Kraus VB, Blanco FJ, Englund M, Henrotin Y, Lohmander LS, Losina E, et al. OARSI Clinical Trials Recommendations: soluble biomarker assessments in clinical trials in osteoarthritis. Osteoarthritis Cartilage. 2015;23(5):686–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
National Institute for Health and Care Excellence (NICE). Autologous chondrocyte implantation for treating symptomatic articular cartilage defects of the knee. Technology appraisal guidance [TA477]. 4 Oct 2017. https://www.nice.org.uk/guidance/ta477/resources/autologous-chondrocyte-implantation-for-treating-symptomatic-articular-cartilage-defects-of-the-knee-pdf-82604971061701. Accessed 25 Nov 2017.
Hulme CH, Wilson EL, Peffers MJ, Roberts S, Simpson DM, Richardson JB, et al. Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder profiles. Arthritis Res Ther. 2017;19:150.
Article
PubMed
PubMed Central
Google Scholar
Gillogly SD, Voight M, Blackburn T. Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J Orthop Sport Phys Ther. 1998;28(4):241–51.
Article
CAS
Google Scholar
Richardson JB, Caterson B, Evans EH, Ashton BA, Roberts S. Repair of human articular cartilage after implantation of autologous chondrocytes. J Bone Joint Surg Br. 1999;81(6):1064–8.
Article
CAS
PubMed
Google Scholar
Wright KT, Mennan C, Fox H, Richardson JB, Banerjee R, Roberts S. Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regen Med. 2013;8:699–709.
Article
CAS
PubMed
Google Scholar
Bhosale AM, Kuiper JH, Johnson WE, Harrison PE, Richardson JB. Midterm to long-term longitudinal outcome of autologous chondrocyte implantation in the knee joint: a multilevel analysis. Am J Sports Med. 2009;37(Suppl 1):131S–8S.
Article
PubMed
Google Scholar
Wright KT, Kuiper JH, Richardson JB, Gallacher P, Roberts S. The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. Am J Sports Med. 2017;45(8):1806–14.
Article
PubMed
Google Scholar
Dugard MN, Kuiper JH, Parker J, Roberts S, Robinson E, Harrison P, et al. Development of a tool to predict outcome of autologous chondrocyte implantation. Cartilage. 2017;8:119–30.
Article
PubMed
Google Scholar
Hsueh MF, Önnerfjord P, Kraus VB. Biomarkers and proteomic analysis of osteoarthritis. Matrix Biol. 2014;39:56–66.
Article
CAS
PubMed
Google Scholar
Chiaradia E, Pepe M, Tartaglia M, Scoppetta F, D’Ambrosio C, Renzone G, et al. Gambling on putative biomarkers of osteoarthritis and osteochondrosis by equine synovial fluid proteomics. J Proteomics. 2012;75:4478–93.
Article
CAS
PubMed
Google Scholar
Pan X, Huang L, Chen J, Dai Y, Chen X. Analysis of synovial fluid in knee joint of osteoarthritis: 5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Int Orthop. 2012;36(1):57–64.
Article
PubMed
Google Scholar
Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate production via Toll-like receptor 4. Arthritis Res Ther. 2012;14(1):R7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liao W, Li Z, Wang H, Wang J, Fu Y, Bai X. Proteomic analysis of synovial fluid: insight into the pathogenesis of knee osteoarthritis. Int Orthop. 2013;37(6):1045–53.
Article
PubMed
PubMed Central
Google Scholar
Noh R, Park SG, Ju JH, Chi SW, Kim S, Lee CK, et al. Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients. J Microbiol Biotechnol. 2014;24(1):119–26.
Article
CAS
PubMed
Google Scholar
Liao W, Li Z, Zhang H, Li J, Wang K, Yang Y. Proteomic analysis of synovial fluid as an analytical tool to detect candidate biomarkers for knee osteoarthritis. Int J Clin Exp Pathol. 2015;8(9):9975–89.
CAS
PubMed
PubMed Central
Google Scholar
Mateos J, Lourido L, Fernández-Puente P, Calamia V, Fernández-López C, Oreiro N, Ruiz-Romero C, Blanco FJ. Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC–MALDI TOF/TOF. J Proteomics. 2012;75(10):2869–78.
Article
CAS
PubMed
Google Scholar
Ritter SY, Subbaiah R, Bebek G, Crish J, Scanzello CR, Krastins B, et al. Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum. 2013;65(4):981–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Balakrishnan L, Nirujogi RS, Ahmad S, Bhattacharjee M, Manda SS, Renuse S, et al. Proteomic analysis of human osteoarthritis synovial fluid. Clin Proteomics. 2014;11(1):6.
Article
PubMed
PubMed Central
Google Scholar
Balakrishnan L, Bhattacharjee M, Ahmad S, Nirujogi RS, Renuse S, Subbannayya Y, et al. Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients. Clin Proteomics. 2014;11(1):1.
Article
PubMed
PubMed Central
Google Scholar
Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, et al. A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014;13(10):4377–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bhattacharjee M, Balakrishnan L, Renuse S, Advani J, Goel R, Sathe G, et al. Synovial fluid proteome in rheumatoid arthritis. Clin Proteomics. 2016;13:12.
Article
PubMed
PubMed Central
Google Scholar
Wu WW, Wang G, Baek SJ, Shen RF. Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOF. J Proteome Res. 2006;5(3):651–8.
Article
CAS
PubMed
Google Scholar
Bantscheff M, Schirle M, Sweetman G, Rick J, Kuster B. Quantitative mass spectrometry in proteomics: a critical review. Anal Bioanal Chem. 2007;389(4):1017–31.
Article
CAS
PubMed
Google Scholar
Lilley KS, Beynon RJ, Eyers CE, Hubbard SJ. Focus of quantitative proteomics. Proteomics. 2015;15(18):3101–3.
Article
CAS
PubMed
Google Scholar
Herr MM, Fries KM, Upton LG, Edsberg LE. Potential biomarkers of temporomandibular joint disorders. J Oral Maxillofac Surg. 2011;69(1):41–7.
Article
PubMed
Google Scholar
Roberts S, Evans H, Wright K, van Niekerk L, Caterson B, Richardson JB, et al. ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis Cartilage. 2015;23(9):1622–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kraus VB, Stabler TV, Kong SY, Varju G, McDaniel G. Measurement of synovial fluid volume using urea. Osteoarthritis Cartilage. 2007;15(10):1217–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ehrich E, Davies G, Watson D, Bolohnese J, Seidenberg B, Bellamy N. Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and global assessments in patients with osteoarthritis. J Rheumatol. 2000;27(11):2635–41.
CAS
PubMed
Google Scholar
Roos E, Lohmander L. The Knee Injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes. 2003;1:64.
Article
PubMed
PubMed Central
Google Scholar
Saris D, Vanlauwe J, Victor J, Almqvist K, Verdonk R, Bellemans J, et al. Treatment of symptomatic cartilage defects in the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009;37(Suppl 1):10S–9S.
Article
PubMed
Google Scholar
Smith HJ, Richardson JB, Tennant A. Modification and validation of the Lysholm Knee Scale to assess articular cartilage damage. Osteoarthritis Cartilage. 2009;17:53–8.
Article
CAS
PubMed
Google Scholar
Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982;10(3):150–4.
Article
CAS
PubMed
Google Scholar
Stoscheck CM. Protein assay sensitive at nanogram levels. Anal Biochem. 1987;160(2):301–5.
Article
CAS
PubMed
Google Scholar
Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus A, Botting CH, et al. Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development. Front Cell Neurosci. 2016;9:506.
Article
PubMed
PubMed Central
Google Scholar
Fuller H, Slade R, Jovanov-Milošević N, Babić M, Sedmak G, Šimić G, et al. Stathmin is enriched in the developing corticospinal tract. Mol Cell Neurosci. 2015;69:12–21.
Article
CAS
PubMed
Google Scholar
Oliveros JC. VENNY: an interactive tool for comparing lists with Venn diagrams. 2007. http://bioinfogp.cnb.csic.es/tools/venny/. Accessed 28 Sept 2017.
Albert R, Barabasi AL. Statistical mechanics of complex networks. Rev Mod Phys. 2002;74(1):47–97.
Article
Google Scholar
Vidal M, Cusick ME, Barabási AL. Interactome networks and human disease. Cell. 2011;144(6):986–98.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cowley MJ, Pinese M, Kassahn KS, Waddell N, Pearson JV, Grimmond SM, et al. PINA v2.0: mining interactome modules. Nucleic Acids Res. 2012;40(Database issue):D862–5.
Article
CAS
PubMed
Google Scholar
Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12(1):56–68.
Article
PubMed
PubMed Central
Google Scholar
Nepusz T, Yu H, Paccanaro A. Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods. 2012;9:471–2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vastrik I, D’Eustachio P, Schmidt E, Gopinath G, Croft D, de Bono B, et al. Reactome: a curated knowledge base of biologic pathways and processes. Genome Biol. 2008;8:R39.
Article
Google Scholar
Croft D, Mundo AF, Haw R, Milacic M, Weiser J, Wu G, et al. The Reactome pathway knowledgebase. Nucleic Acids Res. 2014;42(Database issue):D472–7.
Article
CAS
PubMed
Google Scholar
Clemmons DR, Busby WH, Garmong A, Schultz DR, Howell DS, Altman RD, et al. Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis. Arthritis Rheum. 2002;46(3):694–703.
Article
CAS
PubMed
Google Scholar
Busby WH, Yocum SA, Rowland M, Kellner D, Lazerwith S, Sverdrup F, et al. Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid. Osteoarthritis Cartilage. 2009;17(4):547–55.
Article
PubMed
Google Scholar
van Osch GJVM, van den Berg WB, Hunziker EB, Hauselmann HJ. Differential effects of IGF-1 and TGFβ-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. Osteoarthritis Cartilage. 1998;6:187–95.
Article
CAS
PubMed
Google Scholar
Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2012;17(12):1674–9.
Article
Google Scholar
Murphy G. Matrix metalloproteinases and their inhibitors. Acta Orthop Scand Suppl. 1995;266:55–60.
CAS
PubMed
Google Scholar
Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. J Zheihang Univ Sci B. 2005;6(11):1045–56.
Article
CAS
Google Scholar
Guney E, Menchem J, Vidal M, Barabasi AL. Network-based in silico drug efficacy screening. Nat Commun. 2016;7:10331.
Article
CAS
PubMed
PubMed Central
Google Scholar