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  1. Rheumatoid arthritis (RA) is a systemic autoimmune disease in which T cells play a pivotal role in the pathogenesis. Knowledge in terms of the CD4 T-cell transcriptome in RA is limited. The aim of this study w...

    Authors: Hua Ye, Jing Zhang, Jun Wang, Yanyan Gao, Yan Du, Chun Li, Minghua Deng, Jianping Guo and Zhanguo Li
    Citation: Arthritis Research & Therapy 2015 17:76
    Content type: Research article Published on:

  2. Type I interferons are pivotal in the activation of autoimmune response in systemic lupus erythematous. However, the pathogenic role of interferon-alpha in patients affected by lupus nephritis remains uncertai...

    Authors: Giuseppe Castellano, Cesira Cafiero, Chiara Divella, Fabio Sallustio, Margherita Gigante, Paola Pontrelli, Giuseppe De Palma, Michele Rossini, Giuseppe Grandaliano and Loreto Gesualdo
    Citation: Arthritis Research & Therapy 2015 17:72
    Content type: Research article Published on:

  3. Systemic sclerosis (SSc) and primary biliary cirrhosis (PBC) are rare polygenic autoimmune diseases (AIDs) characterized by fibroblast dysfunction. Furthermore, both diseases share some genetic bases with othe...

    Authors: Maria Arismendi, Matthieu Giraud, Nadira Ruzehaji, Philippe Dieudé, Eugenie Koumakis, Barbara Ruiz, Paolo Airo, Daniele Cusi, Marco Matucci-Cerinic, Erika Salvi, Giovanna Cuomo, Eric Hachulla, Elisabeth Diot, Paola Caramaschi, Valeria Riccieri, Jérôme Avouac…
    Citation: Arthritis Research & Therapy 2015 17:71
    Content type: Research article Published on:

  5. Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the causal role of cathepsins in OA, monitoring their sp...

    Authors: Louisa Ben-Aderet, Emmanuelle Merquiol, Duha Fahham, Ashok Kumar, Eli Reich, Yael Ben-Nun, Leonid Kandel, Amir Haze, Meir Liebergall, Marta K Kosińska, Juergen Steinmeyer, Boris Turk, Galia Blum and Mona Dvir-Ginzberg
    Citation: Arthritis Research & Therapy 2015 17:69
    Content type: Research article Published on:

  6. Systemic lupus erythematosus (SLE) is a heterogeneous disease with a diverse spectrum of clinical symptoms, ranging from skin rash to end-organ damage. 22q11.21 has been identified as a susceptibility region f...

    Authors: Yan Zhang, Yong-Fei Wang, Jing Yang, Jing Zhang, Liangdan Sun, Nattiya Hirankarn, Hai-Feng Pan, Chak Sing Lau, Tak Mao Chan, Tsz Leung Lee, Alexander Moon Ho Leung, Chi Chiu Mok, Lu Zhang, Jiangshan Jane Shen, Sik Nin Wong, Ka Wing Lee…
    Citation: Arthritis Research & Therapy 2015 17:67
    Content type: Research article Published on:

  7. The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in...

    Authors: Joana M Xavier, Fereydoun Davatchi, Olga Abade, Farhad Shahram, Vânia Francisco, Bahar Sadeghi Abdollahi, Hélder Trindade, Abdolhadi Nadji, Niloofar Mojarad Shafiee, Fahmida Ghaderibarmi, Dário Ligeiro and Sofia A Oliveira
    Citation: Arthritis Research & Therapy 2015 17:81
    Content type: Research article Published on:

  8. This randomized, double-blind, phase II study evaluated the pharmacodynamics, safety and tolerability of ISIS 329993 (ISIS-CRPRx), an antisense oligonucleotide, in patients with active rheumatoid arthritis (RA).

    Authors: Marshelle S Warren, Steven G Hughes, Walter Singleton, Mason Yamashita and Mark C Genovese
    Citation: Arthritis Research & Therapy 2015 17:80
    Content type: Research article Published on:

  9. There is argument over the benefits and risks of drugs for treating chronic musculoskeletal pain. This study compared the efficacy, safety, and tolerability of diclofenac, ibuprofen, naproxen, celecoxib, and e...

    Authors: Anneloes van Walsem, Shaloo Pandhi, Richard M Nixon, Patricia Guyot, Andreas Karabis and R Andrew Moore
    Citation: Arthritis Research & Therapy 2015 17:66
    Content type: Research article Published on:

  10. Transglutaminase 2 (TG2), a protein crosslinking enzyme with multiple biochemical functions, has been connected to various inflammatory processes. In this study, the involvement of TG2 in monosodium urate (MSU...

    Authors: Jia-Hau Yen, Ling-Chung Lin, Meng-Chi Chen, Zsolt Sarang, Pui-Ying Leong, I-Chang Chang, Jeng-Dong Hsu, Jiunn-Horng Chen, Yu-Fan Hsieh, Anna Pallai, Krisztina Köröskényi, Zsuzsa Szondy and Gregory J Tsay
    Citation: Arthritis Research & Therapy 2015 17:65
    Content type: Research article Published on:

  11. High mobility group box-1 (HMGB1), a typical damage-associated molecular pattern (DAMP) protein, is associated with inflammatory conditions and tissue damage. Our recent study found that circulating HMGB1 leve...

    Authors: Chen Wang, Huan Wang, Dong-Yuan Chang, Jian Hao, Ming-Hui Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2015 17:64
    Content type: Research article Published on:

  12. We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tum...

    Authors: Ariana Montes, Eva Perez-Pampin, Federico Navarro-Sarabia, Virginia Moreira, Arturo Rodríguez de la Serna, Berta Magallares, Yiannis Vasilopoulos, Theologia Sarafidou, Antonio Fernández-Nebro, María del Carmen Ordóñez, Javier Narváez, Juan D Cañete, Ana Marquez, Dora Pascual-Salcedo, Beatriz Joven, Patricia Carreira…
    Citation: Arthritis Research & Therapy 2015 17:63
    Content type: Research article Published on:

  13. The aim of this study was to examine whether the cumulative inflammatory burden is associated with an increase in arterial stiffness in a prospective cohort of psoriatic arthritis (PsA) patients.

    Authors: Jiayun Shen, Qing Shang, Edmund K Li, Ying-Ying Leung, Emily W Kun, Lai-Wa Kwok, Martin Li, Tena K Li, Tracy Y Zhu, Cheuk-Man Yu and Lai-Shan Tam
    Citation: Arthritis Research & Therapy 2015 17:75
    Content type: Research article Published on:

  14. Abnormal oxidative stress has been described in systemic sclerosis (SSc) and previous works from our laboratory demonstrated an increased generation of reactive oxygen species (ROS) by SSc fibroblasts and mono...

    Authors: Donatella Amico, Tatiana Spadoni, Marina Rovinelli, Marta Serafini, Giovanna D’Amico, Nadia Campelli, Silvia Svegliati Baroni and Armando Gabrielli
    Citation: Arthritis Research & Therapy 2015 17:68
    Content type: Research article Published on:

  15. Hepatitis C virus (HCV) infection can be detected in virtually all patients with cryoglobulinemic vasculitis (CV). Among its many effects, the virus is able to stimulate the production of thymic stromal lymphopoi...

    Authors: Domenico Sansonno, Sabino Russi, Silvia Sansonno, Fabio Pavone and Franco Dammacco
    Citation: Arthritis Research & Therapy 2015 17:62
    Content type: Research article Published on:

  16. Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker ...

    Authors: Zafar Mahmood, Khalid Muhammad, Marc Schmalzing, Petra Roll, Thomas Dörner and Hans-Peter Tony
    Citation: Arthritis Research & Therapy 2015 17:61
    Content type: Research article Published on:

  17. Early degenerative changes in the nucleus pulposus (NP) are observed after the disappearance of notochordal cells (NCs). Thus, it has been suggested that NCs play an important role in maintaining the NP and ma...

    Authors: Irene TM Arkesteijn, Lucas A Smolders, Sandra Spillekom, Frank M Riemers, Esther Potier, Björn P Meij, Keita Ito and Marianna A Tryfonidou
    Citation: Arthritis Research & Therapy 2015 17:60
    Content type: Research article Published on:

  18. The aims of the present study were: (a) to examine the agreement between subjective (assessed via the International Physical Activity Questionnaire; IPAQ) and objective (accelerometry; GT3X) physical activity ...

    Authors: Chen-an Yu, Peter C Rouse, Jet JCS Veldhuijzen Van Zanten, Nikos Ntoumanis, George D Kitas, Joan L Duda and George S Metsios
    Citation: Arthritis Research & Therapy 2015 17:59
    Content type: Research article Published on:

  19. Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow an...

    Authors: Stephen Kelly, Michele Bombardieri, Frances Humby, Nora Ng, Alessandra Marrelli, Sudeh Riahi, Maria DiCicco, Arti Mahto, Lu Zou, Debasish Pyne, Rebecca E Hands and Costantino Pitzalis
    Citation: Arthritis Research & Therapy 2015 17:58
    Content type: Research article Published on:

  20. Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3...

    Authors: Yoshinao Muro, Yuji Hosono, Kazumitsu Sugiura, Yasushi Ogawa, Tsuneyo Mimori and Masashi Akiyama
    Citation: Arthritis Research & Therapy 2015 17:57
    Content type: Research article Published on:

  21. Rheumatoid arthritis (RA) is characterized by decreased androgen levels, which was the first hormonal abnormality described. Several studies indicated that steroidogenesis is directed towards endogenous glucoc...

    Authors: Klaus Stark, Rainer H Straub, Jozef Rovenský, Stanislava Blažičková, Gabriele Eiselt and Martin Schmidt
    Citation: Arthritis Research & Therapy 2015 17:56
    Content type: Research article Published on:

  22. We previously reported that most patients with rheumatoid arthritis (RA) and moderate cardiovascular disease (CVD) risk according to the Systematic COronary Evaluation score (SCORE) experience carotid artery p...

    Authors: Alfonso Corrales, Patrick H Dessein, Linda Tsang, Trinitario Pina, Ricardo Blanco, Carlos Gonzalez-Juanatey, Javier Llorca and Miguel A Gonzalez-Gay
    Citation: Arthritis Research & Therapy 2015 17:55
    Content type: Research article Published on:

  23. Chondrocytes rely primarily on glycolysis to meet cellular energy needs, but recent studies implicate impaired mitochondrial function in osteoarthritis (OA) pathogenesis. Our objectives were to investigate the...

    Authors: Rachel S Lane, Yao Fu, Satoshi Matsuzaki, Michael Kinter, Kenneth M Humphries and Timothy M Griffin
    Citation: Arthritis Research & Therapy 2015 17:54
    Content type: Research article Published on:

  24. The lacrimal gland (LG) of the CD25-/- model of Sjögren’s syndrome (SS) has high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific contribution of these cytokines to the onset and se...

    Authors: Fang Bian, Flavia L Barbosa, Rosa M Corrales, Flavia SA Pelegrino, Eugene A Volpe, Stephen C Pflugfelder and Cintia S de Paiva
    Citation: Arthritis Research & Therapy 2015 17:53
    Content type: Research article Published on:

  25. Intra-articular injection of hyaluronic acid (HA) is often used as therapy for knee osteoarthritis because it is less expensive and less aggressive than total knee replacement. Therefore, it is important to do...

    Authors: Heng Zhang, Ke Zhang, Xianlong Zhang, Zhenan Zhu, Shigui Yan, Tiansheng Sun, Ai Guo, John Jones, R Grant Steen, Bin Shan, Jenny Zhang and Jianhao Lin
    Citation: Arthritis Research & Therapy 2015 17:51
    Content type: Research article Published on:

  26. Development of non-invasive molecular imaging techniques that are based on cellular changes in inflammation has been of active interest for arthritis diagnosis. This technology will allow real-time detection o...

    Authors: Marion M Chan, Brian D Gray, Koon Y Pak and Dunne Fong
    Citation: Arthritis Research & Therapy 2015 17:50
    Content type: Research article Published on:

  27. The advent of anti-tumor necrosis factor alpha (anti-TNFα) drugs has considerably improved medical management in rheumatoid arthritis (RA) patients, although it has been reported to be ineffective in a fractio...

    Authors: Carmen Castro-Villegas, Carlos Pérez-Sánchez, Alejandro Escudero, Ileana Filipescu, Miriam Verdu, Patricia Ruiz-Limón, Ma Angeles Aguirre, Yolanda Jiménez-Gomez, Pilar Font, Antonio Rodriguez-Ariza, Juan Ramon Peinado, Eduardo Collantes-Estévez, Rocío González-Conejero, Constantino Martinez, Nuria Barbarroja and Chary López-Pedrera
    Citation: Arthritis Research & Therapy 2015 17:49
    Content type: Research article Published on:

  28. Treat-to-target (T2T) strategies using a protocol of pre-defined adjustments of disease-modifying anti-rheumatic drugs (DMARDs) according to disease activity improve outcomes for patients with rheumatoid arthr...

    Authors: Nasir Wabe, Michael J Sorich, Mihir D Wechalekar, Leslie G Cleland, Leah McWilliams, Anita Lee, Llewellyn Spargo, Robert G Metcalf, Cindy Hall, Susanna M Proudman and Michael D Wiese
    Citation: Arthritis Research & Therapy 2015 17:48
    Content type: Research article Published on:

  29. The goal of this study was to investigate (1) the associations of rheumatoid arthritis (RA)-related inflammation or rheumatoid factor/anti-cyclic citrullinated peptide (anti-CCP) positivity with lipid profiles...

    Authors: Der-Yuan Chen, Yi-Ming Chen, Tsu-Yi Hsieh, Chia-Wei Hsieh, Chi-Chen Lin and Joung-Liang Lan
    Citation: Arthritis Research & Therapy 2015 17:52
    Content type: Research article Published on:

  30. The aim of this study was to examine the prevalence and functional effects of antibodies directed against Factor (F)Xa and other serine proteases (SP) in patients with antiphospholipid syndrome (APS).

    Authors: Bahar Artim-Esen, Charis Pericleous, Ian Mackie, Vera M Ripoll, David Latchman, David Isenberg, Anisur Rahman, Yiannis Ioannou and Ian Giles
    Citation: Arthritis Research & Therapy 2015 17:47
    Content type: Research article Published on:

  31. The introduction of tumor necrosis factor-alpha (TNF-α) antagonists has substantially improved patient’s clinical outcome in rheumatoid arthritis (RA). However, nearly 20% to 40% of RA patients do not respond ...

    Authors: Sabine Blaschke, Kathinka Rinke, Michael Maring, Thomas Flad, Susann Patschan, Olaf Jahn, Claudia A Mueller, Gerhard A Mueller and Hassan Dihazi
    Citation: Arthritis Research & Therapy 2015 17:45
    Content type: Research article Published on:

  33. In patients with systemic sclerosis (SSc), digital ischemia results from an occlusive microvasculopathy that may not respond adequately to conventional vasodilators. Endothelin receptor antagonists can potenti...

    Authors: Nilanjana Bose, James Bena and Soumya Chatterjee
    Citation: Arthritis Research & Therapy 2015 17:44
    Content type: Research article Published on:

  34. Pathological bone changes differ considerably between inflammatory arthritic diseases and most studies have focused on bone erosion. Collagen-induced arthritis (CIA) is a model for rheumatoid arthritis, which,...

    Authors: Katja CM Denninger, Thomas Litman, Troels Marstrand, Kristian Moller, Lars Svensson, Tord Labuda and Åsa Andersson
    Citation: Arthritis Research & Therapy 2015 17:43
    Content type: Research article Published on:

  35. Several studies have shown that osteoarthritis (OA) is strongly associated with metabolism-related disorders, highlighting OA as the fifth component of the metabolic syndrome (MetS). On the basis of our previo...

    Authors: Fotini Kostopoulou, Konstantinos N Malizos, Ioanna Papathanasiou and Aspasia Tsezou
    Citation: Arthritis Research & Therapy 2015 17:42
    Content type: Research article Published on:

  36. C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proi...

    Authors: Kyoung-Woon Kim, Bo-Mi Kim, Hee-Won Moon, Sang-Heon Lee and Hae-Rim Kim
    Citation: Arthritis Research & Therapy 2015 17:41
    Content type: Research article Published on:

  37. Only one study has analysed the association between exercise and development of rheumatoid arthritis (RA), showing no association. Aim of this paper was to evaluate the association of physical activity in all ...

    Authors: Daniela Di Giuseppe, Matteo Bottai, Johan Askling and Alicja Wolk
    Citation: Arthritis Research & Therapy 2015 17:40
    Content type: Research article Published on:

  38. Autoantibodies contribute significantly to the pathogenesis of systemic lupus erythematosus (SLE). Unfortunately, the long-lived plasma cells (LLPCs) secreting such autoantibodies are refractory to conventiona...

    Authors: Adriano Taddeo, Laleh Khodadadi, Caroline Voigt, Imtiaz M Mumtaz, Qingyu Cheng, Katrin Moser, Tobias Alexander, Rudolf A Manz, Andreas Radbruch, Falk Hiepe and Bimba F Hoyer
    Citation: Arthritis Research & Therapy 2015 17:39
    Content type: Research article Published on:

  39. It is now well-recognised that patients with autoimmune rheumatic disease (AIRD) have a predisposition to cardiovascular disease that results in increased morbidity and mortality. Following myocardial infarcti...

    Authors: Sharon Van Doornum, Megan Bohensky, Mark A Tacey, Caroline A Brand, Vijaya Sundararajan and Ian P Wicks
    Citation: Arthritis Research & Therapy 2015 17:38
    Content type: Research article Published on:

  40. Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in the joints and soft tissues that can produce acute or chronic arthritis. Several animal models of crystal-induc...

    Authors: Carlos Pineda, Arturo J Fuentes-Gómez, Cristina Hernández-Díaz, Yessica Zamudio-Cuevas, Javier Fernández-Torres, Ambar López-Macay, Ismael Alba-Sánchez, Javier Camacho-Galindo, Lucio Ventura, Luis E Gómez-Quiróz, María Concepción Gutiérrez-Ruíz, Francisco García-Vázquez, Anthony M Reginato, Marwin Gutiérrez and Alberto López-Reyes
    Citation: Arthritis Research & Therapy 2015 17:37
    Content type: Research article Published on:

  41. Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis affecting the aorta and its major branches. Although the disease rarely affects children, it does occur, even in infants. The objective of this ...

    Authors: Despina Eleftheriou, Giulia Varnier, Pavla Dolezalova, Anne-Marie McMahon, Muthana Al-Obaidi and Paul A Brogan
    Citation: Arthritis Research & Therapy 2015 17:36
    Content type: Research article Published on:

  42. Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble thos...

    Authors: Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen and Georg H Stummvoll
    Citation: Arthritis Research & Therapy 2015 17:35
    Content type: Research article Published on:

  43. A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis...

    Authors: Federico Parra-Salcedo, Irazú Contreras-Yáñez, Daniel Elías-López, Carlos A Aguilar-Salinas and Virginia Pascual-Ramos
    Citation: Arthritis Research & Therapy 2015 17:34
    Content type: Research article Published on:

  44. The risk of tendon injury and disease increases significantly with increasing age. The aim of the study was to characterise transcriptional changes in human Achilles tendon during the ageing process in order t...

    Authors: Mandy Jayne Peffers, Yongxiang Fang, Kathleen Cheung, Tim Koh Jia Wei, Peter David Clegg and Helen Lucy Birch
    Citation: Arthritis Research & Therapy 2015 17:33
    Content type: Research article Published on:

  45. CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, w...

    Authors: Hidetoshi Tsushima, Ken Okazaki, Kohei Ishihara, Takahiro Ushijima and Yukihide Iwamoto
    Citation: Arthritis Research & Therapy 2015 17:31
    Content type: Research article Published on:

  46. Previous studies in animal models of osteoarthritis suggest that alendronate (ALN) has antiresorptive and chondroprotective effects, and can reduce osteophyte formation. However, these studies used non-physiol...

    Authors: Mohammad S Khorasani, Sindi Diko, Allison W Hsia, Matthew J Anderson, Damian C Genetos, Dominik R Haudenschild and Blaine A Christiansen
    Citation: Arthritis Research & Therapy 2015 17:30
    Content type: Research article Published on:

  47. The incidence and progression of many autoimmune diseases are sex-biased, which might be explained by the immunomodulating properties of endocrine hormones. Treatment with estradiol potently inhibits experimen...

    Authors: Annica Andersson, Alexandra Stubelius, Merja Nurkkala Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist and Ulrika Islander
    Citation: Arthritis Research & Therapy 2015 17:32
    Content type: Research article Published on:

  48. Cancer cells have long been known to fuel their pathogenic growth habits by sustaining a high glycolytic flux, first described almost 90 years ago as the so-called Warburg effect. Immune cells utilize a simila...

    Authors: Zhen Yang, Eric L Matteson, Jörg J Goronzy and Cornelia M Weyand
    Citation: Arthritis Research & Therapy 2015 17:29
    Content type: Review Published on:

  49. The aim of this study was to investigate the effects of thyroid hormones tri-iodothyronine (T3), thyroxine (T4), and parathyroid hormone (PTH) from the parathyroid glands, known to regulate the developing limb...

    Authors: Jennifer K Lee, Courtney A Gegg, Jerry C Hu, A Hari Reddi and Kyriacos A Athanasiou
    Citation: Arthritis Research & Therapy 2015 17:28
    Content type: Research article Published on:

  50. Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are ...

    Authors: Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun-ichiro Ohta, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Yoshifumi Tada, Takahiko Horiuchi and Koichi Akashi
    Citation: Arthritis Research & Therapy 2015 17:27
    Content type: Research article Published on:
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Arthritis Research & Therapy

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