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  1. Febuxostat immediate release (IR), a xanthine oxidase inhibitor, is indicated for the management of hyperuricemia in patients with gout by lowering urate levels. An extended release (XR) formulation of febuxos...

    Authors: Lhanoo Gunawardhana, Michael A. Becker, Andrew Whelton, Barbara Hunt, Majin Castillo and Kenneth Saag
    Citation: Arthritis Research & Therapy 2018 20:99
  2. Gout is associated with higher cardiovascular risk that increases with disease severity. The objective of this study was to explore the relationship between the extent of monosodium urate (MSU) crystal deposit...

    Authors: Tristan Pascart, Benoist Capon, Agathe Grandjean, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak and Jean-François Budzik
    Citation: Arthritis Research & Therapy 2018 20:97
  3. Work disability remains a significant problem in ankylosing spondylitis (AS) and rheumatoid arthritis (RA), despite biological therapy. This study aimed to test the hypothesis that the prevalent symptom of fat...

    Authors: Katie L. Druce, Laraine Aikman, Maria Dilleen, Annie Burden, Piotr Szczypa and Neil Basu
    Citation: Arthritis Research & Therapy 2018 20:96
  4. In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and huma...

    Authors: Emese Balogh, Douglas J. Veale, Trudy McGarry, Carl Orr, Zoltan Szekanecz, Chin-Teck Ng, Ursula Fearon and Monika Biniecka
    Citation: Arthritis Research & Therapy 2018 20:95
  5. The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the...

    Authors: Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil and Hanna W. van Steenbergen
    Citation: Arthritis Research & Therapy 2018 20:94
  6. Within established rheumatoid arthritis (RA), stress can have pro-inflammatory effects by activating the immune system via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. It is unknow...

    Authors: Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2018 20:93
  7. Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of p...

    Authors: Huoru Zhang, Yan Zhang, Yong-Fei Wang, David Morris, Nattiya Hirankarn, Yujun Sheng, Jiangshan Shen, Hai-Feng Pan, Jing Yang, Sen Yang, Yong Cui, Dong-Qing Ye, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau and Wanling Yang
    Citation: Arthritis Research & Therapy 2018 20:92
  8. The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA).

    Authors: Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Marite Rygg, Martin Rypdal and Ellen Nordal
    Citation: Arthritis Research & Therapy 2018 20:91
  9. Many gout comorbidities (e.g., hypertension) are correlated with serum urate. In this investigation, we identified risk factors (e.g., systolic blood pressure [SBP]), that (1) are associated with incident gout...

    Authors: Mengying Sun, Ana I. Vazquez, Richard J. Reynolds, Jasvinder A. Singh, Mathew Reeves, Tony R. Merriman, Angelo L. Gaffo and Gustavo de los Campos
    Citation: Arthritis Research & Therapy 2018 20:90
  10. Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and murine studies indicate th...

    Authors: R. M. ten Brinck, R. E. M. Toes and A. H. M. van der Helm–van Mil
    Citation: Arthritis Research & Therapy 2018 20:89
  11. ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associate...

    Authors: Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett and Michael Stock
    Citation: Arthritis Research & Therapy 2018 20:88
  12. Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likel...

    Authors: Charlotte H. Hulme, Emma L. Wilson, Heidi R. Fuller, Sally Roberts, James B. Richardson, Pete Gallacher, Mandy J. Peffers, Sally L. Shirran, Catherine H. Botting and Karina T. Wright
    Citation: Arthritis Research & Therapy 2018 20:87
  13. Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targe...

    Authors: Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams III, Christopher Chiu, Michael Sharp, John Alvarez…
    Citation: Arthritis Research & Therapy 2018 20:85
  14. Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vani...

    Authors: Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia and Georg Schett
    Citation: Arthritis Research & Therapy 2018 20:84
  15. Polymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and im...

    Authors: Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E. Lundberg and Marina Korotkova
    Citation: Arthritis Research & Therapy 2018 20:83
  16. Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanism...

    Authors: Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T. H. Jacobsson and Carl Turesson
    Citation: Arthritis Research & Therapy 2018 20:82
  17. Previous studies have revealed that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA), while there are no further clinical studies regarding the role of HBV infection in RA pro...

    Authors: Yu-Lan Chen, Jian-Zi Lin, Ying-Qian Mo, Jian-Da Ma, Qian-Hua Li, Xiao-Ying Wang, Ze-Hong Yang, Tao Yan, Dong-Hui Zheng and Lie Dai
    Citation: Arthritis Research & Therapy 2018 20:81
  18. Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ receptors (FcγRs), thereby modulating the activity o...

    Authors: Irene Di Ceglie, Giuliana Ascone, Niels A. J. Cremers, Annet W. Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J. Sjef Verbeek, Fons A. J. van de Loo, Marije I. Koenders, Peter M. van der Kraan, Arjen B. Blom, Martijn H. J. van den Bosch and Peter L. E. M. van Lent
    Citation: Arthritis Research & Therapy 2018 20:80
  19. This study estimated the extent and predictors of primary nonadherence (i.e., prescriptions made by physicians but not initiated by patients) to methotrexate and to biologics or tofacitinib in rheumatoid arthr...

    Authors: Hong J. Kan, Kirill Dyagilev, Peter Schulam, Suchi Saria, Hadi Kharrazi, David Bodycombe, Charles T. Molta and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2018 20:79
  20. The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples obtained after venous puncture. This study aimed to assess ...

    Authors: Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N. Miner, Glen Hughes, Pascal Richette and Thomas Bardin
    Citation: Arthritis Research & Therapy 2018 20:78

    The Letter to this article has been published in Arthritis Research & Therapy 2019 21:117

  21. Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosi...

    Authors: Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Stefano Soldano
    Citation: Arthritis Research & Therapy 2018 20:77
  22. Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and ...

    Authors: Portia P. E. Flowers, Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Adam P. Goode, Marian T. Hannan, Jordan B. Renner, Joanne M. Jordan and Yvonne M. Golightly
    Citation: Arthritis Research & Therapy 2018 20:76
  23. The purpose of this study was to investigate the frequency and the distribution of inflammatory cell infiltrate in two sets of cutaneous biopsies derived from clinically affected and unaffected skin in patient...

    Authors: Silvia Bosello, Cristiana Angelucci, Gina Lama, Stefano Alivernini, Gabriella Proietti, Barbara Tolusso, Gigliola Sica, Elisa Gremese and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2018 20:75
  24. Knee pain is common with obesity and weight gain being important risk factors. Previous clinical trials have focused on overweight or obese adults with knee pain and osteoarthritis and demonstrated modest effe...

    Authors: Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R. E. Brady, Helena Teede and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2018 20:74
  25. The efficacy of corticosteroids in patients with psoriatic arthritis (PsA) and inflammatory back pain has not been studied to date. In this controlled trial, we aimed to investigate the comparative performance...

    Authors: Muhammad Haroon, Muddassar Ahmad, Muhammad Nouman Baig, Olivia Mason, John Rice and Oliver FitzGerald
    Citation: Arthritis Research & Therapy 2018 20:73
  26. Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim...

    Authors: Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M. Ito, Norihiro Sato and Tatsuya Atsumi
    Citation: Arthritis Research & Therapy 2018 20:72
  27. After publication of the article [1], it has been brought to our attention that the labels in Fig. 2b have been switched and are as a result incorrect. The label for the red line should have the label “non-CAM...

    Authors: Hanbo Yang, Qinglin Peng, Liguo Yin, Shanshan Li, Jingli Shi, Yamei Zhang, Xin Lu, Xiaoming Shu, Sigong Zhang and Guochun Wang
    Citation: Arthritis Research & Therapy 2018 20:71

    The original article was published in Arthritis Research & Therapy 2017 19:259

  28. Tripterygium wilfordii Hook F (TwHF) alone or in combination with methotrexate (MTX) has been shown to be more effective than MTX monotherapy in controlling the manifestations in subjects with disease-modifying a...

    Authors: Yang-zhong Zhou, Li-dan Zhao, Hua Chen, Yan Zhang, Dan-feng Wang, Lin-fang Huang, Qian-wen Lv, Bin Liu, Zhenbin Li, Wei Wei, Hongbin Li, Xiangping Liao, Hui Liu, Xiumei Liu, Hongtao Jin, Junxiang Wang…
    Citation: Arthritis Research & Therapy 2018 20:70
  29. African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health ...

    Authors: April Barnado, Robert J. Carroll, Carolyn Casey, Lee Wheless, Joshua C. Denny and Leslie J. Crofford
    Citation: Arthritis Research & Therapy 2018 20:69
  30. Although infrequent, some rheumatoid arthritis (RA) patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission. The absence of RA-specific autoantibodies, such as anticitrullinated ...

    Authors: L. E. Burgers, D. M. Boeters, M. Reijnierse and A. H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2018 20:68
  31. Osteoclasts have been strongly implicated in osteoarthritic cartilage degradation, at least indirectly via bone resorption, and have been shown to degrade cartilage in vitro. The osteoclast resorption processe...

    Authors: Henrik Löfvall, Hannah Newbould, Morten A. Karsdal, Morten H. Dziegiel, Johan Richter, Kim Henriksen and Christian S. Thudium
    Citation: Arthritis Research & Therapy 2018 20:67
  32. Anticitrullinated protein antibodies (ACPA) and citrullinated proteins play key roles in the pathogenesis of rheumatoid arthritis (RA). Many candidate citrullinated antigens have been identified in joints, but...

    Authors: Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2018 20:66
  33. The aim of this study was to assess the outcomes of remission induction in patients with IgG4-related disease (IgG4-RD) in our cohort, and to investigate the characteristics, prognosis, and risk factors in the...

    Authors: Liwen Wang, Panpan Zhang, Mu Wang, Ruie Feng, Yamin Lai, Linyi Peng, Yunyun Fei, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang and Wen Zhang
    Citation: Arthritis Research & Therapy 2018 20:65
  34. Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain.

    Authors: Daiga Kishimoto, Yohei Kirino, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Kaoru Takase-Minegishi, Hiroto Nakano, Ikuma Kato, Kiyotaka Nagahama, Ryusuke Yoshimi, Kazuhiko Igarashi, Ichiro Aoki and Hideaki Nakajima
    Citation: Arthritis Research & Therapy 2018 20:64
  35. Authors: Giovanni Orsolini, Ombretta Viapiana, Maurizio Rossini, Giovanni Adami, Cristian Caimmi, Angelo Fassio and Davide Gatti
    Citation: Arthritis Research & Therapy 2018 20:63

    The original article was published in Arthritis Research & Therapy 2018 20:16

  36. Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→in...

    Authors: Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Irmgard Förster, John A. Hamilton and Andrew D. Cook
    Citation: Arthritis Research & Therapy 2018 20:62
  37. Adalimumab was effective in treating patients with nonradiographic axial spondyloarthritis (nr-axSpA) in the 12-week ABILITY-1 trial. We present long-term efficacy and safety results of adalimumab from the ope...

    Authors: Désirée van der Heijde, Joachim Sieper, Walter P. Maksymowych, Robert G. Lambert, Su Chen, Maja Hojnik, Jaclyn K. Anderson and Aileen L. Pangan
    Citation: Arthritis Research & Therapy 2018 20:61
  38. Tofacitinib is the first oral Janus kinase inhibitor approved for the treatment of rheumatoid arthritis (RA). We compared the effectiveness and safety of tofacitinib, disease-modifying antirheumatic drugs (DMA...

    Authors: Marina Amaral de Ávila Machado, Cristiano Soares de Moura, Steve Ferreira Guerra, Jeffrey R. Curtis, Michal Abrahamowicz and Sasha Bernatsky
    Citation: Arthritis Research & Therapy 2018 20:60

    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:198

  39. Defining environmental factors responsible for development of autoimmunity in rheumatoid arthritis (RA) is critical for understanding mechanisms of disease initiation and propagation. Notably, a history of cig...

    Authors: Laura C. Cappelli, Maximilian F. Konig, Allan C. Gelber, Clifton O. Bingham III and Erika Darrah
    Citation: Arthritis Research & Therapy 2018 20:59
  40. Europe and North America have been leaders in rheumatology for many years. However, for more than a decade now the East Asian region has been catching up dramatically. Some aspects of rheumatology in East Asia...

    Authors: Kazuhiko Yamamoto, Yeong-Wook Song and Zhan-guo Li
    Citation: Arthritis Research & Therapy 2018 20:58
  41. The aim was to assess patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with filgotinib during two phase 2b, 24-week, randomized, placebo-controlled studies.

    Authors: Mark Genovese, Rene Westhovens, Luc Meuleners, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Arthur Kavanaugh
    Citation: Arthritis Research & Therapy 2018 20:57
  42. Published methods for quantification of magnetic resonance imaging (MRI) evidence of inflammation in the sacroiliac joint lack validation in pediatric populations. We evaluated the reliability and construct va...

    Authors: Pamela F. Weiss, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko, David M. Biko, Joel Paschke, Timothy G. Brandon, Rui Xiao and Nancy A. Chauvin
    Citation: Arthritis Research & Therapy 2018 20:56
  43. Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) synovial fibroblasts are incompletely understood. We explored actions of MTX in view of circadian transcriptions of synovial fibr...

    Authors: Kohjin Suzuki, Kohsuke Yoshida, Takeshi Ueha, Kenta Kaneshiro, Ayako Nakai, Naonori Hashimoto, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Natsuko Nakagawa, Yoshitada Sakai and Akira Hashiramoto
    Citation: Arthritis Research & Therapy 2018 20:55
  44. Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the regulation of pathogenesis of adult-onset Still’s disease (AOSD) has n...

    Authors: Huihui Chi, Dongzhou Liu, Yue Sun, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Yufeng Yin, Mengru Liu, Xinyao Wu, Zhuochao Zhou, Jialin Teng, Chengde Yang and Yutong Su
    Citation: Arthritis Research & Therapy 2018 20:54
  45. Diuretics have been associated with impaired response and refractoriness in gout, but whether this effect is still present with new urate-lowering drugs (ULD) and treat-to-target strategies is unknown. The aim...

    Authors: Laura Ranieri, Carolina Contero, Maria-Luisa Peral, Irene Calabuig, Pedro Zapater and Mariano Andres
    Citation: Arthritis Research & Therapy 2018 20:53

    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:241

  46. The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two ...

    Authors: Florian Weigold, Jeannine Günther, Moritz Pfeiffenberger, Otavio Cabral-Marques, Elise Siegert, Duska Dragun, Aurélie Philippe, Ann-Katrin Regensburger, Andreas Recke, Xinhua Yu, Frank Petersen, Rusan Catar, Robert Biesen, Falk Hiepe, Gerd R. Burmester, Harald Heidecke…
    Citation: Arthritis Research & Therapy 2018 20:52
  47. Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid arthritis (RA). However, approximately one quarter of patients discontinue MTX within 12 months. MTX failure, defined as MTX cessa...

    Authors: James Bluett, Jamie C. Sergeant, Alex J. MacGregor, Jacqueline R. Chipping, Tarnya Marshall, Deborah P. M. Symmons and Suzanne M. M. Verstappen
    Citation: Arthritis Research & Therapy 2018 20:50
  48. A key feature of joints in rheumatoid arthritis (RA) is the formation of hyperplastic destructive pannus tissue, which is orchestrated by activated fibroblast-like synoviocytes (FLS). We have demonstrated that...

    Authors: Beatrice Bergström, Hans Carlsten and Anna-Karin Hultgård Ekwall
    Citation: Arthritis Research & Therapy 2018 20:49

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  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

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