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  1. Autoreactive T cells are a central element in many systemic autoimmune diseases. The generation of these pathogenic T cells is instructed by antigen-presenting cells (APCs). However, signaling pathways in APCs...

    Authors: Stephan Blüml, Emine Sahin, Victoria Saferding, Eliana Goncalves-Alves, Eva Hainzl, Birgit Niederreiter, Anastasia Hladik, Tobias Lohmeyer, Julia S. Brunner, Michael Bonelli, Marije I. Koenders, Wim B. van den Berg, Giulio Superti-Furga, Josef S. Smolen, Gernot Schabbauer and Kurt Redlich
    Citation: Arthritis Research & Therapy 2015 17:230
    Content type: Research article Published on:

  2. Bone is an integral part of the osteoarthritis (OA) process. We conducted a systematic literature review in order to understand the relationship between non-conventional radiographic imaging of subchondral bon...

    Authors: Andrew J. Barr, T. Mark Campbell, Devan Hopkinson, Sarah R. Kingsbury, Mike A. Bowes and Philip G. Conaghan
    Citation: Arthritis Research & Therapy 2015 17:228
    Content type: Research article Published on:

  3. Semaphorin 4A (Sema4A) plays critical roles in many physiological and pathological processes including neuronal development, angiogenesis, immune response regulation, autoimmunity, and infectious diseases. The...

    Authors: Lin Wang, Guanhua Song, Yabing Zheng, Weiwei Tan, Jihong Pan, Yu Zhao and Xiaotian Chang
    Citation: Arthritis Research & Therapy 2015 17:227
    Content type: Research article Published on:

  4. The western population is ageing. It is unknown whether age at diagnosis affects the severity of Rheumatoid Arthritis (RA), we therefore performed the present study.

    Authors: Lukas Mangnus, Hanna W. van Steenbergen, Elisabet Lindqvist, Elisabeth Brouwer, Monique Reijnierse, Tom WJ Huizinga, Peter K. Gregersen, Ewa Berglin, Solbritt Rantapää-Dahlqvist, Désirée van der Heijde and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2015 17:222
    Content type: Research article Published on:

  5. Although the role of platelets in rheumatoid arthritis (RA) is relatively unexplored, recent studies point towards a contribution of platelets in arthritis. We set out to determine platelet phenotype in RA and...

    Authors: Kim L.L. Habets, Leendert A. Trouw, E.W. Nivine Levarht, Suzanne J.A. Korporaal, Petra A.M. Habets, Philip de Groot, Tom W.J. Huizinga and René E.M. Toes
    Citation: Arthritis Research & Therapy 2015 17:209
    Content type: Research article Published on:

  6. The aim of this study was to clarify the effectiveness of various imaging modalities and characteristic imaging features in the screening of IgG4-related dacryoadenitis and sialadenitis (IgG4-DS), and to show ...

    Authors: Mayumi Shimizu, Kazutoshi Okamura, Yoshitaka Kise, Yohei Takeshita, Hiroko Furuhashi, Warangkana Weerawanich, Masafumi Moriyama, Yukiko Ohyama, Sachiko Furukawa, Seiji Nakamura and Kazunori Yoshiura
    Citation: Arthritis Research & Therapy 2015 17:223
    Content type: Research article Published on:

  7. Fibromyalgia is characterized by widespread pain and is often accompanied by accessory symptoms. There are limited treatment options for this condition in Japan. Therefore, we conducted a phase III study to as...

    Authors: Masato Murakami, Kenichi Osada, Hiromichi Mizuno, Toshimitsu Ochiai, Levent Alev and Kusuki Nishioka
    Citation: Arthritis Research & Therapy 2015 17:224
    Content type: Research article Published on:

  8. The vascular and nervous systems have several anatomic and molecular mechanism similarities. Emerging evidence suggests that proteins involved in transmitting axonal guidance cues, including members of class I...

    Authors: Celestina Mazzotta, Eloisa Romano, Cosimo Bruni, Mirko Manetti, Gemma Lepri, Silvia Bellando-Randone, Jelena Blagojevic, Lidia Ibba-Manneschi, Marco Matucci-Cerinic and Serena Guiducci
    Citation: Arthritis Research & Therapy 2015 17:221
    Content type: Research article Published on:

  9. Abatacept is a fusion protein of human cytotoxic T-lymphocyte–associated protein (CTLA)-4 and the Fc portion of human immunoglobulin G1 (IgG1). It is believed to be effective in the treatment of rheumatoid art...

    Authors: Diahann TSL Jansen, Hanane el Bannoudi, Ramon Arens, Kim LL Habets, Marjolijn Hameetman, Tom WJ Huizinga, Jeroen N. Stoop and René EM Toes
    Citation: Arthritis Research & Therapy 2015 17:220
    Content type: Research article Published on:

  10. In the new millennium, clinical outcomes in patients with rheumatoid arthritis (RA) have improved. Despite a large number of register data, there is a lack of data reflecting the entire outpatient RA populatio...

    Authors: Glenn Haugeberg, Inger Johanne Widding Hansen, Dag Magnar Soldal and Tuulikki Sokka
    Citation: Arthritis Research & Therapy 2015 17:219
    Content type: Research article Published on:

  11. Blisibimod is a potent B cell-activating factor (BAFF) antagonist that binds to both cell membrane-expressed and soluble BAFF. The goal of these first-in-human studies was to characterize the safety, tolerabil...

    Authors: William Stohl, Joan T. Merrill, R. John Looney, Jill Buyon, Daniel J. Wallace, Michael H. Weisman, Ellen M. Ginzler, Blaire Cooke, Donna Holloway, Arunan Kaliyaperumal, Kameswara Rao Kuchimanchi, Tsui Chern Cheah, Erik Rasmussen, John Ferbas, Shelley S. Belouski, Wayne Tsuji…
    Citation: Arthritis Research & Therapy 2015 17:215
    Content type: Research article Published on:

  12. Chronic low back pain due to intervertebral disc (IVD) degeneration is associated with increased levels of inflammatory mediators. Current medical treatment consists of oral anti-inflammatory drugs to alleviat...

    Authors: Nicole Willems, Hsiao-yin Yang, Marloes L. P. Langelaan, Anna R. Tellegen, Guy C. M. Grinwis, Hendrik-Jan C. Kranenburg, Frank M. Riemers, Saskia G. M. Plomp, Eric G. M. Craenmehr, Wouter J. A. Dhert, Nicole E. Papen-Botterhuis, Björn P. Meij, Laura B. Creemers and Marianna A. Tryfonidou
    Citation: Arthritis Research & Therapy 2015 17:214
    Content type: Research article Published on:

  13. Systemic rheumatic conditions are often accompanied by intraocular inflammatory disease (termed uveitis). Despite the frequent manifestation of uveitis with arthritis, very little is understood of the underlying ...

    Authors: Ellen J. Lee, Emily E. Vance, Brieanna R. Brown, Paige S. Snow, Jenna S. Clowers, Shimon Sakaguchi and Holly L. Rosenzweig
    Citation: Arthritis Research & Therapy 2015 17:218
    Content type: Research article Published on:

  16. Tyrosine kinase inhibitors (TKI) are medications of interest in the treatment of Systemic Sclerosis (SSc) because of their ability to inhibit pathways involved in fibrosis. In this open-label pilot trial, our ...

    Authors: Jessica K. Gordon, Viktor Martyanov, Cynthia Magro, Horatio F. Wildman, Tammara A. Wood, Wei-Ti Huang, Mary K. Crow, Michael L. Whitfield and Robert F. Spiera
    Citation: Arthritis Research & Therapy 2015 17:213
    Content type: Research article Published on:

  17. Structural alterations in intra-articular and subchondral compartments are hallmarks of osteoarthritis, a degenerative disease that causes pain and disability in the aging population. Protein kinase C delta (P...

    Authors: Xiaohong Yang, Dian Teguh, Jian-Ping Wu, Bo He, Thomas Brett Kirk, Shengnan Qin, Siming Li, Honghui Chen, Wei Xue, Benjamin Ng, Shek Man Chim, Jennifer Tickner and Jiake Xu
    Citation: Arthritis Research & Therapy 2015 17:210
    Content type: Research article Published on:

  18. Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these patients, particularly with the widespread use of...

    Authors: Teresa A. Simon, Adam Thompson, Kunal K. Gandhi, Marc C. Hochberg and Samy Suissa
    Citation: Arthritis Research & Therapy 2015 17:212
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:100

  19. The aim was to study the association between 25-hydroxyvitamin D (25(OH)D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD).

    Authors: Ana Urruticoechea-Arana, María A. Martín-Martínez, Santos Castañeda, Carlos A. Sanchez Piedra, Carlos González-Juanatey, Javier Llorca, Federico Díaz-Gonzalez and Miguel A. González-Gay
    Citation: Arthritis Research & Therapy 2015 17:211
    Content type: Research article Published on:

  20. There is evidence that interferon is involved in the pathogenesis of primary Sjögren’s syndrome (pSS). The interferon-inducible IFI16 protein, normally expressed in cell nuclei, may be overexpressed, mislocali...

    Authors: Alessia Alunno, Valeria Caneparo, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Roberto Giacomelli, Marisa Gariglio, Santo Landolfo and Roberto Gerli
    Citation: Arthritis Research & Therapy 2015 17:208
    Content type: Research article Published on:

  21. Antibodies against mutated citrullinated vimentin (AMCV) represent a useful diagnostic marker with correlation to disease activity in patients with rheumatoid arthritis (RA). Since seropositivity for citrullin...

    Authors: Luisa Lindenberg, Lydia Spengler, Holger Bang, Thomas Dorner, Aleksej L Maslyanskiy, Sergey V Lapin, Elena I Ilivanova, Lorena Martinez-Gamboa, Hans Bastian, Esther Wittenborn, Karl Egerer, Gerd-R Burmester and Eugen Feist
    Citation: Arthritis Research & Therapy 2015 17:206
    Content type: Research article Published on:

  22. Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since th...

    Authors: Jonatan Leffler, Katarzyna Ciacma, Birgitta Gullstrand, Anders A. Bengtsson, Myriam Martin and Anna M. Blom
    Citation: Arthritis Research & Therapy 2015 17:205
    Content type: Research article Published on:

  23. Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the centra...

    Authors: David Andrew Rice, Thomas Graven-Nielsen, Gwyn Nancy Lewis, Peter John McNair and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2015 17:204
    Content type: Research article Published on:

  25. The pathophysiology of cutaneous lupus erythematosus (CLE) encompasses the complex interactions between genetics, the environment, and cells and their products. Recent data have provided enhanced understanding...

    Authors: Jordan C Achtman and Victoria P Werth
    Citation: Arthritis Research & Therapy 2015 17:182
    Content type: Review Published on:

  26. Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. Gene variants directly affect the normal processes of a series of physiological and biochemical reactions, and therefore ...

    Authors: Weiying Zheng and Shaoqi Rao
    Citation: Arthritis Research & Therapy 2015 17:202
    Content type: Research article Published on:

  27. Approximately 30 % of juvenile idiopathic arthritis (JIA) patients fail to respond to anti-TNF treatment. When clinical remission is induced, some patients relapse after treatment has been stopped. We tested t...

    Authors: Janneke Anink, Lisette W. A. Van Suijlekom-Smit, Marieke H. Otten, Femke H. M. Prince, Marion A. J. van Rossum, Koert M. Dolman, Esther P. A. H. Hoppenreijs, Rebecca ten Cate, Simona Ursu, Lucy R. Wedderburn, Gerd Horneff, Michael Frosch, Thomas Vogl, Faekah Gohar, Dirk Foell, Johannes Roth…
    Citation: Arthritis Research & Therapy 2015 17:200
    Content type: Research article Published on:

  28. A major problem in cartilage repair is the lack of chondrogenic cells migrating from healthy tissue into defects. Cartilage is essentially avascular and therefore its healing is not considered to involve monon...

    Authors: Niina Hopper, Frances Henson, Roger Brooks, Erden Ali, Neil Rushton and John Wardale
    Citation: Arthritis Research & Therapy 2015 17:199
    Content type: Research article Published on:

  29. Significant pulmonary vascular disease is a leading cause of death in patients with scleroderma, and early detection and early medical intervention are important, as they may delay disease progression and impr...

    Authors: Zsuzsanna McMahan, Florian Schoenhoff, Jennifer E. Van Eyk, Fredrick M. Wigley and Laura K. Hummers
    Citation: Arthritis Research & Therapy 2015 17:201
    Content type: Research article Published on:

  30. IL-17 has a putative role in the pathophysiology of Sjogren’s syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated ...

    Authors: Changgong Wu, Zhimin Wang, Lee Zourelias, Hiteshi Thakker and Michael J. Passineau
    Citation: Arthritis Research & Therapy 2015 17:198
    Content type: Research article Published on:

  31. Use of disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) may prevent joint damage and potentially reduce joint replacement surgeries. We assessed the association between RA drug use ...

    Authors: Cristiano S. Moura, Michal Abrahamowicz, Marie-Eve Beauchamp, Diane Lacaille, Yishu Wang, Gilles Boire, Paul R. Fortin, Louis Bessette, Claire Bombardier, Jessica Widdifield, John G. Hanly, Debbie Feldman, Walter Maksymowych, Christine Peschken, Cheryl Barnabe, Steve Edworthy…
    Citation: Arthritis Research & Therapy 2015 17:197
    Content type: Research article Published on:

  33. Transforming growth factor (TGF)-β and interleukin (IL)-13 play a crucial role in the pathogenesis of systemic sclerosis (SSc), partly through activation of collagen production that leads to fibrosis. The aim ...

    Authors: Julie Baraut, Dominique Farge, Francette Jean-Louis, Ingrid Masse, Elena Ivan Grigore, Lucas C. M. Arruda, Jérôme Lamartine, Franck Verrecchia and Laurence Michel
    Citation: Arthritis Research & Therapy 2015 17:196
    Content type: Research article Published on:

  34. Giant cell arteritis (GCA) is an autoimmune disease commonest in Northern Europe and Scandinavia. Previous studies report various associations with HLA-DRB1*04 and HLA-DRB1*01; HLA-DRB1 alleles show a gradient in...

    Authors: Sarah Louise Mackie, John C. Taylor, Lubna Haroon-Rashid, Stephen Martin, Bhaskar Dasgupta, Andrew Gough, Michael Green, Lesley Hordon, Stephen Jarrett, Colin T. Pease, Jennifer H. Barrett, Richard Watts and Ann W. Morgan
    Citation: Arthritis Research & Therapy 2015 17:195
    Content type: Research article Published on:

  35. Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no animal scleroderma esophagus models and esophageal sm...

    Authors: Jaclyn N. Taroni, Viktor Martyanov, Chiang-Ching Huang, J. Matthew Mahoney, Ikuo Hirano, Brandon Shetuni, Guang-Yu Yang, Darren Brenner, Barbara Jung, Tammara A. Wood, Swati Bhattacharyya, Orit Almagor, Jungwha Lee, Arlene Sirajuddin, John Varga, Rowland W. Chang…
    Citation: Arthritis Research & Therapy 2015 17:194
    Content type: Research article Published on:

  36. We previously reported that low ratio of osteoprotegerin (OPG) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was associated with Disease Activity Score in 28 joints (DAS28) remission at 6 ...

    Authors: Rachel Audo, Claire Daien, Laura Papon, Cédric Lukas, Olivier Vittecoq, Michael Hahne, Bernard Combe and Jacques Morel
    Citation: Arthritis Research & Therapy 2015 17:193
    Content type: Research article Published on:

  37. Bone morphogenetic proteins (BMPs) are multifunctional secreted growth factors regulating a broad spectrum of functions in numerous systems. An increased expression and production of specific BMPs have been de...

    Authors: Alberto Varas, Jaris Valencia, Fabien Lavocat, Víctor G. Martínez, Ndiémé Ndongo Thiam, Laura Hidalgo, Lidia M. Fernández-Sevilla, Rosa Sacedón, Angeles Vicente and Pierre Miossec
    Citation: Arthritis Research & Therapy 2015 17:192
    Content type: Research article Published on:

  38. Substantial weakness of the quadriceps muscles is typically observed in patients with arthritis. This is partly due to ongoing neural inhibition that prevents the quadriceps from being fully activated. Evidenc...

    Authors: David Andrew Rice, Peter John McNair, Gwyn Nancy Lewis and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2015 17:191
    Content type: Research article Published on:

  39. Pre-naïve B cells represent an intermediate stage in human B-cell development with some functions of mature cells, but their involvement in immune responses is unknown. The aim of this study was to determine t...

    Authors: Ji Hyun Sim, Hang-Rae Kim, Soog-Hee Chang, In Je Kim, Peter E. Lipsky and Jisoo Lee
    Citation: Arthritis Research & Therapy 2015 17:190
    Content type: Research article Published on:

  40. Postmenopausal women with rheumatoid arthritis (RA) have increased risk of developing osteoporosis due to chronic inflammation and estrogen deprivation. Collagen antibody-induced arthritis (CAIA), an experimen...

    Authors: Louise Grahnemo, Annica Andersson, Merja Nurkkala-Karlsson, Alexandra Stubelius, Marie K. Lagerquist, Mattias N. D. Svensson, Claes Ohlsson, Hans Carlsten and Ulrika Islander
    Citation: Arthritis Research & Therapy 2015 17:189
    Content type: Research article Published on:

  41. The performance of ultrasound (US) in the diagnosis of acute gouty (MSU) arthritis and calcium pyrophosphate (CPP) arthritis is not yet well defined. Most studies evaluated US as the basis for diagnosing cryst...

    Authors: Pascal Zufferey, Roxana Valcov, Isabelle Fabreguet, Alexandre Dumusc, Patrick Omoumi and Alexander So
    Citation: Arthritis Research & Therapy 2015 17:188
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2015 17:255

  42. Schnitzler’s syndrome (SchS) is a disabling autoinflammatory disorder, characterized by a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) ...

    Authors: Heleen D. de Koning, Joost Schalkwijk, Monique Stoffels, Johanna Jongekrijg, Joannes F. M. Jacobs, Eugène Verwiel, Hans J. P. M. Koenen, Frank Preijers, Dirk Holzinger, Irma Joosten, Jos W. M. van der Meer and Anna Simon
    Citation: Arthritis Research & Therapy 2015 17:187
    Content type: Research article Published on:

  43. Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohi...

    Authors: Wei Li, Yan Chen, Zhi-Peng Sun, Zhi-Gang Cai, Tong-Tong Li, Lei Zhang, Min-Xian Huang, Hong Hua, Mei Li, Xia Hong, Jia-Zeng Su, Zhu-Yan Zhang, Yan-Ying Liu, Jing He, Zhan-Guo Li, Yan Gao…
    Citation: Arthritis Research & Therapy 2015 17:186
    Content type: Research article Published on:

  44. Measuring lupus disease activity accurately remains a challenging and demanding task given the complex multi-system nature of lupus, an illness known for its variability between patients and within the same pa...

    Authors: Jamal Mikdashi and Ola Nived
    Citation: Arthritis Research & Therapy 2015 17:183
    Content type: Review Published on:

  45. Cytokines produced by B cells are believed to play important roles in autoimmune diseases. CD22 targeting by epratuzumab has been demonstrated to inhibit phosphorylation of B cell receptor (BCR) downstream sig...

    Authors: Vanessa Fleischer, Julia Sieber, Sarah J. Fleischer, Anthony Shock, Guido Heine, Capucine Daridon and Thomas Dörner
    Citation: Arthritis Research & Therapy 2015 17:185
    Content type: Research article Published on:

  46. To investigate the connection between the intensity of initial symptoms of inflammation and locomotor outcome in rheumatoid arthritis, we examined the relationship between long-term locomotor abnormalities and...

    Authors: Claude Mossiat, Davy Laroche, Clément Prati, Thierry Pozzo, Céline Demougeot and Christine Marie
    Citation: Arthritis Research & Therapy 2015 17:184
    Content type: Research article Published on:

  47. In ankylosing spondylitis (AS), joint remodeling leading to joint ankylosis involves cartilage fusion. Here, we analyzed whether chondrocyte hypertrophy is involved in cartilage fusion and subsequent joint rem...

    Authors: Janine Bleil, Joachim Sieper, Rene Maier, Uwe Schlichting, Axel Hempfing, Uta Syrbe and Heiner Appel
    Citation: Arthritis Research & Therapy 2015 17:170
    Content type: Research article Published on:

  48. Juvenile idiopathic arthritis (JIA) is a frequent childhood rheumatic disease characterized by chronic inflammation. The latter has been related to impairment of arterial functional-structural properties, athe...

    Authors: Jaanika Ilisson, Maksim Zagura, Kersti Zilmer, Erik Salum, Kaire Heilman, Anneli Piir, Vallo Tillmann, Jaak Kals, Mihkel Zilmer and Chris Pruunsild
    Citation: Arthritis Research & Therapy 2015 17:180
    Content type: Research article Published on:

  50. The foot is largely overlooked in calls for better characterisation of clinical phenotypes in osteoarthritis (OA). Yet the midfoot complex in particular has the potential to provide important insights into OA ...

    Authors: Martin J. Thomas, George Peat, Trishna Rathod, Michelle Marshall, Andrew Moore, Hylton B. Menz and Edward Roddy
    Citation: Arthritis Research & Therapy 2015 17:178
    Content type: Research article Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 4.4
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Arthritis Research & Therapy

ISSN: 1478-6362

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