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362 result(s) within Volume 16 of Arthritis Research & Therapy

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  1. Dermal vascular smooth muscle cells (DVSMCs) are important for vascular wall fibrosis in microangiopathy of systemic sclerosis (SSc). T helper 17 cell-associated cytokines, particularly interleukin-17A (IL-17A...

    Authors: Mengguo Liu, Ji Yang, Xiaojing Xing, Xiangxiang Cui and Ming Li
    Citation: Arthritis Research & Therapy 2014 16:4223
    Content type: Research article Published on:

  2. Interleukin-7 (IL-7) is a cytokine essential for T-cell lymphopoiesis, survival and polarization with an emerging role in autoimmunity. We previously demonstrated reduced levels of circulating IL-7 in rheumato...

    Authors: Sarah M Churchman, Jehan J El-Jawhari, Agata N Burska, Rekha Parmar, Vincent Goëb, Philip G Conaghan, Paul Emery and Frederique Ponchel
    Citation: Arthritis Research & Therapy 2014 16:511
    Content type: Research article Published on:

  3. Localized scleroderma is an inflammatory disease in its first stages and a fibrotic process in later stages, principally mediated by the transforming growth factor β. To date, there is no standard treatment. T...

    Authors: Marco Rodríguez-Castellanos, Alberto Tlacuilo-Parra, Sergio Sánchez-Enríquez, Ezequiel Vélez-Gómez and Elizabeth Guevara-Gutiérrez
    Citation: Arthritis Research & Therapy 2014 16:510
    Content type: Research article Published on:

  4. Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation ...

    Authors: Wahida Rahman and Anthony H Dickenson
    Citation: Arthritis Research & Therapy 2014 16:509
    Content type: Research article Published on:

  5. Vaccinations are administered to patients to induce a protective immune response, resulting in immunological memory. Preventing infection through the use of vaccines is particularly important in immunocompromi...

    Authors: Zsuzsanna H McMahan and Clifton O Bingham III
    Citation: Arthritis Research & Therapy 2014 16:506
    Content type: Review Published on:

  7. No abstract

    Authors: Patrick H Dessein, Angela J Woodiwiss, Gavin R Norton, Linda Tsang and Ahmed Solomon
    Citation: Arthritis Research & Therapy 2014 16:503
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2013 15:R128

  8. Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro. In this study, we used a posttraumatic osteoarthritis (OA) mouse model to test whether ...

    Authors: Daniel J Leong, Marwa Choudhury, Regina Hanstein, David M Hirsh, Sun Jin Kim, Robert J Majeska, Mitchell B Schaffler, John A Hardin, David C Spray, Mary B Goldring, Neil J Cobelli and Hui B Sun
    Citation: Arthritis Research & Therapy 2014 16:508
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:1

  9. Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other th...

    Authors: Camille Roubille, Jean-Pierre Raynauld, François Abram, Patrice Paiement, Marc Dorais, Philippe Delorme, Louis Bessette, André D Beaulieu, Johanne Martel-Pelletier and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2014 16:507
    Content type: Research article Published on:

  10. High joint loading, knee muscle weakness, and poor proprioceptive acuity are important factors that have been linked to knee osteoarthritis (OA). We previously reported that those with unilateral hip OA and bi...

    Authors: Najia Shakoor, Kharma C Foucher, Markus A Wimmer, Rachel A Mikolaitis-Preuss, Louis F Fogg and Joel A Block
    Citation: Arthritis Research & Therapy 2014 16:455
    Content type: Research article Published on:

  11. Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of this review ...

    Authors: Georg Pongratz and Rainer H Straub
    Citation: Arthritis Research & Therapy 2014 16:504
    Content type: Review Published on:

  12. Marked weakness of the quadriceps muscles is typically observed following injury, surgery or pathology affecting the knee joint. This is partly due to ongoing neural inhibition that prevents the central nervou...

    Authors: David Andrew Rice, Peter John McNair, Gwyn Nancy Lewis and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2014 16:502
    Content type: Research article Published on:

  13. Patients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)—a condition thought to represent early-stage pulmonary arterial vasculopathy. Based ...

    Authors: Scott H Visovatti, Oliver Distler, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Diana Bonderman, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, James R Seibold, Juan-Vicente Torres-Martin, Martin Doelberg, Harbajan Chadha-Boreham, Daniel M Rosenberg, Vallerie V McLaughlin and Dinesh Khanna
    Citation: Arthritis Research & Therapy 2014 16:493
    Content type: Research article Published on:

  14. Joint injury is a potent risk factor for osteoarthritis, the most important musculoskeletal disease affecting humankind. Yet the population incidence of soft tissue knee injury is not well documented. Using he...

    Authors: Jonas B Thorlund, Adam G Culvenor and Charles Ratzlaff
    Citation: Arthritis Research & Therapy 2014 16:499
    Content type: Editorial Published on:

  15. Biosimilars that were not compared in clinical trials with the compound innovator are not true biosimilars (biocopies) and are associated with risks that the clinical rheumatologist should be aware of before g...

    Authors: Morton Scheinberg and Gilberto Castañeda-Hernández
    Citation: Arthritis Research & Therapy 2014 16:501
    Content type: Commentary Published on:

  16. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 ...

    Authors: Irene Arroyo-Villa, María-Belén Bautista-Caro, Alejandro Balsa, Pilar Aguado-Acín, María-Gema Bonilla-Hernán, Chamaida Plasencia, Alejandro Villalba, Laura Nuño, Amaya Puig-Kröger, Emilio Martín-Mola and María-Eugenia Miranda-Carús
    Citation: Arthritis Research & Therapy 2014 16:500
    Content type: Research article Published on:

  17. Members of the peptidylarginine deiminase (PAD) family catalyse the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullination of proteins is well described in rheumatoid arthritis ...

    Authors: Dres Damgaard, Ladislav Senolt, Michael Friberg Nielsen, Ger J Pruijn and Claus H Nielsen
    Citation: Arthritis Research & Therapy 2014 16:498
    Content type: Research article Published on:

  18. This study aimed to investigate rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status and levels as predictors of mortality in two large cohorts of patients with early inflammatory arthr...

    Authors: Jennifer H Humphreys, Jessica AB van Nies, Jackie Chipping, Tarnya Marshall, Annette HM van der Helm-van Mil, Deborah PM Symmons and Suzanne MM Verstappen
    Citation: Arthritis Research & Therapy 2014 16:483
    Content type: Research article Published on:

  19. Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjögren’s syndrome (SjS) are inflammatory systemic autoimmune diseases (SADs) that share several clinical and pathological features. The shared...

    Authors: Daniel Toro-Domínguez, Pedro Carmona-Sáez and Marta E Alarcón-Riquelme
    Citation: Arthritis Research & Therapy 2014 16:489
    Content type: Research article Published on:

  20. The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene express...

    Authors: Yinxian Wen, Jing Li, Linlong Wang, Kai Tie, Jacques Magdalou, Liaobin Chen and Hui Wang
    Citation: Arthritis Research & Therapy 2014 16:484
    Content type: Research article Published on:

  21. Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone lo...

    Authors: Neha Dixit, Dennis J Wu, Yesser H Belgacem, Laura N Borodinsky, M Eric Gershwin and Iannis E Adamopoulos
    Citation: Arthritis Research & Therapy 2014 16:496
    Content type: Research article Published on:

  22. Polymyalgia rheumatica (PMR) is a common inflammatory disease in older people characterized by shoulder and/or pelvic girdle, and cervical and, occasionally, lumbar pain. Interspinous bursitis has been suggest...

    Authors: Dario Camellino, Francesco Paparo, Silvia Morbelli, Maurizio Cutolo, Gianmario Sambuceti and Marco A Cimmino
    Citation: Arthritis Research & Therapy 2014 16:492
    Content type: Research article Published on:

  23. The aim of this study was to investigate PD-1/PD-L1 involvement in the hyporesponsiveness of rheumatoid arthritis (RA) synovial fluid (SF) CD4 T cells upon stimulation by thymic stromal lymphopoietin (TSLP)–pr...

    Authors: Frederique M Moret, Kim MG van der Wurff-Jacobs, Johannes WJ Bijlsma, Floris PJG Lafeber and Joel AG van Roon
    Citation: Arthritis Research & Therapy 2014 16:497
    Content type: Research article Published on:

  24. Prior studies have established altered microbiota and immunologic reactivity to enteric commensal organisms in inflammatory bowel disease (IBD). Since intestinal inflammation is present in a subset of patients...

    Authors: Matthew L Stoll, Ranjit Kumar, Casey D Morrow, Elliot J Lefkowitz, Xiangqin Cui, Anna Genin, Randy Q Cron and Charles O Elson
    Citation: Arthritis Research & Therapy 2014 16:486
    Content type: Research article Published on:

  25. Gout results from an innate immune response to monosodium urate (MSU) crystals deposited in joints. Increased very low-density lipoprotein (VLDL) has been associated with gout. The apolipoprotein B (apo B), wh...

    Authors: Humaira Rasheed, Angela Hsu, Nicola Dalbeth, Lisa K Stamp, Sally McCormick and Tony R Merriman
    Citation: Arthritis Research & Therapy 2014 16:495
    Content type: Research article Published on:

  26. The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of ...

    Authors: Yoshitaka Kawanishi, Tomoyuki Nakasa, Takeshi Shoji, Michio Hamanishi, Ryo Shimizu, Naosuke Kamei, Muhammad Andry Usman and Mitsuo Ochi
    Citation: Arthritis Research & Therapy 2014 16:488
    Content type: Research article Published on:

  27. In clinical practice, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly discontinued after response to biologic therapy is achieved in patients with axial spondyloarthritis (axSpA), but the impact of ...

    Authors: Maxime Dougados, Emily Wood, Bernard Combe, Thierry Schaeverbeke, Corinne Miceli-Richard, Francis Berenbaum, Nandan Koppiker, Arnaud Dubanchet and Isabelle Logeart
    Citation: Arthritis Research & Therapy 2014 16:481
    Content type: Research article Published on:

  28. To investigate if decreased histone deacetylase 4 (HDAC4) is associated with human osteoarthritis (OA) cartilage degeneration by releasing HDAC4 inhibition of runt-related transcription factor-2 (Runx2) result...

    Authors: Kun Cao, Lei Wei, Zhiqiang Zhang, Li Guo, Congming Zhang, Yongping Li, Changqi Sun, Xiaojuan Sun, Shaowei Wang, Pengcui Li and Xiaochun Wei
    Citation: Arthritis Research & Therapy 2014 16:491
    Content type: Research article Published on:

  29. The identification of well-defined phenotypes along the course of the disease may open new avenues for personalized management in osteoarthritis (OA). In vivo research carried out in various animal models as well...

    Authors: Jorge A Roman-Blas and Gabriel Herrero-Beaumont
    Citation: Arthritis Research & Therapy 2014 16:494
    Content type: Editorial Published on:

  30. Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels. Neurotrophins (NTs) and their receptors (NTRs) are protein factors for growth,...

    Authors: Kim Heang Ly, Alexis Régent, Elsa Molina, Sofiane Saada, Philippe Sindou, Claire Le-Jeunne, Antoine Brézin, Véronique Witko-Sarsat, François Labrousse, Pierre-Yves Robert, Philippe Bertin, Jean-Louis Bourges, Anne-Laure Fauchais, Elisabeth Vidal, Luc Mouthon and Marie-Odile Jauberteau
    Citation: Arthritis Research & Therapy 2014 16:487
    Content type: Research article Published on:

  33. Repetitive episodes of ischemia and reperfusion (I/R) are a cardinal feature of the pathogenesis of systemic sclerosis (SSc), which precedes tissue fibrosis. The complement system is a key mediator of tissue d...

    Authors: Michael Osthoff, Gene-Siew Ngian, Melinda M Dean, Mandana Nikpour, Wendy Stevens, Susanna Proudman, Damon P Eisen and Joanne Sahhar
    Citation: Arthritis Research & Therapy 2014 16:480
    Content type: Research article Published on:

  34. Activated platelets exert a proinflammatory action that can be largely ascribed to their ability to interact with monocytes. However, the mechanisms that promote dynamic changes in monocyte subsets in rheumato...

    Authors: Meng-yao Rong, Cong-hua Wang, Zhen-biao Wu, Wen Zeng, Zhao-hui Zheng, Qing Han, Jun-feng Jia, Xue-yi Li and Ping Zhu
    Citation: Arthritis Research & Therapy 2014 16:478
    Content type: Research article Published on:

  35. Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the...

    Authors: Koji Takayama, Yohei Kawakami, Makoto Kobayashi, Nick Greco, James H Cummins, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu and Johnny Huard
    Citation: Arthritis Research & Therapy 2014 16:482
    Content type: Research article Published on:

  36. Progression of arterial involvement is often observed in patients with Takayasu arteritis (TA) thought to be in remission. This reflects the failure of currently used biomarkers and activity criteria to detect...

    Authors: Enrico Tombetti, Maria Chiara Di Chio, Silvia Sartorelli, Maurizio Papa, Annalaura Salerno, Barbara Bottazzi, Enrica Paola Bozzolo, Marta Greco, Patrizia Rovere-Querini, Elena Baldissera, Alessandro Del Maschio, Alberto Mantovani, Francesco De Cobelli, Maria Grazia Sabbadini and Angelo A Manfredi
    Citation: Arthritis Research & Therapy 2014 16:479
    Content type: Research article Published on:

  37. Insulin resistance (IR) is a general phenomenon of many physiological states, disease states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis, trauma, painful states such a...

    Authors: Rainer H Straub
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  38. The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in regulating and controlling immune responses. Dysfunction of the HPA axis has been implicated in the pathogenesis of rheumatoid arthritis...

    Authors: Cornelia M Spies, Rainer H Straub, Maurizio Cutolo and Frank Buttgereit
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  39. Glucocorticoids play a pivotal role in the management of many inflammatory rheumatic diseases. The therapeutic effects range from pain relief in arthritides, to disease-modifying effects in early rheumatoid ar...

    Authors: Marlies C van der Goes, Johannes W Jacobs and Johannes W Bijlsma
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  40. The management of rheumatoid arthritis (RA) is primarily based on the use of disease-modifying antirheumatic drugs (DMARDs), mainly comprising synthetic chemical compounds (that is, methotrexate or leflunomide...

    Authors: Maurizio Cutolo, Cornelia M Spies, Frank Buttgereit, Sabrina Paolino and Carmen Pizzorni
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  42. Systemic lupus erythematosus (SLE) is an autoimmune disease associated with a break in self-tolerance reflected by a production of antinuclear autoantibodies. Since autoantibody production can be activated via...

    Authors: Julia Sieber, Capucine Daridon, Sarah J Fleischer, Vanessa Fleischer, Falk Hiepe, Tobias Alexander, Guido Heine, Gerd R Burmester, Simon Fillatreau and Thomas Dörner
    Citation: Arthritis Research & Therapy 2014 16:477
    Content type: Research article Published on:

  43. This study was performed to develop ultrasound composite scores for the assessment of inflammatory and structural lesions in Psoriatic Arthritis (PsA).

    Authors: Anja Ficjan, Rusmir Husic, Judith Gretler, Angelika Lackner, Winfried B Graninger, Marwin Gutierrez, Christina Duftner, Josef Hermann and Christian Dejaco
    Citation: Arthritis Research & Therapy 2014 16:476
    Content type: Research article Published on:

  44. Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports sugg...

    Authors: Christian Gytz Ammitzbøll, Rudi Steffensen, Martin Bøgsted, Kim Hørslev-Petersen, Merete L Hetland, Peter Junker, Julia S Johansen, Jan Pødenphant, Mikkel Østergaard, Torkell Ellingsen and Kristian Stengaard-Pedersen
    Citation: Arthritis Research & Therapy 2014 16:475
    Content type: Research article Published on:

  45. The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis.

    Authors: Lenka Pleštilová, Heřman Mann, Lucie Andrés Cerezo, Ondřej Pecha, Jiří Vencovský and Ladislav Šenolt
    Citation: Arthritis Research & Therapy 2014 16:468
    Content type: Research article Published on:

  46. OX40 and its ligand OX40L are key components in the generation of adaptive memory response and provide necessary co-stimulatory signals for activated effector T cells. Here we investigate the dual roles of the...

    Authors: Julie K Laustsen, Tue K Rasmussen, Kristian Stengaard-Pedersen, Kim Hørslev-Petersen, Merete L Hetland, Mikkel Østergaard, Peter Junker, Malene Hvid and Bent Deleuran
    Citation: Arthritis Research & Therapy 2014 16:474
    Content type: Research article Published on:

  47. Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC...

    Authors: Ine Vanderleyden, Michelle A Linterman and Kenneth GC Smith
    Citation: Arthritis Research & Therapy 2014 16:471
    Content type: Review Published on:

  48. Proinflammatory cytokines are major mediators in the pathogenesis of diseases of joints such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory cytokines such as tumor necr...

    Authors: Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2014 16:470
    Content type: Review Published on:

  49. Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humani...

    Authors: William P Kennedy, J Abraham Simon, Carolyn Offutt, Priscilla Horn, Ann Herman, Michael J Townsend, Meina T Tang, Jane L Grogan, Frank Hsieh and John C Davis
    Citation: Arthritis Research & Therapy 2014 16:467
    Content type: Research article Published on:

  50. Immune checkpoint regulators are critical modulators of the immune system, allowing the initiation of a productive immune response and preventing the onset of autoimmunity. Co-inhibitory and co-stimulatory imm...

    Authors: Sabrina Ceeraz, Elizabeth C Nowak, Christopher M Burns and Randolph J Noelle
    Citation: Arthritis Research & Therapy 2014 16:469
    Content type: Review Published on:
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Arthritis Research & Therapy

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