohorts, this has been noted. All variables were then compared using descriptive statistical tests. Adjustment for disease duration was done when indicated using either a Poisson regression or logistic regression, as appropriate.
Salient features of US Hispanic SLE patients from LUMINA and Latin America Mestizo patients from GLADEL (at diagnosis or at last visit)
LUMINA (n = 114)
GLADEL (n = 619)
Age, mean (SD)
Gender (female), n (%)
Disease duration (years), mean (SD)
Low SESa, n (%)
Health insurance, n (%)
Acute onset, n (%)
ACR criteria numberb, mean (SD)
Disease activity (moderate-high)c, n (%)
Renal disorder, n (%)
SDI score at last visitb, mean (SD)
Renal damage (per SDI, at last visit)d, n (%)
Deceasedd, n (%)
Patients in both cohorts exhibited active disease, with renal involvement and damage being frequent, and overall damage accruing rapidly; however, the US Hispanic patients exhibited a higher mortality. These two patient groups were also of low SES. These data suggest that these two populations share an underlying genetic background which coupled with a poor SES places them at increased risk for severe lupus with unfavorable short, intermediate and long-term outcomes. The less favorable mortality experience of the US Hispanics deserves to be further examined.
Thanks to LUMINA and GLADEL investigators on whose behalf this work is being presented.
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