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  1. Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that s...

    Authors: James N Jarvis, Howard R Petty, Yuhong Tang, Mark Barton Frank, Philippe A Tessier, Igor Dozmorov, Kaiyu Jiang, Andrei Kindzelski, Yanmin Chen, Craig Cadwell, Mary Turner, Peter Szodoray, Julie L McGhee and Michael Centola
    Citation: Arthritis Research & Therapy 2006 8:R154
    Content type: Research article Published on:

  2. The use of cyclo-oxygenase 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of acute myocardial infarction (AMI). The association between the risks of AMI with nonsel...

    Authors: Gurkirpal Singh, Olivia Wu, Peter Langhorne and Rajan Madhok
    Citation: Arthritis Research & Therapy 2006 8:R153
    Content type: Research article Published on:

  3. Increased bone resorption mediated by osteoclasts causes various diseases such as osteoporosis and bone erosion in rheumatoid arthritis (RA). Osteoclasts are derived from the monocyte/macrophage lineage, but t...

    Authors: Yukiko Komano, Toshihiro Nanki, Kenji Hayashida, Ken Taniguchi and Nobuyuki Miyasaka
    Citation: Arthritis Research & Therapy 2006 8:R152
    Content type: Research article Published on:

  4. Rheumatoid arthritis (RA) is characterized by inflammation and an increased risk for cardiovascular disease (CVD). This study investigates possible associations between CVD and the use of conventional disease-...

    Authors: Vokko P van Halm, Michael T Nurmohamed, Jos WR Twisk, Ben AC Dijkmans and Alexandre E Voskuyl
    Citation: Arthritis Research & Therapy 2006 8:R151
    Content type: Research article Published on:

  6. Rheumatoid arthritis (RA) is an autoimmune disease associated with the recognition of self proteins secluded in diarthrodial joints. We have previously established that mice transgenic for the human DR genes a...

    Authors: Yoshihiko Sakurai, David D Brand, Bo Tang, Edward F Rosloniec, John M Stuart, Andrew H Kang and Linda K Myers
    Citation: Arthritis Research & Therapy 2006 8:R150
    Content type: Research article Published on:

  7. Articular cartilage is optimised for bearing mechanical loads. Chondrocytes are the only cells present in mature cartilage and are responsible for the synthesis and integrity of the extracellular matrix. Appro...

    Authors: Jordi Monfort, Natalia Garcia-Giralt, María J López-Armada, Joan C Monllau, Angeles Bonilla, Pere Benito and Francisco J Blanco
    Citation: Arthritis Research & Therapy 2006 8:R149
    Content type: Research article Published on:

  8. Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts ...

    Authors: Mark S Fife, Ana Gutierrez, Emma M Ogilvie, Carmel JW Stock, Jane M Samuel, Wendy Thomson, Lisa F Mack, Cathryn M Lewis and Patricia Woo
    Citation: Arthritis Research & Therapy 2006 8:R148
    Content type: Research article Published on:

  9. Understanding the changes in collagen and proteoglycan content of cartilage due to physical forces is necessary for progress in treating joint disorders, including those due to overuse. Physical forces in the ...

    Authors: Ehsan Saadat, Howard Lan, Sharmila Majumdar, David M Rempel and Karen B King
    Citation: Arthritis Research & Therapy 2006 8:R147
    Content type: Research article Published on:

  11. Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine that regulates cell growth, migration, and survival principally through a TWEAK re...

    Authors: Takashi Ando, Jiro Ichikawa, Masanori Wako, Kyosuke Hatsushika, Yoshiyuki Watanabe, Michitomo Sakuma, Kachio Tasaka, Hideoki Ogawa, Yoshiki Hamada, Hideo Yagita and Atsuhito Nakao
    Citation: Arthritis Research & Therapy 2006 8:R146
    Content type: Research article Published on:

  12. Along with recent innovative approaches resulting in the development of new therapies such as small molecular inhibitors, therapeutic antibodies, recombinant proteins and gene therapy, there is increasing need...

    Authors: Caroline Ospelt and Steffen Gay
    Citation: Arthritis Research & Therapy 2006 8:112
    Content type: Commentary Published on:

  13. The IDDM8 region on chromosome 6q27, first identified as a susceptibility locus for type 1 diabetes, has previously been linked and associated with rheumatoid arthritis (RA). The region contains a number of poten...

    Authors: Anne Hinks, Anne Barton, Sally John, Neil Shephard and Jane Worthington
    Citation: Arthritis Research & Therapy 2006 8:R145
    Content type: Research article Published on:

  14. 'Rhupus' is a rare condition sharing features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). If rhupus is a distinctive entity, an overlap between RA and SLE or a subset of SLE is current...

    Authors: Luis M Amezcua-Guerra, Rashidi Springall, Ricardo Marquez-Velasco, Lorena Gómez-García, Angélica Vargas and Rafael Bojalil
    Citation: Arthritis Research & Therapy 2006 8:R144
    Content type: Research article Published on:

  15. Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows a...

    Authors: Heiner Appel, Christoph Loddenkemper, Zarko Grozdanovic, Harald Ebhardt, Marc Dreimann, Axel Hempfing, Harald Stein, Peter Metz-Stavenhagen, Martin Rudwaleit and Joachim Sieper
    Citation: Arthritis Research & Therapy 2006 8:R143
    Content type: Research article Published on:

  16. Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the metalloproteinase family, specifically the matrix metal...

    Authors: Jennifer M Milner, Andrew D Rowan, Tim E Cawston and David A Young
    Citation: Arthritis Research & Therapy 2006 8:R142
    Content type: Research article Published on:

  17. Conventional treatments for autoimmune diseases have relied heavily on nonspecific immune suppressants, which possess a variety of adverse effects without inhibiting the autoimmune process in a specific manner...

    Authors: Igor Popov, Mu Li, Xiufen Zheng, Hongtao San, Xusheng Zhang, Thomas E Ichim, Motohiko Suzuki, Biao Feng, Costin Vladau, Robert Zhong, Bertha Garcia, Gill Strejan, Robert D Inman and Wei-Ping Min
    Citation: Arthritis Research & Therapy 2006 8:R141
    Content type: Research article Published on:

  18. Nitric oxide (NO) may play important roles in rheumatoid arthritis (RA). RA is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients, we c...

    Authors: J Brice Weinberg, Thomas Lang, William E Wilkinson, David S Pisetsky and E William St Clair
    Citation: Arthritis Research & Therapy 2006 8:R140
    Content type: Research article Published on:

  19. A recent meta-analysis of randomized clinical trials reported by Bongartz and coworkers raised concerns about an increased rate of malignancy and serious infection in rheumatoid arthritis patients treated with...

    Authors: Will Dixon and Alan Silman
    Citation: Arthritis Research & Therapy 2006 8:111
    Content type: Commentary Published on:

  20. Acute full thickness joint surface defects can undergo repair, which involves tissue patterning and endochondral bone formation. Molecular signals regulating this process may contribute to the repair outcome, ...

    Authors: Francesco Dell'Accio, Cosimo De Bari, Noha MF El Tawil, Francesca Barone, Thimios A Mitsiadis, John O'Dowd and Costantino Pitzalis
    Citation: Arthritis Research & Therapy 2006 8:R139
    Content type: Research article Published on:

  21. To further understand the role of neuro-immunological interactions in the pathogenesis of rheumatoid arthritis (RA), we studied the influence of sympathetic neurotransmitters on cytokine production of T cells ...

    Authors: Matthias Wahle, Gesine Hanefeld, Stephan Brunn, Rainer H Straub, Ulf Wagner, Andreas Krause, Holm Häntzschel and Christoph GO Baerwald
    Citation: Arthritis Research & Therapy 2006 8:R138
    Content type: Research article Published on:

  22. The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1-weighted MRI scans were performed on th...

    Authors: Guangju Zhai, James Stankovich, Flavia Cicuttini, Changhai Ding and Graeme Jones
    Citation: Arthritis Research & Therapy 2006 8:R137
    Content type: Research article Published on:

  23. This study was conducted to examine the frequency, phenotype, and functional profile of T lymphocytes that proliferate in response to type I collagen (CI) in patients with scleroderma (SSc). Peripheral blood m...

    Authors: Kenneth J Warrington, Usha Nair, Laura D Carbone, Andrew H Kang and Arnold E Postlethwaite
    Citation: Arthritis Research & Therapy 2006 8:R136
    Content type: Research article Published on:

  25. Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. S...

    Authors: Eiva Bernotiene, Gaby Palmer and Cem Gabay
    Citation: Arthritis Research & Therapy 2006 8:217
    Content type: Review Published on:

  26. The therapeutic success of biological agents, especially the tumour necrosis factor (TNF) inhibitors, has opened a new chapter in the book of therapies for rheumatoid arthritis. Nevertheless, more than 50% of ...

    Authors: Josef S Smolen and Ravinder N Maini
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 8 Supplement 2

    The Erratum to this article has been published in Arthritis Research & Therapy 2006 8:407

  27. IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of...

    Authors: Peter E Lipsky
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 8 Supplement 2

  28. Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase pro...

    Authors: Cem Gabay
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 8 Supplement 2

  31. Knee osteoarthritis (OA) results, at least in part, from overloading and inflammation leading to cartilage degradation. Prostaglandin E2 (PGE2) is one of the main catabolic factors involved in OA. Its synthesis i...

    Authors: Marjolaine Gosset, Francis Berenbaum, Arlette Levy, Audrey Pigenet, Sylvie Thirion, Jean-Louis Saffar and Claire Jacques
    Citation: Arthritis Research & Therapy 2006 8:R135
    Content type: Research article Published on:

  32. Relapsing polychondritis (RP) is a human autoimmune disease of unknown etiology in which cartilaginous sites are destroyed by cyclic inflammatory episodes beginning, most commonly, during the fourth or fifth d...

    Authors: Jennifer L Lamoureux, Jane Hoyt Buckner, Chella S David and David S Bradley
    Citation: Arthritis Research & Therapy 2006 8:R134
    Content type: Research article Published on:

  33. The aim of this study was to evaluate new and previously hypothesised non-genetic risk factors for serologic subtypes of rheumatoid arthritis (RA) defined by the presence or absence of auto-antibodies to cycli...

    Authors: Merete Pedersen, Søren Jacobsen, Mette Klarlund, Bo V Pedersen, Allan Wiik, Jan Wohlfahrt and Morten Frisch
    Citation: Arthritis Research & Therapy 2006 8:R133
    Content type: Research article Published on:

  34. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by destruction of bone and cartilage, which is mediated, in part, by synovial fibroblasts. Matrix metalloproteinases (MMPs) are a large...

    Authors: Angela Pakozdi, Mohammad A Amin, Christian S Haas, Rita J Martinez, G Kenneth Haines 3rd, Lanie L Santos, Eric F Morand, John R David and Alisa E Koch
    Citation: Arthritis Research & Therapy 2006 8:R132
    Content type: Research article Published on:

  35. In the present study we evaluated the impact of baseline antinuclear antibody (ANA) status and use of methotrexate on development of infliximab-related infusion reactions in patients with rheumatoid arthritis ...

    Authors: Meliha C Kapetanovic, Lotta Larsson, Lennart Truedsson, Gunnar Sturfelt, Tore Saxne and Pierre Geborek
    Citation: Arthritis Research & Therapy 2006 8:R131
    Content type: Research article Published on:

  36. Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for t...

    Authors: Anne R Kinderlerer, Rivka Steinberg, Michael Johns, Sarah K Harten, Elaine A Lidington, Dorian O Haskard, Patrick H Maxwell and Justin C Mason
    Citation: Arthritis Research & Therapy 2006 8:R130
    Content type: Research article Published on:

  37. This open-label, phase I/II study investigated the safety and efficacy of epratuzumab, a humanised anti-CD22 monoclonal antibody, in the treatment of patients with active primary Sjögren's syndrome (pSS). Sixt...

    Authors: Serge D Steinfeld, Laure Tant, Gerd R Burmester, Nick KW Teoh, William A Wegener, David M Goldenberg and Olivier Pradier
    Citation: Arthritis Research & Therapy 2006 8:R129
    Content type: Research article Published on:

  38. Several recent publications have established a strong association between anti-cyclic citrullinated peptide antibody (anti-CCP)-positive rheumatoid arthritis (RA) and carriage of shared epitope (SE) alleles. A...

    Authors: Devesh Mewar, Annabel Coote, David J Moore, Ioanna Marinou, Jodie Keyworth, Marion C Dickson, Doug S Montgomery, Michael H Binks and Anthony G Wilson
    Citation: Arthritis Research & Therapy 2006 8:R128
    Content type: Research article Published on:

  39. Despite its potent ability to inhibit proinflammatory cytokine synthesis, interleukin (IL)-10 has a marginal clinical effect in rheumatoid arthritis (RA) patients. Recent evidence suggests that IL-10 induces m...

    Authors: Koji Takasugi, Masahiro Yamamura, Mitsuhiro Iwahashi, Fumio Otsuka, Jiro Yamana, Katsue Sunahori, Masanori Kawashima, Masao Yamada and Hirofumi Makino
    Citation: Arthritis Research & Therapy 2006 8:R126
    Content type: Research article Published on:

  40. Cartilage destruction in osteoarthritis (OA) is thought to be mediated by two main enzyme families; the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, whereas enzymes from t...

    Authors: Rose K Davidson, Jasmine G Waters, Lara Kevorkian, Clare Darrah, Adele Cooper, Simon T Donell and Ian M Clark
    Citation: Arthritis Research & Therapy 2006 8:R124
    Content type: Research article Published on:

  41. Chronic graft-versus-host disease (GVHD) induced in (C57BL/6 × DBA/2) F1 (BDF1) mice by the injection of DBA/2 mouse spleen cells represents histopathological changes associated with systemic lupus erythematos...

    Authors: Takanori Kuroiwa, Tsuyoshi Iwasaki, Takehito Imado, Masahiro Sekiguchi, Jiro Fujimoto and Hajime Sano
    Citation: Arthritis Research & Therapy 2006 8:R123
    Content type: Research article Published on:

  42. We studied the diagnostic performance of the anti-human citrullinated fibrinogen antibody (AhFibA) ELISA for rheumatoid arthritis (RA) in a consecutive cohort (population 1) and evaluated the agreement between...

    Authors: Bert Vander Cruyssen, Tineke Cantaert, Leonor Nogueira, Cyril Clavel, Leen De Rycke, Amélie Dendoven, Mireille Sebag, Dieter Deforce, Christian Vincent, Dirk Elewaut, Guy Serre and Filip De Keyser
    Citation: Arthritis Research & Therapy 2006 8:R122
    Content type: Research article Published on:

  43. The present study focused on the evaluation of the effects of operant behavioural (OBT) and cognitive behavioural (CBT) treatments for fibromyalgia syndrome (FMS). One hundred and twenty-five patients who fulf...

    Authors: Kati Thieme, Herta Flor and Dennis C Turk
    Citation: Arthritis Research & Therapy 2006 8:R121
    Content type: Research article Published on:

  44. Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis (RA). In contrast, high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of ...

    Authors: Karim Raza, Dagmar Scheel-Toellner, Chi-Yeung Lee, Darrell Pilling, S John Curnow, Francesco Falciani, Victor Trevino, Kanta Kumar, Lakhvir K Assi, Janet M Lord, Caroline Gordon, Christopher D Buckley and Mike Salmon
    Citation: Arthritis Research & Therapy 2006 8:R120
    Content type: Research article Published on:

  45. Antibodies directed against citrullinated vimentin are members of the family of autoantibodies reactive with citrullinated proteins and are among the most specific serological markers for the diagnosis of rheu...

    Authors: Christian Dejaco, Werner Klotz, Heike Larcher, Christina Duftner, Michael Schirmer and Manfred Herold
    Citation: Arthritis Research & Therapy 2006 8:R119
    Content type: Research article Published on:

  46. A hallmark of systemic lupus erythematosus (SLE) is the appearance of autoantibodies to nuclear antigens, including autoantibodies directed to the heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2), which o...

    Authors: Ruth Fritsch-Stork, Daniela Müllegger, Karl Skriner, Beatrice Jahn-Schmid, Josef S Smolen and Günter Steiner
    Citation: Arthritis Research & Therapy 2006 8:R118
    Content type: Research article Published on:

  47. Association of a functional promoter polymorphism mapping to the Fc receptor-like 3 (FCRL3) gene has recently been reported and replicated with rheumatoid arthritis (RA) in Japanese populations. The aim of this s...

    Authors: Stephen Eyre, John Bowes, Catherine Potter, Jane Worthington and Anne Barton
    Citation: Arthritis Research & Therapy 2006 8:R117
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2008 10:405

  48. Although a temporal artery biopsy is the gold standard for the diagnosis of giant cell arteritis (GCA), there is considerable evidence that characteristic signs demonstrated by colour duplex sonography (CDS) o...

    Authors: Maria Karahaliou, George Vaiopoulos, Spiros Papaspyrou, Meletios A Kanakis, Konstantinos Revenas and Petros P Sfikakis
    Citation: Arthritis Research & Therapy 2006 8:R116
    Content type: Research article Published on:

  49. The objective of this work was to identify genes involved in impaired angiogenesis by comparing the transcriptosomes of microvascular endothelial cells from normal subjects and patients affected by systemic sc...

    Authors: Betti Giusti, Gabriella Fibbi, Francesca Margheri, Simona Serratì, Luciana Rossi, Filippo Poggi, Ilaria Lapini, Alberto Magi, Angela Del Rosso, Marina Cinelli, Serena Guiducci, Bashar Kahaleh, Laura Bazzichi, Stefano Bombardieri, Marco Matucci-Cerinic, Gian Franco Gensini…
    Citation: Arthritis Research & Therapy 2006 8:R115
    Content type: Research article Published on:

  50. Reactivation of latent Mycobacterium tuberculosis (Mtb) infection is a major complication of anti-tumour necrosis factor (TNF)-α treatment, but its mechanism is not fully understood. We evaluated the effect of th...

    Authors: Haïfa Hamdi, Xavier Mariette, Véronique Godot, Karin Weldingh, Abdul Monem Hamid, Maria-Victoria Prejean, Gabriel Baron, Marc Lemann, Xavier Puechal, Maxime Breban, Francis Berenbaum, Jean-Charles Delchier, René-Marc Flipo, Bertrand Dautzenberg, Dominique Salmon, Marc Humbert…
    Citation: Arthritis Research & Therapy 2006 8:R114
    Content type: Research article Published on:
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Arthritis Research & Therapy

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