Zhao Q, Eberspaecher H, Lefebvre V, De Crombrugghe B: Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev Dyn. 1997, 209: 377-386. 10.1002/(SICI)1097-0177(199708)209:4<377::AID-AJA5>3.0.CO;2-F.
Article
CAS
PubMed
Google Scholar
Buckwalter JA, Saltzman C, Brown T: The impact of osteoarthritis: implications for research. Clin Orthop Relat Res. 2004, S6-15. 10.1097/01.blo.0000143938.30681.9d.
Google Scholar
Aigner T, McKenna L: Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci. 2002, 59: 5-18. 10.1007/s00018-002-8400-3.
Article
CAS
PubMed
Google Scholar
Aigner T, Gebhard PM, Schmid E, Bau B, Harley V, Poschl E: SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes. Matrix Biol. 2003, 22: 363-372. 10.1016/S0945-053X(03)00049-0.
Article
CAS
PubMed
Google Scholar
Brew CJ, Andrew JG, Boot-Handford R, Hardingham TE: Late osteoarthritic cartilage shows down regulation of SOX9 and aggrecan expression but little evidence of chondrocyte hypertrophy. Trans Orthop Res Soc. 2004, 50: 938-
Google Scholar
Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M: SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem. 2000, 275: 10738-10744. 10.1074/jbc.275.15.10738.
Article
CAS
PubMed
Google Scholar
Zhang P, Jimenez SA, Stokes DG: Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9. J Biol Chem. 2003, 278: 117-123. 10.1074/jbc.M208049200.
Article
CAS
PubMed
Google Scholar
Bridgewater LC, Lefebvre V, de Crombrugghe B: Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem. 1998, 273: 14998-15006. 10.1074/jbc.273.24.14998.
Article
CAS
PubMed
Google Scholar
Kou I, Ikegawa S: SOX9-dependent and -independent transcriptional regulation of human cartilage link protein. J Biol Chem. 2004, 279: 50942-50948. 10.1074/jbc.M406786200.
Article
CAS
PubMed
Google Scholar
Wagner T, Wirth J, Meyer J, Zabel B, Held M, Zimmer J, Pasantes J, Bricarelli FD, Keutel J, Hustert E, et al: Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell. 1994, 79: 1111-1120. 10.1016/0092-8674(94)90041-8.
Article
CAS
PubMed
Google Scholar
Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B: Sox9 is required for cartilage formation. Nat Genet. 1999, 22: 85-89. 10.1038/8792.
Article
CAS
PubMed
Google Scholar
Stokes DG, Liu G, Dharmavaram R, Hawkins D, Piera-Velazquez S, Jimenez SA: Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem J. 2001, 360: 461-470. 10.1042/0264-6021:3600461.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hardingham T, Tew S, Murdoch A: Tissue engineering: chondrocytes and cartilage. Arthritis Res. 2002, 4 (Suppl 3): S63-68. 10.1186/ar561.
Article
PubMed Central
PubMed
Google Scholar
Li Y, Tew SR, Russell AM, Gonzalez K, Hardingham TE, Hawkins RE: Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Eng. 2004, 10: 575-584. 10.1089/107632704323061933.
Article
CAS
PubMed
Google Scholar
Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE: Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage. 2005, 13: 80-89. 10.1016/j.joca.2004.10.011.
Article
PubMed
Google Scholar
Lefebvre V, Huang W, Harley VR, Goodfellow PN, de Crombrugghe B: SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol. 1997, 17: 2336-2346.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kellgren JH, Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957, 16: 494-502.
Article
PubMed Central
CAS
PubMed
Google Scholar
MAXD. [http://www.bioinf.manchester.ac.uk/microarray/maxd/]
Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP: Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 2002, 30: e15-10.1093/nar/30.4.e15.
Article
PubMed Central
PubMed
Google Scholar
MIAMExpress. [http://www.ebi.ac.uk/miamexpress/]
Reno C, Marchuk L, Sciore P, Frank CB, Hart DA: Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. Biotechniques. 1997, 22: 1082-1086.
CAS
PubMed
Google Scholar
Flannery CR, Little CB, Caterson B, Hughes CE: Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Matrix Biol. 1999, 18: 225-237. 10.1016/S0945-053X(99)00024-4.
Article
CAS
PubMed
Google Scholar
Al-Taher A, Bashein A, Nolan T, Hollingsworth M, Brady G: Global cDNA amplification combined with real-time RT-PCR: accurate quantification of multiple human potassium channel genes at the single cell level. Yeast. 2000, 17: 201-210. 10.1002/1097-0061(20000930)17:3<201::AID-YEA30>3.0.CO;2-R.
Article
PubMed Central
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Vista browser. [http://pipeline.lbl.gov/cgi-bin/gateway2]
Loots GG, Ovcharenko I, Pachter L, Dubchak I, Rubin EM: rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res. 2002, 12: 832-839. 10.1101/gr.225502. Article published online before print in April 2002.
Article
PubMed Central
PubMed
Google Scholar
Liacini A, Sylvester J, Li WQ, Zafarullah M: Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes. Arthritis Res Ther. 2005, 7: R777-783. 10.1186/ar1735.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, Nakamura K, Kawaguchi H, Ikegawa S, Chung UI: The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum. 2004, 50: 3561-3573. 10.1002/art.20611.
Article
CAS
PubMed
Google Scholar
Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H: S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep. 2007
Google Scholar
Shi J, Schmitt-Talbot E, DiMattia DA, Dullea RG: The differential effects of IL-1 and TNF-alpha on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells. Inflamm Res. 2004, 53: 377-389. 10.1007/s00011-004-1271-3.
Article
CAS
PubMed
Google Scholar
Schaefer JF, Millham ML, de Crombrugghe B, Buckbinder L: FGF signaling antagonizes cytokine-mediated repression of Sox9 in SW1353 chondrosarcoma cells. Osteoarthritis Cartilage. 2003, 11: 233-241. 10.1016/S1063-4584(02)00354-0.
Article
CAS
PubMed
Google Scholar
Tsuda M, Takahashi S, Takahashi Y, Asahara H: Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. J Biol Chem. 2003, 278: 27224-27229. 10.1074/jbc.M303471200.
Article
CAS
PubMed
Google Scholar
Gebauer M, Saas J, Sohler F, Haag J, Soder S, Pieper M, Bartnik E, Beninga J, Zimmer R, Aigner T: Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta. Osteoarthritis Cartilage. 2005, 13: 697-708. 10.1016/j.joca.2005.04.004.
Article
CAS
PubMed
Google Scholar
Fielding PE, Fielding CJ: A cholesteryl ester transfer complex in human plasma. Proc Natl Acad Sci USA. 1980, 77: 3327-3330. 10.1073/pnas.77.6.3327.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeng C, Spielman AI, Vowels BR, Leyden JJ, Biemann K, Preti G: A human axillary odorant is carried by apolipoprotein D. Proc Natl Acad Sci USA. 1996, 93: 6626-6630. 10.1073/pnas.93.13.6626.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J: Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum. 2004, 50: 2521-2530. 10.1002/art.20441.
Article
CAS
PubMed
Google Scholar
Gebauer M, Saas J, Haag J, Dietz U, Takigawa M, Bartnik E, Aigner T: Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage. Arthritis Res Ther. 2005, 7: R274-284. 10.1186/ar1479.
Article
PubMed Central
CAS
PubMed
Google Scholar
Most P, Bernotat J, Ehlermann P, Pleger ST, Reppel M, Borries M, Niroomand F, Pieske B, Janssen PM, Eschenhagen T, et al: S100A1: a regulator of myocardial contractility. Proc Natl Acad Sci USA. 2001, 98: 13889-13894. 10.1073/pnas.241393598.
Article
PubMed Central
CAS
PubMed
Google Scholar
Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T: A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. Hum Mol Genet. 1995, 4: 2339-2346. 10.1093/hmg/4.12.2339.
Article
CAS
PubMed
Google Scholar
Ihanamaki T, Saamanen AM, Suominen J, Pelliniemi LJ, Harley V, Vuorio E, Salminen H: Expression of Sox9 and type IIA procollagen during ocular development and aging in transgenic Del1 mice with a mutation in the type II collagen gene. Eur J Ophthalmol. 2002, 12: 450-458.
CAS
PubMed
Google Scholar
Qin Y, Kong LK, Poirier C, Truong C, Overbeek PA, Bishop CE: Long-range activation of Sox9 in Odd Sex (Ods) mice. Hum Mol Genet. 2004, 13: 1213-1218. 10.1093/hmg/ddh141.
Article
CAS
PubMed
Google Scholar
Elson GC, Lelievre E, Guillet C, Chevalier S, Plun-Favreau H, Froger J, Suard I, de Coignac AB, Delneste Y, Bonnefoy JY, et al: CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci. 2000, 3: 867-872. 10.1038/78765.
Article
CAS
PubMed
Google Scholar
Lelievre E, Plun-Favreau H, Chevalier S, Froger J, Guillet C, Elson GC, Gauchat JF, Gascan H: Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J Biol Chem. 2001, 276: 22476-22484. 10.1074/jbc.M101681200.
Article
CAS
PubMed
Google Scholar