Skip to main content

Articles

Page 117 of 155

  2. Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition. In this study, we sought to explore mechanisms by which...

    Authors: Julia J Inglis, Ahuva Nissim, Delphine M Lees, Stephen P Hunt, Yuti Chernajovsky and Bruce L Kidd
    Citation: Arthritis Research & Therapy 2005 7:R807
    Content type: Research article Published on:

  3. Blocking tumor necrosis factor-α either with monoclonal antibodies or with soluble receptor constructs has been proven to be effective with an acceptable safety profile in patients with rheumatoid arthritis, a...

    Authors: Filip Van den Bosch, Filip De Keyser, Herman Mielants and Eric M Veys
    Citation: Arthritis Research & Therapy 2005 7:121
    Content type: Commentary Published on:

  4. Frequent assessments of rheumatoid arthritis (RA) disease activity allow timely adaptation of therapy, which is essential in preventing disease progression. However, values of acute phase reactants (APRs) are ...

    Authors: Daniel Aletaha, Valerie PK Nell, Tanja Stamm, Martin Uffmann, Stephan Pflugbeil, Klaus Machold and Josef S Smolen
    Citation: Arthritis Research & Therapy 2005 7:R796
    Content type: Research article Published on:

  5. Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset ...

    Authors: Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley and Mike Salmon
    Citation: Arthritis Research & Therapy 2005 7:R784
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:226

  8. Interleukin-1 (IL-1), IL-17 and tumor necrosis factor alpha (TNF-α) are the main proinflammatory cytokines implicated in cartilage breakdown by matrix metalloproteinase (MMPs) in arthritic joints. We studied t...

    Authors: Abdelhamid Liacini, Judith Sylvester, Wen Qing Li and Muhammad Zafarullah
    Citation: Arthritis Research & Therapy 2005 7:R777
    Content type: Research article Published on:

  9. The human leukocyte antigen B27 (HLA-B27) transgenic rat is a model of human inflammatory bowel disease, rheumatoid arthritis and psoriasis. Studies of chronic inflammation in other rat models have demonstrate...

    Authors: James C Keith Jr, Irma M Sainz, Irma Isordia-Salas, Robin A Pixley, Yelena Leathurby, Leo M Albert and Robert W Colman
    Citation: Arthritis Research & Therapy 2005 7:R769
    Content type: Research article Published on:

  10. Hyaluronan (HA), an important component of connective tissues, is highly metabolically active, but the mechanisms involved in its catabolism are still largely unknown. We hypothesized that a protein similar to...

    Authors: Hafida El Hajjaji, Ada Asbury Cole and Daniel-Henri Manicourt
    Citation: Arthritis Research & Therapy 2005 7:R756
    Content type: Research article Published on:

  11. Systemic-onset juvenile idiopathic arthritis (SJIA) is a disease of unknown etiology with an unpredictable response to treatment. We examined two groups of patients to determine whether there are serum protein...

    Authors: Takako Miyamae, David E Malehorn, Bonnie Lemster, Masaaki Mori, Tomoyuki Imagawa, Shumpei Yokota, William L Bigbee, Manda Welsh, Klaus Klarskov, Norihiro Nishomoto, Abbe N Vallejo and Raphael Hirsch
    Citation: Arthritis Research & Therapy 2005 7:R746
    Content type: Research article Published on:

  12. Various dermatological conditions have been reported during tumor necrosis factor (TNF)-α-blocking therapy, but until now no prospective studies have been focused on this aspect. The present study was set up t...

    Authors: Marcel Flendrie, Wynand HPM Vissers, Marjonne CW Creemers, Elke MGJ de Jong, Peter CM van de Kerkhof and Piet LCM van Riel
    Citation: Arthritis Research & Therapy 2005 7:R666
    Content type: Research article Published on:

  13. In this study, we investigated the hypotheses that in human intervertebral disc (IVD) degeneration there is local production of the cytokine IL-1, and that this locally produced cytokine can induce the cellula...

    Authors: Christine Lyn Le Maitre, Anthony J Freemont and Judith Alison Hoyland
    Citation: Arthritis Research & Therapy 2005 7:R732
    Content type: Research article Published on:

  14. This dynamic magnetic resonance imaging (MRI) study is concerned with a prospective evaluation of wrist synovitis in patients with psoriatic arthritis (PsA) in comparison with patients with rheumatoid arthriti...

    Authors: Marco A Cimmino, Massimiliano Parodi, Stefania Innocenti, Giulia Succio, Simone Banderali, Enzo Silvestri and Giacomo Garlaschi
    Citation: Arthritis Research & Therapy 2005 7:R725
    Content type: Research article Published on:

  15. B-cell depletive therapies have beneficial effects in patients suffering from rheumatoid arthritis. Nevertheless, the role of B cells in the pathogenesis of the disease is not clear. In particular, it is not k...

    Authors: Anne-Sophie Rouzière, Christian Kneitz, Arumugam Palanichamy, Thomas Dörner and Hans-Peter Tony
    Citation: Arthritis Research & Therapy 2005 7:R714
    Content type: Research article Published on:

  16. Anti-PM/Scl antibodies represent a specific serological marker for a subset of patients with scleroderma (Scl) and polymyositis (PM), and especially with the PM/Scl overlap syndrome (PM/Scl). Anti-PM/Scl react...

    Authors: Michael Mahler, Reinout Raijmakers, Cornelia Dähnrich, Martin Blüthner and Marvin J Fritzler
    Citation: Arthritis Research & Therapy 2005 7:R704
    Content type: Research article Published on:

  17. Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis (RA), exhibits anti-inflammatory, antiproliferative and immunosuppressive effects. Although most of the ...

    Authors: Bernhard M Kirsch, Maximilian Zeyda, Karl Stuhlmeier, Johannes Grisar, Josef S Smolen, Bruno Watschinger, Thomas M Stulnig, Walter H Hörl, Gerhard J Zlabinger and Marcus D Säemann
    Citation: Arthritis Research & Therapy 2005 7:R694
    Content type: Research article Published on:

  18. Bone is integral to the pathogenesis of osteoarthritis (OA). Whether the bone area of the tibial plateau changes over time in subjects with knee OA is unknown. We performed a cohort study to describe this and ...

    Authors: Yuanyuan Wang, Anita E Wluka and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2005 7:R687
    Content type: Research article Published on:

  19. To assess the potential use of hyaluronic acid (HA) as adjuvant therapy in rheumatoid arthritis, the anti-inflammatory and chondroprotective effects of HA were analysed in experimental rat antigen-induced arth...

    Authors: Andreas Roth, Jürgen Mollenhauer, Andreas Wagner, Reneè Fuhrmann, Albrecht Straub, Rudolf A Venbrocks, Peter Petrow, Rolf Bräuer, Harald Schubert, Jörg Ozegowski, Gundela Peschel, Peter J Müller and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2005 7:R677
    Content type: Research article Published on:

  21. Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and ...

    Authors: Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura and Toshikatsu Hanada
    Citation: Arthritis Research & Therapy 2005 7:100
    Content type: Review Published on:

  22. The objective was to improve understanding of adverse events occurring with celecoxib in the treatment of osteoarthritis and rheumatoid arthritis. Data were extracted from company clinical trial reports of ran...

    Authors: R Andrew Moore, Sheena Derry, Geoffrey T Makinson and Henry J McQuay
    Citation: Arthritis Research & Therapy 2005 7:R644
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2005 8:401

  23. Cardiovascular event rates are markedly increased in rheumatoid arthritis (RA), and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to card...

    Authors: Patrick H Dessein, Barry I Joffe and Sham Singh
    Citation: Arthritis Research & Therapy 2005 7:R634
    Content type: Research article Published on:

  24. To determine the efficacy and safety of risedronate in patients with knee osteoarthritis (OA), the British study of risedronate in structure and symptoms of knee OA (BRISK), a 1-year prospective, double-blind,...

    Authors: Tim D Spector, Philip G Conaghan, J Christopher Buckland-Wright, Patrick Garnero, Gary A Cline, John F Beary, David J Valent and Joan M Meyer
    Citation: Arthritis Research & Therapy 2005 7:R625
    Content type: Research article Published on:

  25. Authors: Xenofon Baraliakos, Joachim Listing, Jan Brandt, Angela Zink, Rieke Alten, Gerd Burmester, Erika Gromnica-Ihle, Herbert Kellner, Matthias Schneider, Helmut Sörensen, Hennig Zeidler, Martin Rudwaleit, Joachim Sieper and Juergen Braun
    Citation: Arthritis Research & Therapy 2005 7:113
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2005 7:R439

  26. Heme oxygenase-1 (HO-1), an inducible heme-degrading enzyme, is expressed by macrophages and endothelial cells in response to various stresses. Because ferritin synthesis is stimulated by Fe2+, which is a product...

    Authors: Yohei Kirino, Mitsuhiro Takeno, Mika Iwasaki, Atsuhisa Ueda, Shigeru Ohno, Akira Shirai, Heiwa Kanamori, Katsuaki Tanaka and Yoshiaki Ishigatsubo
    Citation: Arthritis Research & Therapy 2005 7:R616
    Content type: Research article Published on:

  27. T cells have an important role during the development of autoimmune diseases. In adjuvant arthritis, a model for rheumatoid arthritis, we found that the percentage of CD4+ T cells expressing the activation marker...

    Authors: Elmieke PJ Boot, Gerben A Koning, Gert Storm, Josée PA Wagenaar-Hilbers, Willem van Eden, Linda A Everse and Marca HM Wauben
    Citation: Arthritis Research & Therapy 2005 7:R604
    Content type: Research article Published on:

  28. The prognostic value of two antibodies targeting citrullinated antigens, anti-Sa and anti-cyclic citrullinated peptide (CCP), present at inclusion, was evaluated prospectively in a cohort of 165 consecutive pa...

    Authors: Gilles Boire, Pierre Cossette, Artur J de Brum-Fernandes, Patrick Liang, Théophile Niyonsenga, Zhijie J Zhou, Nathalie Carrier, Claude Daniel and Henri-A Ménard
    Citation: Arthritis Research & Therapy 2005 7:R592
    Content type: Research article Published on:

  29. Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficac...

    Authors: Eric M Ruderman and Richard M Pope
    Citation: Arthritis Research & Therapy 2005 7(Suppl 2):S21
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 2

  30. Rheumatoid arthritis (RA) is a common destructive inflammatory disease that affects 0.5–1% of the population in many countries. Even though several new treatments have been introduced for patients with RA, a c...

    Authors: Vivianne Malmström, Christina Trollmo and Lars Klareskog
    Citation: Arthritis Research & Therapy 2005 7(Suppl 2):S15
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 2

  31. T cells, in particular CD4+ T cells, have been implicated in mediating many aspects of autoimmune inflammation. However, current evidence suggests that the role played by CD4+ T cells in the development of rheuma...

    Authors: Alla Skapenko, Jan Leipe, Peter E Lipsky and Hendrik Schulze-Koops
    Citation: Arthritis Research & Therapy 2005 7(Suppl 2):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 2

  33. Apart from the deletion of autoreactive T cells in the thymus, various methods exist in the peripheral immune system to control specific human immune responses to self-antigens. One of these mechanisms involve...

    Authors: Jan Leipe, Alla Skapenko, Peter E Lipsky and Hendrik Schulze-Koops
    Citation: Arthritis Research & Therapy 2005 7:93
    Content type: Review Published on:

  34. The objective of the present study was to investigate the effect of leptin, alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse ...

    Authors: Miguel Otero, Rocío Lago, Francisca Lago, Juan Jesús Gomez Reino and Oreste Gualillo
    Citation: Arthritis Research & Therapy 2005 7:R581
    Content type: Research article Published on:

  35. At present only few biological data are available to indicate whether psoriatic arthritis (PsA) is part of the spondyloarthropathy (SpA) concept, whether it is a separate disease entity or a heterogeneous dise...

    Authors: Elli Kruithof, Dominique Baeten, Leen De Rycke, Bernard Vandooren, Dirk Foell, Johannes Roth, Juan D Cañete, Annemieke M Boots, Eric M Veys and Filip De Keyser
    Citation: Arthritis Research & Therapy 2005 7:R569
    Content type: Research article Published on:

  36. Autologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in ...

    Authors: Tommi Tallheden, Catherine Bengtsson, Camilla Brantsing, Eva Sjögren-Jansson, Lars Carlsson, Lars Peterson, Mats Brittberg and Anders Lindahl
    Citation: Arthritis Research & Therapy 2005 7:R560
    Content type: Research article Published on:

  37. Articular cartilage (hyaline cartilage) defects resulting from traumatic injury or degenerative joint disease do not repair themselves spontaneously. Therefore, such defects may require novel regenerative stra...

    Authors: Koji Hattori, Yoshinori Takakura, Hajime Ohgushi, Takashi Habata, Kota Uematsu, Jun Yamauchi, Kenji Yamashita, Takashi Fukuchi, Masao Sato and Ken Ikeuchi
    Citation: Arthritis Research & Therapy 2005 7:R552
    Content type: Research article Published on:

  38. The development of drug-induced lupus remains a matter of concern in patients treated with anti-tumour necrosis factor (TNF) alpha. The incidence of such adverse effects is unknown. We undertook a retrospectiv...

    Authors: Michel De Bandt, Jean Sibilia, Xavier Le Loët, Sebastian Prouzeau, Bruno Fautrel, Christian Marcelli, Eric Boucquillard, Jean Louis Siame and Xavier Mariette
    Citation: Arthritis Research & Therapy 2005 7:R545
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:235

  39. Synovial fluid from patients with various arthritides contains procoagulant, cell-derived microparticles. Here we studied whether synovial microparticles modulate the release of chemokines and cytokines by fib...

    Authors: René J Berckmans, Rienk Nieuwland, Maarten C Kraan, Marianne CL Schaap, Desirée Pots, Tom JM Smeets, Augueste Sturk and Paul P Tak
    Citation: Arthritis Research & Therapy 2005 7:R536
    Content type: Research article Published on:

  41. The ank (progressive ankylosis) mutant mouse, which has a nonsense mutation in exon 12 of the inorganic pyrophosphate regulator gene (ank), exhibits aberrant joint ankylosis similar to human ankylosing spondyliti...

    Authors: Hing Wo Tsui, Robert D Inman, Andrew D Paterson, John D Reveille and Florence WL Tsui
    Citation: Arthritis Research & Therapy 2005 7:R513
    Content type: Research article Published on:

  42. Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and enzymes from the ADAMT...

    Authors: David A Young, Rachel L Lakey, Caroline J Pennington, Debra Jones, Lara Kevorkian, Dylan R Edwards, Timothy E Cawston and Ian M Clark
    Citation: Arthritis Research & Therapy 2005 7:R503
    Content type: Research article Published on:

  43. Systemic lupus erythematosus and its murine equivalent, modelled in the New Zealand Black and New Zealand White (NZB × NZW)F1 hybrid strain, are polygenic inflammatory diseases, probably reflecting an autoimmune ...

    Authors: James I Elliott, John H McVey and Christopher F Higgins
    Citation: Arthritis Research & Therapy 2005 7:R468
    Content type: Research article Published on:

  44. Autoantibodies directed against citrulline-containing proteins have an impressive specificity of nearly 100% in patients with rheumatoid arthritis and have been suggested to be involved in the disease pathogen...

    Authors: Karin Lundberg, Suzanne Nijenhuis, Erik R Vossenaar, Karin Palmblad, Walter J van Venrooij, Lars Klareskog, AJW Zendman and Helena Erlandsson Harris
    Citation: Arthritis Research & Therapy 2005 7:R458
    Content type: Research article Published on:

  45. We analyzed the clinical response and the time to relapse after discontinuation of continuous long-term infliximab therapy in patients with ankylosing spondylitis (AS). After 3 years of infliximab therapy, all...

    Authors: Xenofon Baraliakos, Joachim Listing, Jan Brandt, Martin Rudwaleit, Joachim Sieper and Juergen Braun
    Citation: Arthritis Research & Therapy 2005 7:R439
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2005 7:113

  46. Rheumatoid arthritis (RA) is a chronic inflammatory disease that produces synovial proliferation and joint erosions. The pathologic lesions of RA are driven through the production of inflammatory mediators in ...

    Authors: James C Keith Jr, Leo M Albert, Yelena Leathurby, Max Follettie, Lili Wang, Lisa Borges-Marcucci, Christopher C Chadwick, Robert J Steffan and Douglas C Harnish
    Citation: Arthritis Research & Therapy 2005 7:R427
    Content type: Research article Published on:

  47. Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains unclear. Th...

    Authors: Loes Linsen, Marielle Thewissen, Kurt Baeten, Veerle Somers, Piet Geusens, Jef Raus and Piet Stinissen
    Citation: Arthritis Research & Therapy 2005 7:R493
    Content type: Research article Published on:

  48. Rat models are frequently used for finding genes contributing to the arthritis phenotype. In most studies, however, limitations in the number of animals result in a low resolution. As a result, the linkage bet...

    Authors: Lars Andersson, Greta Petersen, Per Johnson and Fredrik Ståhl
    Citation: Arthritis Research & Therapy 2005 7:R485
    Content type: Research article Published on:

  49. Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various ...

    Authors: Shingo Nakayamada, Hitoshi Kurose, Kazuyoshi Saito, Akira Mogami and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2005 7:R476
    Content type: Research article Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us