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  1. The aim of our study was to identify new early rheumatoid arthritis (RA) autoantibodies.

    Authors: Vincent Goëb, Marlène Thomas-L'Otellier, Romain Daveau, Roland Charlionet, Patrice Fardellone, Xavier Le Loët, François Tron, Danièle Gilbert and Olivier Vittecoq
    Citation: Arthritis Research & Therapy 2009 11:R38
    Content type: Research article Published on:

  2. Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) independent of traditional risk factors. The aim of this study was to analyze the associations between diet, body...

    Authors: Ann-Charlotte Elkan, Niclas Håkansson, Johan Frostegård, Tommy Cederholm and Ingiäld Hafström
    Citation: Arthritis Research & Therapy 2009 11:R37
    Content type: Research article Published on:

  3. Inflammation is an important feature of many joint diseases, and levels of cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little is known about the magnitude an...

    Authors: Janny C de Grauw, Chris HA van de Lest and Paul René van Weeren
    Citation: Arthritis Research & Therapy 2009 11:R35
    Content type: Research article Published on:

  4. Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues such ...

    Authors: Thomas V Stabler, Samuel S Byers, Robert D Zura and Virginia Byers Kraus
    Citation: Arthritis Research & Therapy 2009 11:R34
    Content type: Research article Published on:

  5. Although the clinical effects of infliximab therapy in rheumatoid arthritis have been documented extensively, the biological effects of this intervention continue to be defined. We sought to examine the impact...

    Authors: Ravi C Dwivedi, Navjot Dhindsa, Oleg V Krokhin, John Cortens, John A Wilkins and Hani S El-Gabalawy
    Citation: Arthritis Research & Therapy 2009 11:R32
    Content type: Research article Published on:

  6. Second-generation autologous chondrocyte implantation with scaffolds stabilizing the grafts is a clinically effective procedure for cartilage repair. In this ongoing prospective observational case report study...

    Authors: Peter C Kreuz, Sebastian Müller, Christian Ossendorf, Christian Kaps and Christoph Erggelet
    Citation: Arthritis Research & Therapy 2009 11:R33
    Content type: Research article Published on:

  7. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. It is unknown whether the adipose mass and the distribution of adipose mass are associated with the risk of p...

    Authors: Yuanyuan Wang, Julie Anne Simpson, Anita E Wluka, Andrew J Teichtahl, Dallas R English, Graham G Giles, Stephen Graves and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2009 11:R31
    Content type: Research article Published on:

  8. In systemic sclerosis (SSc) little evidence for the effectiveness of anti-inflammatory and immunosuppressive therapy exists. The objective of this study was to determine the extent to which SSc patients are tr...

    Authors: Nicolas Hunzelmann, Pia Moinzadeh, Ekkehard Genth, Thomas Krieg, Walter Lehmacher, Inga Melchers, Michael Meurer, Ulf Müller-Ladner, Thorsten M Olski, Christiane Pfeiffer, Gabriela Riemekasten, Eckhard Schulze-Lohoff, Cord Sunderkoetter and Manfred Weber
    Citation: Arthritis Research & Therapy 2009 11:R30
    Content type: Research article Published on:

  9. In a paper by Zimmermann and colleagues in this issue of Arthritis Research & Therapy, results of extended laboratory research with the drug combination of prednisolone and dipyridamole are reported. There seems ...

    Authors: Johannes WG Jacobs and Johannes WJ Bijlsma
    Citation: Arthritis Research & Therapy 2009 11:105
    Content type: Editorial Published on:

  11. Idiopathic aortitis is a rare condition characterized by giant cell or lymphoplasmacytic inflammation of the aorta. The purpose of this study was to describe risk factors for the development of idiopathic aort...

    Authors: Vaidehi R Chowdhary, Cynthia S Crowson, Kimberly P Liang, Clement J Michet Jr, Dylan V Miller, Kenneth J Warrington and Eric L Matteson
    Citation: Arthritis Research & Therapy 2009 11:R29
    Content type: Research article Published on:

  14. In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monoc...

    Authors: Katharina Hanke, Cornelia Dähnrich, Claudia S Brückner, Dörte Huscher, Mike Becker, Anthonina Jansen, Wolfgang Meyer, Karl Egerer, Falk Hiepe, Gerd R Burmester, Wolfgang Schlumberger and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2009 11:R28
    Content type: Research article Published on:

  15. Systemic lupus erythematosus is characterized by production of autoantibodies to RNA or DNA–protein complexes such as small nuclear ribonucleoproteins (snRNPs). A role of Epstein–Barr virus in the pathogenesis...

    Authors: Claudia Azucena Palafox Sánchez, Minoru Satoh, Edward KL Chan, Wendy C Carcamo, José Francisco Muñoz Valle, Gerardo Orozco Barocio, Edith Oregon Romero, Rosa Elena Navarro Hernández, Mario Salazar Páramo, Antonio Cabral Castañeda and Mónica Vázquez del Mercado
    Citation: Arthritis Research & Therapy 2009 11:R27
    Content type: Research article Published on:

  16. Aggressive treatment with disease-modifying antirheumatic drugs (DMARDs) plays a major role in improving early rheumatoid arthritis (RA) patient outcomes. Persistence and adherence with medication occurs varia...

    Authors: Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Antonio R Villa, Javier Cabiedes and Marina Rull-Gabayet
    Citation: Arthritis Research & Therapy 2009 11:R26
    Content type: Research article Published on:

  17. Activated synovial fibroblasts are thought to play a major role in the destruction of cartilage in chronic, inflammatory rheumatoid arthritis (RA). However, profound insight into the pathogenic mechanisms and ...

    Authors: David Pretzel, Dirk Pohlers, Sönke Weinert and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2009 11:R25
    Content type: Research article Published on:

  18. The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such as ...

    Authors: Margaret K Gatumu, Kathrine Skarstein, Adrian Papandile, Jeffrey L Browning, Roy A Fava and Anne Isine Bolstad
    Citation: Arthritis Research & Therapy 2009 11:R24
    Content type: Research article Published on:

  20. Anti-PM/Scl antibodies are present in sera from patients with polymyositis (PM), systemic sclerosis (SSc), and PM/SSc overlap syndromes. The prevalence of antibodies against the 75- and 100-kDa PM/Scl proteins...

    Authors: Katharina Hanke, Claudia S Brückner, Cornelia Dähnrich, Dörte Huscher, Lars Komorowski, Wolfgang Meyer, Anthonia Janssen, Marina Backhaus, Mike Becker, Angela Kill, Karl Egerer, Gerd R Burmester, Falk Hiepe, Wolfgang Schlumberger and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2009 11:R22
    Content type: Research article Published on:

  21. The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different ...

    Authors: Balint Farkas, Ferenc Boldizsar, Oktavia Tarjanyi, Anna Laszlo, Simon M Lin, Gabor Hutas, Beata Tryniszewska, Aaron Mangold, Gyorgy Nagyeri, Holly L Rosenzweig, Alison Finnegan, Katalin Mikecz and Tibor T Glant
    Citation: Arthritis Research & Therapy 2009 11:R21
    Content type: Research article Published on:

  22. Psoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psori...

    Authors: Oliver FitzGerald and Robert Winchester
    Citation: Arthritis Research & Therapy 2009 11:214
    Content type: Review Published on:

  23. The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ...

    Authors: Christine L Le Maitre, Pauline Baird, Anthony J Freemont and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2009 11:R20
    Content type: Research article Published on:

  25. Decreased vascular responses to salivary gland stimulation are observed in Sjögren's syndrome patients. We investigate whether impaired vascular responses to parasympathetic stimulation and muscarinic receptor...

    Authors: Ellen Berggreen, Krister Nyløkken, Nicolas Delaleu, Hamijeta Hajdaragic-Ibricevic and Malin V Jonsson
    Citation: Arthritis Research & Therapy 2009 11:R18
    Content type: Research article Published on:

  26. The aim of the study was to investigate synovial immunopathology differences between early Behçet disease (BD) and psoriatic arthritis (PsA).

    Authors: Juan D Cañete, Raquel Celis, Troy Noordenbos, Conchita Moll, Jose A Gómez-Puerta, Pilar Pizcueta, Antonio Palacin, Paul P Tak, Raimon Sanmartí and Dominique Baeten
    Citation: Arthritis Research & Therapy 2009 11:R17
    Content type: Research article Published on:

  27. In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such h...

    Authors: Christopher L Murphy, Brendan L Thoms, Rasilaben J Vaghjiani and Jérôme E Lafont
    Citation: Arthritis Research & Therapy 2009 11:213
    Content type: Review Published on:

  28. The rheumatoid arthritis (RA) synovium is characterised by the presence of an aggressive population of activated synovial fibroblasts (RASFs) that are prominently involved in the destruction of articular carti...

    Authors: Noreen Pundt, Marvin A Peters, Christina Wunrau, Simon Strietholt, Carsten Fehrmann, Katja Neugebauer, Christine Seyfert, Frans van Valen, Thomas Pap and Ingmar Meinecke
    Citation: Arthritis Research & Therapy 2009 11:R16
    Content type: Research article Published on:

  29. Rheumatoid arthritis (RA) leads to progressive destruction of articular cartilage. This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and phar...

    Authors: Kristin Andreas, Thomas Häupl, Carsten Lübke, Jochen Ringe, Lars Morawietz, Anja Wachtel, Michael Sittinger and Christian Kaps
    Citation: Arthritis Research & Therapy 2009 11:R15
    Content type: Research article Published on:

  31. Diseases such as degenerative or rheumatoid arthritis are accompanied by joint destruction. Clinically applied tissue engineering technologies like autologous chondrocyte implantation, matrix-assisted chondroc...

    Authors: Jochen Ringe and Michael Sittinger
    Citation: Arthritis Research & Therapy 2009 11:211
    Content type: Review Published on:

  32. This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed significantly to th...

    Authors: Georg Schett
    Citation: Arthritis Research & Therapy 2009 11:210
    Content type: Review Published on:

  33. During the decade since the launch of Arthritis Research, the application of gene therapy to the rheumatic diseases has experienced the same vicissitudes as the field of gene therapy as a whole. There have been c...

    Authors: Christopher H Evans, Steven C Ghivizzani and Paul D Robbins
    Citation: Arthritis Research & Therapy 2009 11:209
    Content type: Review Published on:

  35. Rheumatic diseases are a diverse group of disorders. Most of these diseases are heterogeneous in nature and show varying responsiveness to treatment. Because our understanding of the molecular complexity of rh...

    Authors: Lisa GM van Baarsen, Carina L Bos, Tineke CTM van der Pouw Kraan and Cornelis L Verweij
    Citation: Arthritis Research & Therapy 2009 11:207
    Content type: Review Published on:

  40. Antigen receptor signaling in lymphocytes has been clearly implicated in the pathogenesis of the rheumatic diseases. Here, we review evidence from mouse models in which B-cell and T-cell signaling machinery is...

    Authors: Julie Zikherman and Arthur Weiss
    Citation: Arthritis Research & Therapy 2009 11:202
    Content type: Review Published on:

  41. Osteoarthritis (OA) is a debilitating disease with poorly defined aetiology. Multiple signals are involved in directing the formation of cartilage during development and the vitamin A derivatives, the retinoid...

    Authors: Ian D Welch, Matthew F Cowan, Frank Beier and Tully M Underhill
    Citation: Arthritis Research & Therapy 2009 11:R14
    Content type: Research article Published on:

  42. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumour necrosis factor (TNF) family member capable of inducing apoptosis in many cell types.

    Authors: Anak ASSK Dharmapatni, Malcolm D Smith, David M Findlay, Christopher A Holding, Andreas Evdokiou, Michael J Ahern, Helen Weedon, Paul Chen, Gavin Screaton, Xiao N Xu and David R Haynes
    Citation: Arthritis Research & Therapy 2009 11:R13
    Content type: Research article Published on:

  44. Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic w...

    Authors: Grant R Zimmermann, William Avery, Alyce L Finelli, Melissa Farwell, Christopher C Fraser and Alexis A Borisy
    Citation: Arthritis Research & Therapy 2009 11:R12
    Content type: Research article Published on:

  45. Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of th...

    Authors: David J Hunter, Lou Gerstenfeld, Gavin Bishop, A David Davis, Zach D Mason, Tom A Einhorn, Rose A Maciewicz, Pete Newham, Martyn Foster, Sonya Jackson and Elise F Morgan
    Citation: Arthritis Research & Therapy 2009 11:R11
    Content type: Research article Published on:

  48. An adequate supply of oxygen and nutrients is essential for survival and metabolism of cells, and consequentially for normal homeostasis. Alterations in tissue oxygen tension have been postulated to contribute...

    Authors: Barbara Muz, Moddasar N Khan, Serafim Kiriakidis and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2009 11:201
    Content type: Review Published on:

  50. The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we i...

    Authors: Anne-Christine Bay-Jensen, Nadine CB Tabassi, Lene V Sondergaard, Thomas L Andersen, Frederik Dagnaes-Hansen, Patrick Garnero, Moustapha Kassem and Jean-Marie Delaissé
    Citation: Arthritis Research & Therapy 2009 11:R9
    Content type: Research article Published on:
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Arthritis Research & Therapy

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