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  1. Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and th...

    Authors: Nicolas Delaleu, Cuong Q Nguyen, Ammon B Peck and Roland Jonsson
    Citation: Arthritis Research & Therapy 2011 13:217
    Content type: Review Published on:

  2. The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout. There is no evidence f...

    Authors: Jade E Hollis-Moffatt, Peter J Gow, Andrew A Harrison, John Highton, Peter BB Jones, Lisa K Stamp, Nicola Dalbeth and Tony R Merriman
    Citation: Arthritis Research & Therapy 2011 13:R85
    Content type: Research article Published on:

  3. Magnetic resonance imaging (MRI) was used to study the hand and wrist in very early rheumatoid arthritis (RA), and the results were compared with early and established disease.

    Authors: Paraskevi E Kosta, Paraskevi V Voulgari, Anastasia K Zikou, Alexandros A Drosos and Maria I Argyropoulou
    Citation: Arthritis Research & Therapy 2011 13:R84
    Content type: Research article Published on:

  4. Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in ...

    Authors: Yvonne C Lee, Jing Cui, Bing Lu, Michelle L Frits, Christine K Iannaccone, Nancy A Shadick, Michael E Weinblatt and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2011 13:R83
    Content type: Research article Published on:

  5. Methotrexate (MTX) has been shown to modify infliximab pharmacokinetics in rheumatoid arthritis. However, its combination with infliximab in the treatment of ankylosing spondylitis (AS) is not recommended. The...

    Authors: Denis Mulleman, Francine Lauféron, Daniel Wendling, David Ternant, Emilie Ducourau, Gilles Paintaud and Philippe Goupille
    Citation: Arthritis Research & Therapy 2011 13:R82
    Content type: Research article Published on:

  7. Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical...

    Authors: Takao Koike
    Citation: Arthritis Research & Therapy 2011 13:113
    Content type: Editorial Published on:

  8. Notochordal cells (NCs) are influential in development of the intervertebral disc (IVD) and species that retain NCs do not degenerate. IVD repair using bone marrow derived mesenchymal stem cells (MSCs) is an a...

    Authors: Devina Purmessur, Rachel M Schek, Rosalyn D Abbott, Bryan A Ballif, Karolyn E Godburn and James C Iatridis
    Citation: Arthritis Research & Therapy 2011 13:R81
    Content type: Research article Published on:

  9. Interferon regulatory factor 5 gene (IRF5) polymorphisms are strongly associated with several diseases, including systemic lupus erythematosus (SLE). The association includes risk and protective components. They ...

    Authors: Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Tony Kwan, Jacek Majewski, Juan J Gomez-Reino and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2011 13:R80
    Content type: Research article Published on:

  10. MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work ...

    Authors: Kristina Kapinas and Anne M Delany
    Citation: Arthritis Research & Therapy 2011 13:220
    Content type: Review Published on:

  11. Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at th...

    Authors: Kazuo Okamoto and Hiroshi Takayanagi
    Citation: Arthritis Research & Therapy 2011 13:219
    Content type: Review Published on:

  12. Previously, a dominant role of the adaptive immune system in the pathogenesis of Sjögren's syndrome was suspected. Recent advances, however, have revealed a major role of the type I IFN pathway, documented by ...

    Authors: Hui Zhi Low and Torsten Witte
    Citation: Arthritis Research & Therapy 2011 13:218
    Content type: Review Published on:

  13. The translational and predictive value of animal models highly depends on the validity of respective readout parameters. In arthritis research, there has been a shift from sole threshold testing for pain-relat...

    Authors: Michael K Boettger, Johannes Leuchtweis, Hans-Georg Schaible and Manuela Schmidt
    Citation: Arthritis Research & Therapy 2011 13:R79
    Content type: Research article Published on:

  14. The primary objectives were to explore the associations between a comprehensive ultrasonographic (US) assessment of joints, tendons and bursae and previously described reduced joint counts (7-, 12-, 28- and 44...

    Authors: Hilde Berner Hammer and Tore K Kvien
    Citation: Arthritis Research & Therapy 2011 13:R78
    Content type: Research article Published on:

  17. Structural changes of bone and cartilage are a hallmark of inflammatory joint diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Despite certain similaritie...

    Authors: Georg Schett, Laura C Coates, Zoe R Ash, Stefanie Finzel and Phillip G Conaghan
    Citation: Arthritis Research & Therapy 2011 13(Suppl 1):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  18. Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes...

    Authors: Ferdinand C Breedveld and Bernard Combe
    Citation: Arthritis Research & Therapy 2011 13(Suppl 1):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  19. Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are immune-mediated conditions that share an inflammatory mechanism fuelled by excessive cytokines, particularly TNF. Contro...

    Authors: Josef S Smolen and Paul Emery
    Citation: Arthritis Research & Therapy 2011 13(Suppl 1):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  21. The purpose of this study was to elucidate the effects of histone deacetylase inhibition on the phenotype and function of dendritic cells and on arthritis in SKG mice.

    Authors: Kenta Misaki, Akio Morinobu, Jun Saegusa, Shimpei Kasagi, Masaaki Fujita, Yoshiaki Miyamoto, Fumichika Matsuki and Shunichi Kumagai
    Citation: Arthritis Research & Therapy 2011 13:R77
    Content type: Research article Published on:

  22. Endothelin-1, a vasoconstrictor peptide, influences cartilage metabolism mainly via endothelin receptor type A (ETA). Along with the inflammatory nonapeptide vasodilator bradykinin (BK), which acts via bradyki...

    Authors: Gabriel N Kaufman, Charlotte Zaouter, Barthélémy Valteau, Pierre Sirois and Florina Moldovan
    Citation: Arthritis Research & Therapy 2011 13:R76
    Content type: Research article Published on:

  23. Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to ...

    Authors: Hans-Peter Tony, Gerd Burmester, Hendrik Schulze-Koops, Mathias Grunke, Joerg Henes, Ina Kötter, Judith Haas, Leonore Unger, Svjetlana Lovric, Marion Haubitz, Rebecca Fischer-Betz, Gamal Chehab, Andrea Rubbert-Roth, Christof Specker, Jutta Weinerth, Julia Holle…
    Citation: Arthritis Research & Therapy 2011 13:R75
    Content type: Research article Published on:

  24. Antinuclear antibodies (ANAs), usually detected by indirect immunofluorescence on HEp-2 cells, are identified in 90% of patients with systemic sclerosis (SSc). Thus, approximately 10% of SSc patients have no r...

    Authors: Guillaume Bussone, Hanadi Dib, Mathieu C Tamby, Cedric Broussard, Christian Federici, Geneviève Woimant, Luc Camoin, Loïc Guillevin and Luc Mouthon
    Citation: Arthritis Research & Therapy 2011 13:R74
    Content type: Research article Published on:

  25. Biosimilars are protein products that are sufficiently similar to a biopharmaceutical already approved by a regulatory agency. Several biotechnology companies and generic drug manufacturers in Asia and Europe ...

    Authors: Jonathan Kay
    Citation: Arthritis Research & Therapy 2011 13:112
    Content type: Commentary Published on:

  26. The presence of anti-topoisomerase I (topo I) antibodies is a classic scleroderma (SSc) marker presumably associated with a unique clinical subset. Here the clinical association of anti-topo I was reevaluated ...

    Authors: Minoru Satoh, Malgorzata E Krzyszczak, Yi Li, Angela Ceribelli, Steven J Ross, Edward KL Chan, Mark S Segal, Michael R Bubb, Eric S Sobel and Westley H Reeves
    Citation: Arthritis Research & Therapy 2011 13:R73
    Content type: Research article Published on:

  27. The aim of this study was to investigate whether serum biomarker levels of C2C, C1,2C, CS846, and CPII can predict the long-term course of disease activity and radiographic progression early in the disease cou...

    Authors: Marije F Bakker, Suzanne MM Verstappen, Paco MJ Welsing, Johannes WG Jacobs, Zalima N Jahangier, Maaike J van der Veen, Johannes WJ Bijlsma and Floris PJG Lafeber
    Citation: Arthritis Research & Therapy 2011 13:R70
    Content type: Research article Published on:

  28. Interleukin (IL)-6-type cytokines exert their effects through activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade. The JAK/STAT pathways play an impor...

    Authors: Kiyoshi Migita, Atsumasa Komori, Takafumi Torigoshi, Yumi Maeda, Yasumori Izumi, Yuka Jiuchi, Taiichiro Miyashita, Minoru Nakamura, Satoru Motokawa and Hiromi Ishibashi
    Citation: Arthritis Research & Therapy 2011 13:R72
    Content type: Research article Published on:

  29. High Mobility Group Box 1 (HMGB1) is a nuclear non-histone protein. HMGB1, which is secreted by inflammatory cells and passively released from apoptotic and necrotic cells, may act as a pro-inflammatory mediat...

    Authors: Deena A Abdulahad, Johanna Westra, Johannes Bijzet, Pieter C Limburg, Cees GM Kallenberg and Marc Bijl
    Citation: Arthritis Research & Therapy 2011 13:R71
    Content type: Research article Published on:

  30. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagn...

    Authors: Morten A Karsdal, Thasia Woodworth, Kim Henriksen, Walter P Maksymowych, Harry Genant, Philippe Vergnaud, Claus Christiansen, Tanja Schubert, Per Qvist, Georg Schett, Adam Platt and Anne-Christine Bay-Jensen
    Citation: Arthritis Research & Therapy 2011 13:215
    Content type: Review Published on:

  31. Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) ...

    Authors: Yvonne C Lee, Nicholas J Nassikas and Daniel J Clauw
    Citation: Arthritis Research & Therapy 2011 13:211
    Content type: Review Published on:

  36. The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders.

    Authors: Terrance P O'Hanlon, Lisa G Rider, Lu Gan, Rick Fannin, Richard S Paules, David M Umbach, Clarice R Weinberg, Ruchir R Shah, Deepak Mav, Mark F Gourley and Frederick W Miller
    Citation: Arthritis Research & Therapy 2011 13:R69
    Content type: Research article Published on:

  38. Janus kinase 2 (JAK2) is involved in the downstream activation of signal transducer and activator of transcription 3 (STAT3) and STAT5 and is responsible for transducing signals for several proinflammatory cyt...

    Authors: Kristine L Stump, Lily D Lu, Pawel Dobrzanski, Cynthia Serdikoff, Diane E Gingrich, Ben J Dugan, Thelma S Angeles, Mark S Albom, Mark A Ator, Bruce D Dorsey, Bruce A Ruggeri and Matthew M Seavey
    Citation: Arthritis Research & Therapy 2011 13:R68
    Content type: Research article Published on:

  39. One aim of modern pharmacologic treatment in rheumatoid arthritis (RA) is to prevent joint destruction and reduce the need for surgery. Our purpose was to investigate secular trends in the incidence of primary...

    Authors: Korosh Hekmat, Lennart Jacobsson, Jan-Åke Nilsson, Ingemar F Petersson, Otto Robertsson, Göran Garellick and Carl Turesson
    Citation: Arthritis Research & Therapy 2011 13:R67
    Content type: Research article Published on:

  41. Hyperuricemia is the most important risk factor for gouty arthritis. The quandary is how to predict which patient with asymptomatic hyperuricemia will develop gouty arthritis. Can ultrasonography help identify...

    Authors: Naomi Schlesinger
    Citation: Arthritis Research & Therapy 2011 13:107
    Content type: Editorial Published on:

  42. The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-react...

    Authors: Annica Hedberg, Elin S Mortensen and Ole P Rekvig
    Citation: Arthritis Research & Therapy 2011 13:214
    Content type: Review Published on:

  43. IL-17-producing CD4+ T-helper cells (Th17 cells) have been recognised as important drivers of pathogenesis in a multitude of inflammatory diseases, including arthritis. The cytokines and transcription factors tha...

    Authors: Thomas Kamradt and Hyun-Dong Chang
    Citation: Arthritis Research & Therapy 2011 13:106
    Content type: Commentary Published on:

  44. Our purpose was to test the hypothesis that hyperuricemia is associated with coronary artery calcification (CAC) among a relatively healthy population, and that the extent of calcification is directly proporti...

    Authors: Eswar Krishnan, Bhavik J Pandya, Lorinda Chung and Omar Dabbous
    Citation: Arthritis Research & Therapy 2011 13:R66
    Content type: Research article Published on:

  45. Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA). We re-...

    Authors: Saedis Saevarsdottir, Bo Ding, Kristjan Steinsson, Gerdur Grondal, Helgi Valdimarsson, Lars Alfredsson, Lars Klareskog and Leonid Padyukov
    Citation: Arthritis Research & Therapy 2011 13:R65
    Content type: Research article Published on:

  46. Mesenchymal stem cells (MSC) are highly attractive for use in cartilage regeneration. To date, MSC are usually recruited from subchondral bone marrow using microfracture. Recent data suggest that isolated cell...

    Authors: David Pretzel, Stefanie Linss, Steffen Rochler, Michaela Endres, Christian Kaps, Saifeddin Alsalameh and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2011 13:R64
    Content type: Research article Published on:

  47. Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various systemic symptoms and multiple organ damage. We clarify biological and functional abnormalities in SLE by compar...

    Authors: Hooi-Ming Lee, Hidehiko Sugino, Chieko Aoki and Norihiro Nishimoto
    Citation: Arthritis Research & Therapy 2011 13:R63
    Content type: Research article Published on:

  48. Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and...

    Authors: Jun Wu, Carl Ekman, Andreas Jönsen, Gunnar Sturfelt, Anders A Bengtsson, Anders Gottsäter, Bengt Lindblad, Elisabet Lindqvist, Tore Saxne and Björn Dahlbäck
    Citation: Arthritis Research & Therapy 2011 13:R62
    Content type: Research article Published on:

  49. Systemic sclerosis (SSc) complicated by pulmonary arterial hypertension (PAH) carries a poor prognosis, despite pulmonary vascular dilating therapy. Platelet-derived growth factor receptor-β (PDGFR-β) and epid...

    Authors: Maria J Overbeek, Anco Boonstra, Alexandre E Voskuyl, Madelon C Vonk, Anton Vonk-Noordegraaf, Maria PA van Berkel, Wolter J Mooi, Ben AC Dijkmans, Laurens S Hondema, Egbert F Smit and Katrien Grünberg
    Citation: Arthritis Research & Therapy 2011 13:R61
    Content type: Research article Published on:

  50. Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines. The het...

    Authors: Christian Lood, Martin Stenström, Helena Tydén, Birgitta Gullstrand, Eva Källberg, Tomas Leanderson, Lennart Truedsson, Gunnar Sturfelt, Fredrik Ivars and Anders A Bengtsson
    Citation: Arthritis Research & Therapy 2011 13:R60
    Content type: Research article Published on:
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Arthritis Research & Therapy

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