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  1. The overall benefit of intensive treatment strategies in rheumatoid arthritis (RA) remains uncertain. We explored how reductions in disability and improvements in quality of life scores are affected by alterna...

    Authors: Aneela N. Mian, Fowzia Ibrahim, David L. Scott and James Galloway
    Citation: Arthritis Research & Therapy 2016 18:142
    Content type: Research article Published on:

  2. Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and e...

    Authors: Natasja Stæhr Gudmann, Heidi Lausten Munk, Anne Friesgaard Christensen, Leif Ejstrup, Grith Lykke Sørensen, Anne Gitte Loft, Morten Asser Karsdal, Anne-Christine Bay-Jensen, Yi He, Anne Sofie Siebuhr and Peter Junker
    Citation: Arthritis Research & Therapy 2016 18:141
    Content type: Research article Published on:

  3. The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribu...

    Authors: Sofia E. M. Andersson, Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Anna Stern, Louise Henningsson, Bibo Liang, Katrin Thorarinsdottir, Jan Kihlberg, Rikard Holmdahl, Inga-Lill MÃ¥rtensson, Kenth Gustafsson and Inger Gjertsson
    Citation: Arthritis Research & Therapy 2016 18:140
    Content type: Research article Published on:

  4. Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the ant...

    Authors: Shin Ebihara, Hideaki Tajima and Masao Ono
    Citation: Arthritis Research & Therapy 2016 18:139
    Content type: Research article Published on:

  5. Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, which is characterized by inflammation of synovial joints leading to the destruction of cartilage and bone. Infiltrating mast cells can be foun...

    Authors: Daniël van der Velden, H. Maxime Lagraauw, Anouk Wezel, Pierre Launay, Johan Kuiper, Tom W. J. Huizinga, René E. M. Toes, Ilze Bot and Jeroen N. Stoop
    Citation: Arthritis Research & Therapy 2016 18:138
    Content type: Research article Published on:

  6. This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON).

    Authors: Malin Ernberg, Nikolaos Christidis, Bijar Ghafouri, Indre Bileviciute-Ljungar, Monika Löfgren, Anette Larsson, Annie Palstam, Jan Bjersing, Kaisa Mannerkorpi, Eva Kosek and Björn Gerdle
    Citation: Arthritis Research & Therapy 2016 18:137
    Content type: Research article Published on:

  7. Polymyositis (PM) and dermatomyositis (DM) are autoimmune muscle diseases, conventionally treated with high doses of glucocorticoids in combination with immunosuppressive drugs. Treatment is often dissatisfyin...

    Authors: Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova and Ingrid E. Lundberg
    Citation: Arthritis Research & Therapy 2016 18:136
    Content type: Research article Published on:

  8. There is a lack of information about the sensitivity, specificity and costs new diagnostic tests should have to improve early diagnosis of rheumatoid arthritis (RA). Our objective was to explore the early cost...

    Authors: Leander R. Buisman, Jolanda J. Luime, Mark Oppe, Johanna M. W. Hazes and Maureen P. M. H. Rutten-van Mölken
    Citation: Arthritis Research & Therapy 2016 18:135
    Content type: Research article Published on:

  9. Lupus nephritis (LN) is a complex chronic autoimmune disease of unknown etiology characterized by loss of tolerance against several self-antigens. Cytokines are known to be central players in LN pathogenesis. ...

    Authors: Èlia Ripoll, Laura de Ramon, Juliana Draibe, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó and Juan Torras
    Citation: Arthritis Research & Therapy 2016 18:134
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:152

  10. The aim of this study was to assess the effects of soluble sialic acid-binding immunoglobulin-type lectin (sSiglec)-9 on joint inflammation and destruction in a murine collagen-induced arthritis (CIA) model an...

    Authors: Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro and Akihito Yamamoto
    Citation: Arthritis Research & Therapy 2016 18:133
    Content type: Research article Published on:

  11. Patients with ankylosing spondylitis (AS), who by definition have radiographic sacroiliitis, typically experience symptoms for a decade or more before being diagnosed. Yet, even patients without radiographic s...

    Authors: Ruben Burgos-Vargas, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen and Bonnie Vlahos
    Citation: Arthritis Research & Therapy 2016 18:132
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:154

  12. Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the...

    Authors: Elena Schiopu, Soumya Chatterjee, Vivien Hsu, Armando Flor, Daniel Cimbora, Kaushik Patra, Wenliang Yao, Jing Li, Katie Streicher, Kathleen McKeever, Barbara White, Eliezer Katz, Jorn Drappa, Sarah Sweeny and Ronald Herbst
    Citation: Arthritis Research & Therapy 2016 18:131
    Content type: Research article Published on:

  13. Recently, autoantibodies against novel UH-RA peptides (UH-RA.1 and UH-RA.21) were identified as candidate biomarkers for patients with rheumatoid arthritis (RA) who are seronegative for the current diagnostic ...

    Authors: Liesbeth M. De Winter, Piet Geusens, Jan Lenaerts, Johan Vanhoof, Piet Stinissen and Veerle Somers
    Citation: Arthritis Research & Therapy 2016 18:130
    Content type: Research article Published on:

  14. Subacromial pain syndrome (SAPS) accounts for around 50 % of all cases of shoulder pain. The most commonly used treatments are glucocorticosteroid (steroid) injections and exercise therapy; however, despite tr...

    Authors: Karen Ellegaard, Robin Christensen, Sara Rosager, Cecilie Bartholdy, Søren Torp-Pedersen, Thomas Bandholm, Bente Danneskiold-Samsøe, Henning Bliddal and Marius Henriksen
    Citation: Arthritis Research & Therapy 2016 18:129
    Content type: Research article Published on:

  15. Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely unknown. This study aimed to determine whether cu...

    Authors: Zhuo Zhang, Daniel J. Leong, Lin Xu, Zhiyong He, Angela Wang, Mahantesh Navati, Sun J. Kim, David M. Hirsh, John A. Hardin, Neil J. Cobelli, Joel M. Friedman and Hui B. Sun
    Citation: Arthritis Research & Therapy 2016 18:128
    Content type: Research article Published on:

  16. Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially limited spectrum of reactivities that gra...

    Authors: Linda Johansson, Federico Pratesi, Mikael Brink, Lisbeth Ärlestig, Claudia D’Amato, Debora Bartaloni, Paola Migliorini and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2016 18:127
    Content type: Research article Published on:

  17. The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has be...

    Authors: Gianfranco Ferraccioli, Barbara Tolusso and Elisa Gremese
    Citation: Arthritis Research & Therapy 2016 18:126
    Content type: Editorial Published on:

  18. Notochordal cell conditioned medium (NCCM) derived from non-chondrodystrophic dogs has pro-anabolic and anti-catabolic effects upon nucleus pulposus (NP) cells. Here, for the first time, we assessed the abilit...

    Authors: Sebastian Müller, Lina Acevedo, Xiaomei Wang, M. Zia Karim, Ajay Matta, Arne Mehrkens, Stefan Schaeren, Sandra Feliciano, Marcel Jakob, Ivan Martin, Andrea Barbero and W. Mark Erwin
    Citation: Arthritis Research & Therapy 2016 18:125
    Content type: Research article Published on:

  19. MicroRNAs (miRNAs) are small RNAs that regulate gene expression by targeting mRNA. It was proved that some miRNAs are significantly deregulated in rheumatoid arthritis (RA). MicroRNA-125b negatively regulates ...

    Authors: Veronika Hruskova, Romana Jandova, Lucia Vernerova, Herman Mann, Ondrej Pecha, Klara Prajzlerova, Karel Pavelka, Jiri Vencovsky, Maria Filkova and Ladislav Senolt
    Citation: Arthritis Research & Therapy 2016 18:124
    Content type: Research article Published on:

  20. Scleroderma is a systemic autoimmune disease characterized mainly by skin manifestations and involvement of various visceral organs, especially the lungs. Lung involvement is the leading cause of mortality in ...

    Authors: Padmanabha D. Shenoy, Manish Bavaliya, Sujith Sashidharan, Kaveri Nalianda and Sreelakshmi Sreenath
    Citation: Arthritis Research & Therapy 2016 18:123
    Content type: Research article Published on:

  23. Authors: Francesca Ometto, Bernd Raffeiner, Livio Bernardi, Costantino Botsios, Nicola Veronese, Leonardo Punzi and Andrea Doria
    Citation: Arthritis Research & Therapy 2016 18:120
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:89

  24. A possible association between mucosal immunization and inflammation, as well as the initiation and propagation of rheumatoid arthritis (RA), is attracting renewed interest. The aim of this study was to evalua...

    Authors: Karin Roos, Klara Martinsson, Michael Ziegelasch, Yngve Sommarin, Anna Svärd, Thomas Skogh and Alf Kastbom
    Citation: Arthritis Research & Therapy 2016 18:119
    Content type: Research article Published on:

  25. Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain unknown. We aimed to explore the hypothesis that RTX m...

    Authors: Dimitrios Daoussis, Athanassios Tsamandas, Ioannis Antonopoulos, Alexandra Filippopoulou, Dionysios J. Papachristou, Nicholaos I. Papachristou, Andrew P. Andonopoulos and Stamatis-Nick Liossis
    Citation: Arthritis Research & Therapy 2016 18:118
    Content type: Research article Published on:

  26. Gout is the most common inflammatory arthropathy of metabolic origin and it is characterized by intense inflammation, the underlying mechanisms of which are unknown. The aim of this study was to evaluate the o...

    Authors: Yessica Zamudio-Cuevas, Karina Martínez-Flores, Javier Fernández-Torres, Yahir A. Loissell-Baltazar, Daniel Medina-Luna, Ambar López-Macay, Javier Camacho-Galindo, Cristina Hernández-Díaz, Mónica G. Santamaría-Olmedo, Edgar Oliver López-Villegas, Francesca Oliviero, Anna Scanu, Jorge Francisco Cerna-Cortés, Marwin Gutierrez, Carlos Pineda and Alberto López-Reyes
    Citation: Arthritis Research & Therapy 2016 18:117
    Content type: Research article Published on:

  27. Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. Women with FM also report disability, in terms of negative consequences on activities of daily livin...

    Authors: Annie Palstam, Anette Larsson, Monika Löfgren, Malin Ernberg, Jan Bjersing, Indre Bileviciute-Ljungar, Björn Gerdle, Eva Kosek and Kaisa Mannerkorpi
    Citation: Arthritis Research & Therapy 2016 18:116
    Content type: Research article Published on:

  28. Increasing numbers of patients (up to 40 %) with rheumatoid arthritis (RA) achieve remission, yet it remains to be elucidated whether this also normalizes their cardiovascular risk. Short-term treatment with T...

    Authors: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed and Erik S. G. Stroes
    Citation: Arthritis Research & Therapy 2016 18:115
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:298

  29. Discordance between patient and physician ratings of rheumatoid arthritis (RA) severity occurs in clinical practice and correlates with pain scores and measurements of joint disease. However, information is la...

    Authors: Josef S. Smolen, Vibeke Strand, Andrew S. Koenig, Annette Szumski, Sameer Kotak and Thomas V. Jones
    Citation: Arthritis Research & Therapy 2016 18:114
    Content type: Research article Published on:

  30. Endothelin-1 (ET-1) is important in the pathogenesis of systemic sclerosis (SSc). ET-1 binds two receptors, endothelin type A (ETA) and endothelin type B (ETB). Dual ETA/ETB receptor antagonists and a selective E...

    Authors: Kengo Akashi, Jun Saegusa, Sho Sendo, Keisuke Nishimura, Takuya Okano, Keiko Yagi, Masashi Yanagisawa, Noriaki Emoto and Akio Morinobu
    Citation: Arthritis Research & Therapy 2016 18:113
    Content type: Research article Published on:

  31. Nearly all secreted proteins are glycosylated, and serum glycoproteins that exhibit disease-associated glycosylation changes have potential to be biomarkers. In rheumatoid arthritis (RA), C-reactive protein (C...

    Authors: Masaru Takeshita, Atsushi Kuno, Katsuya Suzuki, Atsushi Matsuda, Hiroko Shimazaki, Tomomi Nakagawa, Yuki Otomo, Yasuaki Kabe, Makoto Suematsu, Hisashi Narimatsu and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2016 18:112
    Content type: Research article Published on:

  32. Antiphospholipid antibodies (aPL) can be detected in asymptomatic carriers and infectious patients. The aim was to investigate whether a novel line immunoassay (LIA) differentiates between antiphospholipid syn...

    Authors: Dirk Roggenbuck, Maria Orietta Borghi, Valentina Somma, Thomas Büttner, Peter Schierack, Katja Hanack, Claudia Grossi, Caterina Bodio, Paolo Macor, Philipp von Landenberg, Francesco Boccellato, Michael Mahler and Pier Luigi Meroni
    Citation: Arthritis Research & Therapy 2016 18:111
    Content type: Research article Published on:

  34. To examine the roles of long noncoding RNAs (lncRNAs) in the regulation of primary Sjögren’s syndrome (pSS) and reveal the expression profile of lncRNAs in labial salivary glands (LSGs) in pSS patients.

    Authors: Huan Shi, Ningning Cao, Yiping Pu, Lisong Xie, Lingyan Zheng and Chuangqi Yu
    Citation: Arthritis Research & Therapy 2016 18:109
    Content type: Research article Published on:

  35. The aim was to compare the effect of etanercept (ETN) and conventional synthetic disease-modifying anti-rheumatic drug (DMARD) therapy on serum amyloid A (SAA) levels and to determine whether SAA reflects rheu...

    Authors: Yong Gil Hwang, Goundappa K. Balasubramani, Ilinca D. Metes, Marc C. Levesque, S. Louis Bridges Jr. and Larry W. Moreland
    Citation: Arthritis Research & Therapy 2016 18:108
    Content type: Research article Published on:

  36. Anti-SSA/Ro60 and anti-SSB/La are essential serological biomarkers for rheumatic diseases, specifically Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). Currently, laboratory detection technolog...

    Authors: Lida Esfandiary, Nirupama Gupta, Alexandria Voigt, Arun Wanchoo, Edward K. L. Chan, Sukesh Sukumaran and Cuong Q. Nguyen
    Citation: Arthritis Research & Therapy 2016 18:107
    Content type: Research article Published on:

  37. In this study, we sought to identify definitive biomarkers associated with disease activity in primary Sjögren’s syndrome (pSS).

    Authors: Ayumi Nishikawa, Katsuya Suzuki, Yoshiaki Kassai, Yuumi Gotou, Maiko Takiguchi, Takahiro Miyazaki, Keiko Yoshimoto, Hidekata Yasuoka, Kunihiro Yamaoka, Rimpei Morita, Akihiko Yoshimura and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2016 18:106
    Content type: Research article Published on:

  38. Estrogen deficiency is closely related to the development of menopausal arthritis. Estrogen replacement therapy (ERT) shows a protective effect against the osteoarthritis. However, the underlying mechanism of ...

    Authors: Yujie Liang, Li Duan, Jianyi Xiong, Weiming Zhu, Qisong Liu, Daming Wang, Wei Liu, Zigang Li and Daping Wang
    Citation: Arthritis Research & Therapy 2016 18:105
    Content type: Research article Published on:

  40. Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma...

    Authors: Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko and Christine Beeton
    Citation: Arthritis Research & Therapy 2016 18:103
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:122

  41. Citrullination catalysed by peptidylarginine deiminases (PADs) plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and, possibly, several other i...

    Authors: Dres Damgaard, Mads Emil Bjørn, Maria A. Steffensen, Ger J. M. Pruijn and Claus H. Nielsen
    Citation: Arthritis Research & Therapy 2016 18:102
    Content type: Research article Published on:

  42. Authors: Daniela Impellizzeri, Emanuela Esposito, Rosanna Di Paola, Akbar Ahmad, Michela Campolo, Angelo Peli, Valeria Maria Morittu, Domenico Britti and Salvatore Cuzzocrea
    Citation: Arthritis Research & Therapy 2016 18:101
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2013 15:4055

  44. Scleroderma is an antigen-driven T cell-mediated autoimmune disease. Presence of anti-topoisomerase-I antibodies is associated with pulmonary fibrosis and predicts increased mortality. Characterization of auto...

    Authors: Andrea Fava, Raffaello Cimbro, Fredrick M. Wigley, Qing-Rong Liu, Antony Rosen and Francesco Boin
    Citation: Arthritis Research & Therapy 2016 18:99
    Content type: Research article Published on:

  45. The pathogenesis of necrosis of the femoral head (NFH) remains elusive. Limited studies were conducted to investigate the molecular mechanism of hip articular cartilage damage in NFH. We conducted genome-wide ...

    Authors: Ruiyu Liu, Qi Liu, Kunzheng Wang, Xiaoqian Dang and Feng Zhang
    Citation: Arthritis Research & Therapy 2016 18:98
    Content type: Research article Published on:

  46. Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin...

    Authors: Sadaf Ashraf, Karyn S. Bouhana, Jed Pheneger, Steven W. Andrews and David A. Walsh
    Citation: Arthritis Research & Therapy 2016 18:97
    Content type: Research article Published on:

  47. In addition to anti-citrullinated protein antibodies (ACPAs), antibodies targeting carbamylated (i.e., homocitrullinated) proteins (anti-CarP antibodies) have been described in rheumatoid arthritis (RA). Howev...

    Authors: Evan Reed, Xia Jiang, Nastya Kharlamova, A. Jimmy Ytterberg, Anca I. Catrina, Lena Israelsson, Linda Mathsson-Alm, Monika Hansson, Lars Alfredsson, Johan Rönnelid and Karin Lundberg
    Citation: Arthritis Research & Therapy 2016 18:96
    Content type: Research article Published on:

  48. Sjögren’s syndrome (SjS) monocytes have a pro-inflammatory phenotype, which may influence SjS pathogenesis. MicroRNAs (miRNAs) are small endogenously expressed molecules that can inhibit protein expression of ...

    Authors: Adrienne E. G. Williams, Kevin Choi, Annie L. Chan, Yun Jong Lee, Westley H. Reeves, Michael R. Bubb, Carol M. Stewart and Seunghee Cha
    Citation: Arthritis Research & Therapy 2016 18:95
    Content type: Research article Published on:

  49. Factors associated with care concordant with the American College of Rheumatology (ACR) recommendations for the use of disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) are unknown.

    Authors: Leslie R. Harrold, George W. Reed, Joel M. Kremer, Jeffrey R. Curtis, Daniel H. Solomon, Marc C. Hochberg, Arthur Kavanaugh, Katherine C. Saunders, Ying Shan, Tanya M. Spruill, Dimitrios A. Pappas and Jeffrey D. Greenberg
    Citation: Arthritis Research & Therapy 2016 18:94
    Content type: Research article Published on:

  50. TNF inhibitors have been used as a treatment for moderate to severe RA patients. However, reliable biomarkers that predict therapeutic response to TNF inhibitors are lacking. In this study, we investigated whe...

    Authors: Bobby Kwanghoon Han, Igor Kuzin, John P. Gaughan, Nancy J. Olsen and Andrea Bottaro
    Citation: Arthritis Research & Therapy 2016 18:93
    Content type: Research article Published on:
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Arthritis Research & Therapy

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