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  1. The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with bone fragility are unclear. We aimed to investigate the association between BMLs, bone mineral density (B...

    Authors: Seiya Ota, Daisuke Chiba, Eiji Sasaki, Gentaro Kumagai, Yuji Yamamoto, Shigeyuki Nakaji, Eiichi Tsuda and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2019 21:113
    Content type: Research article Published on:

  2. Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in the treatment of moderate-to-severe psoriasis (PsO)...

    Authors: A. Deodhar, P. J. Mease, I. B. McInnes, X. Baraliakos, K. Reich, A. Blauvelt, C. Leonardi, B. Porter, A. Das Gupta, A. Widmer, L. Pricop and T. Fox
    Citation: Arthritis Research & Therapy 2019 21:111
    Content type: Research article Published on:

  3. Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier int...

    Authors: Helena Tydén, Christian Lood, Andreas Jönsen, Birgitta Gullstrand, Robin Kahn, Petrus Linge, Sunil B. Kumaraswamy, Björn Dahlbäck and Anders A. Bengtsson
    Citation: Arthritis Research & Therapy 2019 21:110
    Content type: Research article Published on:

  5. To investigate the expression of peptidylarginine deiminases (PADIs) during macrophage differentiation and its role in inflammatory responses.

    Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu
    Citation: Arthritis Research & Therapy 2019 21:108
    Content type: Research article Published on:

  6. Interferons (IFNs) are considered to be key molecules in the pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III IFNs in a large cohort of patients with systemic lupus ...

    Authors: Vilija Oke, Iva Gunnarsson, Jessica Dorschner, Susanna Eketjäll, Agneta Zickert, Timothy B. Niewold and Elisabet Svenungsson
    Citation: Arthritis Research & Therapy 2019 21:107
    Content type: Research article Published on:

  7. Autologous hematopoietic stem cell transplantation (aHSCT) is performed in patients with aggressive forms of systemic sclerosis (SSc). The profile of B cell reconstitution after aHSCT is not fully understood. ...

    Authors: Michael Gernert, Hans-Peter Tony, Eva Christina Schwaneck, Ottar Gadeholt and Marc Schmalzing
    Citation: Arthritis Research & Therapy 2019 21:106
    Content type: Research article Published on:

  8. Lupus nephritis (LN) is a representative manifestation in systemic lupus erythematosus (SLE). Some studies have shown that myeloid-derived suppressor cells (MDSCs) play a vital role in the regulation of the SL...

    Authors: Dan Li, Guoping Shi, Jiali Wang, Dongya Zhang, Yuchen Pan, Huan Dou and Yayi Hou
    Citation: Arthritis Research & Therapy 2019 21:105
    Content type: Research article Published on:

  9. There is limited evidence supporting the long-term effect of a foot care package that includes footwear for people with gout. The aim of this study was to investigate the effectiveness of a footwear interventi...

    Authors: Mike Frecklington, Nicola Dalbeth, Peter McNair, Trish Morpeth, Alain C. Vandal, Peter Gow and Keith Rome
    Citation: Arthritis Research & Therapy 2019 21:104
    Content type: Research article Published on:

  10. Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic s...

    Authors: Tomoaki Higuchi, Kae Takagi, Akiko Tochimoto, Yuki Ichimura, Takanari Norose, Yasuhiro Katsumata, Ikuko Masuda, Hisashi Yamanaka, Toshiro Morohoshi and Yasushi Kawaguchi
    Citation: Arthritis Research & Therapy 2019 21:103
    Content type: Research article Published on:

  11. Clinical guidelines recommend pneumococcal and tetanus vaccinations in patients with rheumatoid arthritis (RA). Baricitinib is an oral, selective Janus kinase (JAK) 1/JAK 2 inhibitor and is approved for the tr...

    Authors: Kevin L. Winthrop, Clifton O. Bingham III, Wendy J. Komocsar, John Bradley, Maher Issa, Rena Klar and Cynthia E. Kartman
    Citation: Arthritis Research & Therapy 2019 21:102
    Content type: Research article Published on:

  12. Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, pl...

    Authors: Peter C. Taylor, Didier Saurigny, Jiri Vencovsky, Tsutomu Takeuchi, Tadashi Nakamura, Galina Matsievskaia, Barbara Hunt, Thomas Wagner and Bernard Souberbielle
    Citation: Arthritis Research & Therapy 2019 21:101
    Content type: Research article Published on:

  13. Ultrasound (US) is sensitive for detecting joint and tendon inflammation in patients with rheumatoid arthritis (RA). So far, which grade of abnormalities on US corresponds to clinical manifestations is unclear...

    Authors: Xiaoying Sun, Xuerong Deng, Wenhui Xie, Liujun Wang, Yu Wang and Zhuoli Zhang
    Citation: Arthritis Research & Therapy 2019 21:100
    Content type: Research article Published on:

  14. Following publication of the original article [1], the authors reported an error in Table 2.

    Authors: Yoshiya Tanaka, Kazuteru Wada, Yoshinori Takahashi, Owen Hagino, Hubert van Hoogstraten, Neil M. H. Graham and Hideto Kameda
    Citation: Arthritis Research & Therapy 2019 21:99
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:79

  15. To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data.

    Authors: Hiromu Ito, Shinjiro Tominari, Yasuharu Tabara, Takeo Nakayama, Moritoshi Furu, Tomotoshi Kawata, Masayuki Azukizawa, Kazuya Setoh, Takahisa Kawaguchi, Fumihiko Matsuda and Shuichi Matsuda
    Citation: Arthritis Research & Therapy 2019 21:98
    Content type: Research article Published on:

  16. Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain, and the treatment of IDD is costly and relatively ineffective. Dysregulation of microRNAs (miRNAs) has been repo...

    Authors: Qi Yang, Xiao-Peng Guo, Yan-Li Cheng and Yang Wang
    Citation: Arthritis Research & Therapy 2019 21:97
    Content type: Research article Published on:

  17. Systemic sclerosis (SSc) can lead to ischemic complications such as digital ulcers (DUs). The aim of the study was to find predictors of DUs by clinical and new imaging methods.

    Authors: S. Friedrich, S. Lüders, A. M. Glimm, S. G. Werner, G. Schmittat, G. R. Burmester, M. Backhaus, G. Riemekasten and S. Ohrndorf
    Citation: Arthritis Research & Therapy 2019 21:96
    Content type: Research article Published on:

  18. Systemic sclerosis (SSc) is an autoimmune disease associated with immune abnormalities and widespread vascular lesions, including increased intimal and medial thickness. These changes may be reflected in early...

    Authors: Rania M. Gamal, Hanan Sayed M. Abozaid, Mohmed Zidan, Mohamed Aboel-Kassem F. Abdelmegid, Mohmed Raouf Abdel-Razek, Sahar Abdel-Rahman Alsayed, Amr F. Mourad, Nashwa Mostafa A. Azoz, Lobna Abdel-Wahid Mohram and Daniel E. Furst
    Citation: Arthritis Research & Therapy 2019 21:95
    Content type: Research article Published on:

  19. Impaired vascular pathophysiology and increased cardiovascular (CV) mortality are associated with rheumatoid arthritis (RA). To date, no genomic analysis of RA- and RA treatment-related vascular pathophysiolog...

    Authors: Szilárd Póliska, Timea Besenyei, Edit Végh, Attila Hamar, Anita Pusztai, Andrea Váncsa, Nóra Bodnár, Szilvia Szamosi, Mária Csumita, György Kerekes, Zoltán Szabó, Zoltán Nagy, Gabriella Szűcs, Sándor Szántó, Gábor Zahuczky, László Nagy…
    Citation: Arthritis Research & Therapy 2019 21:94
    Content type: Research article Published on:

  20. Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with differen...

    Authors: Hai Qin Xie, Wei Wei Zhang, De Sheng Sun, Xiang Mei Chen, Shu Fang Yuan, Zheng Hua Gong and Li Liu
    Citation: Arthritis Research & Therapy 2019 21:93
    Content type: Research article Published on:

  21. This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation.

    Authors: Yan Ye, Mei Liu, Longhai Tang, Fang Du, Yuanhua Liu, Pei Hao, Qiong Fu, Qiang Guo, Qingran Yan, Xiaoming Zhang and Chunde Bao
    Citation: Arthritis Research & Therapy 2019 21:92
    Content type: Research article Published on:

  22. The aim of this study is to evaluate the retention rates and reasons for discontinuation for seven biological disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting of patients with rheumatoid...

    Authors: Kosuke Ebina, Motomu Hashimoto, Wataru Yamamoto, Toru Hirano, Ryota Hara, Masaki Katayama, Akira Onishi, Koji Nagai, Yonsu Son, Hideki Amuro, Keiichi Yamamoto, Yuichi Maeda, Koichi Murata, Sadao Jinno, Tohru Takeuchi, Makoto Hirao…
    Citation: Arthritis Research & Therapy 2019 21:91
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:114

  23. Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients a...

    Authors: Helen Michelle McGettrick
    Citation: Arthritis Research & Therapy 2019 21:90
    Content type: Editorial Published on:

    The original article was published in Arthritis Research & Therapy 2018 20:265

  24. Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5 mg and 10 mg twice daily (BID) for up to 9.5 years in patients with rheumatoid a...

    Authors: Jürgen Wollenhaupt, Eun-Bong Lee, Jeffrey R. Curtis, Joel Silverfield, Ketti Terry, Koshika Soma, Chris Mojcik, Ryan DeMasi, Sander Strengholt, Kenneth Kwok, Irina Lazariciu, Lisy Wang and Stanley Cohen
    Citation: Arthritis Research & Therapy 2019 21:89
    Content type: Research article Published on:

  25. Recent data suggest that anti-TNF doses can be reduced in ankylosing spondylitis (AS) patients. Some authors even propose withdrawing treatment in patients in clinical remission; however, at present there is n...

    Authors: Mireia Moreno, Jordi Gratacós, Vicenç Torrente-Segarra, Raimon Sanmarti, Rosa Morlà, Caridad Pontes, Maria Llop and Xavier Juanola
    Citation: Arthritis Research & Therapy 2019 21:88
    Content type: Research article Published on:

  26. Abnormal glycolytic metabolism contributes to joint inflammation and destruction in rheumatoid arthritis (RA). We examine the expression and function of hexokinases in RA and evaluate the potential of their sp...

    Authors: Guanhua Song, Qiqi Lu, Hua Fan, Xiumei Zhang, Luna Ge, Ruisong Tian, Shiguan Wang, Tingting Feng, Jihong Pan, Jingjing Feng, Yabo Xiao, Xin Yi, Ningxin Ren and Lin Wang
    Citation: Arthritis Research & Therapy 2019 21:87
    Content type: Research article Published on:

  27. Data on survival and prognosis factors in incident cohorts are scarce in systemic sclerosis (SStc). To describe survival, standardized mortality ratio (SMR), and prognosis factors in systemic sclerosis (SSc), ...

    Authors: M. R. Pokeerbux, J. Giovannelli, L. Dauchet, L. Mouthon, C. Agard, J. C. Lega, Y. Allanore, P. Jego, B. Bienvenu, S. Berthier, A. Mekinian, E. Hachulla and D. Launay
    Citation: Arthritis Research & Therapy 2019 21:86
    Content type: Research article Published on:

  28. Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in diseas...

    Authors: DeAnna Baker Frost, Bethany Wolf, Christine Peoples, Jessica Fike, Katherine Silver, Maureen Laffoon, Thomas A. Medsger Jr and Carol Feghali-Bostwick
    Citation: Arthritis Research & Therapy 2019 21:85
    Content type: Research article Published on:

  29. ABP 501 was evaluated in a phase 3 single-arm, open-label extension (OLE) study to collect additional safety and efficacy data in patients with rheumatoid arthritis (RA).

    Authors: Stanley Cohen, Jose L. Pablos, Karel Pavelka, Gerard Anton Müller, Alan Matsumoto, Alan Kivitz, Hui Wang and Eswar Krishnan
    Citation: Arthritis Research & Therapy 2019 21:84
    Content type: Research article Published on:

  30. Obesity is associated with numerous comorbidities including some rheumatic conditions. Through adipose-derived inflammation, obesity has been shown to induce increased initiation, progression, and worse respon...

    Authors: Eric Lespessailles, Emneh Hammoud, Hechmi Toumi and Nada Ibrahim-Nasser
    Citation: Arthritis Research & Therapy 2019 21:83
    Content type: Review Published on:

  31. No population-based study has investigated the cumulative incidence of pulmonary arterial hypertension (PAH) in patients with newly diagnosed systemic lupus erythematosus (SLE) or the survival impact of PAH in...

    Authors: Hung-An Chen, Tsai-Ching Hsu, Su-Ching Yang, Chia-Tse Weng, Chun-Hsin Wu, Chien-Yao Sun and Chun-Yu Lin
    Citation: Arthritis Research & Therapy 2019 21:82
    Content type: Research article Published on:

  32. Systemic sclerosis (SSc) is an immune-mediated fibrotic disease affecting skin, lung and gut which are all sites with an established microbiome. Altered microbial flora may occur and contribute to the initiati...

    Authors: Christopher P. Denton and Charles Murray
    Citation: Arthritis Research & Therapy 2019 21:81
    Content type: Editorial Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:49

  33. The vast majority of patients with systemic lupus erythematosus (SLE) complain about fatigue. They also report fatigue as one of their most debilitating symptoms. Yet, in clinical practice, fatigue is only rar...

    Authors: Alice Horisberger, Delphine Courvoisier and Camillo Ribi
    Citation: Arthritis Research & Therapy 2019 21:80
    Content type: Research article Published on:

  34. Sarilumab is a human immunoglobulin G1 anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6 from binding to membrane-bound and soluble IL-6 receptor α. This bridging study assessed the effic...

    Authors: Yoshiya Tanaka, Kazuteru Wada, Yoshinori Takahashi, Owen Hagino, Hubert van Hoogstraten, Neil M. H. Graham and Hideto Kameda
    Citation: Arthritis Research & Therapy 2019 21:79
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:99

  35. Hypoxia plays an important role in the proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), leading to pathology of RA. This study was conducted to evaluate hypoxia-induced microRNAs (h...

    Authors: Shanshan Yu, Ying Lu, Ming Zong, Qi Tan and Lieying Fan
    Citation: Arthritis Research & Therapy 2019 21:78
    Content type: Research article Published on:

  36. ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout ...

    Authors: Blanka Stiburkova, Katerina Pavelcova, Marketa Pavlikova, Pavel Ješina and Karel Pavelka
    Citation: Arthritis Research & Therapy 2019 21:77
    Content type: Research article Published on:

  37. The role of the complement system in the pathogenesis of systemic sclerosis (SSc) is controversial. This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion in...

    Authors: Michael Osthoff, Veronika K. Jaeger, Ingmar A. F. M. Heijnen, Marten Trendelenburg, Suzana Jordan, Oliver Distler and Ulrich A. Walker
    Citation: Arthritis Research & Therapy 2019 21:76
    Content type: Research article Published on:

  38. The 17DD-yellow fever (YF) vaccine induces a long-lasting protective immunity, resulting from humoral and cellular immunological memory. The treatment of rheumatoid arthritis (RA) patients with disease-modifyi...

    Authors: Clarissa de Castro Ferreira, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Karen Torres, Larissa Chaves Freire, Ismael Artur da Costa-Rocha, Ana Cristina Vanderley Oliveira, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho and Lícia Maria Henrique da Mota
    Citation: Arthritis Research & Therapy 2019 21:75
    Content type: Research article Published on:

  39. Tendon disease is a significant global healthcare burden whereby patients experience pain and disability; however, the mechanisms that underlie inflammation and pain are poorly understood. Herein, we investiga...

    Authors: Filip Bergqvist, Andrew J. Carr, Kim Wheway, Bridget Watkins, Udo Oppermann, Per-Johan Jakobsson and Stephanie G. Dakin
    Citation: Arthritis Research & Therapy 2019 21:74
    Content type: Research article Published on:

  41. Resolvin D1 (RvD1), an important member of resolvins, exerts a wide spectrum of biological effects, including resolution of inflammation, tissue repair, and preservation of cell viability. The aim of the present ...

    Authors: Houda Abir Benabdoun, Merve Kulbay, Elsa-Patricia Rondon, Francis Vallières, Qin Shi, Julio Fernandes, Hassan Fahmi and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2019 21:72
    Content type: Research article Published on:

  42. A retrospective study was performed to investigate the clinical features and associated factors of invasive mycoses (IM) in patients with connective tissue disease (CTD) from Southern China.

    Authors: Minxi Lao, Zhongping Zhan, Fan Su, Hao Li, Zheng Yang, Haihong Chen, Liuqin Liang and Dongying Chen
    Citation: Arthritis Research & Therapy 2019 21:71
    Content type: Research article Published on:

  43. The specific function of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE) and the mechanism of their involvement in related pathological changes remain to be elucidated, so, in this study, w...

    Authors: Hui Ye, Xue Wang, Lei Wang, Xiaoying Chu, Xuanxuan Hu, Li Sun, Minghua Jiang, Hong Wang, Zihan Wang, Han Zhao, Xinyu Yang and Jianguang Wang
    Citation: Arthritis Research & Therapy 2019 21:70
    Content type: Research article Published on:

  44. Following publication of the original article [1], the authors reported an error in the spelling of Lorenzo Dagna’s name.

    Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera and Lorenzo Dagna
    Citation: Arthritis Research & Therapy 2019 21:69
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:54

  45. Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammati...

    Authors: Anna Katri, Aneta Dąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium and Kim Henriksen
    Citation: Arthritis Research & Therapy 2019 21:68
    Content type: Research article Published on:

  46. Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore ...

    Authors: Victoria K. Welsh, Lorna E. Clarson, Christian D. Mallen and John McBeth
    Citation: Arthritis Research & Therapy 2019 21:67
    Content type: Research article Published on:

  47. The aim of our study was to investigate the influence of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and body mass index (BMI) on circulating drug levels and clinical response to t...

    Authors: Borja Hernández-Breijo, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Ana Martínez-Feito, Andrea Jochems, Eva L. Kneepkens, Gerrit J. Wolbink, Theo Rispens, Cristina Diego, Dora Pascual-Salcedo and Alejandro Balsa
    Citation: Arthritis Research & Therapy 2019 21:66
    Content type: Research article Published on:

  49. Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) every week or every other week and prednisone tapering achieved superior rates of sustained remission to patients treated with placebo an...

    Authors: Vibeke Strand, Sophie Dimonaco, Katie Tuckwell, Micki Klearman, Neil Collinson and John H. Stone
    Citation: Arthritis Research & Therapy 2019 21:64
    Content type: Research article Published on:

  50. Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP...

    Authors: Déborah Puyraimond-Zemmour, Benjamin Granger, Anna Molto, Cécile Gaujoux-Viala, Francis Guillemin, Adeline Ruyssen-Witrand, Maxime Dougados, Bruno Fautrel and Laure Gossec
    Citation: Arthritis Research & Therapy 2019 21:63
    Content type: Research article Published on:
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Arthritis Research & Therapy

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