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  2. TNF inhibitors are currently considered both effective and cost-effective in patients with active rheumatoid arthritis (RA), particularly in patients who have not responded fully to methotrexate. There is subs...

    Authors: David L Scott and Gabrielle Kingsley
    Citation: Arthritis Research & Therapy 2010 12:115
    Content type: Editorial Published on:

  4. We aimed to replicate the strong associations that a recent genome wide association study (GWAS) has found between 16 single nucleotide polymorphisms (SNPs) and response to anti-tumour necrosis factor (TNF) tr...

    Authors: Marian Suarez-Gestal, Eva Perez-Pampin, Manuel Calaza, Juan J Gomez-Reino and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2010 12:R72
    Content type: Research article Published on:

  5. The etiology of the autoimmune disease systemic lupus erythematosus is not known, but aberrant apoptosis and/or insufficient clearance of apoptotic material have been assigned a pivotal role. During apoptosis,...

    Authors: Justin H Fransen, Johan van der Vlag, Jurjen Ruben, Gosse J Adema, Jo H Berden and Luuk B Hilbrands
    Citation: Arthritis Research & Therapy 2010 12:207
    Content type: Review Published on:

  6. An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1β release from leucocytes lies at the heart of a casc...

    Authors: Nathalie Busso and Alexander So
    Citation: Arthritis Research & Therapy 2010 12:206
    Content type: Review Published on:

  8. We determined the contribution of the methylene tetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C gene polymorphisms to the susceptibility to rheumatoid arthritis (RA). We also assessed whether these two MT...

    Authors: Rogelio Palomino-Morales, Carlos Gonzalez-Juanatey, Tomas R Vazquez-Rodriguez, Luis Rodriguez, Jose A Miranda-Filloy, Benjamin Fernandez-Gutierrez, Javier Llorca, Javier Martin and Miguel A Gonzalez-Gay
    Citation: Arthritis Research & Therapy 2010 12:R71
    Content type: Research article Published on:

  11. The association of idiopathic inflammatory myositis (IIM) and malignancies has been reported, but rarely in Asian countries. Our aim was to investigate the risk of cancer among IIM patients without a prior his...

    Authors: Yi-Ju Chen, Chun-Ying Wu, Yu-Lin Huang, Chang-Bi Wang, Jui-Lung Shen and Yun-Ting Chang
    Citation: Arthritis Research & Therapy 2010 12:R70
    Content type: Research article Published on:

  12. Vasculopathy, including altered vasoreactivity and abnormal large vessel biomechanics, is a hallmark of systemic sclerosis (SSc). However, the pathogenic link with other aspects of the disease is less clear. T...

    Authors: Emma C Derrett-Smith, Audrey Dooley, Korsa Khan, Xu Shi-wen, David Abraham and Christopher P Denton
    Citation: Arthritis Research & Therapy 2010 12:R69
    Content type: Research article Published on:

  13. Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory recept...

    Authors: Diego Catalán, Octavio Aravena, Francisca Sabugo, Pamela Wurmann, Lilian Soto, Alexis M Kalergis, Miguel Cuchacovich and Juan C Aguillón
    Citation: Arthritis Research & Therapy 2010 12:R68
    Content type: Research article Published on:

  14. Patients with rheumatoid arthritis (RA) have an increased risk of infection and this risk appears to be higher with anti-TNF (tumor necrosis factor) agents. We pooled data from the cumulative abatacept RA clin...

    Authors: Teresa A Simon, Johan Askling, Diane Lacaille, Jarrod Franklin, Frederick Wolfe, Allison Covucci, Samy Suissa and Marc C Hochberg
    Citation: Arthritis Research & Therapy 2010 12:R67
    Content type: Research article Published on:

  15. Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the periphery and involved tissues of...

    Authors: Yihong Yao, Brandon W Higgs, Laura Richman, Barbara White and Bahija Jallal
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  16. Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems es...

    Authors: Steven A Greenberg
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  17. Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of pl...

    Authors: Lars Rönnblom
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  18. Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells...

    Authors: Angélica M Delgado-Vega, Marta E Alarcón-Riquelme and Sergey V Kozyrev
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  19. Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be an...

    Authors: George D Kalliolias and Lionel B Ivashkiv
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  21. Forkhead box p3 (FoxP3)-expressing regulatory T cells (Tregs) have been clearly implicated in the control of autoimmune disease in murine models. In addition, ectopic expression of FoxP3 conveys a Treg phenoty...

    Authors: Rizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yuzhang Wu and Jianxun Song
    Citation: Arthritis Research & Therapy 2010 12:R66
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2012 14:401

  22. The objective of this study was to model the effects of transforming growth factor beta (TGF-β) and platelet-derived growth factor (PDGF), both present in rheumatoid arthritis (RA) synovia, on the behavior of ...

    Authors: Sanna Rosengren, Maripat Corr and David L Boyle
    Citation: Arthritis Research & Therapy 2010 12:R65
    Content type: Research article Published on:

  23. The aim of the present study was to determine the brain areas associated with fibromyalgia, and whether pretreatment regional cerebral blood flow (rCBF) can predict response to gabapentin treatment.

    Authors: Chie Usui, Kotaro Hatta, Nagafumi Doi, Atsushi Nakanishi, Hiroyuki Nakamura, Kusuki Nishioka and Heii Arai
    Citation: Arthritis Research & Therapy 2010 12:R64
    Content type: Research article Published on:

  24. The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) ≥ 8.0 mg/dL in a six-month trial.

    Authors: Michael A Becker, H Ralph Schumacher, Luis R Espinoza, Alvin F Wells, Patricia MacDonald, Eric Lloyd and Christopher Lademacher
    Citation: Arthritis Research & Therapy 2010 12:R63
    Content type: Research article Published on:

  25. The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rhe...

    Authors: Alejandro Balsa, Arancha Cabezón, Gisela Orozco, Tatiana Cobo, Eugenia Miranda-Carus, Miguel Ángel López-Nevot, José Luis Vicario, Emilio Martín-Mola, Javier Martín and Dora Pascual-Salcedo
    Citation: Arthritis Research & Therapy 2010 12:R62
    Content type: Research article Published on:

  26. Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that mainly affects synovial joints. Biologics directed against tumor-necrosis-factor (TNF)-α are efficacious in the treatment of RA. However, th...

    Authors: Onno J Arntz, Jeroen Geurts, Sharon Veenbergen, Miranda B Bennink, Ben T van den Brand, Shahla Abdollahi-Roodsaz, Wim B van den Berg and Fons A van de Loo
    Citation: Arthritis Research & Therapy 2010 12:R61
    Content type: Research article Published on:

  27. SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases. The purpose of this study was to examine whether inh...

    Authors: Jiu-Cun Wang, Syeling Lai, Xinjian Guo, Xuefeng Zhang, Benoit de Crombrugghe, Sonali Sonnylal, Frank C Arnett and Xiaodong Zhou
    Citation: Arthritis Research & Therapy 2010 12:R60
    Content type: Research article Published on:

  28. The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional...

    Authors: Xuebing Feng, Rongliang Li, Jing Huang, Huayong Zhang, Lina Zhu, Bingzhu Hua, Betty P Tsao and Lingyun Sun
    Citation: Arthritis Research & Therapy 2010 12:R59
    Content type: Research article Published on:

  29. To examine the natural history of subchondral bone cysts and to determine whether knee cartilage loss and risk of joint replacement is higher in knees with cysts, compared with those with bone marrow lesions (...

    Authors: Stephanie K Tanamas, Anita E Wluka, Jean-Pierre Pelletier, Johanne Martel-Pelletier, François Abram, Yuanyuan Wang and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2010 12:R58
    Content type: Research article Published on:

  30. This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception co...

    Authors: Ann W Morgan, James I Robinson, Philip G Conaghan, Stephen G Martin, Elizabeth MA Hensor, Michael D Morgan, Lori Steiner, Henry A Erlich, Hock-Chye Gooi, Anne Barton, Jane Worthington and Paul Emery
    Citation: Arthritis Research & Therapy 2010 12:R57
    Content type: Research article Published on:

  31. Calcium crystals exist in the knee joint fluid of up to 65% of osteoarthritis (OA) patients and the presence of these calcium crystals correlates with the radiographic evidence of hyaline cartilaginous degener...

    Authors: Yubo Sun, David R Mauerhan, Patrick R Honeycutt, Jeffrey S Kneisl, H James Norton, Natalia Zinchenko, Edward N Hanley Jr and Helen E Gruber
    Citation: Arthritis Research & Therapy 2010 12:R56
    Content type: Research article Published on:

  32. Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated the effects of accumulating at least 30 minutes of self-selected l...

    Authors: Kevin R Fontaine, Lora Conn and Daniel J Clauw
    Citation: Arthritis Research & Therapy 2010 12:R55
    Content type: Research article Published on:

  33. An over-expression of CD19 has been shown in B cells of systemic sclerosis (SSc) and B cells are thought to contribute to the induction of skin fibrosis in the tight skin mouse model. The aim was to define the...

    Authors: Silvia Bosello, Maria De Santis, Gina Lama, Cristina Spanò, Cristiana Angelucci, Barbara Tolusso, Gigliola Sica and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2010 12:R54
    Content type: Research article Published on:

  34. Interleukin (IL)-17 is a proinflammatory cytokine that is produced largely by a unique CD4+ T-helper (Th) subset called Th17 cells. The development of Th17 cells is suppressed by interferon (IFN)-γ produced by Th...

    Authors: Kamini Shah, Won-Woo Lee, Seung-Hyun Lee, Sang Hyun Kim, Seong Wook Kang, Joe Craft and Insoo Kang
    Citation: Arthritis Research & Therapy 2010 12:R53
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2010 12:402

  35. The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal musc...

    Authors: Maurizio Vitadello, Andrea Doria, Elena Tarricone, Anna Ghirardello and Luisa Gorza
    Citation: Arthritis Research & Therapy 2010 12:R52
    Content type: Research article Published on:

  36. The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis (GCA).

    Authors: Rogelio J Palomino-Morales, Tomas R Vazquez-Rodriguez, Orlando Torres, Inmaculada C Morado, Santos Castañeda, Jose A Miranda-Filloy, Jose L Callejas-Rubio, Benjamin Fernandez-Gutierrez, Miguel A Gonzalez-Gay and Javier Martin
    Citation: Arthritis Research & Therapy 2010 12:R51
    Content type: Research article Published on:

  37. Glucocorticoid (GC)-induced osteoporosis is a frequent complication in patients with rheumatoid arthritis. However, little information exists about the consequences of GC use in patients with early arthritis. ...

    Authors: Monica Ibañez, Ana M Ortiz, Isabel Castrejón, J Alberto García-Vadillo, Inmaculada Carvajal, Santos Castañeda and Isidoro González-Álvaro
    Citation: Arthritis Research & Therapy 2010 12:R50
    Content type: Research article Published on:

  38. The first few months after symptom onset represents a pathologically distinct phase in rheumatoid arthritis (RA). We used relevant experimental models to define the pathological role of interferon-γ (IFN-γ) du...

    Authors: Charlotte E Page, Shaun Smale, Sara M Carty, Nicholas Amos, Sarah N Lauder, Rhian M Goodfellow, Peter J Richards, Simon A Jones, Nicholas Topley and Anwen S Williams
    Citation: Arthritis Research & Therapy 2010 12:R49
    Content type: Research article Published on:

  39. B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...

    Authors: Stacey R Dillon, Brandon Harder, Kenneth B Lewis, Margaret D Moore, Hong Liu, Thomas R Bukowski, Nels B Hamacher, Megan M Lantry, Mark Maurer, Cecile M Krejsa, Jeff L Ellsworth, Susan Pederson, Keith B Elkon, Mark H Wener, Maria Dall'Era and Jane A Gross
    Citation: Arthritis Research & Therapy 2010 12:R48
    Content type: Research article Published on:

  40. Decreased number and impaired functions of endothelial progenitor cells (EPCs) leading to impaired vasculogenesis have been associated with rheumatoid arthritis (RA). Defective vasculogenesis has also been imp...

    Authors: Zoltán Szekanecz and Alisa E Koch
    Citation: Arthritis Research & Therapy 2010 12:110
    Content type: Editorial Published on:

  41. Applying a cross-sectional analysis to a sample of 2,627 African-American and Caucasian adults aged ≥ 45 years from the Johnston County Osteoarthritis Project, we studied the association between educational at...

    Authors: Leigh F Callahan, Jack Shreffler, Bernadette C Siaton, Charles G Helmick, Britta Schoster, Todd A Schwartz, Jiu-Chiuan Chen, Jordan B Renner and Joanne M Jordan
    Citation: Arthritis Research & Therapy 2010 12:R46
    Content type: Research article Published on:

  42. The repellent factor family of Slit molecules has been described to have repulsive function in the developing nervous system on growing axons expressing the Robo receptors. However, until today no data are ava...

    Authors: Alexandra E Denk, Simone Kaufmann, Klaus Stark, Jörg Schedel, Torsten Lowin, Thomas Schubert and Anja K Bosserhoff
    Citation: Arthritis Research & Therapy 2010 12:R45
    Content type: Research article Published on:

  43. Inflammatory joint destruction in rheumatoid arthritis (RA) may be triggered by autoantibodies, the production of which is supported by autoreactive T cells. Studies on RA and animal models of the disease sugg...

    Authors: Adrienn Angyal, Colt Egelston, Tamás Kobezda, Katalin Olasz, Anna László, Tibor T Glant and Katalin Mikecz
    Citation: Arthritis Research & Therapy 2010 12:R44
    Content type: Research article Published on:

  44. The purpose of this study was to investigate the effectiveness of adalimumab in enthesitis and peripheral arthritis in patients with ankylosing spondylitis (AS).

    Authors: Martin Rudwaleit, Pascal Claudepierre, Martina Kron, Sonja Kary, Robert Wong and Hartmut Kupper
    Citation: Arthritis Research & Therapy 2010 12:R43
    Content type: Research article Published on:

  45. A subgroup of patients with primary Sjögren's Syndrome (SS) and positive anticentromere antibodies (ACA) were recognized as having features intermediate between SS and systemic sclerosis (SSc). Our goal was to...

    Authors: Vasiliki-Kalliopi K Bournia, Konstantina D Diamanti, Panayiotis G Vlachoyiannopoulos and Haralampos M Moutsopoulos
    Citation: Arthritis Research & Therapy 2010 12:R47
    Content type: Research article Published on:

  47. Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly with demographic, functional, occupational, and...

    Authors: Tuulikki Sokka, Hannu Kautiainen, Theodore Pincus, Suzanne MM Verstappen, Amita Aggarwal, Rieke Alten, Daina Andersone, Humeira Badsha, Eva Baecklund, Miguel Belmonte, Jürgen Craig-Müller, Licia Maria Henrique da Mota, Alexander Dimic, Nihal A Fathi, Gianfranco Ferraccioli, Wataru Fukuda…
    Citation: Arthritis Research & Therapy 2010 12:R42
    Content type: Research article Published on:

  48. Pristane-induced arthritis (PIA) in the rat has been described as an animal model of inflammatory arthritis which exhibits features similar to rheumatoid arthritis in humans, such as a chronic, destructive, an...

    Authors: Markus H Hoffmann, Rudolf Hopf, Birgit Niederreiter, Heinz Redl, Josef S Smolen and Günter Steiner
    Citation: Arthritis Research & Therapy 2010 12:R41
    Content type: Research article Published on:

  49. Analysis of autoantibodies (AAB) by indirect immunofluorescence (IIF) is a basic tool for the serological diagnosis of systemic rheumatic disorders. Automation of autoantibody IIF reading including pattern rec...

    Authors: Karl Egerer, Dirk Roggenbuck, Rico Hiemann, Max-Georg Weyer, Thomas Büttner, Boris Radau, Rosemarie Krause, Barbara Lehmann, Eugen Feist and Gerd-Rüdiger Burmester
    Citation: Arthritis Research & Therapy 2010 12:R40
    Content type: Research article Published on:

  50. Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variant...

    Authors: Anne Friesgaard Christensen, Grith Lykke Sørensen, Kim Hørslev-Petersen, Uffe Holmskov, Hanne Merete Lindegaard, Kirsten Junker, Merete Lund Hetland, Kristian Stengaard-Pedersen, Søren Jacobsen, Tine Lottenburger, Torkell Ellingsen, Lis Smedegaard Andersen, Ib Hansen, Henrik Skjødt, Jens Kristian Pedersen, Ulrik Birk Lauridsen…
    Citation: Arthritis Research & Therapy 2010 12:R39
    Content type: Research article Published on:
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Arthritis Research & Therapy

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