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  1. We have recently shown that cardiolipin (CL) and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. In this study, we investigate the immunoreactivity ...

    Authors: Cristiano Alessandri, Maurizio Sorice, Michele Bombardieri, Paola Conigliaro, Agostina Longo, Tina Garofalo, Valeria Manganelli, Fabrizio Conti, Mauro Degli Esposti and Guido Valesini
    Citation: Arthritis Research & Therapy 2006 8:R180
    Content type: Research article Published on:

  2. Osteoarthritis (OA) is characterized by articular cartilage degradation and hypertrophic bone changes with osteophyte formation and abnormal bone remodeling. Two groups of OA patients were identified via the p...

    Authors: Kelitha Maxis, Aline Delalandre, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicolas Duval and Daniel Lajeunesse
    Citation: Arthritis Research & Therapy 2006 8:R181
    Content type: Research article Published on:

  3. Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full pu...

    Authors: R Andrew Moore and Sheena Derry
    Citation: Arthritis Research & Therapy 2006 8:R182
    Content type: Research article Published on:

  4. Infection imposes a serious burden on patients with systemic lupus erythematosus (SLE). The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently, the lect...

    Authors: Irene EM Bultink, Dörte Hamann, Marc A Seelen, Margreet H Hart, Ben AC Dijkmans, Mohamed R Daha and Alexandre E Voskuyl
    Citation: Arthritis Research & Therapy 2006 8:R183
    Content type: Research article Published on:

  5. The aim of the present study was to evaluate the relative contribution of human leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical expression of psoriatic arthritis (PsA). One hun...

    Authors: Ruben Queiro, Segundo Gonzalez, Carlos López-Larrea, Mercedes Alperi, Cristina Sarasqueta, Jose Luis Riestra and Javier Ballina
    Citation: Arthritis Research & Therapy 2006 8:R185
    Content type: Research article Published on:

  6. The prevalence of ischemic heart disease and atherosclerosis is increased in patients with rheumatoid arthritis (RA). In the general population, but not in patients with systemic lupus erythematosus, the Frami...

    Authors: Cecilia P Chung, Annette Oeser, Ingrid Avalos, Tebeb Gebretsadik, Ayumi Shintani, Paolo Raggi, Tuulikki Sokka, Theodore Pincus and C Michael Stein
    Citation: Arthritis Research & Therapy 2006 8:R186
    Content type: Research article Published on:

  7. There is an increasing body of evidence that synovitis plays a role in the progression of osteoarthritis and that overproduction of cytokines and growth factors from the inflamed synovium can influence the pro...

    Authors: Jan Bondeson, Shane D Wainwright, Sarah Lauder, Nick Amos and Clare E Hughes
    Citation: Arthritis Research & Therapy 2006 8:R187
    Content type: Research article Published on:

  8. Previous studies have shown a generalised increase in bone mass in patients with osteoarthritis (OA). Using molecular histomorphometry, this study examined the in vivo expression of mRNA encoding bone anabolic fa...

    Authors: Le-Hoa Truong, Julia S Kuliwaba, Helen Tsangari and Nicola L Fazzalari
    Citation: Arthritis Research & Therapy 2006 8:R188
    Content type: Research article Published on:

  9. Vascular endothelial growth factor (VEGF) promotes cartilage-degrading pathways, and there is evidence for the involvement of reactive oxygen species (ROS) in cartilage degeneration. However, a relationship be...

    Authors: Jakob Fay, Deike Varoga, Christoph J Wruck, Bodo Kurz, Mary B Goldring and Thomas Pufe
    Citation: Arthritis Research & Therapy 2006 8:R189
    Content type: Research article Published on:

  10. Numerous investigations have reported the efficacy of exogenous hyaluronan (HA) in modulating acute and chronic inflammation. The current study was performed to determine the in vitro effects of lower and higher ...

    Authors: Kelly S Santangelo, Amanda L Johnson, Amy S Ruppert and Alicia L Bertone
    Citation: Arthritis Research & Therapy 2007 9:R1
    Content type: Research article Published on:

  13. Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology. Effective treatment of this disorder has been hampered by the lack of availability of agents that selectively target affected join...

    Authors: Dong Wang, Scott C Miller, Xin-Ming Liu, Brian Anderson, Xu Sherry Wang and Steven R Goldring
    Citation: Arthritis Research & Therapy 2007 9:R2
    Content type: Research article Published on:

  14. People exposed to sunlight can develop erythema, DNA damage, and photoimmunosupression. Extended exposure of normal epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered thr...

    Authors: Melanie K Kuechle and Keith B Elkon
    Citation: Arthritis Research & Therapy 2007 9:101
    Content type: Editorial Published on:

  15. Quantitative traits such as complex diseases are controlled by many small-effect genes that are difficult to identify. Here we present a novel strategy to identify the candidate genes for small-effect quantita...

    Authors: Xinhua Yu, Kristin Bauer, Dirk Koczan, Hans-Jürgen Thiesen and Saleh M Ibrahim
    Citation: Arthritis Research & Therapy 2007 9:R3
    Content type: Research article Published on:

  16. Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many patients suffering from arthritis pain and inflammation....

    Authors: Edwin SL Chan, Hongwei Zhang, Patricia Fernandez, Sari D Edelman, Michael H Pillinger, Louis Ragolia, Thomas Palaia, Steven Carsons and Allison B Reiss
    Citation: Arthritis Research & Therapy 2007 9:R4
    Content type: Research article Published on:

  17. We have recently demonstrated that the rheumatoid arthritis (RA) shared epitope (SE) acts as a ligand that triggers nitric oxide (NO) signaling in opposite cells. Given the known pro-oxidative effect of NO and...

    Authors: Song Ling, Zhanguo Li, Olga Borschukova, Liqun Xiao, Paul Pumpens and Joseph Holoshitz
    Citation: Arthritis Research & Therapy 2007 9:R5
    Content type: Research article Published on:

  18. Innervation of the joint with thinly myelinated and unmyelinated sensory nerve fibres is crucial for the occurrence of joint pain. During inflammation in the joint, sensory fibres show changes in the expressio...

    Authors: Gisela Segond von Banchet, Jonny Richter, Marion Hückel, Christina Rose, Rolf Bräuer and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2007 9:R6
    Content type: Research article Published on:

  19. Inhibition of tumour necrosis factor (TNF)-alpha with biological molecules has proven an effective treatment for rheumatoid arthritis, achieving a 20% improvement in American College of Rheumatology score in u...

    Authors: David Gould, Nasim Yousaf, Rewas Fatah, Maria Cristina Subang and Yuti Chernajovsky
    Citation: Arthritis Research & Therapy 2007 9:R7
    Content type: Research article Published on:

  20. Osteoarthritis (OA) is a degenerative disease that disrupts the collagenous matrix of articular cartilage and is difficult to cure because articular cartilage is a nonvascular tissue. Treatment of OA has targe...

    Authors: Yoo-Sin Park, Si-Woong Lim, Il-Hoon Lee, Tae-Jin Lee, Jong-Sung Kim and Jin Soo Han
    Citation: Arthritis Research & Therapy 2007 9:R8
    Content type: Research article Published on:

  21. The antibody-mediated targeted delivery of cytokines to sites of disease is a promising avenue for cancer therapy, but it is largely unexplored for the treatment of chronic inflammatory conditions. Using both ...

    Authors: Eveline Trachsel, Frank Bootz, Michela Silacci, Manuela Kaspar, Hartwig Kosmehl and Dario Neri
    Citation: Arthritis Research & Therapy 2007 9:R9
    Content type: Research article Published on:

  22. Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro

    Authors: Alan Tyndall, Ulrich A Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia…
    Citation: Arthritis Research & Therapy 2007 9:301
    Content type: Meeting report Published on:

  23. Pseudoporphyria (PP) is characterized by skin fragility, blistering and scarring in sun-exposed skin areas without abnormalities in porphyrin metabolism. The phenylpropionic acid derivative group of nonsteroid...

    Authors: Susanne G Schäd, Andrea Kraus, Imme Haubitz, Jiri Trcka, Henning Hamm and Hermann J Girschick
    Citation: Arthritis Research & Therapy 2007 9:R10
    Content type: Research article Published on:

  24. Patient Acceptable Symptom State (PASS) is an absolute threshold proposed for symptomatic variables in osteoarthritis (OA) to determine the point beyond which patients consider themselves well and, as such, ar...

    Authors: Maxime Dougados, Alan Moore, Shaohua Yu and Xavier Gitton
    Citation: Arthritis Research & Therapy 2007 9:R11
    Content type: Research article Published on:

  25. Recent studies have implicated the dying cell as a potential reservoir of modified autoantigens that might initiate and drive systemic autoimmunity in susceptible hosts. A number of subunits of the exosome, a ...

    Authors: Geurt Schilders, Reinout Raijmakers, Kelen CR Malmegrim, Lieselotte Vande Walle, Xavier Saelens, Wilma Vree Egberts, Walther J van Venrooij, Peter Vandenabeele and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2007 9:R12
    Content type: Research article Published on:

  26. Preclinical osteoarthritis (OA) models are often employed in studies investigating disease-modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal evaluation of OA pathogenesis in a...

    Authors: C Thomas G Appleton, David D McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M Bernier, James L Henry, David W Holdsworth and Frank Beier
    Citation: Arthritis Research & Therapy 2007 9:R13
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:407

  27. The etiology of osteoarthritis is multifactorial, with inflammatory, metabolic, and mechanical causes. Pain in osteoarthritis is initiated by mild intra-articular inflammation and degeneration of articular car...

    Authors: Bettina Beyreuther, Noëlle Callizot and Thomas Stöhr
    Citation: Arthritis Research & Therapy 2007 9:R14
    Content type: Research article Published on:

  28. Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in animal models of autoimmune diseases. Chemokines play an important role in the development of autoimmune diseases in...

    Authors: Hitoshi Hasegawa, Atsushi Inoue, Masatake Muraoka, Jun Yamanouchi, Tatsuhiko Miyazaki and Masaki Yasukawa
    Citation: Arthritis Research & Therapy 2007 9:R15
    Content type: Research article Published on:

  29. A recent prospective study showed that higher consumption of red meat and total protein was associated with increased risk for inflammatory polyarthritis. We therefore prospectively examined the relationship b...

    Authors: Elizabeth Benito-Garcia, Diane Feskanich, Frank B Hu, Lisa A Mandl and Elizabeth W Karlson
    Citation: Arthritis Research & Therapy 2007 9:R16
    Content type: Research article Published on:

  30. Non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclo-oxygenase-2 (COX-2) inhibitors, cause upper gastrointestinal (GI) symptoms that are relieved by treatment with esomeprazole. We assesse...

    Authors: Christopher J Hawkey, Nicholas J Talley, James M Scheiman, Roger H Jones, Göran Långström, Jorgen Næsdal and Neville D Yeomans
    Citation: Arthritis Research & Therapy 2007 9:R17
    Content type: Research article Published on:

  31. A major question concerning the immunopathology of rheumatoid arthritis is why the disease is localized to particular joints. A possible explanation could be the presence within the synovium of cells that fost...

    Authors: Takahiro Ochi, Hideki Yoshikawa, Tomoko Toyosaki-Maeda and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2007 9:201
    Content type: Review Published on:

  32. Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of...

    Authors: Steven K Lundy, Sujata Sarkar, Laura A Tesmer and David A Fox
    Citation: Arthritis Research & Therapy 2007 9:202
    Content type: Review Published on:

  33. Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption p...

    Authors: Georg Schett
    Citation: Arthritis Research & Therapy 2007 9:203
    Content type: Review Published on:

  34. Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential ...

    Authors: Catherine M Kolf, Elizabeth Cho and Rocky S Tuan
    Citation: Arthritis Research & Therapy 2007 9:204
    Content type: Review Published on:

  35. Aseptic loosening of a joint prosthesis is associated with remodelling of bone tissue in the vicinity of the prosthesis. In the present study, we investigated the effects of synovial fluid (SF) from patients w...

    Authors: Martin K Andersson, Pernilla Lundberg, Acke Ohlin, Mark J Perry, Anita Lie, André Stark and Ulf H Lerner
    Citation: Arthritis Research & Therapy 2007 9:R18
    Content type: Research article Published on:

  36. Rheumatoid arthritis is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. Oxidized low-density lipoprotein (oxLDL), the ant...

    Authors: Evangelia S Lourida, Athanasios N Georgiadis, Eleni C Papavasiliou, Athanasios I Papathanasiou, Alexandros A Drosos and Alexandros D Tselepis
    Citation: Arthritis Research & Therapy 2007 9:R19
    Content type: Research article Published on:

  37. In this study we examine the extracellular role of galectin-3 (gal-3) in joint tissues. Following intra-articular injection of gal-3 or vehicle in knee joints of mice, histological evaluation of articular cart...

    Authors: Audrée Janelle-Montcalm, Christelle Boileau, Françoise Poirier, Jean-Pierre Pelletier, Mélanie Guévremont, Nicolas Duval, Johanne Martel-Pelletier and Pascal Reboul
    Citation: Arthritis Research & Therapy 2007 9:R20
    Content type: Research article Published on:

  38. We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic change...

    Authors: Changhai Ding, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Abram, Jean-Pierre Raynauld, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2007 9:R21
    Content type: Research article Published on:

  39. In chronic inflammatory diseases, such as rheumatoid arthritis, inflammation acts as an independent cardiovascular risk factor and the use of anti-inflammatory drugs, such as anti-tumor necrosis factor alpha (...

    Authors: Jean Frédéric Boyer, Patricia Balard, Hélène Authier, Bruno Faucon, José Bernad, Bernard Mazières, Jean-Luc Davignon, Alain Cantagrel, Bernard Pipy and Arnaud Constantin
    Citation: Arthritis Research & Therapy 2007 9:R22
    Content type: Research article Published on:

  40. Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this combination, even ...

    Authors: Makoto Soejima, Tomoko Sugiura, Yasushi Kawaguchi, Manabu Kawamoto, Yasuhiro Katsumata, Kae Takagi, Ayako Nakajima, Tadayuki Mitamura, Akio Mimori, Masako Hara and Naoyuki Kamatani
    Citation: Arthritis Research & Therapy 2007 9:R23
    Content type: Research article Published on:

  41. Estrogen deficiency is one of the most frequent causes of osteoporosis in women and a possible cause of bone loss in men. But the mechanism involved remains largely unknown. Estrogen deficiency leads to an inc...

    Authors: Roberto Pacifici
    Citation: Arthritis Research & Therapy 2007 9:102
    Content type: Commentary Published on:

  42. There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently pre...

    Authors: Claudia Mauri and Michael R Ehrenstein
    Citation: Arthritis Research & Therapy 2007 9:205
    Content type: Review Published on:

  43. CTLA-4 encodes cytotoxic T lymphocyte-associated antigen-4, a cell-surface molecule providing a negative signal for T-cell activation. CTLA-4 gene polymorphisms have been widely studied in connection with genetic...

    Authors: Jacques-Eric Gottenberg, Pascale Loiseau, Mariam Azarian, Chun Chen, Nicolas Cagnard, Eric Hachulla, Xavier Puechal, Jean Sibilia, Dominique Charron, Xavier Mariette and Corinne Miceli-Richard
    Citation: Arthritis Research & Therapy 2007 9:R24
    Content type: Research article Published on:

  44. Functional links between bone remodeling and the immune system in chronic inflammatory arthritis are mediated, in part, by the ligand of receptor activator of nuclear factor-kappa-B (RANK-L). Because neutrophi...

    Authors: Patrice E Poubelle, Arpita Chakravarti, Maria J Fernandes, Karine Doiron and Andrée-Anne Marceau
    Citation: Arthritis Research & Therapy 2007 9:R25
    Content type: Research article Published on:

  45. The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were ...

    Authors: Leonid Kalichman, Yuqing Zhang, Jingbo Niu, Joyce Goggins, Daniel Gale, Yanyan Zhu, David T Felson and David J Hunter
    Citation: Arthritis Research & Therapy 2007 9:R26
    Content type: Research article Published on:

  46. The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping ...

    Authors: Pierre-Antoine Gourraud, Philippe Dieudé, Jean-Frédéric Boyer, Leonor Nogueira, Anne Cambon-Thomsen, Bernard Mazières, François Cornélis, Guy Serre, Alain Cantagrel and Arnaud Constantin
    Citation: Arthritis Research & Therapy 2007 9:R27
    Content type: Research article Published on:

  47. Monosodium urate crystals stimulate monocytes and macrophages to release IL-1β through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes wit...

    Authors: Alexander So, Thibaut De Smedt, Sylvie Revaz and Jürg Tschopp
    Citation: Arthritis Research & Therapy 2007 9:R28
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:233

  48. Significant levels of circulating immune complexes (ICs) containing rheumatoid factors and immunoglobulin G in peripheral blood are a characteristic feature of rheumatoid arthritis (RA). ICs interact through F...

    Authors: Anna-Marie Fairhurst, Paul K Wallace, Ali SM Jawad and Nicolas J Goulding
    Citation: Arthritis Research & Therapy 2007 9:R29
    Content type: Research article Published on:

  49. Cell therapy, pioneered for the treatment of malignancies in the form of bone marrow transplantation, has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem...

    Authors: Francesco Dazzi, Jacob M van Laar, Andrew Cope and Alan Tyndall
    Citation: Arthritis Research & Therapy 2007 9:206
    Content type: Review Published on:

  50. Joint inflammation and destruction have been linked to the deregulation of the highly synthetic fibroblast-like synoviocytes (FLSs), and much of our current understanding of the mechanisms that underlie synovi...

    Authors: Tracey Weiler, Qiujiang Du, Oleg Krokhin, Werner Ens, Ken Standing, Hani El-Gabalawy and John A Wilkins
    Citation: Arthritis Research & Therapy 2007 9:R30
    Content type: Research article Published on:
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