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  1. In hepatitis C virus (HCV)-related mixed cryoglobulinemia (MCG), the nonenveloped HCV core protein (HCV-Cp) is a constituent of the characteristic cold-precipitating immune complexes (ICs). A possible correlat...

    Authors: Sabino Russi, Domenico Sansonno, Maria Addolorata Mariggiò, Angela Vinella, Fabio Pavone, Gianfranco Lauletta, Silvia Sansonno and Franco Dammacco
    Citation: Arthritis Research & Therapy 2014 16:R73
    Content type: Research article Published on:

  3. In addition to the pivotal roles of mast cells in allergic diseases, recent data suggest that mast cells play crucial roles in a variety of autoimmune responses. However, their roles in the pathogenesis of aut...

    Authors: Masaya Yokota, Kotaro Suzuki, Koji Tokoyoda, Kazuyuki Meguro, Junichi Hosokawa, Shigeru Tanaka, Kei Ikeda, Takashi Mikata, Toshinori Nakayama, Hitoshi Kohsaka and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2014 16:R72
    Content type: Research article Published on:

  4. In recent years, there has been an increased demand for computer-aided diagnosis (CAD) tools to support clinicians in the field of indirect immunofluorescence. To this aim, academic and industrial research is ...

    Authors: Francesca Buzzulini, Amelia Rigon, Paolo Soda, Leonardo Onofri, Maria Infantino, Luisa Arcarese, Giulio Iannello and Antonella Afeltra
    Citation: Arthritis Research & Therapy 2014 16:R71
    Content type: Research article Published on:

  5. Early diagnosis of and subsequent monitoring of therapy for rheumatoid arthritis (RA) could benefit from detection of (sub)clinical synovitis. Imaging of (sub)clinical arthritis by targeting the translocator p...

    Authors: Yoony YJ Gent, Karin Weijers, Carla FM Molthoff, Albert D Windhorst, Marc C Huisman, Michael Kassiou, Gerrit Jansen, Adriaan A Lammertsma and Conny J van der Laken
    Citation: Arthritis Research & Therapy 2014 16:R70
    Content type: Research article Published on:

  6. Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5 to 1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction. [18F]DPA-714 is a specific tracer o...

    Authors: Géraldine Pottier, Nicholas Bernards, Frédéric Dollé and Raphael Boisgard
    Citation: Arthritis Research & Therapy 2014 16:R69
    Content type: Research article Published on:

  7. Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for de novo vessel formation and p...

    Authors: Takeo Isozaki, M Asif Amin, Ali S Arbab, Alisa E Koch, Christine M Ha, Gautam Edhayan, G Kenneth Haines III and Jeffrey H Ruth
    Citation: Arthritis Research & Therapy 2014 16:R68
    Content type: Research article Published on:

  8. Current musculoskeletal imaging techniques usually target the macro-morphology of articular cartilage or use histological analysis. These techniques are able to reveal advanced osteoarthritic changes in articu...

    Authors: Bo He, Jian Ping Wu, Thomas Brett Kirk, John A Carrino, Chuan Xiang and Jiake Xu
    Citation: Arthritis Research & Therapy 2014 16:205
    Content type: Review Published on:

  9. Currently, there is huge research focus on the development of novel cell-based regeneration and tissue-engineering therapies for the treatment of intervertebral disc degeneration and the associated back pain. ...

    Authors: Louise E Clarke, James C McConnell, Michael J Sherratt, Brian Derby, Stephen M Richardson and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2014 16:R67
    Content type: Research article Published on:

  10. In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheuma...

    Authors: Ana Márquez, Aida Ferreiro-Iglesias, Cristina L Dávila-Fajardo, Ariana Montes, Dora Pascual-Salcedo, Eva Perez-Pampin, Manuel J Moreno-Ramos, Rosa García-Portales, Federico Navarro, Virginia Moreira, César Magro, Rafael Caliz, Miguel Angel Ferrer, Juan José Alegre-Sancho, Beatriz Joven, Patricia Carreira…
    Citation: Arthritis Research & Therapy 2014 16:R66
    Content type: Research article Published on:

  11. Agonistic autoantibodies (Aabs) against the angiotensin II receptor type 1 (AT1R) and the endothelin receptor type A (ETAR) have been identified in patients with systemic sclerosis (SSc). In our present study,...

    Authors: Jeannine Günther, Angela Kill, Mike Oliver Becker, Harald Heidecke, Judith Rademacher, Elise Siegert, Mislav Radić, Gerd-Rüdiger Burmester, Duska Dragun and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2014 16:R65
    Content type: Research article Published on:

  13. Clinical and preclinical studies have shown that supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, the ef...

    Authors: Ana M Torres-Guzman, Carlos E Morado-Urbina, Perla A Alvarado-Vazquez, Rosa I Acosta-Gonzalez, Aracely E Chávez-Piña, Rosa M Montiel-Ruiz and Juan M Jimenez-Andrade
    Citation: Arthritis Research & Therapy 2014 16:R64
    Content type: Research article Published on:

  14. Pegloticase, a PEGylated recombinant porcine uricase, is approved for treating refractory gout at a dose of 8 mg intravenous (IV) every 2 weeks. However, during phase 1 testing, pharmacokinetics supported less...

    Authors: Michael S Hershfield, Nancy J Ganson, Susan J Kelly, Edna L Scarlett, Denise A Jaggers and John S Sundy
    Citation: Arthritis Research & Therapy 2014 16:R63
    Content type: Research article Published on:

  15. A hallmark of systemic autoimmune diseases like systemic lupus erythematosus (SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN type I signature. Recently, T-helper 17 ...

    Authors: Zana Brkic, Odilia BJ Corneth, Cornelia G van Helden-Meeuwsen, Radboud JEM Dolhain, Naomi I Maria, Sandra MJ Paulissen, Nadine Davelaar, Jan Piet van Hamburg, Paul L van Daele, Virgil A Dalm, P Martin van Hagen, Johanna MW Hazes, Marjan A Versnel and Erik Lubberts
    Citation: Arthritis Research & Therapy 2014 16:R62
    Content type: Research article Published on:

  16. Although previous studies found that cigarette smoking is associated with risk of rheumatoid arthritis (RA), the dose-response relationship remains unclear. This meta-analysis quantitatively summarizes accumul...

    Authors: Daniela Di Giuseppe, Andrea Discacciati, Nicola Orsini and Alicja Wolk
    Citation: Arthritis Research & Therapy 2014 16:R61
    Content type: Research article Published on:

  17. The efficacy of pegloticase, a polyethylene glycol (PEG)-conjugated mammalian recombinant uricase, approved for chronic refractory gout, can be limited by the development of antibodies (Ab). Analyses from 2 re...

    Authors: Peter E Lipsky, Leonard H Calabrese, Arthur Kavanaugh, John S Sundy, David Wright, Marsha Wolfson and Michael A Becker
    Citation: Arthritis Research & Therapy 2014 16:R60
    Content type: Research article Published on:

  18. The role of popliteal cysts and subgastrocnemius bursitis in knee joint homeostasis is uncertain. The aim of this study is to describe cross-sectional associations between popliteal cysts, subgastrocnemius bur...

    Authors: Yuelong Cao, Graeme Jones, Weiyu Han, Benny Antony, Xia Wang, Flavia Cicuttini and Changhai Ding
    Citation: Arthritis Research & Therapy 2014 16:R59
    Content type: Research article Published on:

  19. Antineutrophil cytoplasmic antibodies are associated with pauci-immune small-vessel vasculitis and crescentic glomerulonephritis. Cathelicidin LL37 is the human member of a family of antimicrobial peptides tha...

    Authors: Adil Gasim
    Citation: Arthritis Research & Therapy 2014 16:105
    Content type: Editorial Published on:

  20. Recent evidence suggests that tissue accumulation of senescent p16INK4a-positive cells during the life span would be deleterious for tissue functions and could be the consequence of inherent age-associated disord...

    Authors: Didier Philipot, David Guérit, Daniela Platano, Paul Chuchana, Eleonora Olivotto, Francisco Espinoza, Anne Dorandeu, Yves-Marie Pers, Jacques Piette, Rosa Maria Borzi, Christian Jorgensen, Danièle Noel and Jean-Marc Brondello
    Citation: Arthritis Research & Therapy 2014 16:R58
    Content type: Research article Published on:

  22. Type I interferons (IFNs) are implicated in the pathogenesis of systemic sclerosis (SSc). MEDI-546 is an investigational human monoclonal antibody directed against the type I IFN receptor. This Phase 1 study e...

    Authors: Avram Goldberg, Thomas Geppert, Elena Schiopu, Tracy Frech, Vivien Hsu, Robert W Simms, Stanford L Peng, Yihong Yao, Nairouz Elgeioushi, Linda Chang, Bing Wang and Stephen Yoo
    Citation: Arthritis Research & Therapy 2014 16:R57
    Content type: Research article Published on:

  23. Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes a considerable burden for the patient and society. It is not clear yet whether aiming for remission (REM) is worthwhile, especially when ...

    Authors: Helga Radner, Josef S Smolen and Daniel Aletaha
    Citation: Arthritis Research & Therapy 2014 16:R56
    Content type: Research article Published on:

  24. Plasma cells residing in inflamed tissues produce antibodies in chronic inflammatory and systemic autoimmune diseases. This study examined if plasma cells, located within inflamed nasal tissue in granulomatosi...

    Authors: Antje Mueller, Christoph Brieske, Susanne Schinke, Elena Csernok, Wolfgang L Gross, Katrin Hasselbacher, Jan Voswinkel and Konstanze Holl-Ulrich
    Citation: Arthritis Research & Therapy 2014 16:R55
    Content type: Research article Published on:

  25. The objective of this cross-sectional and retrospective cohort study was (1) to determine the usefulness of intima-media thickness (IMT) in contrast to plaque assessment, (2) to examine the value of additive f...

    Authors: Marc Frerix, Johannes Stegbauer, Alexander Kreuter and Stefan Markus Weiner
    Citation: Arthritis Research & Therapy 2014 16:R54
    Content type: Research article Published on:

  28. We assessed the profile and frequency of malignancy subtypes in a large single-centre UK cohort for patients with scleroderma (systemic sclerosis; SSc). We evaluated the cancer risk among SSc patients with dif...

    Authors: Pia Moinzadeh, Carmen Fonseca, Martin Hellmich, Ami A Shah, Cecilia Chighizola, Christopher P Denton and Voon H Ong
    Citation: Arthritis Research & Therapy 2014 16:R53
    Content type: Research article Published on:

  29. Authors: Pedro Recarte-Pelz, Dolors Tàssies, Gerard Espinosa, Begoña Hurtado, Núria Sala, Ricard Cervera, Joan Carles Reverter and Pablo García de Frutos
    Citation: Arthritis Research & Therapy 2014 16:404
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2013 15:R41

  31. Immunofluorescent imaging has been a powerful technique in helping to identify intracellular nuclear and cytoplasmic molecules which are target antigens of autoantibodies in systemic autoimmune disorders. Patt...

    Authors: Eng M Tan
    Citation: Arthritis Research & Therapy 2014 16:104
    Content type: Commentary Published on:

  32. NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment...

    Authors: Sayaka Ito, Yukichi Hara and Tetsuo Kubota
    Citation: Arthritis Research & Therapy 2014 16:R52
    Content type: Research article Published on:

  33. Subjects with primary Sjögren’s syndrome (SjS) have an increased risk of developing B-cell lymphoma and may harbor monoclonal B-cell expansions in the peripheral blood. Expanded B-cell clones could be pathogen...

    Authors: Uri Hershberg, Wenzhao Meng, Bochao Zhang, Nancy Haff, E William St Clair, Philip L Cohen, Patrice D McNair, Ling Li, Marc C Levesque and Eline T Luning Prak
    Citation: Arthritis Research & Therapy 2014 16:R51
    Content type: Research article Published on:

  34. Accumulating data implicate the CD4+ T cell subset (Th17 cells) in rheumatoid arthritis (RA). IL-17 is an inflammatory cytokine that induces tumor necrosis factor (TNF)α, IL-1β and IL-6, all of which are targe...

    Authors: Shrinivas Bishu, Ee Wern Su, Erich R Wilkerson, Kelly A Reckley, Donald M Jones, Mandy J McGeachy, Sarah L Gaffen and Marc C Levesque
    Citation: Arthritis Research & Therapy 2014 16:R50
    Content type: Research article Published on:

  36. Low levels of vitamin D have been associated with several autoimmune disorders including multiple sclerosis, rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus (SLE). The major source of vi...

    Authors: Manamita Mandal, Rina Tripathy, Aditya K Panda, Sarit S Pattanaik, Simanchal Dakua, Anjan Kumar Pradhan, Soumen Chakraborty, Balachandran Ravindran and Bidyut K Das
    Citation: Arthritis Research & Therapy 2014 16:R49
    Content type: Research article Published on:

  37. Circulating nucleosomes released from apoptotic cells are important in the pathogenesis of systemic lupus erythematosus (SLE). Both nucleosomes and anti-nucleosome antibodies are deposited in inflamed tissues ...

    Authors: Sara Croca, Paul Bassett, Charis Pericleous, Karim Fouad Alber, David Latchman, David Isenberg, Ian Giles, Anisur Rahman and Yiannis Ioannou
    Citation: Arthritis Research & Therapy 2014 16:R48
    Content type: Research article Published on:

  38. Micronized dehydrated human amnion/chorion membrane (μ-dHACM) is derived from donated human placentae and has anti-inflammatory, low immunogenic and anti-fibrotic properties. The objective of this study was to...

    Authors: Nick J Willett, Tanushree Thote, Angela SP Lin, Shamus Moran, Yazdan Raji, Sanjay Sridaran, Hazel Y Stevens and Robert E Guldberg
    Citation: Arthritis Research & Therapy 2014 16:R47
    Content type: Research article Published on:

  39. Faecal calprotectin (FC) has been proposed to be a biomarker of gastrointestinal (GI) disease in systemic sclerosis (SSc). The purpose of this study was to extend cross-sectional observations and prospectively...

    Authors: Kristofer Andréasson, Tore Saxne, Agneta Scheja, Izabela Bartosik, Thomas Mandl and Roger Hesselstrand
    Citation: Arthritis Research & Therapy 2014 16:R46
    Content type: Research article Published on:

  40. Antibodies against citrullinated peptides (anti-CCP) and increased levels of cytokines precede the development of rheumatoid arthritis (RA) by several years. Recently, the proteins survivin and Fms-like tyrosi...

    Authors: Maria Bokarewa, Mikael Brink, Malin Erlandsson and Solbritt Rantapää Dahlqvist
    Citation: Arthritis Research & Therapy 2014 16:R45
    Content type: Research article Published on:

  41. Rheumatoid synovial fibroblasts (RASFs) mediate joint inflammation and destruction in rheumatoid arthritis (RA). Endothelial protein C receptor (EPCR) is a specific receptor for the natural anticoagulant activ...

    Authors: Meilang Xue, Kaitlin Shen, Kelly McKelvey, Juan Li, Yee-Ka Agnes Chan, Vicky Hatzis, Lyn March, Christopher B Little, Michael Tonkin and Christopher J Jackson
    Citation: Arthritis Research & Therapy 2014 16:R44
    Content type: Research article Published on:

  42. Pneumocystis pneumonia (PCP) is one of the most prevalent opportunistic infections in patients undergoing immunosuppressive therapy. In this article, we discuss risk factors for PCP development in patients with r...

    Authors: Takayuki Katsuyama, Kazuyoshi Saito, Satoshi Kubo, Masao Nawata and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2014 16:R43
    Content type: Research article Published on:

  43. Spondyloarthritis (SpA) comprises a group of diseases often associated with HLA-B27 and characterized by inflammation of the entheses and joints of the axial skeleton. The inflammatory process in SpA is presum...

    Authors: Tue W Kragstrup, Babak Jalilian, Malene Hvid, Anders Kjærgaard, René Østgård, Berit Schiøttz-Christensen, Anne G Jurik, William H Robinson, Thomas Vorup-Jensen and Bent Deleuran
    Citation: Arthritis Research & Therapy 2014 16:R42
    Content type: Research article Published on:

  44. Since the concept of reprogramming mature somatic cells to generate induced pluripotent stem cells (iPSCs) was demonstrated in 2006, iPSCs have become a potential substitute for embryonic stem cells (ESCs) giv...

    Authors: Jaecheol Lee, Youngkyun Kim, Hyoju Yi, Sebastian Diecke, Juryun Kim, Hyerin Jung, Yeri Alice Rim, Seung Min Jung, Myungshin Kim, Yong Goo Kim, Sung-Hwan Park, Ho-Youn Kim and Ji Hyeon Ju
    Citation: Arthritis Research & Therapy 2014 16:R41
    Content type: Research article Published on:

  45. Clinical trials of new treatments for rheumatoid arthritis (RA) typically require subjects to have an elevated acute phase reactant (APR), in addition to tender and swollen joints. However, despite the elevati...

    Authors: Jonathan Kay, Olga Morgacheva, Susan P Messing, Joel M Kremer, Jeffrey D Greenberg, George W Reed, Ellen M Gravallese and Daniel E Furst
    Citation: Arthritis Research & Therapy 2014 16:R40
    Content type: Research article Published on:

  46. Necrotizing autoimmune myopathies (NAM) have recently been defined as a distinct group of severe acquired myopathies, characterized by prominent myofiber necrosis without significant muscle inflammation. Becau...

    Authors: Laurent Drouot, Yves Allenbach, Fabienne Jouen, Jean-Luc Charuel, Jérémie Martinet, Alain Meyer, Olivier Hinschberger, Brigitte Bader-Meunier, Isabelle Kone-Paut, Emmanuelle Campana-Salort, Bruno Eymard, Anne Tournadre, Lucile Musset, Jean Sibilia, Isabelle Marie, Olivier Benveniste…
    Citation: Arthritis Research & Therapy 2014 16:R39
    Content type: Research article Published on:

  47. Visfatin is an adipokine that may be involved in intertissular joint communication in osteoarthritis (OA). With a homodimeric conformation, it exerts nicotinamide phosphoribosyltransferase (Nampt) enzymatic ac...

    Authors: Marie-Charlotte Laiguillon, Xavier Houard, Carole Bougault, Marjolaine Gosset, Geoffroy Nourissat, Alain Sautet, Claire Jacques, Francis Berenbaum and Jérémie Sellam
    Citation: Arthritis Research & Therapy 2014 16:R38
    Content type: Research article Published on:

  48. Wnt ligands bind to low-density lipoprotein receptor–related protein (LRP) 5 or 6, triggering a cascade of downstream events that include β-catenin signaling. Here we explored the roles of LRP5 in interleukin ...

    Authors: Youngnim Shin, Yun Hyun Huh, Kieun Kim, Suyeon Kim, Ka Hyon Park, Jeong-Tae Koh, Jang-Soo Chun and Je-Hwang Ryu
    Citation: Arthritis Research & Therapy 2014 16:R37
    Content type: Research article Published on:

  49. The patient’s perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication a...

    Authors: Mickaël Hiligsmann, Benedict G Dellaert, Carmen D Dirksen, Trudy van der Weijden, Stefan Goemaere, Jean-Yves Reginster, Verity Watson and Annelies Boonen
    Citation: Arthritis Research & Therapy 2014 16:R36
    Content type: Research article Published on:

  50. Both genetic variation in ATP-binding cassette sub-family G member 2 (ABCG2) and intake of fructose-containing beverages are major risk factors for hyperuricemia and gout. This study aimed to test the hypothesis ...

    Authors: Nicola Dalbeth, Meaghan E House, Gregory D Gamble, Bregina Pool, Anne Horne, Lauren Purvis, Angela Stewart, Marilyn Merriman, Murray Cadzow, Amanda Phipps-Green and Tony R Merriman
    Citation: Arthritis Research & Therapy 2014 16:R34
    Content type: Research article Published on:
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Arthritis Research & Therapy

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