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  1. We aimed to explore pressure pain sensitivity and the function of segmental and plurisegmental exercise-induced hypoalgesia (EIH) in persons with rheumatoid arthritis (RA) compared with healthy control subject...

    Authors: Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren and Eva Kosek
    Citation: Arthritis Research & Therapy 2018 20:48
  2. The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (

    Authors: Peter Nash, Philip J. Mease, Iain B. McInnes, Proton Rahman, Christopher T. Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu and Luminita Pricop
    Citation: Arthritis Research & Therapy 2018 20:47
  3. Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, the histidine-pyridine...

    Authors: Vu Huy Luong, Takenao Chino, Noritaka Oyama, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Tanima Biswas, Akiyuki Hamasaki, Mikako Fujita, Yoshinari Okamoto, Masami Otsuka, Hironobu Ihn and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2018 20:46
  4. MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the ...

    Authors: Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-shuang Liu, Qing-Sheng Mi and Jing-Guo Zhou
    Citation: Arthritis Research & Therapy 2018 20:45
  5. Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To in...

    Authors: Christian Schwedler, Thomas Häupl, Ulrich Kalus, Véronique Blanchard, Gerd-Rüdiger Burmester, Denis Poddubnyy and Berthold Hoppe
    Citation: Arthritis Research & Therapy 2018 20:44
  6. Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is st...

    Authors: Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li and Janak L. Pathak
    Citation: Arthritis Research & Therapy 2018 20:43
  7. Sirukumab, a high-affinity human monoclonal antibody that selectively binds to interleukin-6, has demonstrated efficacy in the treatment of rheumatoid arthritis (RA) in global phase 1 and phase 2 studies. The ...

    Authors: Tsutomu Takeuchi, Hisashi Yamanaka, Masayoshi Harigai, Ryo Tamamura, Yuichi Kato, Yoshifumi Ukyo, Toshikazu Nakano, Benjamin Hsu and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2018 20:42
  8. Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to ar...

    Authors: Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang and Xiong Guo
    Citation: Arthritis Research & Therapy 2018 20:41
  9. The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulnes...

    Authors: Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2018 20:40
  10. Prostaglandin E2 (PGE2) acts via its EP4 receptor as a cytokine amplifier (e.g., interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th) lymphocytes. These mechanisms play ...

    Authors: Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni…
    Citation: Arthritis Research & Therapy 2018 20:39
  11. Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA.

    Authors: Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte and Dominique L. Baeten
    Citation: Arthritis Research & Therapy 2018 20:38
  12. Using self-report questionnaires of key fibromyalgia symptom domains (pain, fatigue, sleep disturbance, function, stiffness, dyscognition, depression, and anxiety), we previously identified four unique symptom...

    Authors: Tanya L. Hoskin, Mary O. Whipple, Sanjeev Nanda and Ann Vincent
    Citation: Arthritis Research & Therapy 2018 20:37
  13. Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increa...

    Authors: Uta Hardt, Anders Larsson, Iva Gunnarsson, Robert M. Clancy, Michelle Petri, Jill P. Buyon, Gregg J. Silverman, Elisabet Svenungsson and Caroline Grönwall
    Citation: Arthritis Research & Therapy 2018 20:36
  14. Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses...

    Authors: Janine S. Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius and Lisa G. M. van Baarsen
    Citation: Arthritis Research & Therapy 2018 20:35
  15. Interleukin-1β (IL-1β) is a pivotal proinflammatory cytokine that is strongly associated with the inflammation of gout. However, the underlying mechanism through which the production of IL-1β is regulated has ...

    Authors: Teng Ma, Xiao Liu, Zhifu Cen, Chuan Xin, Mingfeng Guo, Chaoyu Zou, Wenpeng Song, Rou Xie, Kailun Wang, Hong Zhou, Jun Zhang, Zhen Wang, Ce Bian, Kaijun Cui, Jiong Li, Yu-Quan Wei…
    Citation: Arthritis Research & Therapy 2018 20:34
  16. The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this v...

    Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Gerrie Stoeken, Leendert A. Trouw, Holger Bang, Robbert J. Goekoop, Irene Speyer, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude
    Citation: Arthritis Research & Therapy 2018 20:33
  17. Unfortunately, after publication of this article [1], it was noticed that Table 2 was not correctly formatted during the production process. The corrected Table 2 can be seen below and the original article has...

    Authors: Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Millán, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn and Jasvinder A. Singh
    Citation: Arthritis Research & Therapy 2018 20:32

    The original article was published in Arthritis Research & Therapy 2017 19:267

  18. Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regula...

    Authors: Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox and M. Asif Amin
    Citation: Arthritis Research & Therapy 2018 20:31
  19. Sjögren’s syndrome (SS) is a primary autoimmune disease (pSS) or secondarily associated with other autoimmune diseases (sSS). The mechanisms underlying immune dysregulation in this syndrome remain unknown, and...

    Authors: Yu-Hui Li, Ya-Ping Gao, Jie Dong, Lian-Jie Shi, Xiao-Lin Sun, Ru Li, Xue-Wu Zhang, Yu Liu, Li Long, Jing He, Qun-Jie Zhong, Eric Morand, Guang Yang and Zhan-Guo Li
    Citation: Arthritis Research & Therapy 2018 20:30
  20. Dysregulated production of cytokines has a critical role in systemic lupus. The aim of this work is to identify, by a comprehensive analysis of IL-1 family cytokines and receptors in serum, correlation between...

    Authors: Paola Italiani, Maria Laura Manca, Francesca Angelotti, Daniela Melillo, Federico Pratesi, Ilaria Puxeddu, Diana Boraschi and Paola Migliorini
    Citation: Arthritis Research & Therapy 2018 20:27
  21. We have previously reported that adiponectin (AD), an adipokine that is secreted by adipocytes, correlates well with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD in promotin...

    Authors: Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan and Miaojia Zhang
    Citation: Arthritis Research & Therapy 2018 20:26

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:125

  22. Previously we established an arthritis-prone FcγRIIB-deficient mouse strain (designated KO1). Anti-mouse CD11b mAb (5C6) has been reported to inhibit the recruitment of peripheral CD11b+ myelomonocytic cells from...

    Authors: Mareki Ohtsuji, Qingshun Lin, Hideki Okazaki, Kazuko Takahashi, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura and Sachiko Hirose
    Citation: Arthritis Research & Therapy 2018 20:25
  23. The anti-inflammatory effect of abatacept is most pronounced in patients with high-titer autoantibodies (including anticitrullinated protein antibodies [ACPA] and rheumatoid factor [RF]). Considering that auto...

    Authors: Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang and Georg Schett
    Citation: Arthritis Research & Therapy 2018 20:24
  24. Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. A recent study demonstrated the transdifferentiation...

    Authors: Ryosuke Saigusa, Yoshihide Asano, Takashi Taniguchi, Megumi Hirabayashi, Kouki Nakamura, Shunsuke Miura, Takashi Yamashita, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Ayumi Yoshizaki, Maria Trojanowska and Shinichi Sato
    Citation: Arthritis Research & Therapy 2018 20:23
  25. Anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis (AS). AS-related anterior uveitis frequently presents as acute, recurrent iridocyclitis; therefore, AS is often initi...

    Authors: Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee and Hyeong Gon Yu
    Citation: Arthritis Research & Therapy 2018 20:22
  26. The purpose of this study was to investigate whether white matter microstructure is altered in patients suffering from systemic lupus erythematosus (SLE), and if so, whether such alterations differed between p...

    Authors: Jessika Nystedt, Markus Nilsson, Andreas Jönsen, Petra Nilsson, Anders Bengtsson, Åsa Lilja, Jimmy Lätt, Peter Mannfolk and Pia C Sundgren
    Citation: Arthritis Research & Therapy 2018 20:21
  27. In addition to the kidney, the intestine is one of the most important organs involved in uric acid excretion. However, the mechanism of urate excretion in the intestine remains unclear. Therefore, the relation...

    Authors: Mo Chen, Xiaoyong Lu, Ci Lu, Ning Shen, Yujie Jiang, Menglu Chen and Huaxiang Wu
    Citation: Arthritis Research & Therapy 2018 20:20
  28. Role of Th9 cells and interleukin-9 (IL-9) in human autoimmune diseases such as psoriasis and ulcerative colitis has been explored only very recently. However, their involvement in human rheumatoid arthritis (...

    Authors: Kaustav Chowdhury, Uma Kumar, Soumabha Das, Jaydeep Chaudhuri, Prabin Kumar, Maumita Kanjilal, Parashar Ghosh, Geetabali Sircar, Ravi Kiran Basyal, Uma Kanga, Santu Bandyopadhaya and Dipendra Kumar Mitra
    Citation: Arthritis Research & Therapy 2018 20:18
  29. Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliora...

    Authors: Sabine Adler, Dörte Huscher, Elise Siegert, Yannick Allanore, László Czirják, Francesco DelGaldo, Christopher P. Denton, Oliver Distler, Marc Frerix, Marco Matucci-Cerinic, Ulf Mueller-Ladner, Ingo-Helmut Tarner, Gabriele Valentini, Ulrich A. Walker, Peter M. Villiger and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2018 20:17
  30. Positive anticyclic citrullinated peptide (anti-CCP+) is associated with bone loss in patients with rheumatoid arthritis (RA). However, whether overall positivity or specific levels of anti-CCP are associated ...

    Authors: Tien-Tsai Cheng, Shan-Fu Yu, Fu-Mei Su, Yin-Chou Chen, Ben Yu-Jih Su, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Chi-Hua Ko and Han-Ming Lai
    Citation: Arthritis Research & Therapy 2018 20:16

    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:63

  31. At present, there are no prognostic parameters unequivocally predicting treatment failure in early rheumatoid arthritis (RA) patients. We investigated whether baseline ultrasonography (US) findings of joints, ...

    Authors: D. F. Ten Cate, J. W. G. Jacobs, W. A. A. Swen, J. M. W. Hazes, M. H. de Jager, N. M. Basoski, C. J. Haagsma, J. J. Luime and A. H. Gerards
    Citation: Arthritis Research & Therapy 2018 20:15
  32. Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faeca...

    Authors: Matthew L. Stoll, Pamela F. Weiss, Jennifer E. Weiss, Peter A. Nigrovic, Barbara S. Edelheit, S. Lou Bridges Jr, Maria I. Danila, Charles H. Spencer, Marilynn G. Punaro, Kenneth Schikler, Andreas Reiff, Ranjit Kumar, Randy Q. Cron, Casey D. Morrow and Elliot J. Lefkowitz
    Citation: Arthritis Research & Therapy 2018 20:14
  33. Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which dysregulation of B cells has been recognized. Here, we searched for potential biomarkers of SLE using liquid chromatography-tand...

    Authors: Aya Miyagawa-Hayashino, Hajime Yoshifuji, Koji Kitagori, Shinji Ito, Takuma Oku, Yoshitaka Hirayama, Adeeb Salah, Toshiki Nakajima, Kaori Kiso, Norishige Yamada, Hironori Haga and Tatsuaki Tsuruyama
    Citation: Arthritis Research & Therapy 2018 20:13
  34. Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic disease. Despite its good response to steroid therapy, its treatment protocol is not standardized and the long-te...

    Authors: Xia Hong, Yan-Yan Zhang, Wei Li, Yan-Ying Liu, Zhen Wang, Yan Chen, Yan Gao, Zhi-Peng Sun, Xin Peng, Jia-Zeng Su, Zhi-Gang Cai, Lei Zhang, Jing He, Li-Min Ren, Hong-Yu Yang, Zhan-Guo Li…
    Citation: Arthritis Research & Therapy 2018 20:12
  35. This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR).

    Authors: Anaïs Huwart, Florent Garrigues, Sandrine Jousse-Joulin, Thierry Marhadour, Dewi Guellec, Divi Cornec, Maelenn Gouillou, Alain Saraux and Valérie Devauchelle-Pensec
    Citation: Arthritis Research & Therapy 2018 20:11
  36. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathoge...

    Authors: Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam and Chaim Putterman
    Citation: Arthritis Research & Therapy 2018 20:10
  37. Functional variants of the B cell gene, B cell scaffold protein with ankyrin repeats 1 (BANK1) contribute to rheumatoid arthritis (RA) susceptibility, but their influences on B cell responses are unclear. More...

    Authors: Jie Yang, Jie Ren, Yiming Yang, Juan Sun, Xiaohui Zhou, Shucong Zheng, Dandan Xuan, Yu Xue, Huimin Fan, Jiong Zhang, Hejian Zou, Weiguo Wan and Ning Kong
    Citation: Arthritis Research & Therapy 2018 20:9
  38. The aim was to analyze characteristics that predict remission induction and subsequent loss of remission in patients with moderately active rheumatoid arthritis (RA) who received full-dose combination etanerce...

    Authors: Josef S. Smolen, Annette Szumski, Andrew S. Koenig, Thomas V. Jones and Lisa Marshall
    Citation: Arthritis Research & Therapy 2018 20:8
  39. Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicent...

    Authors: Yumiko Sugiyama, Ryusuke Yoshimi, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Daiga Kishimoto, Yuji Yoshioka, Kouji Kobayashi, Kaoru Takase-Minegishi, Toshiyuki Watanabe, Naoki Hamada, Hideto Nagai, Naomi Tsuchida, Yutaro Soejima, Hiroto Nakano, Reikou Kamiyama…
    Citation: Arthritis Research & Therapy 2018 20:7
  40. The aim was to study urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) as biomarkers of renal disease in systemic lupus erythematosus (SLE).

    Authors: Chi Chiu Mok, Samar Soliman, Ling Yin Ho, Fatma A. Mohamed, Faten Ismail Mohamed and Chandra Mohan
    Citation: Arthritis Research & Therapy 2018 20:6
  41. Significant progress has been made in the understanding of transitional care in rheumatology over the last few decades, yet universal implementation has not been realised and unmet needs continue to be reporte...

    Authors: Janet E. McDonagh and Albert Farre
    Citation: Arthritis Research & Therapy 2018 20:5
  42. Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-systemic autoimmune disease. Interferon type I (IFN-I) plays a pivotal role in the pathogenesis of SLE. The objective of this study was...

    Authors: M. Javad Wahadat, Iris L. A. Bodewes, Naomi I. Maria, Cornelia G. van Helden-Meeuwsen, Annette van Dijk-Hummelman, Eline C. Steenwijk, Sylvia Kamphuis and Marjan A. Versnel
    Citation: Arthritis Research & Therapy 2018 20:4
  43. There is limited information on the epidemiology of psoriatic arthritis (PsA) in general and in Middle Eastern populations in particular. The aims of this study were to estimate the prevalence and incidence ra...

    Authors: Lihi Eder, Arnon Dov Cohen, Ilan Feldhamer, Sari Greenberg-Dotan, Erez Batat and Devy Zisman
    Citation: Arthritis Research & Therapy 2018 20:3
  44. Registry studies provide a valuable source of comparative safety data for tumor necrosis factor inhibitors (TNFi) used in rheumatoid arthritis (RA), but they are subject to channeling bias. Comparing safety ou...

    Authors: Leslie R. Harrold, Heather J. Litman, Katherine C. Saunders, Kimberly J. Dandreo, Bernice Gershenson, Jeffrey D. Greenberg, Robert Low, Jeffrey Stark, Robert Suruki, Srihari Jaganathan, Joel M. Kremer and Mohamed Yassine
    Citation: Arthritis Research & Therapy 2018 20:2
  45. Methotrexate (MTX) remains the anchor drug in rheumatoid arthritis (RA) treatment, but is poorly tolerated or contraindicated in some patients. There is a wealth of data supporting the use of abatacept in comb...

    Authors: Rieke Alten, Harald Burkhardt, Eugen Feist, Klaus Krüger, Juergen Rech, Andrea Rubbert-Roth, Reinhard E. Voll, Yedid Elbez and Christiane Rauch
    Citation: Arthritis Research & Therapy 2018 20:1
  46. Individuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA. This study a...

    Authors: L. Ouboussad, L. Hunt, E. M. A. Hensor, J. L. Nam, N. A. Barnes, P. Emery, M. F. McDermott and M. H. Buch
    Citation: Arthritis Research & Therapy 2017 19:288
  47. Secukinumab, an anti–interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in two phase 3 studies (MEASURE 1 and MEASURE 2). Here, we present 52-week results from ...

    Authors: Karel Pavelka, Alan Kivitz, Eva Dokoupilova, Ricardo Blanco, Marco Maradiaga, Hasan Tahir, Luminita Pricop, Mats Andersson, Aimee Readie and Brian Porter
    Citation: Arthritis Research & Therapy 2017 19:285

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