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  1. Common variable immunodeficiency (CVID) describes a heterogeneous subset of hypogammaglobulinemias of unknown etiology. Typically, patients present with recurrent bacterial infections of the respiratory and ga...

    Authors: Ulrich Salzer, Klaus Warnatz and Hans Hartmut Peter
    Citation: Arthritis Research & Therapy 2012 14:223
    Content type: Review Published on:

  2. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to be important in the development of inflammatory models of rheumatoid arthritis and there is encouraging data that its blockade may ha...

    Authors: Andrew D Cook, Jarrad Pobjoy, Stefan Steidl, Manuela Dürr, Emma L Braine, Amanda L Turner, Derek C Lacey and John A Hamilton
    Citation: Arthritis Research & Therapy 2012 14:R199
    Content type: Research article Published on:

  5. We aimed to investigate the sensitivity and reliability of two-dimensional ultrasonographic endpoints at the metacarpophalageal joints (MCPJs) and their potential to provide an early and objective indication o...

    Authors: Matthew W Seymour, Stephen Kelly, Chan R Beals, Marie-Pierre Malice, James A Bolognese, Bernard J Dardzinski, Amy S Cheng, Corinne E Cummings, Steven S Smugar, Catherine McClinton, Amy Fox, William M Dooley, Constantino Pitzalis and Peter C Taylor
    Citation: Arthritis Research & Therapy 2012 14:R198
    Content type: Research article Published on:

  6. Deletion or mutation of the gene encoding the cartilage extracellular matrix (ECM) protein matrilin-3 (MATN3) results in the early onset of osteoarthritis (OA), suggesting chondroprotective properties of MATN3. T...

    Authors: Chathuraka T Jayasuriya, Mary B Goldring, Richard Terek and Qian Chen
    Citation: Arthritis Research & Therapy 2012 14:R197
    Content type: Research article Published on:

  9. Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differ...

    Authors: Wei Zhang, Jialin Chen, Shufang Zhang and Hong Wei Ouyang
    Citation: Arthritis Research & Therapy 2012 14:221
    Content type: Review Published on:

  11. Multiple studies have shown that glial cells of the spinal cord, such as astrocytes and microglia, have close contact with neurons, suggesting the term tripartite synapse. In these synapses, astrocytes surroun...

    Authors: Francisco Morales, Luis Constandil, Teresa Pelissier, Alejandro Hernández and Claudio Laurido
    Citation: Arthritis Research & Therapy 2012 14:R196
    Content type: Research article Published on:

  12. Genetic and disease-related factors give rise to a wide spectrum of glucocorticoid (GC) sensitivity in rheumatoid arthritis (RA). In clinical practice, GC treatment is not adapted to these differences in GC se...

    Authors: Rogier AM Quax, Jan W Koper, Pascal HP de Jong, Ramona van Heerebeek, Angelique E Weel, Anne M Huisman, Derkjen van Zeben, Frank H de Jong, Steven WJ Lamberts, Johanna MW Hazes and Richard A Feelders
    Citation: Arthritis Research & Therapy 2012 14:R195
    Content type: Research article Published on:

  14. There is a growing prevalence of gout in the US and worldwide. Gout is a recognized risk factor for cardiovascular disease (CVD). It is unclear whether other risk factors for CVD are also associated with incre...

    Authors: Mara A McAdams-DeMarco, Janet W Maynard, Josef Coresh and Alan N Baer
    Citation: Arthritis Research & Therapy 2012 14:R193
    Content type: Research article Published on:

  15. Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppres...

    Authors: Ajay Jain, Henrik S Olsen, Ravi Vyzasatya, Erin Burch, Yukimi Sakoda, Emmanuel Y Mérigeon, Ling Cai, Changwan Lu, Ming Tan, Koji Tamada, Dan Schulze, David S Block and Scott E Strome
    Citation: Arthritis Research & Therapy 2012 14:R192
    Content type: Research article Published on:

  16. Cartilage oligomeric matrix protein (COMP) is a major non-collagenous component of cartilage. Earlier, we developed a new mouse model for rheumatoid arthritis using COMP. This study was undertaken to investiga...

    Authors: Hui Geng, Kutty Selva Nandakumar, Anna Pramhed, Anders Aspberg, Ragnar Mattsson and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2012 14:R191
    Content type: Research article Published on:

  18. Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal c...

    Authors: Diluk RW Kannangara, Sheena N Ramasamy, Praveen L Indraratna, Sophie L Stocker, Garry G Graham, Graham Jones, Ian Portek, Kenneth M Williams and Richard O Day
    Citation: Arthritis Research & Therapy 2012 14:R189
    Content type: Research article Published on:

  19. We investigated early systemic sclerosis (SSc) (that is, Raynaud's phenomenon with SSc marker autoantibodies and/or typical capillaroscopic findings and no manifestations other than puffy fingers or arthritis)...

    Authors: Gabriele Valentini, Serena Vettori, Giovanna Cuomo, Michele Iudici, Virginia D'Abrosca, Domenico Capocotta, Gianmattia Del Genio, Carlo Santoriello and Domenico Cozzolino
    Citation: Arthritis Research & Therapy 2012 14:R188
    Content type: Research article Published on:

  20. Statins, hydroxymethylglutaryl-coenzyme A reductase inhibitors, have been reported to have antiinflammatory and/or immunomodulatory effects and prophylactic and therapeutic effects in collagen-induced arthriti...

    Authors: Jeong Yeon Kim, Eun Young Lee, Eun Bong Lee, Yun Jong Lee, Hyun Jung Yoo, Jiyong Choi and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2012 14:R187
    Content type: Research article Published on:

  21. In this study, we evaluated the activity of the neuroendocrine axes in patients with polymyalgia rheumatica (PMR) before and after tumor necrosis factor (TNF)-α-blocking etanercept treatment, which previously ...

    Authors: Frederik Flindt Kreiner and Henrik Galbo
    Citation: Arthritis Research & Therapy 2012 14:R186
    Content type: Research article Published on:

  22. Complement activation is involved in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atypical hemolytic uremic syndrome (aHUS). Autoantibodies to complement inhibitor factor H (FH), particula...

    Authors: Anna Foltyn Zadura, Peter F Zipfel, Maria I Bokarewa, Gunnar Sturfelt, Andreas Jönsen, Sara C Nilsson, Andreas Hillarp, Tore Saxne, Leendert A Trouw and Anna M Blom
    Citation: Arthritis Research & Therapy 2012 14:R185
    Content type: Research article Published on:

  23. Authors: Chih L Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh and Paul J Utz
    Citation: Arthritis Research & Therapy 2012 14:403
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2012 14:R25

  24. Lupus nephritis (LN) is a severe and frequent manifestation of systemic lupus erythematosus (SLE). Its pathogenesis has not been fully elucidated but immune complexes are considered to contribute to the inflam...

    Authors: Deena A Abdulahad, Johanna Westra, Johannes Bijzet, Sebastian Dolff, Marcory C van Dijk, Pieter C Limburg, Cees GM Kallenberg and Marc Bijl
    Citation: Arthritis Research & Therapy 2012 14:R184
    Content type: Research article Published on:

  25. The mechanism underlying the spontaneous improvement of rheumatoid arthritis (RA) during pregnancy and the subsequent postpartum flare is incompletely understood, and the disease course varies widely between p...

    Authors: Rogier AM Quax, Yaël A de Man, Jan W Koper, Elisabeth FC van Rossum, Sten P Willemsen, Steven WJ Lamberts, Johanna MW Hazes, Radboud JEM Dolhain and Richard A Feelders
    Citation: Arthritis Research & Therapy 2012 14:R183
    Content type: Research article Published on:

  26. Chronic complex musculoskeletal injuries that are slow to heal pose challenges to physicians and researchers alike. Orthobiologics is a relatively newer science that involves application of naturally found mat...

    Authors: Robinder S Dhillon, Edward M Schwarz and Michael D Maloney
    Citation: Arthritis Research & Therapy 2012 14:219
    Content type: Review Published on:

  27. In a recent screening to detect biomarkers in systemic lupus erythematosus (SLE), expression of the iron storage protein, ferritin, was increased. Given that proteins that regulate the storage, transfer and re...

    Authors: Kamala Vanarsa, Yujin Ye, Jie Han, Chun Xie, Chandra Mohan and Tianfu Wu
    Citation: Arthritis Research & Therapy 2012 14:R182
    Content type: Research article Published on:

  28. Inflammatory arthritis is a progressive disease with chronic inflammation of joints, which is mainly characterized by the infiltration of immune cells and synovial hyperproliferation. Monocytes migrate towards...

    Authors: Monique Fangradt, Martin Hahne, Timo Gaber, Cindy Strehl, Roman Rauch, Paula Hoff, Max Löhning, Gerd-Rüdiger Burmester and Frank Buttgereit
    Citation: Arthritis Research & Therapy 2012 14:R181
    Content type: Research article Published on:

  29. Hypoxia and T-helper cell 1 (Th1) cytokine-driven inflammation are key features of rheumatoid arthritis (RA) and contribute to disease pathogenesis by promoting angiogenesis. The objective of our study was to ...

    Authors: Helene Larsen, Barbara Muz, Tak L Khong, Marc Feldmann and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2012 14:R180
    Content type: Research article Published on:

  30. Inflammation plays a key role in the progression of intervertebral disc degeneration, a condition strongly implicated as a cause of lower back pain. The objective of this study was to investigate the therapeut...

    Authors: Deborah J Gorth, Robert L Mauck, Joseph A Chiaro, Bhavana Mohanraj, Nader M Hebela, George R Dodge, Dawn M Elliott and Lachlan J Smith
    Citation: Arthritis Research & Therapy 2012 14:R179
    Content type: Research article Published on:

  31. Fibromyalgia is difficult to treat and requires the use of multiple approaches. This study is a randomized controlled trial of qigong compared with a wait-list control group in fibromyalgia.

    Authors: Mary Lynch, Jana Sawynok, Chok Hiew and Dana Marcon
    Citation: Arthritis Research & Therapy 2012 14:R178
    Content type: Research article Published on:

  32. This study was performed to evaluate the attenuation of osteoarthritic (OA) pathogenesis via disruption of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) signaling with AMD31...

    Authors: Fangyuan Wei, Douglas C Moore, Yanlin Li, Ge Zhang, Xiaochun Wei, Joseph K Lee and Lei Wei
    Citation: Arthritis Research & Therapy 2012 14:R177
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2013 15:410

  33. Immunoglobulin class-switch recombination deficiencies (Ig-CSR-Ds) are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect in...

    Authors: Anne Durandy and Sven Kracker
    Citation: Arthritis Research & Therapy 2012 14:218
    Content type: Review Published on:

  34. Ankylosing spondylitis (AS) is characterized by abnormal bone formation in the spine and the sacroiliac joints. In vitro assays demonstrate that carbonic anhydrase I (CA1) promotes calcium precipitation. This stu...

    Authors: Xiaotian Chang, Yabing Zheng, Qingrui Yang, Lin Wang, Jihong Pan, Yifang Xia, Xinfeng Yan and Jinxiang Han
    Citation: Arthritis Research & Therapy 2012 14:R176
    Content type: Research article Published on:

  35. The treatment of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor alpha (TNFα) biological drugs has dramatically improved the prognosis of these patients. However, a third of the treated pati...

    Authors: Luis Chara, Ana Sánchez-Atrio, Ana Pérez, Eduardo Cuende, Fernando Albarrán, Ana Turrión, Julio Chevarria, Miguel A Sánchez, Jorge Monserrat, Antonio de la Hera, Alfredo Prieto, Ignacio Sanz, David Diaz and Melchor Alvarez-Mon
    Citation: Arthritis Research & Therapy 2012 14:R175
    Content type: Research article Published on:

  36. Identification of patients who are in early stages of lupus is currently done through clinical evaluation and is not greatly facilitated by available diagnostic tests. Profiling for patient characteristics and...

    Authors: Nancy J Olsen, Quan-Zhen Li, Jiexia Quan, Ling Wang, Azza Mutwally and David R Karp
    Citation: Arthritis Research & Therapy 2012 14:R174
    Content type: Research article Published on:

  37. Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA).

    Authors: Petya Dimitrova, Nina Ivanovska, Lyudmila Belenska, Viktoriya Milanova, Wilhelm Schwaeble and Cordula Stover
    Citation: Arthritis Research & Therapy 2012 14:R173
    Content type: Research article Published on:

  38. Sjögren's syndrome (SjS) is a systemic autoimmune disease characterized by decreased salivary and lacrimal gland secretions, resulting in severe dry mouth and dry eyes. Recent studies have suggested that TH17 cel...

    Authors: Byung Ha Lee, Wendy C Carcamo, John A Chiorini, Ammon B Peck and Cuong Q Nguyen
    Citation: Arthritis Research & Therapy 2012 14:R172
    Content type: Research article Published on:

  40. Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 levels, IgG4-positive plasmacytic infiltration, and fibrosis in various organs. The purpose of this s...

    Authors: Hiroto Tsuboi, Naomi Matsuo, Mana Iizuka, Sayaka Tsuzuki, Yuya Kondo, Akihiko Tanaka, Masafumi Moriyama, Isao Matsumoto, Seiji Nakamura and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2012 14:R171
    Content type: Research article Published on:

  41. The purpose of this research was to study the influence of cigarette smoking and alcohol consumption on immune response to heptavalent pneumococcal conjugate vaccine, immunoglobulin levels (Ig) and markers of ...

    Authors: Carmen Roseman, Lennart Truedsson and Meliha Crnkic Kapetanovic
    Citation: Arthritis Research & Therapy 2012 14:R170
    Content type: Research article Published on:

  42. Dysregulated angiogenesis is implicated in the pathogenesis of rheumatoid arthritis (RA). To provide a more profound understanding of arthritis-associated angiogenesis, we evaluated the expression of angiogene...

    Authors: Yvonne Raatz, Saleh Ibrahim, Marc Feldmann and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2012 14:R169
    Content type: Research article Published on:

  43. To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether ...

    Authors: Andre F Steinert, Manuel Weissenberger, Manuela Kunz, Fabian Gilbert, Steven C Ghivizzani, Sascha Göbel, Franz Jakob, Ulrich Nöth and Maximilian Rudert
    Citation: Arthritis Research & Therapy 2012 14:R168
    Content type: Research article Published on:

  44. The immunological and homing properties of mesenchymal stem cells (MSCs) provide a potentially attractive treatment for arthritis. The objective of this study was to determine effects of genetic disparity on t...

    Authors: Catherine Sullivan, J Mary Murphy, Matthew D Griffin, Ryan M Porter, Christopher H Evans, Cathal O'Flatharta, Georgina Shaw and Frank Barry
    Citation: Arthritis Research & Therapy 2012 14:R167
    Content type: Research article Published on:

  47. Diabetes mellitus is a key predictor of mortality in rheumatoid arthritis (RA) patients. Both RA and diabetes increase the risk of cardiovascular disease (CVD), yet understanding of how comorbid RA impacts the...

    Authors: Christie M Bartels, Jessica M Saucier, Carolyn T Thorpe, Amy JH Kind, Nancy Pandhi, Karen E Hansen and Maureen A Smith
    Citation: Arthritis Research & Therapy 2012 14:R166
    Content type: Research article Published on:

  48. Radiographic descriptions of gout have noted the tendency to hypertrophic bone changes. The aim of this study was to characterize the features of new bone formation (NBF) in gout, and to determine the relation...

    Authors: Nicola Dalbeth, Aaron Milligan, Anthony J Doyle, Barnaby Clark and Fiona M McQueen
    Citation: Arthritis Research & Therapy 2012 14:R165
    Content type: Research article Published on:

  49. Although renal pathology is highly predictive of the disease course in lupus nephritis, it cannot be performed serially because of its invasive nature and associated morbidity. The goal of this study is to inv...

    Authors: Sandeep Singh, Tianfu Wu, Chun Xie, Kamala Vanarsa, Jie Han, Tina Mahajan, Ho Bing Oei, Chul Ahn, Xin J Zhou, Chaim Putterman, Ramesh Saxena and Chandra Mohan
    Citation: Arthritis Research & Therapy 2012 14:R164
    Content type: Research article Published on:

  50. Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduc...

    Authors: Michael D Wiese, Matthew Schnabl, Catherine O'Doherty, Llewellyn D Spargo, Michael J Sorich, Leslie G Cleland and Susanna M Proudman
    Citation: Arthritis Research & Therapy 2012 14:R163
    Content type: Research article Published on:
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Arthritis Research & Therapy

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