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  1. In Switzerland, rituximab (RTX) is licenced for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV) but is frequently used off-label to treat other auto-immune diseases (AID), espec...

    Authors: Alexandre Dumusc, Fahad Alromaih, Matthieu Perreau, Thomas Hügle, Pascal Zufferey and Diana Dan
    Citation: Arthritis Research & Therapy 2023 25:91
    Content type: Research Published on:

  4. To evaluate baseline hemoglobin (Hb) and radiographic progression over time in patients enrolled in the Brigham and Women’s Rheumatoid Arthritis Sequential Study (BRASS) registry.

    Authors: Nancy Shadick, Owen Hagino, Amy Praestgaard, Stefano Fiore, Michael Weinblatt and Gerd Burmester
    Citation: Arthritis Research & Therapy 2023 25:88
    Content type: Research Published on:

  5. Dopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4+ T cells express all the five subtypes of DRs, D1R to D5R. Although CD4+ T cells have been invo...

    Authors: Xiao-Qin Wang, Huan-Huan Cai, Qiao-Wen Deng, Ya-Zhou Chang, Yu-Ping Peng and Yi-Hua Qiu
    Citation: Arthritis Research & Therapy 2023 25:87
    Content type: Research Published on:

  6. The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthr...

    Authors: Marta Valero, Carlos Sánchez-Piedra, Mercedes Freire, María Colazo, Noemí Busquets, Erardo Meriño-Ibarra, Carlos Rodríguez-Lozano, Sara Manrique, Cristina Campos, Fernando Sánchez-Alonso and Isabel Castrejón
    Citation: Arthritis Research & Therapy 2023 25:86
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:210

  7. Insulin resistance affects a substantial proportion of patients with rheumatoid arthritis (RA). Skeletal muscle mitochondrial dysfunction results in the accumulation of lipid intermediates that interfere with ...

    Authors: Douglas R. Moellering, Kelley Smith-Johnston, Christian Kelley, Melissa J. Sammy, Jason Benedict, Guy Brock, Jillian Johnson, Kedryn K. Baskin, Wael N. Jarjour, Martha A. Belury, Peter J. Reiser, Prabhakara R. Nagareddy and Beatriz Y. Hanaoka
    Citation: Arthritis Research & Therapy 2023 25:85
    Content type: Research Published on:

  8. Systemic sclerosis (SSc) is a multi-organ disease with impaired health-related quality of life (HRQoL). The EULAR SSc Impact of Disease (ScleroID) is a newly introduced SSc-specific patient-reported outcome to...

    Authors: Gabriella Nagy, Rucsandra Dobrota, Mike Oliver Becker, Tünde Minier, Cecília Varjú, Gábor Kumánovics, Oliver Distler and László Czirják
    Citation: Arthritis Research & Therapy 2023 25:84
    Content type: Research Published on:

  9. Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate  their effects by decreasing the methylation status...

    Authors: Yulia S. Kehayova, J. Mark Wilkinson, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2023 25:83
    Content type: Research Published on:

  10. Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h.

    Authors: Mudit Bhargava, Chirag Rajkumar Kopp, Shankar Naidu, Deba Prasad Dhibar, Atul Saroch, Alka Khadwal, Tarun Narang, Siddharth Jain, Aastha Khullar, Bidya Leishangthem, Aman Sharma, Susheel Kumar, Shefali Sharma, Sanjay Jain and Varun Dhir
    Citation: Arthritis Research & Therapy 2023 25:82
    Content type: Research Published on:

  11. Previous studies have repeatedly found distinct brain morphometric changes in patients with fibromyalgia (FM), mainly affecting gray and white matter abnormalities in areas related to sensory and affective pai...

    Authors: Benjamin Mosch, Verena Hagena, Stephan Herpertz and Martin Diers
    Citation: Arthritis Research & Therapy 2023 25:81
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:89

  12. Radiographic progression and course of inflammation over 2 years in patients with non-radiographic axial spondyloarthritis (nr-axSpA) from the phase 3, randomized, PREVENT study are reported here.

    Authors: Juergen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip Van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, Désirée van der Heijde, Tingting Zhuang, Anna Stefanska, Aimee Readie, Hanno B. Richards and Atul Deodhar
    Citation: Arthritis Research & Therapy 2023 25:80
    Content type: Research Published on:

  13. Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren’s syndrome (SS) in humans is still controversial. Based on th...

    Authors: Meng Zhao, Feiran Wei, Han Li, Zemin Wang, Shuai Wang, Yangyang Liu, Gaoqiang Fei, You Ge and Pingmin Wei
    Citation: Arthritis Research & Therapy 2023 25:79
    Content type: Research Published on:

  14. Avascular necrosis is a common organ damage in SLE patients, which can influence patients’ life quality. Conflicting results exist in risk factors of AVN in SLE patients. The aim of this study was to illustrat...

    Authors: Cheng Cheng, Can Huang, Zhen Chen, Feng Zhan, Xinwang Duan, Yongfu Wang, Cheng Zhao, Zhenbiao Wu, Jian Xu, Hongbin Li, Min Yang, Rui Wu, Jiuliang Zhao, Shangzhu Zhang, Qian Wang, Xiaomei Leng…
    Citation: Arthritis Research & Therapy 2023 25:78
    Content type: Research Published on:

  15. To describe the clinical phenotype and prognosis of people in the Australian Scleroderma (SSc) Cohort Study with pulmonary arterial hypertension (PAH) with or without interstitial lung disease (ILD).

    Authors: Jessica L. Fairley, Dylan Hansen, Laura Ross, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jennifer Walker, Lauren V. Host, Kathleen Morrisroe, Diane Apostolopoulous, Nava Ferdowsi, Michelle Wilson, Maryam Tabesh, Wendy Stevens and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2023 25:77
    Content type: Research Published on:

  16. Systemic lupus erythematosus (SLE) is an intractable disease characterized by autoantibody production and autoreactive B and T cell proliferation. Although several studies have revealed multiple genetic and en...

    Authors: Koji Kitagori, Takuma Oku, Masaki Wakabayashi, Tomoya Nakajima, Ran Nakashima, Kosaku Murakami, Yoshitaka Hirayama, Yasushi Ishihama, Koichiro Ohmura, Akio Morinobu, Tsuneyo Mimori and Hajime Yoshifuji
    Citation: Arthritis Research & Therapy 2023 25:76
    Content type: Research Published on:

  17. Outdoor air pollution has been found to trigger systemic inflammatory responses and aggravate the activity of certain rheumatic diseases. However, few studies have explored the influence of air pollution on th...

    Authors: Chung-Mao Kao, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen and Hsin-Hua Chen
    Citation: Arthritis Research & Therapy 2023 25:75
    Content type: Research Published on:

  18. Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease, the pathogenesis of which is not clear. Clinical remission, or decreased disease activity, is the aim of treatment for RA. Howe...

    Authors: Jianghua Chen, Shilin Li, Jing Zhu, Wei Su, Congcong Jian, Jie Zhang, Jianhong Wu, Tingting Wang, Weihua Zhang, Fanwei Zeng, Shengjia Chang, Lihua Jia, Jiang Su, Yi Zhao, Jing Wang and Fanxin Zeng
    Citation: Arthritis Research & Therapy 2023 25:74
    Content type: Research Published on:

  19. Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA). Chemokines and the CC chemokine scavenger receptor ACKR2 are upreg...

    Authors: Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes and Gerard Graham
    Citation: Arthritis Research & Therapy 2023 25:73
    Content type: Research Published on:

  20. Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain and function is poorly understood. This study exami...

    Authors: Dale E. Fournier, Matthew A. Veras, Courtney R. Brooks, Diana Quinonez, Magali Millecamps, Laura S. Stone and Cheryle A. Séguin
    Citation: Arthritis Research & Therapy 2023 25:72
    Content type: Research Published on:

  21. Authors: Yuxue Nie, Boyuan Sun, Xin He, Minmin Zheng, Di Wu, Yunjiao Yang, Li Zhang, Wei Bai, Nan Jiang, Lin Qiao, Can Huang, Shuang Zhou, Jiaxin Zhou, Linyi Peng, Jingwen Niu, Mengtao Li…
    Citation: Arthritis Research & Therapy 2023 25:71
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:50

  22. To (i) determine whether sustained disease activity states, as measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS), impact function...

    Authors: Walter P. Maksymowych, Robert D. Inman, Louis Bessette, Proton Rahman, Emmanouil Rampakakis, Odalis Asin-Milan, Meagan Rachich, Anne Marilise Marrache and Allen J. Lehman
    Citation: Arthritis Research & Therapy 2023 25:70
    Content type: Research Published on:

  23. Dermatomyositis (DM) is an acquired autoimmune disease that can cause damage to various organs, including the heart muscle. However, the mechanisms underlying myocardial injury in DM are not yet fully understood.

    Authors: Yue Zhang, Linwei Shan, Dongyu Li, Yinghong Tang, Wei Qian, Jiayi Dai, Mengdi Du, Xiaoxuan Sun, Yinsu Zhu, Qiang Wang and Lei Zhou
    Citation: Arthritis Research & Therapy 2023 25:69
    Content type: Research Published on:

  24. As significant advances in the field of treatment for rheumatoid arthritis (RA), there is a great need to identify the healthcare outcomes such as treatment satisfaction and health-related quality of life (HRQ...

    Authors: Seong-Kyu Kim, Sang-Heon Lee, Jiyu Sun, Soo Hyun Lee, Ja-Young Jeon, Hyun-Jeong Yoo and Jung-Yoon Choe
    Citation: Arthritis Research & Therapy 2023 25:68
    Content type: Research Published on:

  25. AVERT-2 (a phase IIIb, two-stage study) evaluated abatacept + methotrexate versus methotrexate alone, in methotrexate-naive, anti-citrullinated protein antibody-positive patients with early (≤ 6 months), activ...

    Authors: Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W. J. Huizinga, Gustavo Citera, Kuan-Hsiang Gary Huang, Chun Wu, Sean E. Connolly, Yedid Elbez, Robert Wong, Karissa Lozenski and Roy Fleischmann
    Citation: Arthritis Research & Therapy 2023 25:67
    Content type: Research Published on:

  26. Neutrophils have a critical role in the pathogenesis of rheumatoid arthritis (RA) with immune system dysfunction. However, the molecular mechanisms of this process mediated by neutrophils still remain elusive....

    Authors: Tao Chen, Zhen Zhou, Minge Peng, Huifang Hu, Rui Sun, Jiayi Xu, Chenxi Zhu, Yanhong Li, Qiuping Zhang, Yubin Luo, Bin Yang, Lunzhi Dai, Yi Liu, Luis E. Muñoz, Liesu Meng, Martin Herrmann…
    Citation: Arthritis Research & Therapy 2023 25:66
    Content type: Research Published on:

  27. Predicting radiographic progression in axial spondyloarthritis (axSpA) remains limited because of the complex interaction between multiple associated factors and individual variability in real-world settings. ...

    Authors: In-Woon Baek, Seung Min Jung, Yune-Jung Park, Kyung-Su Park and Ki-Jo Kim
    Citation: Arthritis Research & Therapy 2023 25:65
    Content type: Research Published on:

  28. Transforming growth factor beta (TGF-β1) is a multifunctional cytokine that has anti-inflammatory and immunosuppressive effects. TGF-β1 has been linked to cardiovascular disease in the general population. The ...

    Authors: Fuensanta Gómez-Bernal, Juan Carlos Quevedo-Abeledo, María García-González, Yolanda Fernández-Cladera, Agustín F. González-Rivero, Candelaria Martín-González, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2023 25:64
    Content type: Research Published on:

  29. We aimed to explore activation of the Notch signaling pathway in knee-innervating lumbar dorsal root ganglia (DRG) in the course of experimental osteoarthritis (OA) in mice, and its role in knee hyperalgesia.

    Authors: Lai Wang, Shingo Ishihara, Jun Li, Rachel E. Miller and Anne-Marie Malfait
    Citation: Arthritis Research & Therapy 2023 25:63
    Content type: Research Published on:

  30. The p53 isoform Δ133p53β is known to be associated with cancers driven by inflammation. Many of the features associated with the development of inflammation in rheumatoid arthritis (RA) parallel those evident ...

    Authors: Anna K. Wiles, Sunali Mehta, Melanie Millier, Adele G. Woolley, Kunyu Li, Kim Parker, Marina Kazantseva, Michelle Wilson, Katie Young, Sarah Bowie, Sankalita Ray, Tania L. Slatter, Lisa K. Stamp, Paul A. Hessian and Antony W. Braithwaite
    Citation: Arthritis Research & Therapy 2023 25:62
    Content type: Research Published on:

  31. The characteristics of muscle degeneration in individual quadriceps in early knee osteoarthritis (OA) and the association of muscle quantity and quality on knee dysfunction remain unclear. This study aimed to ...

    Authors: Masashi Taniguchi, Yoshihiro Fukumoto, Masahide Yagi, Tetsuya Hirono, Momoko Yamagata, Akihiro Asayama, Shogo Okada, Ryusuke Nakai, Masashi Kobayashi and Noriaki Ichihashi
    Citation: Arthritis Research & Therapy 2023 25:61
    Content type: Research Published on:

  32. Ozoralizumab (OZR), a tumor necrosis factor alpha (TNFα) inhibitor, is a NANOBODY® compound that binds to TNFα and human serum albumin. The main objective of this study was to analyze the pharmacokinetics (PK) of...

    Authors: Tsutomu Takeuchi, Yukihiro Chino, Masafumi Kawanishi, Megumi Nakanishi, Hirotaka Watase, Yoko Mano, Yuri Sato, Saeko Uchida and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2023 25:60
    Content type: Research Published on:

  33. Efforts to develop effective disease-modifying drugs to treat osteoarthritis have so far proved unsuccessful with a number of promising drug candidates from pre-clinical studies failing to show efficacy in cli...

    Authors: Raewyn C. Poulsen, Lekha Jain and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2023 25:59
    Content type: Review Published on:

  34. We examined the association between levothyroxine use and longitudinal MRI biomarkers for thigh muscle mass and composition in at-risk participants for knee osteoarthritis (KOA) and their mediatory role in sub...

    Authors: Bahram Mohajer, Kamyar Moradi, Ali Guermazi, Jennifer S. R. Mammen, David J. Hunter, Frank W. Roemer and Shadpour Demehri
    Citation: Arthritis Research & Therapy 2023 25:58
    Content type: Research Published on:

  36. The objective of this post-hoc analysis was to assess the efficacy and safety of upadacitinib in psoriatic arthritis (PsA) patients with axial involvement.

    Authors: Xenofon Baraliakos, Roberto Ranza, Andrew Östör, Francesco Ciccia, Laura C. Coates, Simona Rednic, Jessica A. Walsh, Kevin Douglas, Tianming Gao, Koji Kato, In-Ho Song, Fabiana Ganz and Atul Deodhar
    Citation: Arthritis Research & Therapy 2023 25:56
    Content type: Research Published on:

  37. Rheumatoid arthritis (RA) is a typical, progressive autoimmune disease. Its occurrence and development are associated with dysregulation of T and B cell numbers. However, the specific immune characteristics of...

    Authors: Rui Su, Baochen Li, Ruihe Wu, Yuhuan Xie, Anqi Gao, Chong Gao, Xiaofeng Li and Caihong Wang
    Citation: Arthritis Research & Therapy 2023 25:55
    Content type: Research Published on:

  38. Lumbar facet joint (LFJ) degeneration is one of the main causes of low back pain (LBP). Mechanical stress leads to the exacerbation of LFJ degeneration, but the underlying mechanism remains unknown. This study...

    Authors: Jinyun Zhao, Chengjun Li, Tian Qin, Yuxin Jin, Rundong He, Yi Sun, Zhide Liu, Tianding Wu, Chunyue Duan, Yong Cao and Jianzhong Hu
    Citation: Arthritis Research & Therapy 2023 25:54
    Content type: Research Published on:

  39. Increasing evidence have demonstrated the N6-methyladenosine (m6A) plays critical roles in osteoarthritis (OA) progression, but the role of m6A in OA has not been completely illuminated. Herein, we investigated t...

    Authors: Wengang Liu, Tao Jiang, Wei Zheng, Jiayuan Zhang, Anan Li, Chao Lu and Zhaowei Lin
    Citation: Arthritis Research & Therapy 2023 25:53
    Content type: Research Published on:

  40. Authors: Arnd Heiligenhaus, Jens Klotsche and Kirsten Minden
    Citation: Arthritis Research & Therapy 2023 25:52
    Content type: Correspondence Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:41

    The Research article to this article has been published in Arthritis Research & Therapy 2020 22:81

  41. To estimate the global prevalence of hip osteoarthritis (HOA) through a systematic review and meta-analysis, and to determine by regression analysis the respective relationships between age and sex, and sex an...

    Authors: Zijuan Fan, Lei Yan, Haifeng Liu, Xiaoke Li, Kenan Fan, Qiang Liu, Jiao Jiao Li and Bin Wang
    Citation: Arthritis Research & Therapy 2023 25:51
    Content type: Research Published on:

  42. Neuropsychiatric involvement is one of the major concerns in systemic lupus erythematosus (SLE). The therapeutic effect of intrathecal treatment of methotrexate and dexamethasone has been investigated in some ...

    Authors: Yuxue Nie, Boyuan Sun, Xin He, Minmin Zheng, Di Wu, Yunjiao Yang, Li Zhang, Wei Bai, Nan Jiang, Lin Qiao, Can Huang, Shuang Zhou, Jiaxin Zhou, Linyi Peng, Jingwen Niu, Mengtao Li…
    Citation: Arthritis Research & Therapy 2023 25:50
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:71

  43. Patients with rheumatoid arthritis (RA) have a rising possibility of acquiring certain kinds of cancers than the general public. The causal risk association between RA and hepatocellular carcinoma (HCC) remain...

    Authors: Yuzhuo Zhang, Yudong Zhang, Peng He, Fan Ge, Zhenyu Huo and Guibin Qiao
    Citation: Arthritis Research & Therapy 2023 25:49
    Content type: Research Published on:

  45. Optical spectral transmission (OST) is a modern diagnostic modality, able to assess the blood-specific absorption of light transmitted through a tissue, promising quantification of inflammation in the finger a...

    Authors: Konstantinos Triantafyllias, Tatjana Marinoska, Caroline Heller, Michele de Blasi, Muthuraman Muthuraman and Andreas Schwarting
    Citation: Arthritis Research & Therapy 2023 25:47
    Content type: Research Published on:

  46. Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. Thi...

    Authors: Yusuke Manabe, Tomohiko Ishibashi, Ryotaro Asano, Shuichi Tonomura, Yuichi Maeda, Daisuke Motooka, Jin Ueda, Masahiro Yanagawa, Yuko Edamoto-Taira, Tomomi Chikaishi-Kirino, Takeshi Masaki, Tadakatsu Inagaki, Shota Nakamura, Yoshinori Katada, Makoto Okazawa, Masashi Narazaki…
    Citation: Arthritis Research & Therapy 2023 25:46
    Content type: Research Published on:

  47. Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pu...

    Authors: Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang and Lin Huang
    Citation: Arthritis Research & Therapy 2023 25:45
    Content type: Research Published on:

  48. The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop interstitial lung disease which remains a clinical challenge. Understandi...

    Authors: Tilia Selldén, Carina Kärrman Mårdh, Martin Joelsson, Jenny Vikgren, Åse Johnsson, Gunilla Larsson, Daniel Glinatsi, Kajsa Stubendorff, Karin Svensson, Inger Gjertsson, Anna Rudin, Anna-Carin Lundell and Anna-Karin Hultgård Ekwall
    Citation: Arthritis Research & Therapy 2023 25:44
    Content type: Research Published on:

  49. To introduce a prospective cohort for rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) and to identify their clinical features in comparison with RA patients without ILD.

    Authors: Hyoungyoung Kim, Soo-Kyung Cho, Yeo-Jin Song, Juyeon Kang, Seung-A Jeong, Hye Won Kim, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae-Hyun Yoo, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Su Jin Hong…
    Citation: Arthritis Research & Therapy 2023 25:43
    Content type: Research Published on:

  50. The roles of gut microbiota in the pathogenesis of SLE have been receiving much attention during recent years. However, it remains unknown how fecal microbiota transplantation (FMT) and microbial metabolites a...

    Authors: Xiaoqing Yi, Cancan Huang, Chuyi Huang, Ming Zhao and Qianjin Lu
    Citation: Arthritis Research & Therapy 2023 25:42
    Content type: Research Published on:
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