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  1. Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis, including peptides induced downstream of tumor necrosis factor-α as well as the monocyte/T cell-attracting chemokines RANT...

    Authors: Aleksi Sedo, Jonathan S Duke-Cohan, Eva Balaziova and Liliana R Sedova
    Citation: Arthritis Research & Therapy 2005 7:253
    Content type: Review Published on:

  2. Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA), but little is understood about their citrullinated target antigens. We have detected a candidate citrullinated prote...

    Authors: Andrew Kinloch, Verena Tatzer, Robin Wait, David Peston, Karin Lundberg, Phillipe Donatien, David Moyes, Peter C Taylor and Patrick J Venables
    Citation: Arthritis Research & Therapy 2005 7:R1421
    Content type: Research article Published on:

  4. CD3+CD4+CD28null and CD3+CD8+CD28null T cells are enriched in patients with immune-mediated diseases compared with healthy controls. This study shows that CD4+CD28null T cells express Toll-like receptors recogniz...

    Authors: Bernd Raffeiner, Christian Dejaco, Christina Duftner, Werner Kullich, Christian Goldberger, Sandra C Vega, Michael Keller, Beatrix Grubeck-Loebenstein and Michael Schirmer
    Citation: Arthritis Research & Therapy 2005 7:R1412
    Content type: Research article Published on:

  5. Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally. Abnormal vitamin B6 status in rheumatoid arthritis has been associated with spontaneous tumor necrosis...

    Authors: En-Pei I Chiang, Jacob Selhub, Pamela J Bagley, Gerard Dallal and Ronenn Roubenoff
    Citation: Arthritis Research & Therapy 2005 7:R1404
    Content type: Research article Published on:

  6. We showed previously that nucleophosmin (NPM), a nucleolar phosphoprotein, is recognized by sera from (NZW × BXSB)F1 (WB) mice, a model of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome. In the...

    Authors: Aurelia Lartigue, Laurent Drouot, Fabienne Jouen, Roland Charlionet, François Tron and Danièle Gilbert
    Citation: Arthritis Research & Therapy 2005 7:R1394
    Content type: Research article Published on:

  8. A loss of T cell tolerance underlies the development of most autoimmune diseases. The design of therapeutic strategies to reinstitute immune tolerance, however, is hampered by uncertainty regarding the molecul...

    Authors: Jody L Bonnevier, Ruan Zhang and Daniel L Mueller
    Citation: Arthritis Research & Therapy 2005 7:233
    Content type: Review Published on:

  9. The objective of this study was to examine HLA-DRB1 and HLA-DQB1 genotypes in patients with severe extra-articular rheumatoid arthritis (ExRA) and to compare them with the genotypes of rheumatoid arthritis (RA) p...

    Authors: Carl Turesson, Daniel J Schaid, Cornelia M Weyand, Lennart TH Jacobsson, Jörg J Goronzy, Ingemar F Petersson, Gunnar Sturfelt, Britt-Marie Nyhäll-Wåhlin, Lennart Truedsson, Sonja A Dechant and Eric L Matteson
    Citation: Arthritis Research & Therapy 2005 7:R1386
    Content type: Research article Published on:

  10. Patients with systemic autoimmune diseases usually produce high levels of antibodies to self-antigens (autoantigens). The repertoire of common autoantigens is remarkably limited, yet no readily understandable ...

    Authors: Philip L Carl, Brenda RS Temple and Philip L Cohen
    Citation: Arthritis Research & Therapy 2005 7:R1360
    Content type: Research article Published on:

  11. Joint space width (JSW) and narrowing (JSN) measurements on radiographs are currently the best way to assess disease severity or progression in hip osteoarthritis, yet we lack data regarding the most accurate ...

    Authors: Emmanuel Maheu, Christian Cadet, Marc Marty, Maxime Dougados, Salah Ghabri, Isabelle Kerloch, Bernard Mazières, Tim D Spector, Eric Vignon and Michel G Lequesne
    Citation: Arthritis Research & Therapy 2005 7:R1375
    Content type: Research article Published on:

  12. A small cell-permeable compound, dehydroxymethylepoxyquinomicin (DHMEQ), does not inhibit phosphorylation and degradation of IκB (inhibitor of nuclear factor-κB [NF-κB]) but selectively inhibits nuclear transl...

    Authors: Kyoko Wakamatsu, Toshihiro Nanki, Nobuyuki Miyasaka, Kazuo Umezawa and Tetsuo Kubota
    Citation: Arthritis Research & Therapy 2005 7:R1348
    Content type: Research article Published on:

  13. Osteoarthritis (OA) is a common joint disease, mainly effecting the elderly population. The cause of OA seems to be an imbalance in catabolic and anabolic factors that develops with age. IL-1 is a catabolic fa...

    Authors: EN Blaney Davidson, A Scharstuhl, EL Vitters, PM van der Kraan and WB van den Berg
    Citation: Arthritis Research & Therapy 2005 7:R1338
    Content type: Research article Published on:

  14. The aim of the present study was to investigate the association between exposure to mineral oil and the risk of developing rheumatoid arthritis (RA), and in addition to perform a separate analysis on the major...

    Authors: Berit Sverdrup, Henrik Källberg, Camilla Bengtsson, Ingvar Lundberg, Leonid Padyukov, Lars Alfredsson and Lars Klareskog
    Citation: Arthritis Research & Therapy 2005 7:R1296
    Content type: Research article Published on:

  15. Microsomal prostaglandin E synthase (mPGES)-1 is a newly identified inducible enzyme of the arachidonic acid cascade with a key function in prostaglandin (PG)E2 synthesis. We investigated the kinetics of inducibl...

    Authors: Arnaud Bianchi, David Moulin, Sylvie Sebillaud, Meriem Koufany, Marie-Madeleine Galteau, Patrick Netter, Bernard Terlain and Jean-Yves Jouzeau
    Citation: Arthritis Research & Therapy 2005 7:R1325
    Content type: Research article Published on:

  16. Antibodies specific for glucose-6-phosphate isomerase (G6PI) from T-cell receptor transgenic K/BxN mice are known to induce arthritis in mice, and immunization of DBA/1 mice with G6PI led to acute arthritis wi...

    Authors: Robert Bockermann, David Schubert, Thomas Kamradt and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2005 7:R1316
    Content type: Research article Published on:

  17. Previous studies have reported that mesenchymal stem cells (MSC) may be isolated from the synovial membrane by the same protocol as that used for synovial fibroblast cultivation, suggesting that MSC correspond...

    Authors: Farida Djouad, Claire Bony, Thomas Häupl, Gilles Uzé, Najiba Lahlou, Pascale Louis-Plence, Florence Apparailly, François Canovas, Thierry Rème, Jacques Sany, Christian Jorgensen and Danièle Noël
    Citation: Arthritis Research & Therapy 2005 7:R1304
    Content type: Research article Published on:

  18. We studied the long term impact of running and other aerobic exercise on musculoskeletal pain in a cohort of healthy aging male and female seniors who had been followed for 14 years. We conducted a prospective...

    Authors: Bonnie Bruce, James F Fries and Deborah P Lubeck
    Citation: Arthritis Research & Therapy 2005 7:R1263
    Content type: Research article Published on:

  20. Mutations of the p62/Sequestosome 1 gene (p62/SQSTM1) account for both sporadic and familial forms of Paget's disease of bone (PDB). We originally described a methionine→valine substitution at codon 404 (M404V) o...

    Authors: Alberto Falchetti, Marco Di Stefano, Francesca Marini, Francesca Del Monte, Alessia Gozzini, Laura Masi, Annalisa Tanini, Antonietta Amedei, Annamaria Carossino, Giancarlo Isaia and Maria Luisa Brandi
    Citation: Arthritis Research & Therapy 2005 7:R1289
    Content type: Research article Published on:

  21. Eighteen Caucasian (white, Middle East and Asian) children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis (sJIA) were enrolled in this open label,...

    Authors: Patricia Woo, Nicholas Wilkinson, Anne-Marie Prieur, Taunton Southwood, Valentina Leone, Polly Livermore, Helena Wythe, David Thomson and Tadamitsu Kishimoto
    Citation: Arthritis Research & Therapy 2005 7:R1281
    Content type: Research article Published on:

  22. Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7α-hydroxy-dehydroepiandrosterone (7α-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone...

    Authors: John Dulos, Allard Kaptein, Annemieke Kavelaars, Cobi Heijnen and Annemieke Boots
    Citation: Arthritis Research & Therapy 2005 7:R1271
    Content type: Research article Published on:

  23. Nonsteroidal anti-inflammatory drugs (NSAIDs) are highly effective in treating the pain and inflammation associated with osteoarthritis and rheumatoid arthritis, but it is well recognized that these agents are...

    Authors: James M Scheiman and A Mark Fendrick
    Citation: Arthritis Research & Therapy 2005 7(Suppl 4):S23
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 4

  24. Conventional 'nonselective' nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation; however, the potential gastrointestinal risks associated with their use can...

    Authors: Jeffrey S Borer and Lee S Simon
    Citation: Arthritis Research & Therapy 2005 7(Suppl 4):S14
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 4

  25. Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used classes of medications to treat pain and inflammation. However, gastrointestinal complications associated with NSAIDs a...

    Authors: David A Peura and Lawrence Goldkind
    Citation: Arthritis Research & Therapy 2005 7(Suppl 4):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 4

  26. Nonsteroidal anti-inflammatory drugs (NSAIDs), including both traditional nonselective NSAIDs and the selective cyclo-oxygenase (COX)-2 inhibitors, are among the most widely used medications in the USA. Tradit...

    Authors: Steven B Abramson and Arthur L Weaver
    Citation: Arthritis Research & Therapy 2005 7(Suppl 4):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 4

  27. The successful use of biologicals in the treatment of rheumatoid arthritis, psoriatic arthritis and spondyloarthritis has had a major impact on the management of these conditions. The challenge in the developm...

    Authors: Yuti Chernajovsky
    Citation: Arthritis Research & Therapy 2005 7:227
    Content type: Commentary Published on:

  28. Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators, including the disability scor...

    Authors: En-Pei Chiang, Donald E Smith, Jacob Selhub, Gerard Dallal, Yi-Cheng Wang and Ronenn Roubenoff
    Citation: Arthritis Research & Therapy 2005 7:R1254
    Content type: Research article Published on:

  29. Extracellular fibrinolysis, controlled by the membrane-bound fibrinolytic system, is involved in cartilage damage and rheumatoid arthritis (RA) synovitis. Estrogen status and metabolism seem to be impaired in ...

    Authors: S Guiducci, A Del Rosso, M Cinelli, F Perfetto, R Livi, A Rossi, A Gabrielli, R Giacomelli, N Iori, G Fibbi, M Del Rosso and M Matucci Cerinic
    Citation: Arthritis Research & Therapy 2005 7:R1244
    Content type: Research article Published on:

  30. Surgical synovectomy to remove the inflammatory synovium can temporarily ameliorate rheumatoid inflammation and delay the progress of joint destruction. An efficient medically induced programmed cell death (ap...

    Authors: Haidi Zhang, Guangping Gao, Gilda Clayburne and H Ralph Schumacher
    Citation: Arthritis Research & Therapy 2005 7:R1235
    Content type: Research article Published on:

  31. Levels of soluble tumour necrosis factor receptors (sTNFRs) are elevated in the circulation of patients with rheumatoid arthritis (RA). Although these receptors can act as natural inhibitors of tumour necrosis...

    Authors: John R Glossop, Peter T Dawes, Nicola B Nixon and Derek L Mattey
    Citation: Arthritis Research & Therapy 2005 7:R1227
    Content type: Research article Published on:

  32. Autoantibodies against short recombinant fragments of fibrillin-1 produced in bacterial expression systems have been found in tight-skin mouse, systemic sclerosis, mixed connective tissue disease, and primary ...

    Authors: Jürgen Brinckmann, Nico Hunzelmann, Ehab El-Hallous, Thomas Krieg, Lynn Y Sakai, Sven Krengel and Dieter P Reinhardt
    Citation: Arthritis Research & Therapy 2005 7:R1221
    Content type: Research article Published on:

  34. Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN)...

    Authors: Franco Capsoni, Piercarlo Sarzi-Puttini and Alberto Zanella
    Citation: Arthritis Research & Therapy 2005 7:208
    Content type: Review Published on:

  35. Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial...

    Authors: Hans-Joachim Anders, Daniel Zecher, Rahul D Pawar and Prashant S Patole
    Citation: Arthritis Research & Therapy 2005 7:215
    Content type: Review Published on:

  36. CXCL12 (stromal cell-derived factor 1) is a unique biological ligand for the chemokine receptor CXCR4. We previously reported that treatment with a specific CXCR4 antagonist, AMD3100, exerts a beneficial effec...

    Authors: Bert De Klerck, Lies Geboes, Sigrid Hatse, Hilde Kelchtermans, Yves Meyvis, Kurt Vermeire, Gary Bridger, Alfons Billiau, Dominique Schols and Patrick Matthys
    Citation: Arthritis Research & Therapy 2005 7:R1208
    Content type: Research article Published on:

  37. The protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene encodes for lymphoid tyrosine phosphatase LYP, involved in the negative regulation of early T-cell activation. An association has recently been r...

    Authors: Philippe Dieudé, Sophie Garnier, Laëtitia Michou, Elisabeth Petit-Teixeira, Elodie Glikmans, Céline Pierlot, Sandra Lasbleiz, Thomas Bardin, Bernard Prum and François Cornélis
    Citation: Arthritis Research & Therapy 2005 7:R1200
    Content type: Research article Published on:

  42. A genetic association of the ENPP1 gene with primary hand osteoarthritis was recently reported in this journal. ENPP1 encodes an enzyme that regulates soft tissue calcification. The study as it stands is far from...

    Authors: John Loughlin
    Citation: Arthritis Research & Therapy 2005 7:187
    Content type: Commentary Published on:

  43. Stimulation of monocytes/macrophages after cell contact with preactivated T cells has been suggested to contribute to the excessive TNF-α production in rheumatoid arthritis (RA). In this study, T cell-contact-...

    Authors: Manuela Rossol, Sylke Kaltenhäuser, Roger Scholz, Holm Häntzschel, Sunna Hauschildt and Ulf Wagner
    Citation: Arthritis Research & Therapy 2005 7:R1189
    Content type: Research article Published on:

  44. We introduce Synoviolin as a novel pathogenic factor in rheumatoid arthritis (RA). Experimental studies indicate that this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the...

    Authors: Satoshi Yamasaki, Naoko Yagishita, Kaneyuki Tsuchimochi, Kusuki Nishioka and Toshihiro Nakajima
    Citation: Arthritis Research & Therapy 2005 7:181
    Content type: Commentary Published on:

  45. Somatic mutations of mitochondrial DNA have been detected in various pathologies such as cancer, neurodegenerative diseases, cardiac disorders and aging in general. Now it has been found that patients with rhe...

    Authors: Caroline Ospelt and Steffen Gay
    Citation: Arthritis Research & Therapy 2005 7:179
    Content type: Commentary Published on:

  47. Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/B×N mice, although some groups have reported that few healthy humans retain these antibodies. The expressio...

    Authors: Isao Matsumoto, Hua Zhang, Yoshifumi Muraki, Taichi Hayashi, Takanori Yasukochi, Yuko Kori, Daisuke Goto, Satoshi Ito, Akito Tsutsumi and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2005 7:R1183
    Content type: Research article Published on:

  48. Tetrathiomolybdate (TM), a drug developed for Wilson's disease, produces an anti-angiogenic and anti-inflammatory effect by reducing systemic copper levels. TM therapy has proved effective in inhibiting the gr...

    Authors: Atsushi Omoto, Yutaka Kawahito, Igor Prudovsky, Yasunori Tubouchi, Mizuho Kimura, Hidetaka Ishino, Makoto Wada, Makie Yoshida, Masataka Kohno, Rikio Yoshimura, Toshikazu Yoshikawa and Hajime Sano
    Citation: Arthritis Research & Therapy 2005 7:R1174
    Content type: Research article Published on:

  49. ADAMs (a disintegrin and metalloproteinases) comprise a new gene family of metalloproteinases, and may play roles in cell-cell interaction, cell migration, signal transduction, shedding of membrane-anchored pr...

    Authors: Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
    Citation: Arthritis Research & Therapy 2005 7:R1158
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:244

  50. Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we investigated th...

    Authors: Birgit Görtz, Silvia Hayer, Birgit Tuerck, Jochen Zwerina, Josef S Smolen and Georg Schett
    Citation: Arthritis Research & Therapy 2005 7:R1140
    Content type: Research article Published on:
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Arthritis Research & Therapy

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