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  1. IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosc...

    Authors: Sara Croca, Paul Bassett, Sharon Chambers, Maria Davari, Karim Fouad Alber, Oliver Leach, Yiannis Ioannou, Ian Giles, David Isenberg and Anisur Rahman
    Citation: Arthritis Research & Therapy 2015 17:26
    Content type: Research article Published on:

  2. The presence of a new autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, has been identified in rheumatoid arthritis (RA). The presence of anti-CarP antibodies was evaluated in samples take...

    Authors: Mikael Brink, Marije K Verheul, Johan Rönnelid, Ewa Berglin, Rikard Holmdahl, Rene EM Toes, Lars Klareskog, Leendert A Trouw and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2015 17:25
    Content type: Research article Published on:

  3. Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and...

    Authors: Wafa Bouaziz, Thomas Funck-Brentano, Hilène Lin, Caroline Marty, Hang-Korng Ea, Eric Hay and Martine Cohen-Solal
    Citation: Arthritis Research & Therapy 2015 17:24
    Content type: Research article Published on:

  5. The link between cardiovascular disease (CVD) and patients with chronic inflammation is not clearly understood. We examined a knock-in mouse expressing a poly-ubiquitin-binding-defective mutant of the protein ...

    Authors: Naveed Akbar, Sambit Nanda, Jill Belch, Philip Cohen and Faisel Khan
    Citation: Arthritis Research & Therapy 2015 17:22
    Content type: Research article Published on:

  6. Previous randomized controlled trials have led to conflicting findings regarding the effects of exercise on depressive symptoms in adults with arthritis and other rheumatic conditions (AORC). The purpose of th...

    Authors: George A Kelley, Kristi S Kelley and Jennifer M Hootman
    Citation: Arthritis Research & Therapy 2015 17:21
    Content type: Research article Published on:

  7. Microfracture does not properly repair full-thickness cartilage defects. The purpose of this study was to evaluate the effect of intraarticular injection of the small-molecule compound kartogenin (KGN) on the ...

    Authors: Xingquan Xu, Dongquan Shi, Yeshuai Shen, Zhihong Xu, Jin Dai, Dongyang Chen, Huajian Teng and Qing Jiang
    Citation: Arthritis Research & Therapy 2015 17:20
    Content type: Research article Published on:

  8. Occupational exposure to heavy lifting and stair climbing are associated with radiographic hip osteoarthritis (OA). This study examined whether these activities are associated with early structural hip joint c...

    Authors: Andrew J Teichtahl, Sam Smith, Yuanyuan Wang, Anita E Wluka, Richard O’Sullivan, Graham G Giles and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:19
    Content type: Research article Published on:

  10. Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective, hence driving the demand for new experimental ther...

    Authors: Sue Ellen Verbrugge, Rik J Scheper, Willem F Lems, Tanja D de Gruijl and Gerrit Jansen
    Citation: Arthritis Research & Therapy 2015 17:17
    Content type: Review Published on:

  11. Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), wh...

    Authors: Giuseppe A Ramirez, Patrizia Rovere-Querini, Maria Grazia Sabbadini and Angelo A Manfredi
    Citation: Arthritis Research & Therapy 2015 17:16
    Content type: Review Published on:

  13. Gout is the most common inflammatory arthritis worldwide and is the only type of chronic arthritis that potentially can be ‘cured’. However, data on gout incidence, prevalence and management, assessed at multi...

    Authors: Chang-Fu Kuo, Matthew J Grainge, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Weiya Zhang and Michael Doherty
    Citation: Arthritis Research & Therapy 2015 17:13
    Content type: Research article Published on:

  14. The aim of this study was to assess long-term golimumab therapy in rheumatoid arthritis (RA) patients who discontinued previous tumor necrosis factor-α (TNF)-inhibitor(s).

    Authors: Josef S Smolen, Jonathan Kay, Mittie Doyle, Robert Landewé, Eric L Matteson, Norman Gaylis, Jürgen Wollenhaupt, Frederick T Murphy, Stephen Xu, Yiying Zhou and Elizabeth C Hsia
    Citation: Arthritis Research & Therapy 2015 17:14
    Content type: Research article Published on:

  15. Tocilizumab (TCZ), an anti-interleukin-6 receptor antibody, is clinically effective against rheumatoid arthritis (RA), and several reports have indicated how TCZ influences a number of mechanisms underlying RA...

    Authors: Jun Kikuchi, Misato Hashizume, Yuko Kaneko, Keiko Yoshimoto, Naoshi Nishina and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2015 17:10
    Content type: Research article Published on:

  16. Inflammatory destructive arthritis, like rheumatoid arthritis (RA), is characterized by invasion of synovial fibroblasts (SF) into the articular cartilage and erosion of the underlying bone, leading to progres...

    Authors: Stefan Wäldele, Christina Koers-Wunrau, Denise Beckmann, Adelheid Korb-Pap, Corinna Wehmeyer, Thomas Pap and Berno Dankbar
    Citation: Arthritis Research & Therapy 2015 17:12
    Content type: Research article Published on:

  17. Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of di...

    Authors: Nalinie Joharatnam, Daniel F McWilliams, Deborah Wilson, Maggie Wheeler, Ira Pande and David A Walsh
    Citation: Arthritis Research & Therapy 2015 17:11
    Content type: Research article Published on:

  18. Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examine...

    Authors: Elena B Lugli, Raquel ESM Correia, Roman Fischer, Karin Lundberg, Ken R Bracke, Anna B Montgomery, Benedikt M Kessler, Guy G Brusselle and Patrick J Venables
    Citation: Arthritis Research & Therapy 2015 17:9
    Content type: Research article Published on:

  19. Rheumatoid arthritis (RA) patients with autoantibodies against collagen type II (CII) are characterized by acute RA onset with elevated inflammatory measures and early joint erosions as well as increased produ...

    Authors: Vivek Anand Manivel, Azita Sohrabian, Marius C Wick, Mohammed Mullazehi, Lena Douhan Håkansson and Johan Rönnelid
    Citation: Arthritis Research & Therapy 2015 17:8
    Content type: Research article Published on:

  20. There is evidence that early screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. We compared the predictive accuracy of two recently published screening algorithm...

    Authors: Yanjie Hao, Vivek Thakkar, Wendy Stevens, Kathleen Morrisroe, David Prior, Candice Rabusa, Peter Youssef, Eli Gabbay, Janet Roddy, Jennifer Walker, Jane Zochling, Joanne Sahhar, Peter Nash, Susan Lester, Maureen Rischmueller, Susanna M Proudman…
    Citation: Arthritis Research & Therapy 2015 17:7
    Content type: Research article Published on:

  21. CD55, a glycosylphosphatidylinositol-anchored, complement-regulating protein (decay-accelerating factor), is expressed by fibroblast-like synoviocytes (FLS) with high local abundance in the intimal lining laye...

    Authors: Olga N Karpus, Hans P Kiener, Birgit Niederreiter, A Seda Yilmaz-Elis, Jos van der Kaa, Valeria Ramaglia, Ramon Arens, Josef S Smolen, Marina Botto, Paul P Tak, J Sjef Verbeek and Jörg Hamann
    Citation: Arthritis Research & Therapy 2015 17:6
    Content type: Research article Published on:

  22. Cathepsin K (catK) expression is increased in cartilage, bone and synovium during osteoarthritis (OA). To study the role of catK expression and elevated cathepsin activity in the synovium on cartilage destruct...

    Authors: Sirkka Kyostio-Moore, Susan Piraino, Patricia Berthelette, Nance Moran, Joseph Serriello, Alison Bendele, Cathleen Sookdeo, Bindu Nambiar, Patty Ewing, Donna Armentano and Gloria L Matthews
    Citation: Arthritis Research & Therapy 2015 17:5
    Content type: Research article Published on:

  23. Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder that has pain and loss of joint function as major pathological features. In the present study, we explored the mechanisms of possib...

    Authors: Hui Wang, Xiang Zhang, Ji-Ye He, Xin-Feng Zheng, De Li, Zheng Li, Jun-Feng Zhu, Chao Shen, Gui-Quan Cai and Xiao-Dong Chen
    Citation: Arthritis Research & Therapy 2015 17:4
    Content type: Research article Published on:

  24. In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) network presented a new set of criteria (SLICC-12) to classify systemic lupus erythematosus (SLE). The present study is the first to eval...

    Authors: Anna Ighe, Örjan Dahlström, Thomas Skogh and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2015 17:3
    Content type: Research article Published on:

  25. Our objective was to find out if there are antibodies binding to homocitrulline-containing type I and II collagen carboxyterminal telopeptides in sera of patients with rheumatoid arthritis (RA), and if these a...

    Authors: Sanna Turunen, Pekka Hannonen, Marja-Kaisa Koivula, Leila Risteli and Juha Risteli
    Citation: Arthritis Research & Therapy 2015 17:2
    Content type: Research article Published on:

  26. The severity of joint damage progression in rheumatoid arthritis (RA) is heritable. Several genetic variants have been identified, but together explain only part of the total genetic effect. Variants in Interleuk...

    Authors: Hanna W van Steenbergen, Luis Rodríguez-Rodríguez, Ewa Berglin, Alexandra Zhernakova, Rachel Knevel, Jose Ivorra-Cortés, Tom WJ Huizinga, Benjamin Fernández-Gutiérrez, Peter K Gregersen, Solbritt Rantapää-Dahlqvist and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2015 17:1
    Content type: Research article Published on:

  27. Dermal vascular smooth muscle cells (DVSMCs) are important for vascular wall fibrosis in microangiopathy of systemic sclerosis (SSc). T helper 17 cell-associated cytokines, particularly interleukin-17A (IL-17A...

    Authors: Mengguo Liu, Ji Yang, Xiaojing Xing, Xiangxiang Cui and Ming Li
    Citation: Arthritis Research & Therapy 2014 16:4223
    Content type: Research article Published on:

  28. Interleukin-7 (IL-7) is a cytokine essential for T-cell lymphopoiesis, survival and polarization with an emerging role in autoimmunity. We previously demonstrated reduced levels of circulating IL-7 in rheumato...

    Authors: Sarah M Churchman, Jehan J El-Jawhari, Agata N Burska, Rekha Parmar, Vincent Goëb, Philip G Conaghan, Paul Emery and Frederique Ponchel
    Citation: Arthritis Research & Therapy 2014 16:511
    Content type: Research article Published on:

  29. Localized scleroderma is an inflammatory disease in its first stages and a fibrotic process in later stages, principally mediated by the transforming growth factor β. To date, there is no standard treatment. T...

    Authors: Marco Rodríguez-Castellanos, Alberto Tlacuilo-Parra, Sergio Sánchez-Enríquez, Ezequiel Vélez-Gómez and Elizabeth Guevara-Gutiérrez
    Citation: Arthritis Research & Therapy 2014 16:510
    Content type: Research article Published on:

  30. Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation ...

    Authors: Wahida Rahman and Anthony H Dickenson
    Citation: Arthritis Research & Therapy 2014 16:509
    Content type: Research article Published on:

  31. Vaccinations are administered to patients to induce a protective immune response, resulting in immunological memory. Preventing infection through the use of vaccines is particularly important in immunocompromi...

    Authors: Zsuzsanna H McMahan and Clifton O Bingham III
    Citation: Arthritis Research & Therapy 2014 16:506
    Content type: Review Published on:

  33. No abstract

    Authors: Patrick H Dessein, Angela J Woodiwiss, Gavin R Norton, Linda Tsang and Ahmed Solomon
    Citation: Arthritis Research & Therapy 2014 16:503
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2013 15:R128

  34. Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro. In this study, we used a posttraumatic osteoarthritis (OA) mouse model to test whether ...

    Authors: Daniel J Leong, Marwa Choudhury, Regina Hanstein, David M Hirsh, Sun Jin Kim, Robert J Majeska, Mitchell B Schaffler, John A Hardin, David C Spray, Mary B Goldring, Neil J Cobelli and Hui B Sun
    Citation: Arthritis Research & Therapy 2014 16:508
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:1

  35. Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other th...

    Authors: Camille Roubille, Jean-Pierre Raynauld, François Abram, Patrice Paiement, Marc Dorais, Philippe Delorme, Louis Bessette, André D Beaulieu, Johanne Martel-Pelletier and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2014 16:507
    Content type: Research article Published on:

  36. High joint loading, knee muscle weakness, and poor proprioceptive acuity are important factors that have been linked to knee osteoarthritis (OA). We previously reported that those with unilateral hip OA and bi...

    Authors: Najia Shakoor, Kharma C Foucher, Markus A Wimmer, Rachel A Mikolaitis-Preuss, Louis F Fogg and Joel A Block
    Citation: Arthritis Research & Therapy 2014 16:455
    Content type: Research article Published on:

  37. Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of this review ...

    Authors: Georg Pongratz and Rainer H Straub
    Citation: Arthritis Research & Therapy 2014 16:504
    Content type: Review Published on:

  38. Marked weakness of the quadriceps muscles is typically observed following injury, surgery or pathology affecting the knee joint. This is partly due to ongoing neural inhibition that prevents the central nervou...

    Authors: David Andrew Rice, Peter John McNair, Gwyn Nancy Lewis and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2014 16:502
    Content type: Research article Published on:

  39. Patients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)—a condition thought to represent early-stage pulmonary arterial vasculopathy. Based ...

    Authors: Scott H Visovatti, Oliver Distler, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Diana Bonderman, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, James R Seibold, Juan-Vicente Torres-Martin, Martin Doelberg, Harbajan Chadha-Boreham, Daniel M Rosenberg, Vallerie V McLaughlin and Dinesh Khanna
    Citation: Arthritis Research & Therapy 2014 16:493
    Content type: Research article Published on:

  40. Joint injury is a potent risk factor for osteoarthritis, the most important musculoskeletal disease affecting humankind. Yet the population incidence of soft tissue knee injury is not well documented. Using he...

    Authors: Jonas B Thorlund, Adam G Culvenor and Charles Ratzlaff
    Citation: Arthritis Research & Therapy 2014 16:499
    Content type: Editorial Published on:

  41. Biosimilars that were not compared in clinical trials with the compound innovator are not true biosimilars (biocopies) and are associated with risks that the clinical rheumatologist should be aware of before g...

    Authors: Morton Scheinberg and Gilberto Castañeda-Hernández
    Citation: Arthritis Research & Therapy 2014 16:501
    Content type: Commentary Published on:

  42. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 ...

    Authors: Irene Arroyo-Villa, María-Belén Bautista-Caro, Alejandro Balsa, Pilar Aguado-Acín, María-Gema Bonilla-Hernán, Chamaida Plasencia, Alejandro Villalba, Laura Nuño, Amaya Puig-Kröger, Emilio Martín-Mola and María-Eugenia Miranda-Carús
    Citation: Arthritis Research & Therapy 2014 16:500
    Content type: Research article Published on:

  43. Members of the peptidylarginine deiminase (PAD) family catalyse the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullination of proteins is well described in rheumatoid arthritis ...

    Authors: Dres Damgaard, Ladislav Senolt, Michael Friberg Nielsen, Ger J Pruijn and Claus H Nielsen
    Citation: Arthritis Research & Therapy 2014 16:498
    Content type: Research article Published on:

  44. This study aimed to investigate rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status and levels as predictors of mortality in two large cohorts of patients with early inflammatory arthr...

    Authors: Jennifer H Humphreys, Jessica AB van Nies, Jackie Chipping, Tarnya Marshall, Annette HM van der Helm-van Mil, Deborah PM Symmons and Suzanne MM Verstappen
    Citation: Arthritis Research & Therapy 2014 16:483
    Content type: Research article Published on:

  45. Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjögren’s syndrome (SjS) are inflammatory systemic autoimmune diseases (SADs) that share several clinical and pathological features. The shared...

    Authors: Daniel Toro-Domínguez, Pedro Carmona-Sáez and Marta E Alarcón-Riquelme
    Citation: Arthritis Research & Therapy 2014 16:489
    Content type: Research article Published on:

  46. The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene express...

    Authors: Yinxian Wen, Jing Li, Linlong Wang, Kai Tie, Jacques Magdalou, Liaobin Chen and Hui Wang
    Citation: Arthritis Research & Therapy 2014 16:484
    Content type: Research article Published on:

  47. Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone lo...

    Authors: Neha Dixit, Dennis J Wu, Yesser H Belgacem, Laura N Borodinsky, M Eric Gershwin and Iannis E Adamopoulos
    Citation: Arthritis Research & Therapy 2014 16:496
    Content type: Research article Published on:

  48. Polymyalgia rheumatica (PMR) is a common inflammatory disease in older people characterized by shoulder and/or pelvic girdle, and cervical and, occasionally, lumbar pain. Interspinous bursitis has been suggest...

    Authors: Dario Camellino, Francesco Paparo, Silvia Morbelli, Maurizio Cutolo, Gianmario Sambuceti and Marco A Cimmino
    Citation: Arthritis Research & Therapy 2014 16:492
    Content type: Research article Published on:

  49. The aim of this study was to investigate PD-1/PD-L1 involvement in the hyporesponsiveness of rheumatoid arthritis (RA) synovial fluid (SF) CD4 T cells upon stimulation by thymic stromal lymphopoietin (TSLP)–pr...

    Authors: Frederique M Moret, Kim MG van der Wurff-Jacobs, Johannes WJ Bijlsma, Floris PJG Lafeber and Joel AG van Roon
    Citation: Arthritis Research & Therapy 2014 16:497
    Content type: Research article Published on:

  50. Prior studies have established altered microbiota and immunologic reactivity to enteric commensal organisms in inflammatory bowel disease (IBD). Since intestinal inflammation is present in a subset of patients...

    Authors: Matthew L Stoll, Ranjit Kumar, Casey D Morrow, Elliot J Lefkowitz, Xiangqin Cui, Anna Genin, Randy Q Cron and Charles O Elson
    Citation: Arthritis Research & Therapy 2014 16:486
    Content type: Research article Published on:
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Arthritis Research & Therapy

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